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Compile Data Set for Download or QSAR

Found 66 hits of ph data with Target = 'Arginase-1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Arginase-1


(Homo sapiens)
BDBM290365
PNG
((1S,2S)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)
Show SMILES N[C@]1(CCC[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H18BNO4/c11-9(8(12)13)5-1-3-7(9)4-2-6-10(14)15/h7,14-15H,1-6,11H2,(H,12,13)/t7-,9+/m1/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290366
PNG
((1S,2R)-1-amino-2-(3-boronopropyl)cyclopentanecarb...)
Show SMILES N[C@]1(CCC[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H18BNO4/c11-9(8(12)13)5-1-3-7(9)4-2-6-10(14)15/h7,14-15H,1-6,11H2,(H,12,13)/t7-,9-/m0/s1
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n/an/a>5.00E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290367
PNG
((2R,3S)-3-amino-2-(3-boronopropyl)tetrahydrofuran-...)
Show SMILES N[C@]1(CCO[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H16BNO5/c10-8(7(11)12)3-5-15-6(8)2-1-4-9(13)14/h6,13-14H,1-5,10H2,(H,11,12)/t6-,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290368
PNG
((2S,3S)-3-amino-2-(3-boronopropyl)tetrahydrofuran-...)
Show SMILES N[C@]1(CCO[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H16BNO5/c10-8(7(11)12)3-5-15-6(8)2-1-4-9(13)14/h6,13-14H,1-5,10H2,(H,11,12)/t6-,8-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290369
PNG
(3-amino-2-(3-boronopropyl)tetrahydrothiophene-3-ca...)
Show SMILES NC1(CCSC1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H16BNO4S/c10-8(7(11)12)3-5-15-6(8)2-1-4-9(13)14/h6,13-14H,1-5,10H2,(H,11,12)
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n/an/a 1.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290370
PNG
((3R,4S)-4-amino-3-(3-boronopropyl)piperidine-4-car...)
Show SMILES N[C@]1(CCNC[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H19BN2O4/c11-9(8(13)14)3-5-12-6-7(9)2-1-4-10(15)16/h7,12,15-16H,1-6,11H2,(H,13,14)/t7-,9+/m1/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290371
PNG
((3S,4S)-4-amino-3-(3-boronopropyl)piperidine-4-car...)
Show SMILES N[C@]1(CCNC[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H19BN2O4/c11-9(8(13)14)3-5-12-6-7(9)2-1-4-10(15)16/h7,12,15-16H,1-6,11H2,(H,13,14)/t7-,9-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290372
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)5-11-4-6(8)2-1-3-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290373
PNG
((3R,4R)-3-amino-4-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CNC[C@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)5-11-4-6(8)2-1-3-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8+/m1/s1
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n/an/a 1.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290374
PNG
((2R,3S)-3-amino-2-(3-boronopropyl)pyrrolidine-3-ca...)
Show SMILES N[C@]1(CCN[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C8H17BN2O4/c10-8(7(12)13)3-5-11-6(8)2-1-4-9(14)15/h6,11,14-15H,1-5,10H2,(H,12,13)/t6-,8+/m1/s1
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n/an/a>5.00E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290375
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-isobutylpyrro...)
Show SMILES CC(C)CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C12H25BN2O4/c1-9(2)6-15-7-10(4-3-5-13(18)19)12(14,8-15)11(16)17/h9-10,18-19H,3-8,14H2,1-2H3,(H,16,17)/t10-,12-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290376
PNG
((3R,4S)-3-amino-1-benzyl-4-(3-boronopropyl)pyrroli...)
Show SMILES N[C@]1(CN(Cc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C15H23BN2O4/c17-15(14(19)20)11-18(9-12-5-2-1-3-6-12)10-13(15)7-4-8-16(21)22/h1-3,5-6,13,21-22H,4,7-11,17H2,(H,19,20)/t13-,15-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290377
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyridin-3- y...)
Show SMILES N[C@]1(CN(Cc2cccnc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H22BN3O4/c16-14(13(19)20)10-18(8-11-3-2-6-17-7-11)9-12(14)4-1-5-15(21)22/h2-3,6-7,12,21-22H,1,4-5,8-10,16H2,(H,19,20)/t12-,14-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290378
PNG
((3R,4S)-3-amino-1-(2-aminocyclopentyl)-4-(3- boron...)
Show SMILES NC1CCCC1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C13H26BN3O4/c15-10-4-1-5-11(10)17-7-9(3-2-6-14(20)21)13(16,8-17)12(18)19/h9-11,20-21H,1-8,15-16H2,(H,18,19)/t9-,10?,11?,13-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290379
