Compile Data Set for Download or QSAR
maximum 50k data
Found 160 of ph data with Target = 'Bile acid receptor'
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28541(Azepino[4,5-b]indole, 6l | propan-2-yl 3-[(4-fluor...)
Affinity DataEC50:  8nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28542(WAY-362450 | XL335 | propan-2-yl 3-[(3,4-difluorop...)
Affinity DataEC50:  4nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28539(Azepino[4,5-b]indole, 6j | ethyl 3-[(4-chloropheny...)
Affinity DataEC50:  25nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28538(Azepino[4,5-b]indole, 6i | FXR_5 | ethyl 3-[(3,4-d...)
Affinity DataEC50:  12nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28537(Azepino[4,5-b]indole, 6h | ethyl 3-[(4-fluoropheny...)
Affinity DataEC50:  22nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28536(Azepino[4,5-b]indole, 6g | ethyl 3-[(3,4-difluorop...)
Affinity DataEC50:  32nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28535(Azepino[4,5-b]indole, 6f | ethyl 3-[(4-methoxyphen...)
Affinity DataEC50:  60nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28534(Azepino[4,5-b]indole, 6e | ethyl 3-[(4-chloropheny...)
Affinity DataEC50:  73nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28533(Azepino[4,5-b]indole, 6d | ethyl 3-[(4-fluoropheny...)
Affinity DataEC50:  57nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28532(Azepino[4,5-b]indole, 6c | butyl 3-[(4-fluoropheny...)
Affinity DataEC50:  1.10E+3nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28531(Azepino[4,5-b]indole, 6b | propyl 3-[(4-fluorophen...)
Affinity DataEC50:  500nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28530(Azepino[4,5-b]indole, 6a | propan-2-yl 3-[(4-fluor...)
Affinity DataEC50:  500nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28529(Azepino[4,5-b]indole, 1 | ethyl 3-[(4-fluorophenyl...)
Affinity DataEC50:  600nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM30328(MFA-3)
Affinity DatapH: 7.0 T: 2°CAssay Description:To each well of a 96-well assay plate, assay buffer was added containing purified GST-FXR, Eu-labeled anti-GST antibody (Perkin-Elmer), streptavidin-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  8.30E+3nMpH: 7.0 T: 2°CAssay Description:To each well of a 96-well assay plate, assay buffer was added containing purified GST-FXR, Eu-labeled anti-GST antibody (Perkin-Elmer), streptavidin-...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM30327(MFA-2)
Affinity DataEC50:  509nMpH: 7.0 T: 2°CAssay Description:To each well of a 96-well assay plate, assay buffer was added containing purified GST-FXR, Eu-labeled anti-GST antibody (Perkin-Elmer), streptavidin-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM30326(MFA-1)
Affinity DataEC50:  16.9nMpH: 7.0 T: 2°CAssay Description:To each well of a 96-well assay plate, assay buffer was added containing purified GST-FXR, Eu-labeled anti-GST antibody (Perkin-Elmer), streptavidin-...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28540(Azepino[4,5-b]indole, 6k | ethyl 3-[(4-methoxyphen...)
Affinity DataEC50:  29nMpH: 7.0 T: 2°CAssay Description:The assays were performed using CV-1 African Green Monkey Kidney cells transfected with the vectors harboring human FXR, RXR, and luciferase reporter...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21723(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(4-pheny...)
Affinity DataEC50:  3.70E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  2.70E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21724(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(1...)
Affinity DataEC50:  70nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21725((1S,2R,10R,11S,14Z,15S)-14-ethylidene-2,15-dimethy...)
Affinity DataEC50:  1.20E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21722(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(naphtha...)
Affinity DataEC50:  4.00E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21721(3-[(4-{[5-tert-butyl-3-(2,6-dichlorophenyl)-1,2-ox...)
Affinity DataEC50:  1.30E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21720(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(4...)
Affinity DataEC50:  3.39E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21719(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(n...)
Affinity DataEC50:  2.22E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21718(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-ph...)
Affinity DataEC50:  1.58E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21717(3-[(E)-2-(4-{[5-tert-butyl-3-(2,6-dichlorophenyl)-...)
Affinity DataEC50:  1.30E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21716(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-...)
Affinity DataEC50:  840nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21715(3-[benzyl(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  2.50E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21714(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-...)
Affinity DataEC50:  2.10E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21713(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-...)
Affinity DataEC50:  3.10E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21712(3-[(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-...)
Affinity DataEC50:  3.00E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21711(Isoxazole derivative, 11b | N,N-dibenzyl-3-[(E)-2-...)
Affinity DataEC50:  3.51E+4nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21710(3-[(E)-2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(p...)
Affinity DataEC50:  9.00E+3nMpH: 7.2 T: 2°CAssay Description:Compounds were screened for agonist/antagonist activity on FXR-GAL4 chimeric receptors in transiently transfected HEK-293 cells. The EC50/IC50 values...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21679((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-e...)
Affinity DataEC50:  1.18E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21678((2S,4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-5,9...)
Affinity DataEC50:  1.16E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21677((2R,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50:  1.05E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21676((2S,4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-di...)
Affinity DataEC50: >1.00E+5nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  1.30E+4nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  361nMpH: 7.2 T: 2°CAssay Description:To evaluate FXR activity of compounds, COS1 (ATCC) cells were transfected with hFXR expression plasmid, mouse retinoid X receptor expression plasmid,...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM225913(FXR_1)
Affinity DataIC50:  5.61E+4nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM225914(FXR_2)
Affinity DataIC50:  4.64E+3nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM225915(FXR_3)
Affinity DataIC50:  2.63E+5nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM225916(FXR_4)
Affinity DataIC50:  7.19E+3nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM28538(Azepino[4,5-b]indole, 6i | FXR_5 | ethyl 3-[(3,4-d...)
Affinity DataIC50:  1.42E+3nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM225917(FXR_6)
Affinity DataIC50:  59.6nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM225918(FXR_7)
Affinity DataIC50:  239nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM225919(FXR_8)
Affinity DataIC50:  5.24E+3nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBile acid receptor(Homo sapiens (Human))
Exelixis

LigandPNGBDBM225920(FXR_9)
Affinity DataIC50:  6.25E+3nMpH: 7.4Assay Description:The assay buffer contained 50 mM HEPES (pH 7.4), 10 mM NaCl, 5 mM MgCl2 and 0.01% CHAPS. The reactions were incubated for 30 min in the presence of [...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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