BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 198 hits of ph data with Target = 'Calcium channel (Type L)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Calcium channel (Type L)


(HUMAN)
BDBM163526
PNG
(US9688615, 1)
Show SMILES FC(F)(F)c1cc(c2nc(CC3CNC3)[nH]c2c1)C(F)(F)F
Show InChI InChI=1S/C13H11F6N3/c14-12(15,16)7-2-8(13(17,18)19)11-9(3-7)21-10(22-11)1-6-4-20-5-6/h2-3,6,20H,1,4-5H2,(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM163533
PNG
(US9688615, 2)
Show SMILES Clc1cc2nc(CC3CNC3)[nH]c2cc1Cl
Show InChI InChI=1S/C11H11Cl2N3/c12-7-2-9-10(3-8(7)13)16-11(15-9)1-6-4-14-5-6/h2-3,6,14H,1,4-5H2,(H,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM163549
PNG
(US9688615, 3)
Show SMILES CC(C)(C)NC(=O)Cn1c(CC2CNC2)nc2c(cc(cc12)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H22F6N4O/c1-17(2,3)28-15(30)9-29-13-6-11(18(20,21)22)5-12(19(23,24)25)16(13)27-14(29)4-10-7-26-8-10/h5-6,10,26H,4,7-9H2,1-3H3,(H,28,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM163564
PNG
(US9688615, 5)
Show SMILES FC(F)(F)c1ccc(NC(=O)CC2CNC2)nc1
Show InChI InChI=1S/C11H12F3N3O/c12-11(13,14)8-1-2-9(16-6-8)17-10(18)3-7-4-15-5-7/h1-2,6-7,15H,3-5H2,(H,16,17,18)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164199
PNG
(US9688615, 10)
Show SMILES FC(F)(F)c1cc2nc(CC3CNC3)[nH]c2cc1C(F)(F)F
Show InChI InChI=1S/C13H11F6N3/c14-12(15,16)7-2-9-10(3-8(7)13(17,18)19)22-11(21-9)1-6-4-20-5-6/h2-3,6,20H,1,4-5H2,(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164200
PNG
(US9688615, 11)
Show SMILES CC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C15H13F6N3O/c1-7(25)24-5-8(6-24)2-12-22-11-4-9(14(16,17)18)3-10(13(11)23-12)15(19,20)21/h3-4,8H,2,5-6H2,1H3,(H,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164201
PNG
(US9688615, 12)
Show SMILES NCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C15H14F6N4O/c16-14(17,18)8-2-9(15(19,20)21)13-10(3-8)23-11(24-13)1-7-5-25(6-7)12(26)4-22/h2-3,7H,1,4-6,22H2,(H,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164202
PNG
(US9688615, 13)
Show SMILES NCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C16H16F6N4O/c17-15(18,19)9-4-10(16(20,21)22)14-11(5-9)24-12(25-14)3-8-6-26(7-8)13(27)1-2-23/h4-5,8H,1-3,6-7,23H2,(H,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164203
PNG
(US9688615, 14)
Show SMILES CC(C)(N)CC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C18H20F6N4O/c1-16(2,25)6-14(29)28-7-9(8-28)3-13-26-12-5-10(17(19,20)21)4-11(15(12)27-13)18(22,23)24/h4-5,9H,3,6-8,25H2,1-2H3,(H,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164204
PNG
(US9688615, 15)
Show SMILES NCCCC(=O)N1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C17H18F6N4O/c18-16(19,20)10-5-11(17(21,22)23)15-12(6-10)25-13(26-15)4-9-7-27(8-9)14(28)2-1-3-24/h5-6,9H,1-4,7-8,24H2,(H,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164208
PNG
(US9688615, 19)
Show SMILES CC(C)(C)NC(=O)CN1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C19H22F6N4O/c1-17(2,3)28-15(30)9-29-7-10(8-29)4-14-26-13-6-11(18(20,21)22)5-12(16(13)27-14)19(23,24)25/h5-6,10H,4,7-9H2,1-3H3,(H,26,27)(H,28,30)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.12E+3n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164209
PNG
(US9688615, 20)
Show SMILES CC1(CCC1)NC(=O)CN1CC(Cc2nc3c(cc(cc3[nH]2)C(F)(F)F)C(F)(F)F)C1
Show InChI InChI=1S/C20H22F6N4O/c1-18(3-2-4-18)29-16(31)10-30-8-11(9-30)5-15-27-14-7-12(19(21,22)23)6-13(17(14)28-15)20(24,25)26/h6-7,11H,2-5,8-10H2,1H3,(H,27,28)(H,29,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3.90E+3n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164210