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(piperidin)-4...)
Show SMILES N[C@]1(CN(CC2CCNCC2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)10-18(8-11-3-6-17-7-4-11)9-12(14)2-1-5-15(21)22/h11-12,17,21-22H,1-10,16H2,(H,19,20)/t12-,14-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290380
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(3-(4- carbox...)
Show SMILES N[C@]1(CN(CCCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H27BN2O4/c19-17(16(21)22)13-20(12-15(17)9-4-10-18(23)24)11-5-8-14-6-2-1-3-7-14/h1-3,6-7,15,23-24H,4-5,8-13,19H2,(H,21,22)/t15-,17-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290381
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(3-(dimethyla...)
Show SMILES CN(C)CC(C)(C)CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C15H32BN3O4/c1-14(2,9-18(3)4)10-19-8-12(6-5-7-16(22)23)15(17,11-19)13(20)21/h12,22-23H,5-11,17H2,1-4H3,(H,20,21)/t12-,15-/m0/s1
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n/an/a 3.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290382
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(piperidin-3-...)
Show SMILES N[C@]1(CN(CC2CCCNC2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)10-18(8-11-3-2-6-17-7-11)9-12(14)4-1-5-15(21)22/h11-12,17,21-22H,1-10,16H2,(H,19,20)/t11?,12-,14-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290383
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(quinolin-4- ...)
Show SMILES N[C@]1(CN(Cc2ccnc3ccccc23)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H24BN3O4/c20-18(17(23)24)12-22(11-14(18)4-3-8-19(25)26)10-13-7-9-21-16-6-2-1-5-15(13)16/h1-2,5-7,9,14,25-26H,3-4,8,10-12,20H2,(H,23,24)/t14-,18-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290384
PNG
((3R,4S)-1-((1H-imidazol-4-yl)methyl)-3-amino-4-(3-...)
Show SMILES N[C@]1(CN(Cc2c[nH]cn2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C12H21BN4O4/c14-12(11(18)19)7-17(6-10-4-15-8-16-10)5-9(12)2-1-3-13(20)21/h4,8-9,20-21H,1-3,5-7,14H2,(H,15,16)(H,18,19)/t9-,12-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290385
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(piperidin-2-...)
Show SMILES N[C@]1(CN(CC2CCCCN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)10-18(9-12-5-1-2-7-17-12)8-11(14)4-3-6-15(21)22/h11-12,17,21-22H,1-10,16H2,(H,19,20)/t11-,12?,14-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290386
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(3-(4- chloro...)
Show SMILES N[C@]1(CN(CCCc2ccc(Cl)cc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H26BClN2O4/c19-15-7-5-13(6-8-15)3-2-10-21-11-14(4-1-9-18(24)25)17(20,12-21)16(22)23/h5-8,14,24-25H,1-4,9-12,20H2,(H,22,23)/t14-,17-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290387
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(7H-purin-6-y...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)c1ncnc2nc[nH]c12)C(O)=O
Show InChI InChI=1S/C13H19BN6O4/c15-13(12(21)22)5-20(4-8(13)2-1-3-14(23)24)11-9-10(17-6-16-9)18-7-19-11/h6-8,23-24H,1-5,15H2,(H,21,22)(H,16,17,18,19)/t8-,13-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290388
PNG
((3R,4S)-3-amino-1-(2-aminoethyl)-4-(3-boronopropyl...)
Show SMILES NCCN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C10H22BN3O4/c12-4-5-14-6-8(2-1-3-11(17)18)10(13,7-14)9(15)16/h8,17-18H,1-7,12-13H2,(H,15,16)/t8-,10-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290389
PNG
(5-((3R,4S)-3-amino-4-(3-boronopropyl)-3-carboxypyr...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)c1cccnc1)C(O)=O
Show InChI InChI=1S/C13H20BN3O4/c15-13(12(18)19)9-17(11-4-2-6-16-7-11)8-10(13)3-1-5-14(20)21/h2,4,6-7,10,20-21H,1,3,5,8-9,15H2,(H,18,19)/t10-,13-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290390
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(piperidin-4-...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C1CCNCC1)C(O)=O
Show InChI InChI=1S/C13H26BN3O4/c15-13(12(18)19)9-17(11-3-6-16-7-4-11)8-10(13)2-1-5-14(20)21/h10-11,16,20-21H,1-9,15H2,(H,18,19)/t10-,13-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290391
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1,3'-bipyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C1CCNC1)C(O)=O
