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Compile Data Set for Download or QSAR

Found 305 hits of ph data with Target = 'Bromodomain-containing protein 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149947
PNG
(US8975417, 3)
Show SMILES Cc1c2C(N(C(=O)c2nn1C)c1ccc(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H17ClN4O2/c1-11-16-17(21-23(11)3)19(26)24(14-8-9-15(25)22(2)10-14)18(16)12-4-6-13(20)7-5-12/h4-10,18H,1-3H3
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US Patent
n/an/a 580n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149949
PNG
(US8975417, 5)
Show SMILES Cc1[nH]nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C18H14Cl2N4O2/c1-9-14-15(22-21-9)18(26)24(12-7-13(20)17(25)23(2)8-12)16(14)10-3-5-11(19)6-4-10/h3-8,16H,1-2H3,(H,21,22)
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n/an/a 730n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149950
PNG
(US8975417, 6)
Show SMILES Cc1c2C(N(C(=O)c2nn1C)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H16Cl2N4O2/c1-10-15-16(22-24(10)3)19(27)25(13-8-14(21)18(26)23(2)9-13)17(15)11-4-6-12(20)7-5-11/h4-9,17H,1-3H3
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n/an/a 350n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149951
PNG
(US8975417, 7)
Show SMILES Cc1c2[C@H](N(C(=O)c2nn1C)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H16Cl2N4O2/c1-10-15-16(22-24(10)3)19(27)25(13-8-14(21)18(26)23(2)9-13)17(15)11-4-6-12(20)7-5-11/h4-9,17H,1-3H3/t17-/m1/s1
PDB

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n/an/a 100n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149952
PNG
(US8975417, 8)
Show SMILES Cc1c2[C@@H](N(C(=O)c2nn1C)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H16Cl2N4O2/c1-10-15-16(22-24(10)3)19(27)25(13-8-14(21)18(26)23(2)9-13)17(15)11-4-6-12(20)7-5-11/h4-9,17H,1-3H3/t17-/m0/s1
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US Patent
n/an/a 3.60E+4n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149953
PNG
(US8975417, 9)
Show SMILES Cn1cc(cc(Cl)c1=O)N1C(c2c[nH]nc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H12Cl2N4O2/c1-22-8-11(6-13(19)16(22)24)23-15(9-2-4-10(18)5-3-9)12-7-20-21-14(12)17(23)25/h2-8,15H,1H3,(H,20,21)
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n/an/a 210n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149954
PNG
(US8975417, 10)
Show SMILES Cn1cc2C(N(C(=O)c2n1)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14Cl2N4O2/c1-22-8-12(7-14(20)17(22)25)24-16(10-3-5-11(19)6-4-10)13-9-23(2)21-15(13)18(24)26/h3-9,16H,1-2H3
PDB

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n/an/a 150n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149955
PNG
(US8975417, 11)
Show SMILES Cn1cc2[C@H](N(C(=O)c2n1)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14Cl2N4O2/c1-22-8-12(7-14(20)17(22)25)24-16(10-3-5-11(19)6-4-10)13-9-23(2)21-15(13)18(24)26/h3-9,16H,1-2H3/t16-/m1/s1
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n/an/a 140n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149956
PNG
(US8975417, 12)
Show SMILES Cn1cc2[C@@H](N(C(=O)c2n1)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14Cl2N4O2/c1-22-8-12(7-14(20)17(22)25)24-16(10-3-5-11(19)6-4-10)13-9-23(2)21-15(13)18(24)26/h3-9,16H,1-2H3/t16-/m0/s1
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n/an/a>3.70E+4n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149957
PNG
(US8975417, 13)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2cn(C)nc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H17ClN4O2/c1-11-8-14(9-22(2)18(11)25)24-17(12-4-6-13(20)7-5-12)15-10-23(3)21-16(15)19(24)26/h4-10,17H,1-3H3
PDB

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US Patent
n/an/a 180n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149959
