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Found 73 hits of ph data with Target = 'Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092341
PNG
(CHEMBL3581660 | US9675697, Cpd. No. 22)
Show SMILES CCc1n[nH]c(CC)c1-c1nccc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12
Show InChI InChI=1S/C24H25N5O2/c1-6-16-23(17(7-2)28-27-16)24-22-14-11-20(30-5)15(21-12(3)29-31-13(21)4)10-19(14)26-18(22)8-9-25-24/h8-11,26H,6-7H2,1-5H3,(H,27,28)
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UniChem

Similars

US Patent
n/an/an/a 40n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179477
PNG
(US9675697, Cpd. No. 44)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]c4ccccc34)c21
Show InChI InChI=1S/C26H22N4O2/c1-13-24(16-7-5-6-8-19(16)28-13)26-25-17-12-22(31-4)18(23-14(2)30-32-15(23)3)11-21(17)29-20(25)9-10-27-26/h5-12,28-29H,1-4H3
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UniChem
US Patent
n/an/an/a 27n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM179474
PNG
(US9675697, Cpd. No. 25)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)nnc3-c3ccccc3)c21
Show InChI InChI=1S/C27H21N5O2/c1-14-24(26(31-30-14)17-8-6-5-7-9-17)27-25-18-13-22(33-4)19(23-15(2)32-34-16(23)3)12-21(18)29-20(25)10-11-28-27/h5-13H,1-4H3/b27-24-
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UniChem
US Patent
n/an/an/a 60n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM50092310
PNG
(CHEMBL3581661 | US9675697, Cpd. No. 23)
Show SMILES COc1cc2c(cc1-c1c(C)noc1C)[nH]c1ccnc(-c3c(C)[nH]nc3C3CC3)c21
Show InChI InChI=1S/C24H23N5O2/c1-11-21(23(28-27-11)14-5-6-14)24-22-15-10-19(30-4)16(20-12(2)29-31-13(20)3)9-18(15)26-17(22)7-8-25-24/h7-10,14,26H,5-6H2,1-4H3,(H,27,28)
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UniChem

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US Patent
n/an/an/a 29n/an/an/a7.4n/a



THE REGENTS OF THE UNIVERSITY OF MICHIGAN

US Patent


Assay Description
Biotin labeled BRD proteins (10 μg/ml) in kinetic assay buffer (PBS, pH 7.4, 0.1% BSA and 0.01% Tween-20) were immobilized on Super Streptavidin...


US Patent US9675697 (2017)