PNG
(US9688615, 21)
Show SMILES NCc1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C8H7Cl2N3/c9-4-1-6-7(2-5(4)10)13-8(3-11)12-6/h1-2H,3,11H2,(H,12,13)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164211
PNG
(US9688615, 22)
Show SMILES NCC(=O)NCc1nc2cc(Cl)c(Cl)cc2[nH]1
Show InChI InChI=1S/C10H10Cl2N4O/c11-5-1-7-8(2-6(5)12)16-9(15-7)4-14-10(17)3-13/h1-2H,3-4,13H2,(H,14,17)(H,15,16)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164212
PNG
(US9688615, 23)
Show SMILES NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C10H7F6N3/c11-9(12,13)4-1-5(10(14,15)16)8-6(2-4)18-7(3-17)19-8/h1-2H,3,17H2,(H,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164213
PNG
(US9688615, 24)
Show SMILES NCC(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H10F6N4O/c13-11(14,15)5-1-6(12(16,17)18)10-7(2-5)21-8(22-10)4-20-9(23)3-19/h1-2H,3-4,19H2,(H,20,23)(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164215
PNG
(US9688615, 26)
Show SMILES NC1(CC1)c1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H9F6N3/c13-11(14,15)5-3-6(12(16,17)18)8-7(4-5)20-9(21-8)10(19)1-2-10/h3-4H,1-2,19H2,(H,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164217
PNG
(US9688615, 28)
Show SMILES CC(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H9F6N3O/c1-5(22)19-4-9-20-8-3-6(11(13,14)15)2-7(10(8)21-9)12(16,17)18/h2-3H,4H2,1H3,(H,19,22)(H,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164218
PNG
(US9688615, 29)
Show SMILES Fc1ccc(cc1Cl)-c1ccc2nc(Cc3cncnc3)[nH]c2c1
Show InChI InChI=1S/C18H12ClFN4/c19-14-6-12(1-3-15(14)20)13-2-4-16-17(7-13)24-18(23-16)5-11-8-21-10-22-9-11/h1-4,6-10H,5H2,(H,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164219
PNG
(US9688615, 30)
Show SMILES FC(F)(F)COc1ccc(cc1)-c1ccc2nc(Cc3cncnc3)[nH]c2c1
Show InChI InChI=1S/C20H15F3N4O/c21-20(22,23)11-28-16-4-1-14(2-5-16)15-3-6-17-18(8-15)27-19(26-17)7-13-9-24-12-25-10-13/h1-6,8-10,12H,7,11H2,(H,26,27)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164220
PNG
(US9688615, 31)
Show SMILES CC(C)C[C@H](CN)Cc1nc2c(cc(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H19F6N3/c1-8(2)3-9(7-23)4-13-24-12-6-10(15(17,18)19)5-11(14(12)25-13)16(20,21)22/h5-6,8-9H,3-4,7,23H2,1-2H3,(H,24,25)/t9-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164221
PNG
(US9688615, 32)
Show SMILES CC(C)(C)OC(=O)NCc1nc2c(cc(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H15F6N3O2/c1-13(2,3)26-12(25)22-6-10-23-9-5-7(14(16,17)18)4-8(11(9)24-10)15(19,20)21/h4-5H,6H2,1-3H3,(H,22,25)(H,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164222
PNG
(US9688615, 33)
Show SMILES NCCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C11H9F6N3/c12-10(13,14)5-3-6(11(15,16)17)9-7(4-5)19-8(20-9)1-2-18/h3-4H,1-2,18H2,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164223
PNG
(US9688615, 34)
Show SMILES CC(C)(N)Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C13H13F6N3/c1-11(2,20)5-9-21-8-4-6(12(14,15)16)3-7(10(8)22-9)13(17,18)19/h3-4H,5,20H2,1-2H3,(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164224
PNG
(US9688615, 35)
Show SMILES NCCCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H11F6N3/c13-11(14,15)6-4-7(12(16,17)18)10-8(5-6)20-9(21-10)2-1-3-19/h4-5H,1-3,19H2,(H,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164225
PNG
(US9688615, 36)
Show SMILES CC(C)(N)C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C14H14F6N4O/c1-12(2,21)11(25)22-5-9-23-8-4-6(13(15,16)17)3-7(10(8)24-9)14(18,19)20/h3-4H,5,21H2,1-2H3,(H,22,25)(H,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164226
