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Compile Data Set for Download or QSAR

Found 73 hits of ph data with Target = 'Cathepsin L'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cathepsin L


(Capra hircus (Goat))
BDBM192658
PNG
(N’-(2-nitrophenylmethylene)benzohydrazide (1i...)
Show SMILES [O-][N+](=O)c1ccccc1\C=N\NC(=O)c1ccccc1
Show InChI InChI=1S/C14H11N3O3/c18-14(11-6-2-1-3-7-11)16-15-10-12-8-4-5-9-13(12)17(19)20/h1-10H,(H,16,18)/b15-10+
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4.20 -49.7n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192660
PNG
(N’-(4-nitrophenylmethylene)benzohydrazide (1k...)
Show SMILES [O-][N+](=O)c1ccc(\C=N\NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H11N3O3/c18-14(12-4-2-1-3-5-12)16-15-10-11-6-8-13(9-7-11)17(19)20/h1-10H,(H,16,18)/b15-10+
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PubMed
5.53 -49.0n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192659
PNG
(N’-(3-nitrophenylmethylene)benzohydrazide (1j...)
Show SMILES [O-][N+](=O)c1cccc(\C=N\NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11N3O3/c18-14(12-6-2-1-3-7-12)16-15-10-11-5-4-8-13(9-11)17(19)20/h1-10H,(H,16,18)/b15-10+
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PubMed
5.86 -48.9n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192654
PNG
(N’-(4-chlorophenylmethylene)benzohydrazide (1...)
Show SMILES Clc1ccc(\C=N\NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C14H11ClN2O/c15-13-8-6-11(7-9-13)10-16-17-14(18)12-4-2-1-3-5-12/h1-10H,(H,17,18)/b16-10+
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PubMed
6.34 -48.7n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192652
PNG
(N’-(2-chlorophenylmethylene)benzohydrazide (1...)
Show SMILES Clc1ccccc1\C=N\NC(=O)c1ccccc1
Show InChI InChI=1S/C14H11ClN2O/c15-13-9-5-4-8-12(13)10-16-17-14(18)11-6-2-1-3-7-11/h1-10H,(H,17,18)/b16-10+
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7.30 -48.3n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192655
PNG
(N’-(2-methoxyphenylmethylene)benzohydrazide (...)
Show SMILES COc1ccccc1\C=N\NC(=O)c1ccccc1
Show InChI InChI=1S/C15H14N2O2/c1-19-14-10-6-5-9-13(14)11-16-17-15(18)12-7-3-2-4-8-12/h2-11H,1H3,(H,17,18)/b16-11+
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8.14 -48.0n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192653
PNG
(N’-(3-chlorophenylmethylene)benzohydrazide (1...)
Show SMILES Clc1cccc(\C=N\NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C14H11ClN2O/c15-13-8-4-5-11(9-13)10-16-17-14(18)12-6-2-1-3-7-12/h1-10H,(H,17,18)/b16-10+
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8.63 -47.9n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192650
PNG
(N’-(phenylmethylene)benzohydrazide (1a))
Show SMILES O=C(N\N=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C14H12N2O/c17-14(13-9-5-2-6-10-13)16-15-11-12-7-3-1-4-8-12/h1-11H,(H,16,17)/b15-11+
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13 -46.8n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192657
PNG
(N’-(4-methoxyphenylmethylene)benzohydrazide (...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H14N2O2/c1-19-14-9-7-12(8-10-14)11-16-17-15(18)13-5-3-2-4-6-13/h2-11H,1H3,(H,17,18)/b16-11+
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19.8 -45.7n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192656
PNG
(N’-(3-methoxyphenylmethylene)benzohydrazide (...)
Show SMILES COc1cccc(\C=N\NC(=O)c2ccccc2)c1
Show InChI InChI=1S/C15H14N2O2/c1-19-14-9-5-6-12(10-14)11-16-17-15(18)13-7-3-2-4-8-13/h2-11H,1H3,(H,17,18)/b16-11+
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28.6 -44.8n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192668
PNG
(2-phenyl-5-(4-nitrophenyl)-1,3,4-oxadiazole (2k))
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9N3O3/c18-17(19)12-8-6-11(7-9-12)14-16-15-13(20-14)10-4-2-1-3-5-10/h1-9H