BindingDB Entry DOI: 10.7270/Q2CC0XV6
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249273
PNG
(US9458145, 1020-1)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(NCC3CC3)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C21H27N5O3S/c1-12-19(13(2)29-25-12)15-9-17-20(24-21(23-17)22-11-14-7-8-14)18(10-15)30(27,28)26-16-5-3-4-6-16/h9-10,14,16,26H,3-8,11H2,1-2H3,(H2,22,23,24)
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PC sid
UniChem
US Patent
n/an/a 201n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249274
PNG
(US9458145, 1020-4)
Show SMILES CSc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C18H22N4O3S2/c1-10-16(11(2)25-21-10)12-8-14-17(20-18(19-14)26-3)15(9-12)27(23,24)22-13-6-4-5-7-13/h8-9,13,22H,4-7H2,1-3H3,(H,19,20)
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PC sid
UniChem
US Patent
n/an/a 337n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249275
PNG
(US9458145, 1020-5)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)S(C)=O)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C18H22N4O4S2/c1-10-16(11(2)26-21-10)12-8-14-17(20-18(19-14)27(3)23)15(9-12)28(24,25)22-13-6-4-5-7-13/h8-9,13,22H,4-7H2,1-3H3,(H,19,20)
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PC sid
UniChem
US Patent
n/an/a 616n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249276
PNG
(US9458145, 1020-12)
Show SMILES Cc1cnn(C)c1-c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H21N5O/c1-10-9-21-25(4)19(10)15-7-14(17-11(2)24-26-12(17)3)8-16-18(15)23-20(22-16)13-5-6-13/h7-9,13H,5-6H2,1-4H3,(H,22,23)
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PC sid
UniChem
US Patent
n/an/a 138n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249277
PNG
(US9458145, 1020-18)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C25H22N4O/c1-13-6-9-20-18(5-4-10-26-20)22(13)19-11-17(23-14(2)29-30-15(23)3)12-21-24(19)28-25(27-21)16-7-8-16/h4-6,9-12,16H,7-8H2,1-3H3,(H,27,28)
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PC sid
UniChem
US Patent
n/an/a 87.1n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249278
PNG
(US9458145, 1020-19)
Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)
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PC sid
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US Patent
n/an/a 134n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249279
PNG
(US9458145, 1020-28)
Show SMILES CC\C=C(/CC)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H25N3O/c1-5-7-14(6-2)17-10-16(19-12(3)24-25-13(19)4)11-18-20(17)23-21(22-18)15-8-9-15/h7,10-11,15H,5-6,8-9H2,1-4H3,(H,22,23)/b14-7+
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PC sid
UniChem
US Patent
n/an/a 71.8n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249280
PNG
(US9458145, 1020-37)
Show SMILES Cc1noc(C)c1-c1cc(\C=C\c2ccccc2)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C23H21N3O/c1-14-21(15(2)27-26-14)19-12-18(9-8-16-6-4-3-5-7-16)22-20(13-19)24-23(25-22)17-10-11-17/h3-9,12-13,17H,10-11H2,1-2H3,(H,24,25)/b9-8+
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PC sid
UniChem
US Patent
n/an/a 2.09E+3n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249284
PNG
(US9458145, 1020-72)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc(C3CC3)n(C)c12)-c1c(C)noc1C
Show InChI InChI=1S/C21H23N5O/c1-10-18(11(2)24-23-10)16-8-15(19-12(3)25-27-13(19)4)9-17-20(16)26(5)21(22-17)14-6-7-14/h8-9,14H,6-7H2,1-5H3,(H,23,24)
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PC sid
UniChem
US Patent
n/an/a 101n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249285
PNG
(US9458145, 1020-74)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2n(C)c(nc2c1)C1CC1
Show InChI InChI=1S/C26H24N4O/c1-14-7-10-21-19(6-5-11-27-21)23(14)20-12-18(24-15(2)29-31-16(24)3)13-22-25(20)30(4)26(28-22)17-8-9-17/h5-7,10-13,17H,8-9H2,1-4H3
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PC cid
PC sid
UniChem
US Patent
n/an/a 97.1n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249286
PNG
(US9458145, 1020-75)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H21N5O/c1-9-17(10(2)24-23-9)15-7-14(18-11(3)25-26-12(18)4)8-16-19(15)22-20(21-16)13-5-6-13/h7-8,13H,5-6H2,1-4H3,(H,21,22)(H,23,24)
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PC sid
UniChem
US Patent
n/an/a 121n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249287
PNG
(US9458145, 1020-77)
Show SMILES Cc1nc2cc(cc(-c3c(C)n[nH]c3C)c2[nH]1)-c1c(C)noc1C
Show InChI InChI=1S/C18H19N5O/c1-8-16(9(2)22-21-8)14-6-13(17-10(3)23-24-11(17)4)7-15-18(14)20-12(5)19-15/h6-7H,1-5H3,(H,19,20)(H,21,22)
