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Found 413 of ph data with Target = 'Carboxylic ester hydrolase'
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232997((S)-(-)-endo-2-norbornyl-N-n-butylcarbamate)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232998((R)-(+)-endo-2-norbornyl-N-n-butylcarbamate | rac-...)
Affinity DataKi:  3nM ΔG°:  -48.6kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232998((R)-(+)-endo-2-norbornyl-N-n-butylcarbamate | rac-...)
Affinity DataKi:  5nM ΔG°:  -47.4kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232995((R)-(+)-exo-2-norbonyl-N-n-butylcarbamate)
Affinity DataKi:  11nM ΔG°:  -45.4kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232999(rac-(±)-exo-2-norbornyl carbamate)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM232996((S)-(-)-exo-2-norbonyl-N-n-butylcarbamate)
Affinity DataKi:  50nM ΔG°:  -41.7kJ/molepH: 7.0 T: 2°CAssay Description:BChE inhibitions by the carbamate inhibitors were assayed by the Ellman method [Ellman et al., Biochem. Pharm., 7:88-95]. BChE-catalyzed hydrolysis o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10947((1R,10R)-16-methyl-14-{3-[methyl({10-[methyl({3-[(...)
Affinity DataIC50:  5.43E+4nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10948((1R,10R)-16-methyl-14-{3-[methyl({12-[methyl({3-[(...)
Affinity DataIC50:  8.84E+4nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10478(A2A.2HCl | Bis-THA inhibitor 1 | CHEMBL213377 | N-...)
Affinity DataIC50:  102nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10479(A3A.2HCl | Bis-THA inhibitor 2 | CHEMBL378006 | N-...)
Affinity DataIC50:  152nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10480(A4A.2HCl | Bis-THA inhibitor 3 | CHEMBL211313 | N-...)
Affinity DataIC50:  252nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM8962(Bis-THA inhibitor 4 | CHEMBL179732 | N-[5-(1,2,3,4...)
Affinity DataIC50:  329nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM9047(Bis-THA inhibitor 5 | CHEMBL73800 | Hexylene-Linke...)
Affinity DataIC50:  119nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10469(Bis-THA inhibitor 1c | Bis-THA inhibitor 8 | CHEMB...)
Affinity DataIC50:  155nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10470(Bis-THA inhibitor 1d | Bis-THA inhibitor 9 | CHEMB...)
Affinity DataIC50:  167nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  92nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10946((1R,10R)-16-methyl-14-{3-[methyl({8-[methyl({3-[(1...)
Affinity DataIC50:  6.30E+4nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10945((1R,10R)-16-methyl-14-{3-[methyl({6-[methyl({3-[(1...)
Affinity DataIC50:  6.79E+4nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10944((1R,10R)-16-methyl-14-{2-[methyl({8-[methyl({2-[(1...)
Affinity DataIC50:  6.54E+4nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10943((1R,10R)-16-methyl-14-{2-[methyl({6-[methyl({2-[(1...)
Affinity DataIC50:  6.45E+4nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10942((1R,10R)-16-methyl-14-{2-[methyl({3-[methyl({2-[(1...)
Affinity DataIC50:  6.00E+4nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10632((-)-Huperzine B | (1R,10R)-16-methyl-6,14-diazatet...)
Affinity DataIC50:  2.27E+5nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM10441((+)-Huperzine A | (+/-)Huperzine A | (-)-Huperzine...)
Affinity DataIC50:  7.02E+4nMpH: 7.4 T: 2°CAssay Description:The cholinesterase assays were performed using colorimetric method reported by Ellman. Enzyme activity was determined by measuring the absorbance at...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataIC50:  19.6nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM227587(3-fluoro-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50:  1.02nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM227586(3-Fluoro-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50:  3.79nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM227585(3-Fluoro-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50:  4.76nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM227584(2-Fluoro-N-[4-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50:  1.39nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM227583(2-Fluoro-N-[3-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50:  7.80nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM227582(2-Fluoro-N-[2-(1,2,3,4-tetrahydroacridin-9-ylamino...)