Show InChI InChI=1S/C12H24BN3O4/c14-12(11(17)18)8-16(10-3-5-15-6-10)7-9(12)2-1-4-13(19)20/h9-10,15,19-20H,1-8,14H2,(H,17,18)/t9-,10?,12-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290392
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(piperidin-3-...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C1CCCNC1)C(O)=O
Show InChI InChI=1S/C13H26BN3O4/c15-13(12(18)19)9-17(11-4-2-6-16-7-11)8-10(13)3-1-5-14(20)21/h10-11,16,20-21H,1-9,15H2,(H,18,19)/t10-,11?,13-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290393
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyridin-2- y...)
Show SMILES N[C@]1(CN(Cc2ccccn2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H22BN3O4/c16-14(13(19)20)10-18(9-12-5-1-2-7-17-12)8-11(14)4-3-6-15(21)22/h1-2,5,7,11,21-22H,3-4,6,8-10,16H2,(H,19,20)/t11-,14-/m0/s1
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n/an/a 1.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290394
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(4- carboxycy...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C1CCCCC1)C(O)=O
Show InChI InChI=1S/C14H27BN2O4/c16-14(13(18)19)10-17(12-6-2-1-3-7-12)9-11(14)5-4-8-15(20)21/h11-12,20-21H,1-10,16H2,(H,18,19)/t11-,14-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290395
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methyl-1H...)
Show SMILES Cn1ccnc1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C13H23BN4O4/c1-17-6-5-16-11(17)8-18-7-10(3-2-4-14(21)22)13(15,9-18)12(19)20/h5-6,10,21-22H,2-4,7-9,15H2,1H3,(H,19,20)/t10-,13-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290396
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(4-methylpyri...)
Show SMILES Cc1ccncc1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C14H22BN3O4/c1-10-4-6-17-7-12(10)18-8-11(3-2-5-15(21)22)14(16,9-18)13(19)20/h4,6-7,11,21-22H,2-3,5,8-9,16H2,1H3,(H,19,20)/t11-,14-/m0/s1
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n/an/a 1.50E+3n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290397
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(piperidin...)
Show SMILES N[C@]1(CN(CCN2CCCCC2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C15H30BN3O4/c17-15(14(20)21)12-19(10-9-18-7-2-1-3-8-18)11-13(15)5-4-6-16(22)23/h13,22-23H,1-12,17H2,(H,20,21)/t13-,15-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290398
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2- (diethyla...)
Show SMILES CCN(CC)CCN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C14H30BN3O4/c1-3-17(4-2)8-9-18-10-12(6-5-7-15(21)22)14(16,11-18)13(19)20/h12,21-22H,3-11,16H2,1-2H3,(H,19,20)/t12-,14-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290399
PNG
((3R,4S)-4-(3-boronopropyl)-3-(methylamino)pyrrolid...)
Show SMILES CN[C@]1(CNC[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C9H19BN2O4/c1-11-9(8(13)14)6-12-5-7(9)3-2-4-10(15)16/h7,11-12,15-16H,2-6H2,1H3,(H,13,14)/t7-,9-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290400
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((1-methylpip...)
Show SMILES CN1CCCCC1CN1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C15H30BN3O4/c1-18-8-3-2-6-13(18)10-19-9-12(5-4-7-16(22)23)15(17,11-19)14(20)21/h12-13,22-23H,2-11,17H2,1H3,(H,20,21)/t12-,13?,15-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290401
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(pyrrolidin-2...)
Show SMILES N[C@]1(CN(CC2CCCN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C13H26BN3O4/c15-13(12(18)19)9-17(8-11-4-2-6-16-11)7-10(13)3-1-5-14(20)21/h10-11,16,20-21H,1-9,15H2,(H,18,19)/t10-,11?,13-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290402
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(pyrrolidi...)
Show SMILES N[C@]1(CN(CCN2CCCC2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-14(13(19)20)11-18(9-8-17-6-1-2-7-17)10-12(14)4-3-5-15(21)22/h12,21-22H,1-11,16H2,(H,19,20)/t12-,14-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290403
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(((S)-1,2,3,4...)
Show SMILES N[C@]1(CN(C[C@@H]2Cc3ccccc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H28BN3O4/c20-18(17(23)24)12-22(10-15(18)6-3-7-19(25)26)11-16-8-13-4-1-2-5-14(13)9-21-16/h1-2,4-5,15-16,21,25-26H,3,6-12,20H2,(H,23,24)/t15-,16-,18-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290404
PNG
((3R,4S)-3-amino-1-(2-(benzylamino)ethyl)-4-(3- bor...)