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47.3 -43.5n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192667
PNG
(2-phenyl-5-(2-nitrophenyl)-1,3,4-oxadiazole (2i))
Show SMILES [O-][N+](=O)c1ccccc1-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9N3O3/c18-17(19)12-9-5-4-8-11(12)14-16-15-13(20-14)10-6-2-1-3-7-10/h1-9H
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57 -43.0n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM63525
PNG
(2-(3-nitrophenyl)-5-phenyl-1,3,4-oxadiazole | 2-ph...)
Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9N3O3/c18-17(19)12-8-4-7-11(9-12)14-16-15-13(20-14)10-5-2-1-3-6-10/h1-9H
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63.4 -42.7n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM48184
PNG
(2-(3-chlorophenyl)-5-phenyl-1,3,4-oxadiazole | 2-p...)
Show SMILES Clc1cccc(c1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9ClN2O/c15-12-8-4-7-11(9-12)14-17-16-13(18-14)10-5-2-1-3-6-10/h1-9H
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70.2 -42.5n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192662
PNG
(2-phenyl-5-(2-chlorophenyl)-1,3,4-oxadiazole (2c))
Show SMILES Clc1ccccc1-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9ClN2O/c15-12-9-5-4-8-11(12)14-17-16-13(18-14)10-6-2-1-3-7-10/h1-9H
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92.1 -41.8n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192651
PNG
(N’-(4-methylphenylmethylene)benzohydrazide (1...)
Show SMILES Cc1ccc(\C=N\NC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H14N2O/c1-12-7-9-13(10-8-12)11-16-17-15(18)14-5-3-2-4-6-14/h2-11H,1H3,(H,17,18)/b16-11+
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PubMed
95.9 -41.7n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192663
PNG
(2-phenyl-5-(4-chlorophenyl)-1,3,4-oxadiazole (2e))
Show SMILES Clc1ccc(cc1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H9ClN2O/c15-12-8-6-11(7-9-12)14-17-16-13(18-14)10-4-2-1-3-5-10/h1-9H
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99.3 -41.6n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192661
PNG
(2,5-diphenyl-1,3,4-oxadiazole (2a))
Show SMILES c1ccc(cc1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C14H10N2O/c1-3-7-11(8-4-1)13-15-16-14(17-13)12-9-5-2-6-10-12/h1-10H
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124 -41.0n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192665
PNG
(2-phenyl-5-(3-methoxyphenyl)-1,3,4-oxadiazole (2g))
Show SMILES COc1cccc(c1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c1-18-13-9-5-8-12(10-13)15-17-16-14(19-15)11-6-3-2-4-7-11/h2-10H,1H3
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144 -40.6n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192664
PNG
(2-phenyl-5-(2-methoxyphenyl)-1,3,4-oxadiazole (2f))
Show SMILES COc1ccccc1-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c1-18-13-10-6-5-9-12(13)15-17-16-14(19-15)11-7-3-2-4-8-11/h2-10H,1H3
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216 -39.6n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM192666
PNG
(2-phenyl-5-(4-methoxyphenyl)-1,3,4-oxadiazole (2h))
Show SMILES COc1ccc(cc1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c1-18-13-9-7-12(8-10-13)15-17-16-14(19-15)11-5-3-2-4-6-11/h2-10H,1H3
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337 -38.4n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Capra hircus (Goat))
BDBM49356
PNG
(2-(4-methylphenyl)-5-phenyl-1,3,4-oxadiazole | 2-P...)
Show SMILES Cc1ccc(cc1)-c1nnc(o1)-c1ccccc1
Show InChI InChI=1S/C15H12N2O/c1-11-7-9-13(10-8-11)15-17-16-14(18-15)12-5-3-2-4-6-12/h2-10H,1H3
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PubMed
1.36E+3 -34.8n/an/an/an/an/a5.037



Kurukshetra University



Assay Description
The proteolytic activity was estimated at pH 5.0, 37 C using 0.1 M acetate buffer as the incubation medium. The homogenate prepared above was incuba...