PNG
(US9688615, 37)
Show SMILES CC(C)(CN)C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H16F6N4O/c1-13(2,6-22)12(26)23-5-10-24-9-4-7(14(16,17)18)3-8(11(9)25-10)15(19,20)21/h3-4H,5-6,22H2,1-2H3,(H,23,26)(H,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164227
PNG
(US9688615, 38)
Show SMILES NCc1nc2cc(c(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C10H7F6N3/c11-9(12,13)4-1-6-7(19-8(3-17)18-6)2-5(4)10(14,15)16/h1-2H,3,17H2,(H,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164228
PNG
(US9688615, 39)
Show SMILES NCC(=O)NCc1nc2cc(c(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H10F6N4O/c13-11(14,15)5-1-7-8(2-6(5)12(16,17)18)22-9(21-7)4-20-10(23)3-19/h1-2H,3-4,19H2,(H,20,23)(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164229
PNG
(US9688615, 40)
Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)OC(C)(C)C
Show InChI InChI=1S/C16H17F6N3O2/c1-14(2,3)27-13(26)25(4)7-11-23-10-6-8(15(17,18)19)5-9(12(10)24-11)16(20,21)22/h5-6H,7H2,1-4H3,(H,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164230
PNG
(US9688615, 41)
Show SMILES CNCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C11H9F6N3/c1-18-4-8-19-7-3-5(10(12,13)14)2-6(9(7)20-8)11(15,16)17/h2-3,18H,4H2,1H3,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164231
PNG
(US9688615, 42)
Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)CN
Show InChI InChI=1S/C13H12F6N4O/c1-23(10(24)4-20)5-9-21-8-3-6(12(14,15)16)2-7(11(8)22-9)13(17,18)19/h2-3H,4-5,20H2,1H3,(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164232
PNG
(US9688615, 43)
Show SMILES CNCC(=O)N(C)Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C14H14F6N4O/c1-21-5-11(25)24(2)6-10-22-9-4-7(13(15,16)17)3-8(12(9)23-10)14(18,19)20/h3-4,21H,5-6H2,1-2H3,(H,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164237
PNG
(US9688615, 48)
Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(=O)CNC(C)(C)C
Show InChI InChI=1S/C17H20F6N4O/c1-15(2,3)24-7-13(28)27(4)8-12-25-11-6-9(16(18,19)20)5-10(14(11)26-12)17(21,22)23/h5-6,24H,7-8H2,1-4H3,(H,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164238
PNG
(US9688615, 49)
Show SMILES CN(C)Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H11F6N3/c1-21(2)5-9-19-8-4-6(11(13,14)15)3-7(10(8)20-9)12(16,17)18/h3-4H,5H2,1-2H3,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164239
PNG
(US9688615, 50)
Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)C(N)=O
Show InChI InChI=1S/C12H10F6N4O/c1-22(10(19)23)4-8-20-7-3-5(11(13,14)15)2-6(9(7)21-8)12(16,17)18/h2-3H,4H2,1H3,(H2,19,23)(H,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164240
PNG
(US9688615, 51)
Show SMILES FC(F)(F)c1cc(c2nc([nH]c2c1)[C@@H]1CCCN1)C(F)(F)F
Show InChI InChI=1S/C13H11F6N3/c14-12(15,16)6-4-7(13(17,18)19)10-9(5-6)21-11(22-10)8-2-1-3-20-8/h4-5,8,20H,1-3H2,(H,21,22)/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164241
PNG
(US9688615, 52)
Show SMILES FC(F)(F)c1cc(c2nc([nH]c2c1)[C@H]1CCCN1)C(F)(F)F
Show InChI InChI=1S/C13H11F6N3/c14-12(15,16)6-4-7(13(17,18)19)10-9(5-6)21-11(22-10)8-2-1-3-20-8/h4-5,8,20H,1-3H2,(H,21,22)/t8-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164245
PNG
(US9688615, 56)
Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)S(N)(=O)=O
Show InChI InChI=1S/C11H10F6N4O2S/c1-21(24(18,22)23)4-8-19-7-3-5(10(12,13)14)2-6(9(7)20-8)11(15,16)17/h2-3H,4H2,1H3,(H,19,20)(H2,18,22,23)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164246
PNG