PNG
(US8975417, 15)
Show SMILES Cc1cc(cn(C)c1=O)N1[C@H](c2cn(C)nc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H17ClN4O2/c1-11-8-14(9-22(2)18(11)25)24-17(12-4-6-13(20)7-5-12)15-10-23(3)21-16(15)19(24)26/h4-10,17H,1-3H3/t17-/m0/s1
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n/an/a>6.70E+3n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149960
PNG
(US8975417, 16)
Show SMILES Cc1cc(cn(C)c1=O)N1[C@@H](c2cn(C)nc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H17ClN4O2/c1-11-8-14(9-22(2)18(11)25)24-17(12-4-6-13(20)7-5-12)15-10-23(3)21-16(15)19(24)26/h4-10,17H,1-3H3/t17-/m1/s1
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n/an/a 100n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149961
PNG
(US8975417, 17)
Show SMILES Cc1c2C(N(C(=O)c2nn1C1CC1)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-17-18(24-27(11)14-7-8-14)21(29)26(15-9-16(23)20(28)25(2)10-15)19(17)12-3-5-13(22)6-4-12/h3-6,9-10,14,19H,7-8H2,1-2H3
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n/an/a 180n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149962
PNG
(US8975417, 18)
Show SMILES Cc1c2[C@@H](N(C(=O)c2nn1C1CC1)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-17-18(24-27(11)14-7-8-14)21(29)26(15-9-16(23)20(28)25(2)10-15)19(17)12-3-5-13(22)6-4-12/h3-6,9-10,14,19H,7-8H2,1-2H3/t19-/m0/s1
PDB

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n/an/a 3.00E+4n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149963
PNG
(US8975417, 19)
Show SMILES Cc1c2[C@H](N(C(=O)c2nn1C1CC1)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-17-18(24-27(11)14-7-8-14)21(29)26(15-9-16(23)20(28)25(2)10-15)19(17)12-3-5-13(22)6-4-12/h3-6,9-10,14,19H,7-8H2,1-2H3/t19-/m1/s1
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n/an/a 78n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149964
PNG
(US8975417, 20)
Show SMILES Cc1c2C(N(C(=O)c2nn1C1CC1)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClN4O2/c1-12-10-17(11-25(3)21(12)28)26-20(14-4-6-15(23)7-5-14)18-13(2)27(16-8-9-16)24-19(18)22(26)29/h4-7,10-11,16,20H,8-9H2,1-3H3
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US Patent
n/an/a 130n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149965
PNG
(US8975417, 21)
Show SMILES Cc1c2[C@H](N(C(=O)c2nn1C1CC1)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClN4O2/c1-12-10-17(11-25(3)21(12)28)26-20(14-4-6-15(23)7-5-14)18-13(2)27(16-8-9-16)24-19(18)22(26)29/h4-7,10-11,16,20H,8-9H2,1-3H3/t20-/m1/s1
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n/an/a 48n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149966
PNG
(US8975417, 22)
Show SMILES Cc1c2[C@@H](N(C(=O)c2nn1C1CC1)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H21ClN4O2/c1-12-10-17(11-25(3)21(12)28)26-20(14-4-6-15(23)7-5-14)18-13(2)27(16-8-9-16)24-19(18)22(26)29/h4-7,10-11,16,20H,8-9H2,1-3H3/t20-/m0/s1
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n/an/a>6.70E+3n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149967
PNG
(US8975417, 23)
Show SMILES CC1=C2C(N(C(=O)C2=[N](N1)C1CC1)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H22ClN4O2/c1-12-10-17(11-25(3)21(12)28)26-19(14-4-6-15(23)7-5-14)18-13(2)24-27(16-8-9-16)20(18)22(26)29/h4-7,10-11,16,19,24H,8-9H2,1-3H3
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n/an/a 99n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149968
PNG
(US8975417, 24)
Show SMILES Cc1nn(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-17-18(12-3-5-13(22)6-4-12)26(15-9-16(23)20(28)25(2)10-15)21(29)19(17)27(24-11)14-7-8-14/h3-6,9-10,14,18H,7-8H2,1-2H3
PDB

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US Patent
n/an/a 230n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149969
PNG
(US8975417, 25)