Bioorg Chem 67: 64-74 (2016)


Article DOI: 10.1016/j.bioorg.2016.05.003
BindingDB Entry DOI: 10.7270/Q20G3HZB
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93184
PNG
(Cathepsin Inhibitor, Column 6 Row 2)
Show SMILES CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2ccccc2s1)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C35H32N4O4S/c1-23(30(40)22-37-33(41)20-25-12-9-14-26(18-25)28-15-7-8-17-36-28)38-34(42)29(19-24-10-3-2-4-11-24)39-35(43)32-21-27-13-5-6-16-31(27)44-32/h2-18,21,23,29H,19-20,22H2,1H3,(H,37,41)(H,38,42)(H,39,43)/t23?,29-/m0/s1
PDB
MMDB

UniProtKB/TrEMBL

B.MOAD
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18n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93178
PNG
(Cathepsin Inhibitor, Column 4 Row 2)
Show SMILES CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ncccc2c1)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C36H33N5O4/c1-24(33(42)23-39-34(43)21-26-11-7-12-27(19-26)30-14-5-6-17-37-30)40-36(45)32(20-25-9-3-2-4-10-25)41-35(44)29-15-16-31-28(22-29)13-8-18-38-31/h2-19,22,24,32H,20-21,23H2,1H3,(H,39,43)(H,40,45)(H,41,44)/t24?,32-/m0/s1
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36n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93175
PNG
(Cathepsin Inhibitor, Column 3 Row 2)
Show SMILES COc1ccc(cc1OC)C(=O)N[C@@H](Cc1ccccc1)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C35H36N4O6/c1-23(30(40)22-37-33(41)20-25-12-9-13-26(18-25)28-14-7-8-17-36-28)38-35(43)29(19-24-10-5-4-6-11-24)39-34(42)27-15-16-31(44-2)32(21-27)45-3/h4-18,21,23,29H,19-20,22H2,1-3H3,(H,37,41)(H,38,43)(H,39,42)/t23?,29-/m0/s1
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53n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93183
PNG
(Cathepsin Inhibitor, Column 6 Row 1)
Show SMILES CC(C)C[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C32H34N4O4S/c1-20(2)15-26(36-32(40)29-18-24-10-4-5-13-28(24)41-29)31(39)35-21(3)27(37)19-34-30(38)17-22-9-8-11-23(16-22)25-12-6-7-14-33-25/h4-14,16,18,20-21,26H,15,17,19H2,1-3H3,(H,34,38)(H,35,39)(H,36,40)/t21?,26-/m0/s1
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90n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93181
PNG
(Cathepsin Inhibitor, Column 5 Row 2)
Show SMILES CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc2ccccc2n1)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C36H33N5O4/c1-24(33(42)23-38-34(43)22-26-12-9-14-28(20-26)29-15-7-8-19-37-29)39-36(45)32(21-25-10-3-2-4-11-25)41-35(44)31-18-17-27-13-5-6-16-30(27)40-31/h2-20,24,32H,21-23H2,1H3,(H,38,43)(H,39,45)(H,41,44)/t24?,32-/m0/s1
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110n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93172
PNG
(Cathepsin Inhibitor, Column 2 Row 2)