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PC sid
UniChem
US Patent
n/an/a 245n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249288
PNG
(US9458145, 1020-78)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc([nH]c12)C1CC1(F)F)-c1c(C)noc1C
Show InChI InChI=1S/C20H17F2N5O/c1-8-16(9(2)26-25-8)13-5-12(17-10(3)27-28-11(17)4)6-15-18(13)24-19(23-15)14-7-20(14,21)22/h5-6,14H,7H2,1-4H3
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UniChem
US Patent
n/an/a 161n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249289
PNG
(US9458145, 1020-79)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NCC3CC3)nc12)-c1c(C)noc1C
Show InChI InChI=1S/C21H24N6O/c1-10-18(11(2)26-25-10)16-7-15(19-12(3)27-28-13(19)4)8-17-20(16)24-21(23-17)22-9-14-5-6-14/h7-8,14H,5-6,9H2,1-4H3,(H,25,26)(H2,22,23,24)
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US Patent
n/an/a 161n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249290
PNG
(US9458145, 1020-81)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NC3CC3)nc12)-c1c(C)noc1C
Show InChI InChI=1S/C20H22N6O/c1-9-17(10(2)25-24-9)15-7-13(18-11(3)26-27-12(18)4)8-16-19(15)23-20(22-16)21-14-5-6-14/h7-8,14H,5-6H2,1-4H3,(H,24,25)(H2,21,22,23)
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UniChem
US Patent
n/an/a 169n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249291
PNG
(US9458145, 1020-84)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccnc2C)c2nc[nH]c2c1
Show InChI InChI=1S/C19H18N4O/c1-10-5-6-20-11(2)17(10)15-7-14(8-16-19(15)22-9-21-16)18-12(3)23-24-13(18)4/h5-9H,1-4H3,(H,21,22)
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PC cid
PC sid
UniChem
US Patent
n/an/a 481n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249292
PNG
(US9458145, 1020-88)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)
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PC cid
PC sid
UniChem
US Patent
n/an/a 104n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249293
PNG
(US9458145, 1020-89)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)C(O)CCO
Show InChI InChI=1S/C25H24N4O3/c1-13-6-7-19-17(5-4-9-26-19)22(13)18-11-16(23-14(2)29-32-15(23)3)12-20-24(18)28-25(27-20)21(31)8-10-30/h4-7,9,11-12,21,30-31H,8,10H2,1-3H3,(H,27,28)
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n/an/a 379n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249294
PNG
(US9458145, 1020-90)
Show SMILES COc1nc2c(cc(cc2[nH]1)-c1c(C)noc1C)-c1c(C)ccc2ncccc12
Show InChI InChI=1S/C23H20N4O2/c1-12-7-8-18-16(6-5-9-24-18)20(12)17-10-15(21-13(2)27-29-14(21)3)11-19-22(17)26-23(25-19)28-4/h5-11H,1-4H3,(H,25,26)
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n/an/a 110n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249295
PNG
(US9458145, 1020-92)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C23H17F3N4O/c1-11-6-7-17-15(5-4-8-27-17)19(11)16-9-14(20-12(2)30-31-13(20)3)10-18-21(16)29-22(28-18)23(24,25)26/h4-10H,1-3H3,(H,28,29)
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n/an/a 133n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249296
PNG
(US9458145, 1020-96)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc(N)[nH]c12)-c1c(C)noc1C
Show InChI InChI=1S/C17H18N6O/c1-7-14(8(2)22-21-7)12-5-11(15-9(3)23-24-10(15)4)6-13-16(12)20-17(18)19-13/h5-6H,1-4H3,(H,21,22)(H3,18,19,20)
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n/an/a 276n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249297
PNG
(US9458145, 1020-102)
Show SMILES Cc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C28H25N3O2/c1-17-25(18(2)33-31-17)20-15-23(26-24(16-20)29-27(30-26)19-13-14-19)28(32,21-9-5-3-6-10-21)22-11-7-4-8-12-22/h3-12,15-16,19,32H,13-14H2,1-2H3,(H,29,30)
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n/an/a 101n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249298
PNG
(US9458145, 1020-120)
Show SMILES CCC(CC)c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H25N3O/c1-5-13(6-2)16-9-15(18-11(3)23-24-12(18)4)10-17-19(16)22-20(21-17)14-7-8-14/h9-10,13-14H,5-8H2,1-4H3,(H,21,22)
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n/an/a 88.5n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249299
PNG
(US9458145, 1020-121)
Show SMILES Cc1noc(C)c1-c1cc(C(O)C2CCCC2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1S/C21H25N3O2/c1-11-18(12(2)26-24-11)15-9-16(20(25)13-5-3-4-6-13)19-17(10-15)22-21(23-19)14-7-8-14/h9-10,13-14,20,25H,3-8H2,1-2H3,(H,22,23)