Show SMILES N[C@]1(CN(CCNCc2ccccc2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H28BN3O4/c19-17(16(22)23)13-21(12-15(17)7-4-8-18(24)25)10-9-20-11-14-5-2-1-3-6-14/h1-3,5-6,15,20,24-25H,4,7-13,19H2,(H,22,23)/t15-,17-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290405
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(3,4- dich...)
Show SMILES N[C@]1(CN(CCNCc2ccc(Cl)c(Cl)c2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C17H26BCl2N3O4/c19-14-4-3-12(8-15(14)20)9-22-6-7-23-10-13(2-1-5-18(26)27)17(21,11-23)16(24)25/h3-4,8,13,22,26-27H,1-2,5-7,9-11,21H2,(H,24,25)/t13-,17-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290406
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(4- chlorophe...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)Nc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C15H21BClN3O5/c17-11-3-5-12(6-4-11)19-14(23)20-8-10(2-1-7-16(24)25)15(18,9-20)13(21)22/h3-6,10,24-25H,1-2,7-9,18H2,(H,19,23)(H,21,22)/t10-,15-/m0/s1
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Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290407
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((S)-pyrrolid...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)C1CCCN1)C(O)=O
Show InChI InChI=1S/C13H24BN3O5/c15-13(12(19)20)8-17(11(18)10-4-2-6-16-10)7-9(13)3-1-5-14(21)22/h9-10,16,21-22H,1-8,15H2,(H,19,20)/t9-,10?,13-/m0/s1
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US Patent
n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290408
PNG
((3R,4S)-3-amino-1-(2-aminocyclohexyl)-4-(3- borono...)
Show SMILES NC1CCCCC1N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C14H28BN3O4/c16-11-5-1-2-6-12(11)18-8-10(4-3-7-15(21)22)14(17,9-18)13(19)20/h10-12,21-22H,1-9,16-17H2,(H,19,20)/t10-,11?,12?,14-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290409
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(2-(4- chloro...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)Cc1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C16H22BClN2O5/c18-13-5-3-11(4-6-13)8-14(21)20-9-12(2-1-7-17(24)25)16(19,10-20)15(22)23/h3-6,12,24-25H,1-2,7-10,19H2,(H,22,23)/t12-,16-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290410
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(4- fluoroben...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C15H20BFN2O5/c17-12-5-3-10(4-6-12)13(20)19-8-11(2-1-7-16(23)24)15(18,9-19)14(21)22/h3-6,11,23-24H,1-2,7-9,18H2,(H,21,22)/t11-,15-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290411
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(4- methoxybe...)
Show SMILES COc1ccc(cc1)C(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C16H23BN2O6/c1-25-13-6-4-11(5-7-13)14(20)19-9-12(3-2-8-17(23)24)16(18,10-19)15(21)22/h4-7,12,23-24H,2-3,8-10,18H2,1H3,(H,21,22)/t12-,16-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290412
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-(4- fluorophe...)
Show SMILES N[C@]1(CN(C[C@@H]1CCCB(O)O)C(=O)Nc1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C15H21BFN3O5/c17-11-3-5-12(6-4-11)19-14(23)20-8-10(2-1-7-16(24)25)15(18,9-20)13(21)22/h3-6,10,24-25H,1-2,7-9,18H2,(H,19,23)(H,21,22)/t10-,15-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290413
PNG
((3R,4S)-3-amino-4-(3-boronopropyl)-1-((7-chloro-1,...)
Show SMILES N[C@]1(CN(CC2Cc3ccc(Cl)cc3CN2)C[C@@H]1CCCB(O)O)C(O)=O
Show InChI InChI=1S/C18H27BClN3O4/c20-15-4-3-12-7-16(22-8-13(12)6-15)10-23-9-14(2-1-5-19(26)27)18(21,11-23)17(24)25/h3-4,6,14,16,22,26-27H,1-2,5,7-11,21H2,(H,24,25)/t14-,16?,18-/m0/s1
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n/an/a<250n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
Arginase-1


(Homo sapiens)
BDBM290414
PNG
((3R,4S)-3-amino-1-(2-aminophenylsulfonyl)-4-(3- bo...)
Show SMILES Nc1ccccc1S(=O)(=O)N1C[C@H](CCCB(O)O)[C@@](N)(C1)C(O)=O
Show InChI InChI=1S/C14H22BN3O6S/c16-11-5-1-2-6-12(11)25(23,24)18-8-10(4-3-7-15(21)22)14(17,9-18)13(19)20/h1-2,5-6,10,21-22H,3-4,7-9,16-17H2,(H,19,20)/t10-,14-/m0/s1
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n/an/a 625n/an/an/an/a7.425



Mars, Incorporated

US Patent


Assay Description
Inhibition of arginase I (ARG I) and arginase II (ARG II) by Formula I or Formula II compounds is followed spectrophotometrically at 530 nm. The comp...


US Patent US10098902 (2018)

More data for this
Ligand-Target Pair
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