Show SMILES CC(NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccc(cc1)C(F)(F)F)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C34H31F3N4O4/c1-22(30(42)21-39-31(43)20-24-10-7-11-26(18-24)28-12-5-6-17-38-28)40-33(45)29(19-23-8-3-2-4-9-23)41-32(44)25-13-15-27(16-14-25)34(35,36)37/h2-18,22,29H,19-21H2,1H3,(H,39,43)(H,40,45)(H,41,44)/t22?,29-/m0/s1
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120n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93180
PNG
(Cathepsin Inhibitor, Column 5 Row 1)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C33H35N5O4/c1-21(2)17-29(38-32(41)28-15-14-24-10-4-5-13-27(24)37-28)33(42)36-22(3)30(39)20-35-31(40)19-23-9-8-11-25(18-23)26-12-6-7-16-34-26/h4-16,18,21-22,29H,17,19-20H2,1-3H3,(H,35,40)(H,36,42)(H,38,41)/t22?,29-/m0/s1
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130n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93177
PNG
(Cathepsin Inhibitor, Column 4 Row 1)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc2ncccc2c1)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C33H35N5O4/c1-21(2)16-29(38-32(41)26-12-13-28-25(19-26)10-7-15-35-28)33(42)37-22(3)30(39)20-36-31(40)18-23-8-6-9-24(17-23)27-11-4-5-14-34-27/h4-15,17,19,21-22,29H,16,18,20H2,1-3H3,(H,36,40)(H,37,42)(H,38,41)/t22?,29-/m0/s1
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130n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93174
PNG
(Cathepsin Inhibitor, Column 3 Row 1)
Show SMILES COc1ccc(cc1OC)C(=O)N[C@@H](CC(C)C)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C32H38N4O6/c1-20(2)15-26(36-31(39)24-12-13-28(41-4)29(18-24)42-5)32(40)35-21(3)27(37)19-34-30(38)17-22-9-8-10-23(16-22)25-11-6-7-14-33-25/h6-14,16,18,20-21,26H,15,17,19H2,1-5H3,(H,34,38)(H,35,40)(H,36,39)/t21?,26-/m0/s1
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150n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93171
PNG
(Cathepsin Inhibitor, Column 2 Row 1)
Show SMILES CC(C)C[C@H](NC(=O)c1ccc(cc1)C(F)(F)F)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C31H33F3N4O4/c1-19(2)15-26(38-29(41)22-10-12-24(13-11-22)31(32,33)34)30(42)37-20(3)27(39)18-36-28(40)17-21-7-6-8-23(16-21)25-9-4-5-14-35-25/h4-14,16,19-20,26H,15,17-18H2,1-3H3,(H,36,40)(H,37,42)(H,38,41)/t20?,26-/m0/s1
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230n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93185
PNG
(Cathepsin Inhibitor, Column 6 Row 3)
Show SMILES CC(C)[C@H](NC(=O)c1cc2ccccc2s1)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C31H32N4O4S/c1-19(2)29(35-30(38)27-17-23-10-4-5-13-26(23)40-27)31(39)34-20(3)25(36)18-33-28(37)16-21-9-8-11-22(15-21)24-12-6-7-14-32-24/h4-15,17,19-20,29H,16,18H2,1-3H3,(H,33,37)(H,34,39)(H,35,38)/t20?,29-/m0/s1
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>1.00E+3n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93182
PNG
(Cathepsin Inhibitor, Column 5 Row 3)
Show SMILES CC(C)[C@H](NC(=O)c1ccc2ccccc2n1)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C32H33N5O4/c1-20(2)30(37-31(40)27-15-14-23-10-4-5-13-26(23)36-27)32(41)35-21(3)28(38)19-34-29(39)18-22-9-8-11-24(17-22)25-12-6-7-16-33-25/h4-17,20-21,30H,18-19H2,1-3H3,(H,34,39)(H,35,41)(H,37,40)/t21?,30-/m0/s1