Show SMILES Cc1nnc2ccc(cn12)N1C(c2c(C)n(C)nc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H17ClN6O/c1-11-17-18(24-25(11)3)20(28)27(19(17)13-4-6-14(21)7-5-13)15-8-9-16-23-22-12(2)26(16)10-15/h4-10,19H,1-3H3
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n/an/a 270n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149970
PNG
(US8975417, 26 | US8975417, 27)
Show SMILES Cc1[nH]nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C19H17ClN4O2/c1-10-8-14(9-23(3)18(10)25)24-17(12-4-6-13(20)7-5-12)15-11(2)21-22-16(15)19(24)26/h4-9,17H,1-3H3,(H,21,22)
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n/an/a 210n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149970
PNG
(US8975417, 26 | US8975417, 27)
Show SMILES Cc1[nH]nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C19H17ClN4O2/c1-10-8-14(9-23(3)18(10)25)24-17(12-4-6-13(20)7-5-12)15-11(2)21-22-16(15)19(24)26/h4-9,17H,1-3H3,(H,21,22)
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n/an/a 310n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149972
PNG
(US8975417, 28)
Show SMILES Cc1c2C(N(C(=O)c2nn1C)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H19ClN4O2/c1-11-9-15(10-23(3)19(11)26)25-18(13-5-7-14(21)8-6-13)16-12(2)24(4)22-17(16)20(25)27/h5-10,18H,1-4H3
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n/an/a 320n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149973
PNG
(US8975417, 29)
Show SMILES Cc1c2[C@@H](N(C(=O)c2nn1C)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H19ClN4O2/c1-11-9-15(10-23(3)19(11)26)25-18(13-5-7-14(21)8-6-13)16-12(2)24(4)22-17(16)20(25)27/h5-10,18H,1-4H3/t18-/m0/s1
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n/an/a 2.80E+4n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149975
PNG
(US8975417, 31)
Show SMILES Cc1c2C(N(C(=O)c2nn1C)c1cc(F)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H16ClFN4O2/c1-10-15-16(22-24(10)3)19(27)25(13-8-14(21)18(26)23(2)9-13)17(15)11-4-6-12(20)7-5-11/h4-9,17H,1-3H3
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n/an/a 690n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149976
PNG
(US8975417, 32)
Show SMILES Cc1c2C(N(C(=O)c2nn1C)c1ccc(=O)n(C)n1)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H16ClN5O2/c1-10-15-16(21-22(10)2)18(26)24(13-8-9-14(25)23(3)20-13)17(15)11-4-6-12(19)7-5-11/h4-9,17H,1-3H3
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n/an/a 1.20E+3n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149977
PNG
(US8975417, 33)
Show SMILES Cc1noc2ccc(cc12)N1C(c2c(C)n(C)nc2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClN4O2/c1-11-16-10-15(8-9-17(16)28-24-11)26-20(13-4-6-14(22)7-5-13)18-12(2)25(3)23-19(18)21(26)27/h4-10,20H,1-3H3
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n/an/a 3.12E+4n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149978
PNG
(US8975417, 34)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2cnn(C3CC3)c2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H19ClN4O2/c1-12-9-16(11-24(2)20(12)27)25-18(13-3-5-14(22)6-4-13)17-10-23-26(15-7-8-15)19(17)21(25)28/h3-6,9-11,15,18H,7-8H2,1-2H3
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n/an/a 95n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149979
PNG
(US8975417, 35)
Show SMILES Cn1cc(cc(Cl)c1=O)N1C(c2cnn(C3CC3)c2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H16Cl2N4O2/c1-24-10-14(8-16(22)19(24)27)25-17(11-2-4-12(21)5-3-11)15-9-23-26(13-6-7-13)18(15)20(25)28/h2-5,8-10,13,17H,6-7H2,1H3
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n/an/a 140n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149980
PNG
(US8975417, 36)
Show SMILES CC(C)n1ncc2C(N(C(=O)c12)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O2/c1-12(2)26-19-17(10-23-26)18(14-5-7-15(22)8-6-14)25(21(19)28)16-9-13(3)20(27)24(4)11-16/h5-12,18H,1-4H3
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n/an/a 57n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149981
PNG
(US8975417, 37 | US8975417, 39)
Show SMILES Cn1cc(cc(Cl)c1=O)N1C(c2cn(nc2C1=O)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H16Cl2N4O2/c1-24-9-14(8-16(22)19(24)27)26-18(11-2-4-12(21)5-3-11)15-10-25(13-6-7-13)23-17(15)20(26)28/h2-5,8-10,13,18H,6-7H2,1H3
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n/an/a 140n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149982
PNG
(US8975417, 38)
Show SMILES CC(C)n1ncc2C(N(C(=O)c12)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2/c1-11(2)26-18-15(9-23-26)17(12-4-6-13(21)7-5-12)25(20(18)28)14-8-16(22)19(27)24(3)10-14/h4-11,17H,1-3H3
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n/an/a 49n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149981
PNG
(US8975417, 37 | US8975417, 39)
Show SMILES Cn1cc(cc(Cl)c1=O)N1C(c2cn(nc2C1=O)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H16Cl2N4O2/c1-24-9-14(8-16(22)19(24)27)26-18(11-2-4-12(21)5-3-11)15-10-25(13-6-7-13)23-17(15)20(26)28/h2-5,8-10,13,18H,6-7H2,1H3
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n/an/a 78n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149984
PNG
(US8975417, 40)
Show SMILES Cn1cc(cc(Cl)c1=O)N1C(c2c(nn(C3CC3)c2C(F)(F)F)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H15Cl2F3N4O2/c1-28-9-13(8-14(23)19(28)31)29-17(10-2-4-11(22)5-3-10)15-16(20(29)32)27-30(12-6-7-12)18(15)21(24,25)26/h2-5,8-9,12,17H,6-7H2,1H3
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n/an/a 160n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149985
PNG
(US8975417, 41)
Show SMILES CC(C)n1cc2C(N(C(=O)c2n1)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H21ClN4O2/c1-12(2)25-11-17-18(23-25)21(28)26(16-9-13(3)20(27)24(4)10-16)19(17)14-5-7-15(22)8-6-14/h5-12,19H,1-4H3
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n/an/a 75n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149986
PNG
(US8975417, 42)
Show SMILES CC(C)n1cc2C(N(C(=O)c2n1)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C20H18Cl2N4O2/c1-11(2)25-10-15-17(23-25)20(28)26(14-8-16(22)19(27)24(3)9-14)18(15)12-4-6-13(21)7-5-12/h4-11,18H,1-3H3
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n/an/a 91n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149987
PNG
(US8975417, 43)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(nn(C3CC3)c2C(F)(F)F)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClF3N4O2/c1-11-9-15(10-28(2)20(11)31)29-18(12-3-5-13(23)6-4-12)16-17(21(29)32)27-30(14-7-8-14)19(16)22(24,25)26/h3-6,9-10,14,18H,7-8H2,1-2H3
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n/an/a 100n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149988
PNG
(US8975417, 44)
Show SMILES Cn1cc(cc(Cl)c1=O)N1C(c2c(nn(C3CC3)c2C1=O)C(F)(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H15Cl2F3N4O2/c1-28-9-13(8-14(23)19(28)31)29-16(10-2-4-11(22)5-3-10)15-17(20(29)32)30(12-6-7-12)27-18(15)21(24,25)26/h2-5,8-9,12,16H,6-7H2,1H3
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n/an/a 170n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149989
PNG
(US8975417, 45)
Show SMILES Cc1cc(cn(C)c1=O)N1C(c2c(nn(C3CC3)c2C1=O)C(F)(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H18ClF3N4O2/c1-11-9-15(10-28(2)20(11)31)29-17(12-3-5-13(23)6-4-12)16-18(21(29)32)30(14-7-8-14)27-19(16)22(24,25)26/h3-6,9-10,14,17H,7-8H2,1-2H3
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n/an/a 60n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149990
PNG
(US8975417, 46)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2onc(C)c2c1
Show InChI InChI=1S/C29H27ClN6O4/c1-14(2)24-22-23(33-36(24)21-13-31-29(39-6)32-27(21)38-5)28(37)35(25(22)17-7-9-18(30)10-8-17)19-11-15(3)26-20(12-19)16(4)34-40-26/h7-14,25H,1-6H3
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n/an/a 130n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149991
PNG
(US8975417, 47)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(F)(F)F)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C24H17Cl2F3N6O4/c1-33-10-13(8-14(26)21(33)36)34-18(11-4-6-12(25)7-5-11)16-17(22(34)37)32-35(19(16)24(27,28)29)15-9-30-23(39-3)31-20(15)38-2/h4-10,18H,1-3H3
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n/an/a 210n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149992
PNG
(US8975417, 48)
Show SMILES Cc1nn(C2CC2)c2C(=O)N([C@H](c12)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C22H21ClN4O2/c1-12-10-17(11-25(3)21(12)28)26-19(14-4-6-15(23)7-5-14)18-13(2)24-27(16-8-9-16)20(18)22(26)29/h4-7,10-11,16,19H,8-9H2,1-3H3/t19-/m0/s1
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n/an/a>6.70E+3n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149993
PNG
(US8975417, 49)
Show SMILES Cc1nn(C2CC2)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C22H21ClN4O2/c1-12-10-17(11-25(3)21(12)28)26-19(14-4-6-15(23)7-5-14)18-13(2)24-27(16-8-9-16)20(18)22(26)29/h4-7,10-11,16,19H,8-9H2,1-3H3/t19-/m1/s1
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n/an/a 15n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149994
PNG
(US8975417, 50)
Show SMILES Cc1nn(C2CC2)c2C(=O)N([C@H](c12)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-17-18(12-3-5-13(22)6-4-12)26(15-9-16(23)20(28)25(2)10-15)21(29)19(17)27(24-11)14-7-8-14/h3-6,9-10,14,18H,7-8H2,1-2H3/t18-/m0/s1
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n/an/a>6.70E+3n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149995
PNG
(US8975417, 51)
Show SMILES Cc1nn(C2CC2)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-17-18(12-3-5-13(22)6-4-12)26(15-9-16(23)20(28)25(2)10-15)21(29)19(17)27(24-11)14-7-8-14/h3-6,9-10,14,18H,7-8H2,1-2H3/t18-/m1/s1
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n/an/a 17n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149996
PNG
(US8975417, 52)
Show SMILES COc1ncc(c(OC)n1)-n1nc(C)c2C(N(C(=O)c12)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H23ClN6O4/c1-13-10-17(12-30(3)23(13)33)31-20(15-6-8-16(26)9-7-15)19-14(2)29-32(21(19)24(31)34)18-11-27-25(36-5)28-22(18)35-4/h6-12,20H,1-5H3
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n/an/a 63n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149997
PNG
(US8975417, 53)
Show SMILES COc1ncc(c(OC)n1)-n1nc(C)c2C(N(C(=O)c12)c1cc(Cl)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C24H20Cl2N6O4/c1-12-18-19(13-5-7-14(25)8-6-13)31(15-9-16(26)22(33)30(2)11-15)23(34)20(18)32(29-12)17-10-27-24(36-4)28-21(17)35-3/h5-11,19H,1-4H3
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n/an/a 98n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149998
PNG
(US8975417, 54)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1)c1ccc2onc(C)c2c1
Show InChI InChI=1S/C28H25ClN6O4/c1-14(2)24-22-23(32-35(24)20-13-30-28(38-5)31-26(20)37-4)27(36)34(25(22)16-6-8-17(29)9-7-16)18-10-11-21-19(12-18)15(3)33-39-21/h6-14,25H,1-5H3
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n/an/a 480n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149999
PNG
(US8975417, 55 | US8975417, 56)
Show SMILES COc1ncc(c(OC)n1)-n1nc2C(=O)N(C(c2c1C)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C24H20Cl2N6O4/c1-12-18-19(29-32(12)17-10-27-24(36-4)28-21(17)35-3)23(34)31(15-9-16(26)22(33)30(2)11-15)20(18)13-5-7-14(25)8-6-13/h5-11,20H,1-4H3
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n/an/a 98n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
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