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Found 5 hits of ph data with Target = 'Bcl2-antagonist of cell death (BAD)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bcl2-antagonist of cell death (BAD)


(Homo sapiens)
BDBM50424738
PNG
(CHEMBL2314516 | US10093640, Example 1)
Show SMILES OC(=O)c1sc2ccccc2c1CCCOc1cccc2ccccc12
Show InChI InChI=1S/C22H18O3S/c23-22(24)21-18(17-10-3-4-13-20(17)26-21)11-6-14-25-19-12-5-8-15-7-1-2-9-16(15)19/h1-5,7-10,12-13H,6,11,14H2,(H,23,24)
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Similars

US Patent
n/an/a 5.80E+3n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...


US Patent US10093646 (2018)

More data for this
Ligand-Target Pair
Bcl2-antagonist of cell death (BAD)


(Homo sapiens)
BDBM50424727
PNG
(CHEMBL2314173 | US10093640, Example 2)
Show SMILES Cc1cc(OCCCc2c(sc3ccccc23)C(O)=O)cc(C)c1Cl
Show InChI InChI=1S/C20H19ClO3S/c1-12-10-14(11-13(2)18(12)21)24-9-5-7-16-15-6-3-4-8-17(15)25-19(16)20(22)23/h3-4,6,8,10-11H,5,7,9H2,1-2H3,(H,22,23)
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US Patent
n/an/a 1.90E+3n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...


US Patent US10093646 (2018)

More data for this
Ligand-Target Pair
Bcl2-antagonist of cell death (BAD)


(Homo sapiens)
BDBM50424737
PNG
(CHEMBL2314519 | US10093640, Example 21)
Show SMILES OC(=O)c1oc2ccccc2c1CCCOc1cccc2ccccc12
Show InChI InChI=1S/C22H18O4/c23-22(24)21-18(17-10-3-4-12-20(17)26-21)11-6-14-25-19-13-5-8-15-7-1-2-9-16(15)19/h1-5,7-10,12-13H,6,11,14H2,(H,23,24)
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US Patent
n/an/a 4.60E+3n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...


US Patent US10093646 (2018)

More data for this
Ligand-Target Pair
Bcl2-antagonist of cell death (BAD)


(Homo sapiens)
BDBM50424726
PNG
(CHEMBL2314176 | US10093640, Example 6)
Show SMILES Cc1cc(OCCCc2c(sc3cc(Cl)ccc23)C(O)=O)cc(C)c1Cl
Show InChI InChI=1S/C20H18Cl2O3S/c1-11-8-14(9-12(2)18(11)22)25-7-3-4-16-15-6-5-13(21)10-17(15)26-19(16)20(23)24/h5-6,8-10H,3-4,7H2,1-2H3,(H,23,24)
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UniProtKB/SwissProt

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UniChem

Similars

US Patent
n/an/a 990n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...


US Patent US10093646 (2018)

More data for this
Ligand-Target Pair
Bcl2-antagonist of cell death (BAD)


(Homo sapiens)
BDBM50424725
PNG
(CHEMBL2314177 | US10093640, Example 5)
Show SMILES OC(=O)c1sc2cc(Cl)ccc2c1CCCOc1cccc2ccccc12
Show InChI InChI=1S/C22H17ClO3S/c23-15-10-11-17-18(21(22(24)25)27-20(17)13-15)8-4-12-26-19-9-3-6-14-5-1-2-7-16(14)19/h1-3,5-7,9-11,13H,4,8,12H2,(H,24,25)
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PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.10E+3n/an/an/an/a7.525



Novartis AG

US Patent


Assay Description
Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...


US Patent US10093646 (2018)

More data for this
Ligand-Target Pair