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>1.00E+3n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93179
PNG
(Cathepsin Inhibitor, Column 4 Row 3)
Show SMILES CC(C)[C@H](NC(=O)c1ccc2ncccc2c1)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C32H33N5O4/c1-20(2)30(37-31(40)25-12-13-27-24(18-25)10-7-15-34-27)32(41)36-21(3)28(38)19-35-29(39)17-22-8-6-9-23(16-22)26-11-4-5-14-33-26/h4-16,18,20-21,30H,17,19H2,1-3H3,(H,35,39)(H,36,41)(H,37,40)/t21?,30-/m0/s1
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>1.00E+3n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93168
PNG
(Cathepsin Inhibitor, Column 1 Row 1)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C25H32N4O4/c1-16(2)12-22(29-18(4)30)25(33)28-17(3)23(31)15-27-24(32)14-19-8-7-9-20(13-19)21-10-5-6-11-26-21/h5-11,13,16-17,22H,12,14-15H2,1-4H3,(H,27,32)(H,28,33)(H,29,30)/t17?,22-/m0/s1
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>1.00E+3n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93169
PNG
(Cathepsin Inhibitor, Column 1 Row 2)
Show SMILES CC(NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C28H30N4O4/c1-19(31-28(36)25(32-20(2)33)16-21-9-4-3-5-10-21)26(34)18-30-27(35)17-22-11-8-12-23(15-22)24-13-6-7-14-29-24/h3-15,19,25H,16-18H2,1-2H3,(H,30,35)(H,31,36)(H,32,33)/t19?,25-/m0/s1
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>1.00E+3n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93170
PNG
(Cathepsin Inhibitor, Column 1 Row 3)
Show SMILES CC(C)[C@H](NC(C)=O)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C24H30N4O4/c1-15(2)23(28-17(4)29)24(32)27-16(3)21(30)14-26-22(31)13-18-8-7-9-19(12-18)20-10-5-6-11-25-20/h5-12,15-16,23H,13-14H2,1-4H3,(H,26,31)(H,27,32)(H,28,29)/t16?,23-/m0/s1
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>1.00E+3n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93173
PNG
(Cathepsin Inhibitor, Column 2 Row 3)
Show SMILES CC(C)[C@H](NC(=O)c1ccc(cc1)C(F)(F)F)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C30H31F3N4O4/c1-18(2)27(37-28(40)21-10-12-23(13-11-21)30(31,32)33)29(41)36-19(3)25(38)17-35-26(39)16-20-7-6-8-22(15-20)24-9-4-5-14-34-24/h4-15,18-19,27H,16-17H2,1-3H3,(H,35,39)(H,36,41)(H,37,40)/t19?,27-/m0/s1
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>1.00E+3n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM93176
PNG
(Cathepsin Inhibitor, Column 3 Row 3)
Show SMILES COc1ccc(cc1OC)C(=O)N[C@@H](C(C)C)C(=O)NC(C)C(=O)CNC(=O)Cc1cccc(c1)-c1ccccn1
Show InChI InChI=1S/C31H36N4O6/c1-19(2)29(35-30(38)23-12-13-26(40-4)27(17-23)41-5)31(39)34-20(3)25(36)18-33-28(37)16-21-9-8-10-22(15-21)24-11-6-7-14-32-24/h6-15,17,19-20,29H,16,18H2,1-5H3,(H,33,37)(H,34,39)(H,35,38)/t20?,29-/m0/s1
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>1.00E+3n/an/an/an/an/an/a5.5n/a