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n/an/a 95.2n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249300
PNG
(US9458145, 1020-132)
Show SMILES CCC(O)(CC)c1cc(cc2n(C)c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H27N3O2/c1-6-21(25,7-2)16-10-15(18-12(3)23-26-13(18)4)11-17-19(16)22-20(24(17)5)14-8-9-14/h10-11,14,25H,6-9H2,1-5H3
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n/an/a 610n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249301
PNG
(US9458145, 1020-136)
Show SMILES CC1CCC(=O)N1c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H22N4O2/c1-10-4-7-17(25)24(10)16-9-14(18-11(2)23-26-12(18)3)8-15-19(16)22-20(21-15)13-5-6-13/h8-10,13H,4-7H2,1-3H3,(H,21,22)
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n/an/a 823n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249302
PNG
(US9458145, 1020-137)
Show SMILES CCC1CCC(=O)N1c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H24N4O2/c1-4-15-7-8-18(26)25(15)17-10-14(19-11(2)24-27-12(19)3)9-16-20(17)23-21(22-16)13-5-6-13/h9-10,13,15H,4-8H2,1-3H3,(H,22,23)
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n/an/a 187n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249303
PNG
(US9458145, 1020-141)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(Cc3ccccc3)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C24H26N4O3S/c1-15-23(16(2)31-27-15)18-13-20-24(26-22(25-20)12-17-8-4-3-5-9-17)21(14-18)32(29,30)28-19-10-6-7-11-19/h3-5,8-9,13-14,19,28H,6-7,10-12H2,1-2H3,(H,25,26)
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n/an/a 704n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249304
PNG
(US9458145, 1020-148)
Show SMILES Cc1noc(C)c1-c1cc(c2nc(NCC(F)(F)F)[nH]c2c1)S(=O)(=O)NC1CCCC1
Show InChI InChI=1S/C19H22F3N5O3S/c1-10-16(11(2)30-26-10)12-7-14-17(25-18(24-14)23-9-19(20,21)22)15(8-12)31(28,29)27-13-5-3-4-6-13/h7-8,13,27H,3-6,9H2,1-2H3,(H2,23,24,25)
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n/an/a 186n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the two tandem bromodomains, BRD4-1 and BRD4-2, to an acetylated histone H4 peptide was measured using a homogeneous time resolved fluores...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249276
PNG
(US9458145, 1020-12)
Show SMILES Cc1cnn(C)c1-c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H21N5O/c1-10-9-21-25(4)19(10)15-7-14(17-11(2)24-26-12(17)3)8-16-18(15)23-20(22-16)13-5-6-13/h7-9,13H,5-6H2,1-4H3,(H,22,23)
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n/an/a 46.2n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249277
PNG
(US9458145, 1020-18)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C25H22N4O/c1-13-6-9-20-18(5-4-10-26-20)22(13)19-11-17(23-14(2)29-30-15(23)3)12-21-24(19)28-25(27-21)16-7-8-16/h4-6,9-12,16H,7-8H2,1-3H3,(H,27,28)
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n/an/a 14.4n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249278
PNG
(US9458145, 1020-19)
Show SMILES Cc1noc(C)c1-c1cc(-c2cccnc2-c2ccccc2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1S/C26H22N4O/c1-15-23(16(2)31-30-15)19-13-21(25-22(14-19)28-26(29-25)18-10-11-18)20-9-6-12-27-24(20)17-7-4-3-5-8-17/h3-9,12-14,18H,10-11H2,1-2H3,(H,28,29)
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n/an/a 28n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249279
PNG
(US9458145, 1020-28)
Show SMILES CC\C=C(/CC)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C21H25N3O/c1-5-7-14(6-2)17-10-16(19-12(3)24-25-13(19)4)11-18-20(17)23-21(22-18)15-8-9-15/h7,10-11,15H,5-6,8-9H2,1-4H3,(H,22,23)/b14-7+
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n/an/a 18.1n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249280
PNG
(US9458145, 1020-37)
Show SMILES Cc1noc(C)c1-c1cc(\C=C\c2ccccc2)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C23H21N3O/c1-14-21(15(2)27-26-14)19-12-18(9-8-16-6-4-3-5-7-16)22-20(13-19)24-23(25-22)17-10-11-17/h3-9,12-13,17H,10-11H2,1-2H3,(H,24,25)/b9-8+
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n/an/a 3.17E+3n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249281
PNG
(US9458145, 1020-44)
Show SMILES CC(c1ccc(F)cc1)c1cc(cc2nc([nH]c12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C23H22FN3O/c1-12(15-6-8-18(24)9-7-15)19-10-17(21-13(2)27-28-14(21)3)11-20-22(19)26-23(25-20)16-4-5-16/h6-12,16H,4-5H2,1-3H3,(H,25,26)
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n/an/a 22n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249282
PNG
(US9458145, 1020-50)
Show SMILES Cc1noc(C)c1-c1cc(NC2CCCC2)c2nc([nH]c2c1)C1CC1