Affinity DataIC50:  1.19E+3nMpH: 7.4 T: 2°CAssay Description:The test was run as described in the following procedure: stock solution of the test compounds was diluted in phosphate buffer pH 7.4 to give final c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM36553(Prochelators, 3)
Affinity DataIC50:  6.07E+4nMpH: 7.4 T: 2°CAssay Description:Inhibition of AChE and BChE activity in rat brain homogenates using Ellman's method. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Rattus norvegicus (rat))
Shanghai Institute Of Materia Medica

LigandPNGBDBM36552(Prochelators, 2)
Affinity DataIC50:  4.49E+4nMpH: 7.4 T: 2°CAssay Description:Inhibition of AChE and BChE activity in rat brain homogenates using Ellman's method. More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198178(N-allyl-6-methyl-4-(2'-oxopyrrolidin-1'-yl...)
Affinity DataIC50:  3.17E+4nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198179(N-allyl-6-methoxy-4-(2'-oxopyrrolidin-1'-y...)
Affinity DataIC50:  6.22E+4nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198177(N-allyl-4-(2'-oxopyrrolidin-1'-yl)-1,2,3,4...)
Affinity DataIC50:  4.57E+5nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198183(N-allyl-6-bromo-4-(2'-oxopyrrolidin-1'-yl)...)
Affinity DataIC50:  2.91E+4nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198182(N-allyl-6-fluor-4-(2'-oxopyrrolidin-1'-yl)...)
Affinity DataIC50:  1.35E+5nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198181(N-allyl-6-ethyl-4-(2'-oxopyrrolidin-1'-yl)...)
Affinity DataIC50:  2.56E+4nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM10404((1S,12S,14R)-9-methoxy-4-methyl-11-oxa-4-azatetrac...)
Affinity DataIC50:  8.80E+3nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198190(N-propargyl-6-bromo-4-(2'-oxopyrrolidin-1'...)
Affinity DataIC50:  8.95E+5nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198189(N-propargyl-6-fluor-4-(2'-oxopyrrolidin-1'...)
Affinity DataIC50:  8.94E+5nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198188(N-propargyl-6-ethyl-4-(2'-oxopyrrolidin-1'...)
Affinity DataIC50:  1.98E+6nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198187(N-propargyl-6-chloro-4-(2'-oxopyrrolidin-1'...)
Affinity DataIC50:  1.33E+6nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198186(N-propargyl-6-methoxy-4-(2'-oxopyrrolidin-1...)
Affinity DataIC50:  1.21E+6nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198185(N-propargyl-6-methyl-4-(2'-oxopyrrolidin-1'...)
Affinity DataIC50:  4.56E+5nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198180(N-allyl-6-chloro-4-(2'-oxopyrrolidin-1'-yl...)
Affinity DataIC50:  6.23E+4nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM198184(N-propargyl-4-(2'-oxopyrrolidin-1'-yl)-1,2...)
Affinity DataIC50:  8.97E+5nMpH: 7.6 T: 2°CAssay Description:In a 96-well plate, 50 uL of the sample dissolved in phosphate buffer (8 mmol/L K2HPO4, 2.3 mmol/L NaH2PO4, 150 mmol/L NaCl, and 0.05% Tween 20 at pH...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM8963(CHEMBL32823 | Homodimeric Tacrine Analog 3b | N-[7...)
Affinity DataKi:  2nM ΔG°:  -49.7kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM8961(1,2,3,4-tetrahydro-9-acridinamine | 1,2,3,4-tetrah...)
Affinity DataKi:  7nM ΔG°:  -46.5kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
TargetCarboxylic ester hydrolase(Equus caballus (Horse))
Chung Shan Medical University Hospital

LigandPNGBDBM10525(N-[6-(1,2,3,4-tetrahydroacridin-9-ylsulfanyl)hexyl...)
Affinity DataKi:  30nM ΔG°:  -42.9kJ/molepH: 8.0 T: 2°CAssay Description:Inhibition of enzyme activity was measured over a substrate concentration range of 0.01-30 mM and at least six inhibitor concentrations to determine ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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