SmithKline Beecham Pharmaceuticals



Assay Description
Inhibitors were assayed against human liver Cathepsin L and B. Inhibitors were also evaluated for inhibition against purified recombinant Cathepsin ...


J Comb Chem 1: 207-15


BindingDB Entry DOI: 10.7270/Q2HQ3XHJ
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM36813
PNG
(CA-074b)
Show SMILES CCC(C)[C@H](NC(=O)C1OC1NCC(C)C)C(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C18H31N3O5/c1-5-11(4)13(17(23)21-8-6-7-12(21)18(24)25)20-15(22)14-16(26-14)19-9-10(2)3/h10-14,16,19H,5-9H2,1-4H3,(H,20,22)(H,24,25)/t11?,12-,13+,14?,16?/m1/s1
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Article
PubMed
n/an/a>1.00E+4n/an/an/an/a5.525



University of California, San Francisco



Assay Description
Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...


Chem Biol 7: 27-38 (2000)


Article DOI: 10.1124/jpet.104.078303
BindingDB Entry DOI: 10.7270/Q24B2ZN5
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM36814
PNG
(MB-074)
Show SMILES CCC(C)[C@H](NC(=O)C1OC1NCCc1ccc(O)cc1)C(=O)N1OCC[C@@H]1C(O)=O
Show InChI InChI=1S/C21H29N3O7/c1-3-12(2)16(20(27)24-15(21(28)29)9-11-30-24)23-18(26)17-19(31-17)22-10-8-13-4-6-14(25)7-5-13/h4-7,12,15-17,19,22,25H,3,8-11H2,1-2H3,(H,23,26)(H,28,29)/t12?,15-,16+,17?,19?/m1/s1
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n/an/a>1.00E+4n/an/an/an/a5.525



University of California, San Francisco



Assay Description
Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...


Chem Biol 7: 27-38 (2000)


Article DOI: 10.1124/jpet.104.078303
BindingDB Entry DOI: 10.7270/Q24B2ZN5
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM36812
PNG
(CA-074)
Show SMILES CCCNC1OC1C(=O)N[C@@H](C(C)CC)C(=O)N1CCC[C@@H]1C(O)=O
Show InChI InChI=1S/C17H29N3O5/c1-4-8-18-15-13(25-15)14(21)19-12(10(3)5-2)16(22)20-9-6-7-11(20)17(23)24/h10-13,15,18H,4-9H2,1-3H3,(H,19,21)(H,23,24)/t10?,11-,12+,13?,15?/m1/s1
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PubMed
n/an/a>1.00E+4n/an/an/an/a5.525



University of California, San Francisco



Assay Description
Inhibition assay using pre-treatment of recombinant cathepsin-L-like cysteine protease cruzain lacking the carboxy-terminal domain or cathepsin B fr...


Chem Biol 7: 27-38 (2000)


Article DOI: 10.1124/jpet.104.078303
BindingDB Entry DOI: 10.7270/Q24B2ZN5
More data for this
Ligand-Target Pair
Cathepsin L


(Bos taurus (bovine))
BDBM92334
PNG
(Dipeptide nitrile, 7)
Show SMILES CSCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C#N
Show InChI InChI=1S/C19H27N3O3S/c1-19(2,3)25-18(24)22-16(12-14-8-6-5-7-9-14)17(23)21-15(13-20)10-11-26-4/h5-9,15-16H,10-12H2,1-4H3,(H,21,23)(H,22,24)/t15?,16-/m0/s1
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PubMed
270 -39.0n/an/an/an/an/a6.037



Rheinische Friedrich-Wilhelms-Universitat



Assay Description
Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...


J Enzyme Inhib Med Chem 24: 1245-52 (2009)


Article DOI: 10.3109/14756360902797328
BindingDB Entry DOI: 10.7270/Q2Q23XVB
More data for this
Ligand-Target Pair
Cathepsin L


(Bos taurus (bovine))
BDBM92335
PNG
(Dipeptide nitrile, 8)
Show SMILES C[S+](C)CCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C#N
Show InChI InChI=1S/C20H29N3O3S/c1-20(2,3)26-19(25)23-17(13-15-9-7-6-8-10-15)18(24)22-16(14-21)11-12-27(4)5/h6-10,16-17H,11-13H2,1-5H3,(H-,22,23,24,25)/p+1/t16?,17-/m0/s1
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520 -37.3n/an/an/an/an/a6.037



Rheinische Friedrich-Wilhelms-Universitat



Assay Description
Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...