Show InChI InChI=1S/C20H24N4O/c1-11-18(12(2)25-24-11)14-9-16(21-15-5-3-4-6-15)19-17(10-14)22-20(23-19)13-7-8-13/h9-10,13,15,21H,3-8H2,1-2H3,(H,22,23)
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n/an/a 125n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249283
PNG
(US9458145, 1020-57)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccnc2C)c2[nH]c(nc2c1)C1CC1
Show InChI InChI=1S/C22H22N4O/c1-11-7-8-23-12(2)19(11)17-9-16(20-13(3)26-27-14(20)4)10-18-21(17)25-22(24-18)15-5-6-15/h7-10,15H,5-6H2,1-4H3,(H,24,25)
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n/an/a 22.6n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249284
PNG
(US9458145, 1020-72)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc(C3CC3)n(C)c12)-c1c(C)noc1C
Show InChI InChI=1S/C21H23N5O/c1-10-18(11(2)24-23-10)16-8-15(19-12(3)25-27-13(19)4)9-17-20(16)26(5)21(22-17)14-6-7-14/h8-9,14H,6-7H2,1-5H3,(H,23,24)
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n/an/a 12.3n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249285
PNG
(US9458145, 1020-74)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2n(C)c(nc2c1)C1CC1
Show InChI InChI=1S/C26H24N4O/c1-14-7-10-21-19(6-5-11-27-21)23(14)20-12-18(24-15(2)29-31-16(24)3)13-22-25(20)30(4)26(28-22)17-8-9-17/h5-7,10-13,17H,8-9H2,1-4H3
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n/an/a 18.9n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249286
PNG
(US9458145, 1020-75)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(nc12)C1CC1)-c1c(C)noc1C
Show InChI InChI=1S/C20H21N5O/c1-9-17(10(2)24-23-9)15-7-14(18-11(3)25-26-12(18)4)8-16-19(15)22-20(21-16)13-5-6-13/h7-8,13H,5-6H2,1-4H3,(H,21,22)(H,23,24)
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UniChem
US Patent
n/an/a 33.5n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249287
PNG
(US9458145, 1020-77)
Show SMILES Cc1nc2cc(cc(-c3c(C)n[nH]c3C)c2[nH]1)-c1c(C)noc1C
Show InChI InChI=1S/C18H19N5O/c1-8-16(9(2)22-21-8)14-6-13(17-10(3)23-24-11(17)4)7-15-18(14)20-12(5)19-15/h6-7H,1-5H3,(H,19,20)(H,21,22)
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UniChem
US Patent
n/an/a 42.7n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249288
PNG
(US9458145, 1020-78)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2nc([nH]c12)C1CC1(F)F)-c1c(C)noc1C
Show InChI InChI=1S/C20H17F2N5O/c1-8-16(9(2)26-25-8)13-5-12(17-10(3)27-28-11(17)4)6-15-18(13)24-19(23-15)14-7-20(14,21)22/h5-6,14H,7H2,1-4H3
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UniChem
US Patent
n/an/a 25.1n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249289
PNG
(US9458145, 1020-79)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NCC3CC3)nc12)-c1c(C)noc1C
Show InChI InChI=1S/C21H24N6O/c1-10-18(11(2)26-25-10)16-7-15(19-12(3)27-28-13(19)4)8-17-20(16)24-21(23-17)22-9-14-5-6-14/h7-8,14H,5-6,9H2,1-4H3,(H,25,26)(H2,22,23,24)
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UniChem
US Patent
n/an/a 33.6n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249290
PNG
(US9458145, 1020-81)
Show SMILES Cc1n[nH]c(C)c1-c1cc(cc2[nH]c(NC3CC3)nc12)-c1c(C)noc1C
Show InChI InChI=1S/C20H22N6O/c1-9-17(10(2)25-24-9)15-7-13(18-11(3)26-27-12(18)4)8-16-19(15)23-20(22-16)21-14-5-6-14/h7-8,14H,5-6H2,1-4H3,(H,24,25)(H2,21,22,23)
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US Patent
n/an/a 50.7n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249291
PNG
(US9458145, 1020-84)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccnc2C)c2nc[nH]c2c1
Show InChI InChI=1S/C19H18N4O/c1-10-5-6-20-11(2)17(10)15-7-14(8-16-19(15)22-9-21-16)18-12(3)23-24-13(18)4/h5-9H,1-4H3,(H,21,22)
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US Patent
n/an/a 277n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
Bromodomain-containing protein 4 Bromo 1 domain(BRD4 BD1)


(Homo sapiens (Human))
BDBM249292
PNG
(US9458145, 1020-88)
Show SMILES Cc1noc(C)c1-c1cc(-c2c(C)ccc3ncccc23)c2nc([nH]c2c1)-c1cnn(C)c1
Show InChI InChI=1S/C26H22N6O/c1-14-7-8-21-19(6-5-9-27-21)23(14)20-10-17(24-15(2)31-33-16(24)3)11-22-25(20)30-26(29-22)18-12-28-32(4)13-18/h5-13H,1-4H3,(H,29,30)
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US Patent
n/an/a 15.9n/an/an/an/a7.525



Gilead Sciences, Inc.

US Patent


Assay Description
Binding of the bromodomain BRD4-I to an acetylated histone H4 peptide was measured using a bead-based Amplified Luminescent Proximity Homogeneous Ass...


US Patent US9458145 (2016)


BindingDB Entry DOI: 10.7270/Q26Q1W53
More data for this
Ligand-Target Pair
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