(US9688615, 57)
Show SMILES CN(Cc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C12H11F6N3O2S/c1-21(24(2,22)23)5-9-19-8-4-6(11(13,14)15)3-7(10(8)20-9)12(16,17)18/h3-4H,5H2,1-2H3,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164247
PNG
(US9688615, 58)
Show SMILES COC[C@@H](N)C(=O)NCC(=O)N(C)Cc1nc2c(cc(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C17H19F6N5O3/c1-28(13(29)5-25-15(30)10(24)7-31-2)6-12-26-11-4-8(16(18,19)20)3-9(14(11)27-12)17(21,22)23/h3-4,10H,5-7,24H2,1-2H3,(H,25,30)(H,26,27)/t10-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164248
PNG
(US9688615, 59)
Show SMILES FC(F)(F)c1cc(c2[nH]c(Cc3cncnc3)nc2c1)C(F)(F)F
Show InChI InChI=1S/C14H8F6N4/c15-13(16,17)8-2-9(14(18,19)20)12-10(3-8)23-11(24-12)1-7-4-21-6-22-5-7/h2-6H,1H2,(H,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164249
PNG
(US9688615, 60)
Show SMILES CC(C)(C)C(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H15F6N3O/c1-13(2,3)12(25)22-6-10-23-9-5-7(14(16,17)18)4-8(11(9)24-10)15(19,20)21/h4-5H,6H2,1-3H3,(H,22,25)(H,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164250
PNG
(US9688615, 61)
Show SMILES CC(C)(C)CC(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C16H17F6N3O/c1-14(2,3)6-12(26)23-7-11-24-10-5-8(15(17,18)19)4-9(13(10)25-11)16(20,21)22/h4-5H,6-7H2,1-3H3,(H,23,26)(H,24,25)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 6.00E+3n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164251
PNG
(US9688615, 62)
Show SMILES CC(C)(C)NC(=O)NCc1nc2cc(cc(c2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C15H16F6N4O/c1-13(2,3)25-12(26)22-6-10-23-9-5-7(14(16,17)18)4-8(11(9)24-10)15(19,20)21/h4-5H,6H2,1-3H3,(H,23,24)(H2,22,25,26)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164252
PNG
(US9688615, 63)
Show SMILES COCc1nc2c(cc(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C11H8F6N2O/c1-20-4-8-18-7-3-5(10(12,13)14)2-6(9(7)19-8)11(15,16)17/h2-3H,4H2,1H3,(H,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164253
PNG
(US9688615, 64)
Show SMILES COCCc1nc2c(cc(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C12H10F6N2O/c1-21-3-2-9-19-8-5-6(11(13,14)15)4-7(10(8)20-9)12(16,17)18/h4-5H,2-3H2,1H3,(H,19,20)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164254
PNG
(US9688615, 65)
Show SMILES FC(F)(F)Cc1nc2c(cc(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C11H5F9N2/c12-9(13,14)3-7-21-6-2-4(10(15,16)17)1-5(8(6)22-7)11(18,19)20/h1-2H,3H2,(H,21,22)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 7.50E+3n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164255
PNG
(US9688615, 66)
Show SMILES CS(=O)(=O)Cc1nc2c(cc(cc2[nH]1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C11H8F6N2O2S/c1-22(20,21)4-8-18-7-3-5(10(12,13)14)2-6(9(7)19-8)11(15,16)17/h2-3H,4H2,1H3,(H,18,19)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Calcium channel (Type L)


(HUMAN)
BDBM164260
PNG
(US9688615, 71)
Show SMILES FC(F)(F)c1cc(c2[nH]c(Cc3cccnc3)nc2c1)C(F)(F)F
Show InChI InChI=1S/C15H9F6N3/c16-14(17,18)9-5-10(15(19,20)21)13-11(6-9)23-12(24-13)4-8-2-1-3-22-7-8/h1-3,5-7H,4H2,(H,23,24)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a>1.00E+4n/an/an/an/a7.4n/a



SRMLSC

US Patent


Assay Description
To assess the potential cardiac liability of compounds at an early stage in the drug discovery process, a Nav1.5 sodium channel screening assay was b...


US Patent US9688615 (2017)


BindingDB Entry DOI: 10.7270/Q27S7KXH
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 198 total )  |  Next  |  Last  >>
Jump to: