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Compile Data Set for Download or QSAR

Found 147 hits of ph data with Target = 'Bromodomain-containing protein 4 (BRD4 (aa 1-477)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237391
PNG
(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H16N2O3/c1-11-17(12(2)24-21-11)13-8-9-16-15(10-13)19(23,18(22)20-16)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,20,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 51n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237391
PNG
(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H16N2O3/c1-11-17(12(2)24-21-11)13-8-9-16-15(10-13)19(23,18(22)20-16)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,20,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 35n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237391
PNG
(US9393232, 1.1 | US9393232, 1.1a | US9393232, 1.1b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H16N2O3/c1-11-17(12(2)24-21-11)13-8-9-16-15(10-13)19(23,18(22)20-16)14-6-4-3-5-7-14/h3-10,23H,1-2H3,(H,20,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.00E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237394
PNG
(US9393232, 1.2)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H15ClN2O3/c1-10-17(11(2)25-22-10)12-3-8-16-15(9-12)19(24,18(23)21-16)13-4-6-14(20)7-5-13/h3-9,24H,1-2H3,(H,21,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 260n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237395
PNG
(US9393232, 1.3)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1cccc(Cl)c1
Show InChI InChI=1S/C19H15ClN2O3/c1-10-17(11(2)25-22-10)12-6-7-16-15(8-12)19(24,18(23)21-16)13-4-3-5-14(20)9-13/h3-9,24H,1-2H3,(H,21,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 380n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237396
PNG
(US9393232, 1.4)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C19H15FN2O3/c1-10-17(11(2)25-22-10)12-3-8-16-15(9-12)19(24,18(23)21-16)13-4-6-14(20)7-5-13/h3-9,24H,1-2H3,(H,21,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 100n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237397
PNG
(US9393232, 1.5)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(C)cc1
Show InChI InChI=1S/C20H18N2O3/c1-11-4-7-15(8-5-11)20(24)16-10-14(6-9-17(16)21-19(20)23)18-12(2)22-25-13(18)3/h4-10,24H,1-3H3,(H,21,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 180n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237398
PNG
(US9393232, 1.6)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(F)c(C)c1
Show InChI InChI=1S/C20H17FN2O3/c1-10-8-14(5-6-16(10)21)20(25)15-9-13(4-7-17(15)22-19(20)24)18-11(2)23-26-12(18)3/h4-9,25H,1-3H3,(H,22,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 380n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237399
PNG
(US9393232, 1.7)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccccc1C
Show InChI InChI=1S/C20H18N2O3/c1-11-6-4-5-7-15(11)20(24)16-10-14(8-9-17(16)21-19(20)23)18-12(2)22-25-13(18)3/h4-10,24H,1-3H3,(H,21,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 570n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237400
PNG
(US9393232, 1.8)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1ccc(F)c(F)c1
Show InChI InChI=1S/C19H14F2N2O3/c1-9-17(10(2)26-23-9)11-3-6-16-13(7-11)19(25,18(24)22-16)12-4-5-14(20)15(21)8-12/h3-8,25H,1-2H3,(H,22,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 200n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237401
PNG
(US9393232, 1.9)
Show SMILES COc1ccc(cc1)C1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C20H18N2O4/c1-11-18(12(2)26-22-11)13-4-9-17-16(10-13)20(24,19(23)21-17)14-5-7-15(25-3)8-6-14/h4-10,24H,1-3H3,(H,21,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 410n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237402
PNG
(US9393232, 1.10)
Show SMILES COc1ccc(cc1OC)C1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C21H20N2O5/c1-11-19(12(2)28-23-11)13-5-7-16-15(9-13)21(25,20(24)22-16)14-6-8-17(26-3)18(10-14)27-4/h5-10,25H,1-4H3,(H,22,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.30E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237403
PNG
(US9393232, 1.11)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)c1cccc2ccccc12
Show InChI InChI=1S/C23H18N2O3/c1-13-21(14(2)28-25-13)16-10-11-20-19(12-16)23(27,22(26)24-20)18-9-5-7-15-6-3-4-8-17(15)18/h3-12,27H,1-2H3,(H,24,26)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.50E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237404
PNG
(US9393232, 1.12)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C#Cc3ccccc3)c2c1
Show InChI InChI=1S/C21H16N2O3/c1-13-19(14(2)26-23-13)16-8-9-18-17(12-16)21(25,20(24)22-18)11-10-15-6-4-3-5-7-15/h3-9,12,25H,1-2H3,(H,22,24)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237405
PNG
(US9393232, 1.13)
Show SMILES Cc1ccsc1C1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C18H16N2O3S/c1-9-6-7-24-16(9)18(22)13-8-12(4-5-14(13)19-17(18)21)15-10(2)20-23-11(15)3/h4-8,22H,1-3H3,(H,19,21)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 560n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237406
PNG
(US9393232, 1.14)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCCC3)c2c1
Show InChI InChI=1S/C20H24N2O3/c1-12-18(13(2)25-22-12)14-9-10-17-16(11-14)20(24,19(23)21-17)15-7-5-3-4-6-8-15/h9-11,15,24H,3-8H2,1-2H3,(H,21,23)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 98n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237407
PNG
(US9393232, 1.15)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3)c2c1
Show InChI InChI=1S/C19H22N2O3/c1-11-17(12(2)24-21-11)13-8-9-16-15(10-13)19(23,18(22)20-16)14-6-4-3-5-7-14/h8-10,14,23H,3-7H2,1-2H3,(H,20,22)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 77n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237408
PNG
(US9393232, 1.16)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCOCC3)c2c1
Show InChI InChI=1S/C18H20N2O4/c1-10-16(11(2)24-20-10)12-3-4-15-14(9-12)18(22,17(21)19-15)13-5-7-23-8-6-13/h3-4,9,13,22H,5-8H2,1-2H3,(H,19,21)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 630n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237409
PNG
(US9393232, 1.17)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCC3)c2c1
Show InChI InChI=1S/C18H20N2O3/c1-10-16(11(2)23-20-10)12-7-8-15-14(9-12)18(22,17(21)19-15)13-5-3-4-6-13/h7-9,13,22H,3-6H2,1-2H3,(H,19,21)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 270n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237410
PNG
(US9393232, 1.18)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCC3)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-9-15(10(2)22-19-9)11-6-7-14-13(8-11)17(21,16(20)18-14)12-4-3-5-12/h6-8,12,21H,3-5H2,1-2H3,(H,18,20)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 510n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237411
PNG
(US9393232, 1.19)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CC3)c2c1
Show InChI InChI=1S/C16H16N2O3/c1-8-14(9(2)21-18-8)10-3-6-13-12(7-10)16(20,11-4-5-11)15(19)17-13/h3,6-7,11,20H,4-5H2,1-2H3,(H,17,19)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 850n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237412
PNG
(US9393232, 1.20)
Show SMILES CCC1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C15H16N2O3/c1-4-15(19)11-7-10(5-6-12(11)16-14(15)18)13-8(2)17-20-9(13)3/h5-7,19H,4H2,1-3H3,(H,16,18)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.30E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237413
PNG
(US9393232, 1.21)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C#C)c2c1
Show InChI InChI=1S/C15H12N2O3/c1-4-15(19)11-7-10(5-6-12(11)16-14(15)18)13-8(2)17-20-9(13)3/h1,5-7,19H,2-3H3,(H,16,18)
PDB

GoogleScholar
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PC sid
UniChem
US Patent
n/an/a 1.20E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237414
PNG
(US9393232, 1.22)
Show SMILES CC#CC1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C16H14N2O3/c1-4-7-16(20)12-8-11(5-6-13(12)17-15(16)19)14-9(2)18-21-10(14)3/h5-6,8,20H,1-3H3,(H,17,19)
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US Patent
n/an/a 220n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237415
PNG
(US9393232, 1.23)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(CC=C)c2c1
Show InChI InChI=1S/C16H16N2O3/c1-4-7-16(20)12-8-11(5-6-13(12)17-15(16)19)14-9(2)18-21-10(14)3/h4-6,8,20H,1,7H2,2-3H3,(H,17,19)
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US Patent
n/an/a 2.50E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237416
PNG
(US9393232, 1.24)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(CCC=C)c2c1
Show InChI InChI=1S/C17H18N2O3/c1-4-5-8-17(21)13-9-12(6-7-14(13)18-16(17)20)15-10(2)19-22-11(15)3/h4,6-7,9,21H,1,5,8H2,2-3H3,(H,18,20)
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US Patent
n/an/a 430n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237417
PNG
(US9393232, 1.25)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(CCCC=C)c2c1
Show InChI InChI=1S/C18H20N2O3/c1-4-5-6-9-18(22)14-10-13(7-8-15(14)19-17(18)21)16-11(2)20-23-12(16)3/h4,7-8,10,22H,1,5-6,9H2,2-3H3,(H,19,21)
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n/an/a 540n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237418
PNG
(US9393232, 1.26)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(c2c1)C(C)(C)C
Show InChI InChI=1S/C17H20N2O3/c1-9-14(10(2)22-19-9)11-6-7-13-12(8-11)17(21,15(20)18-13)16(3,4)5/h6-8,21H,1-5H3,(H,18,20)
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US Patent
n/an/a 3.20E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237419
PNG
(US9393232, 1.27)
Show SMILES CC(C)C1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C16H18N2O3/c1-8(2)16(20)12-7-11(5-6-13(12)17-15(16)19)14-9(3)18-21-10(14)4/h5-8,20H,1-4H3,(H,17,19)
PDB

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US Patent
n/an/a 2.80E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237420
PNG
(US9393232, 1.28)
Show SMILES CC(=C)CC1(O)C(=O)Nc2ccc(cc12)-c1c(C)noc1C
Show InChI InChI=1S/C17H18N2O3/c1-9(2)8-17(21)13-7-12(5-6-14(13)18-16(17)20)15-10(3)19-22-11(15)4/h5-7,21H,1,8H2,2-4H3,(H,18,20)
PDB

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US Patent
n/an/a 3.90E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237421
PNG
(US9393232, 1.29)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(CCCc3ccccc3)c2c1
Show InChI InChI=1S/C22H22N2O3/c1-14-20(15(2)27-24-14)17-10-11-19-18(13-17)22(26,21(25)23-19)12-6-9-16-7-4-3-5-8-16/h3-5,7-8,10-11,13,26H,6,9,12H2,1-2H3,(H,23,25)
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US Patent
n/an/a 1.60E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237422
PNG
(US9393232, 1.30a | US9393232, 1.30b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3=O)c2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-17(11(2)25-21-10)12-7-8-15-14(9-12)19(24,18(23)20-15)13-5-3-4-6-16(13)22/h7-9,13,24H,3-6H2,1-2H3,(H,20,23)
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n/an/a 70n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237422
PNG
(US9393232, 1.30a | US9393232, 1.30b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(O)(C3CCCCC3=O)c2c1
Show InChI InChI=1S/C19H20N2O4/c1-10-17(11(2)25-21-10)12-7-8-15-14(9-12)19(24,18(23)20-15)13-5-3-4-6-16(13)22/h7-9,13,24H,3-6H2,1-2H3,(H,20,23)
PDB

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n/an/a 650n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237423
PNG
(US9393232, 1.31)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(Cl)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H15ClN2O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,1-2H3,(H,21,23)
PDB

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US Patent
n/an/a 58n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237424
PNG
(US9393232, 1.32)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(OCCO)(c2c1)c1ccccc1
Show InChI InChI=1S/C21H20N2O4/c1-13-19(14(2)27-23-13)15-8-9-18-17(12-15)21(20(25)22-18,26-11-10-24)16-6-4-3-5-7-16/h3-9,12,24H,10-11H2,1-2H3,(H,22,25)
PDB

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n/an/a 79n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237425
PNG
(US9393232, 1.33)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(OCCO)(C3CCCCC3)c2c1
Show InChI InChI=1S/C21H26N2O4/c1-13-19(14(2)27-23-13)15-8-9-18-17(12-15)21(20(25)22-18,26-11-10-24)16-6-4-3-5-7-16/h8-9,12,16,24H,3-7,10-11H2,1-2H3,(H,22,25)
PDB

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n/an/a 82n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237426
PNG
(US9393232, 1.34)
Show SMILES CC(=O)OC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C21H18N2O4/c1-12-19(13(2)27-23-12)15-9-10-18-17(11-15)21(20(25)22-18,26-14(3)24)16-7-5-4-6-8-16/h4-11H,1-3H3,(H,22,25)
PDB

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n/an/a 150n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237427
PNG
(US9393232, 2.1)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(NCCO)(c2c1)c1ccccc1
Show InChI InChI=1S/C21H21N3O3/c1-13-19(14(2)27-24-13)15-8-9-18-17(12-15)21(20(26)23-18,22-10-11-25)16-6-4-3-5-7-16/h3-9,12,22,25H,10-11H2,1-2H3,(H,23,26)
PDB

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n/an/a 70n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
PDB

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n/an/a 150n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
PDB

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n/an/a 24n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237428
PNG
(US9393232, 2.2 | US9393232, 2.2a | US9393232, 2.2b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N)(c2c1)c1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-17(12(2)24-22-11)13-8-9-16-15(10-13)19(20,18(23)21-16)14-6-4-3-5-7-14/h3-10H,20H2,1-2H3,(H,21,23)
PDB

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US Patent
n/an/a 3.60E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237431
PNG
(US9393232, 2.3)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCCCC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O2/c1-16-22(17(2)29-26-16)18-11-12-21-20(15-18)24(23(28)25-21,19-9-5-3-6-10-19)27-13-7-4-8-14-27/h3,5-6,9-12,15H,4,7-8,13-14H2,1-2H3,(H,25,28)
PDB

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n/an/a 84n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237432
PNG
(US9393232, 2.4)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCC(O)CC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C24H25N3O3/c1-15-22(16(2)30-26-15)17-8-9-21-20(14-17)24(23(29)25-21,18-6-4-3-5-7-18)27-12-10-19(28)11-13-27/h3-9,14,19,28H,10-13H2,1-2H3,(H,25,29)
PDB

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n/an/a 36n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237433
PNG
(US9393232, 2.5)
Show SMILES CN1CCN(CC1)C1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C24H26N4O2/c1-16-22(17(2)30-26-16)18-9-10-21-20(15-18)24(23(29)25-21,19-7-5-4-6-8-19)28-13-11-27(3)12-14-28/h4-10,15H,11-14H2,1-3H3,(H,25,29)
PDB

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n/an/a 110n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237434
PNG
(US9393232, 2.6)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N3CCOCC3)(c2c1)c1ccccc1
Show InChI InChI=1S/C23H23N3O3/c1-15-21(16(2)29-25-15)17-8-9-20-19(14-17)23(22(27)24-20,18-6-4-3-5-7-18)26-10-12-28-13-11-26/h3-9,14H,10-13H2,1-2H3,(H,24,27)
PDB

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n/an/a 63n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237507
PNG
(US9393232, 2.7a | US9393232, 2.7b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@@H](CO)c3ccccc3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-17-25(18(2)33-30-17)20-13-14-23-22(15-20)27(26(32)28-23,21-11-7-4-8-12-21)29-24(16-31)19-9-5-3-6-10-19/h3-15,24,29,31H,16H2,1-2H3,(H,28,32)/t24-,27?/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237507
PNG
(US9393232, 2.7a | US9393232, 2.7b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@@H](CO)c3ccccc3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-17-25(18(2)33-30-17)20-13-14-23-22(15-20)27(26(32)28-23,21-11-7-4-8-12-21)29-24(16-31)19-9-5-3-6-10-19/h3-15,24,29,31H,16H2,1-2H3,(H,28,32)/t24-,27?/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 810n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237435
PNG
(US9393232, 2.8a | US9393232, 2.8b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@H](CO)c3ccccc3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-17-25(18(2)33-30-17)20-13-14-23-22(15-20)27(26(32)28-23,21-11-7-4-8-12-21)29-24(16-31)19-9-5-3-6-10-19/h3-15,24,29,31H,16H2,1-2H3,(H,28,32)/t24-,27?/m1/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 510n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237435
PNG
(US9393232, 2.8a | US9393232, 2.8b)
Show SMILES Cc1noc(C)c1-c1ccc2NC(=O)C(N[C@H](CO)c3ccccc3)(c2c1)c1ccccc1
Show InChI InChI=1S/C27H25N3O3/c1-17-25(18(2)33-30-17)20-13-14-23-22(15-20)27(26(32)28-23,21-11-7-4-8-12-21)29-24(16-31)19-9-5-3-6-10-19/h3-15,24,29,31H,16H2,1-2H3,(H,28,32)/t24-,27?/m1/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.20E+3n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 (BRD4 (aa 1-477)


(Homo sapiens (Human))
BDBM237437
PNG
(US9393232, 2.9a | US9393232, 2.9b)
Show SMILES C[C@@H](CO)NC1(C(=O)Nc2ccc(cc12)-c1c(C)noc1C)c1ccccc1
Show InChI InChI=1S/C22H23N3O3/c1-13(12-26)24-22(17-7-5-4-6-8-17)18-11-16(9-10-19(18)23-21(22)27)20-14(2)25-28-15(20)3/h4-11,13,24,26H,12H2,1-3H3,(H,23,27)/t13-,22?/m0/s1
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 860n/an/an/an/a7.5n/a



BeiGene, Ltd

US Patent


Assay Description
The assay was carried out in binding mixtures of the bromodomain protein, 0-10 μM compounds and tetra-acetylated histone peptide (SGRGAC.KGGAC.K...


US Patent US9393232 (2016)


BindingDB Entry DOI: 10.7270/Q25T3JDK
More data for this
Ligand-Target Pair
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