J Enzyme Inhib Med Chem 24: 1245-52 (2009)


Article DOI: 10.3109/14756360902797328
BindingDB Entry DOI: 10.7270/Q2Q23XVB
More data for this
Ligand-Target Pair
Cathepsin L


(Bos taurus (bovine))
BDBM92336
PNG
(Dipeptide nitrile, 10)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC#N)C#N
Show InChI InChI=1S/C18H22N4O3/c1-18(2,3)25-17(24)22-15(11-13-7-5-4-6-8-13)16(23)21-14(12-20)9-10-19/h4-8,14-15H,9,11H2,1-3H3,(H,21,23)(H,22,24)/t14-,15-/m0/s1
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900 -35.9n/an/an/an/an/a6.037



Rheinische Friedrich-Wilhelms-Universitat



Assay Description
Cathepsin enzyme activities were calculated from kinetic measurements performed by fluorimetric detection of the product 7-amino-4-methylcoumarin at ...


J Enzyme Inhib Med Chem 24: 1245-52 (2009)


Article DOI: 10.3109/14756360902797328
BindingDB Entry DOI: 10.7270/Q2Q23XVB
More data for this
Ligand-Target Pair
Cathepsin L


(Mus musculus)
BDBM36332
PNG
(LI-1 | Legumain Inhibitor -1)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N(CC(N)=O)NC(=O)[C@@H]1CCCN1C(C)=O
Show InChI InChI=1S/C15H22N4O7/c1-3-25-15(24)12-11(26-12)14(23)19(7-10(16)21)17-13(22)9-5-4-6-18(9)8(2)20/h9,11-12H,3-7H2,1-2H3,(H2,16,21)(H,17,22)/t9-,11-,12-/m0/s1
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PubMed
n/an/a 2.20E+5n/an/an/an/a6.2525



Stanford University



Assay Description
IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).


ACS Chem Biol 5: 233-43 (2010)


Article DOI: 10.1021/cb900232a
BindingDB Entry DOI: 10.7270/Q2Z31X0W
More data for this
Ligand-Target Pair
Cathepsin L


(Mus musculus)
BDBM36333
PNG
(LI-0 | Legumain Inhibitor -0)
Show SMILES CC(=O)N1CCC[C@H]1C(=O)N[C@H](CCOC(=O)c1c(C)cccc1C)CC(O)=O
Show InChI InChI=1S/C21H28N2O6/c1-13-6-4-7-14(2)19(13)21(28)29-11-9-16(12-18(25)26)22-20(27)17-8-5-10-23(17)15(3)24/h4,6-7,16-17H,5,8-12H2,1-3H3,(H,22,27)(H,25,26)/t16-,17+/m1/s1
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n/an/a>1.00E+6n/an/an/an/a6.2525



Stanford University



Assay Description
IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).


ACS Chem Biol 5: 233-43 (2010)


Article DOI: 10.1021/cb900232a
BindingDB Entry DOI: 10.7270/Q2Z31X0W
More data for this
Ligand-Target Pair
Cathepsin L


(Mus musculus)
BDBM36334
PNG
(CID644294 | JPM 565 | JPM-OEt | US9345789, JPM-Oet)
Show SMILES CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](C(C)CC)C(=O)NCCc1ccc(O)cc1
Show InChI InChI=1S/C20H28N2O6/c1-4-12(3)15(22-19(25)16-17(28-16)20(26)27-5-2)18(24)21-11-10-13-6-8-14(23)9-7-13/h6-9,12,15-17,23H,4-5,10-11H2,1-3H3,(H,21,24)(H,22,25)/t12?,15-,16-,17-/m0/s1
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Article
PubMed
n/an/a 2.98E+3n/an/an/an/a6.2525



Stanford University



Assay Description
IC50 measurements and enzyme kinetics assays were performed on a Spectramax M5 fluorescent plate reader (Molecular Devices).


ACS Chem Biol 5: 233-43 (2010)


Article DOI: 10.1021/cb900232a
BindingDB Entry DOI: 10.7270/Q2Z31X0W
More data for this
Ligand-Target Pair
Cathepsin L


(Homo sapiens (Human))
BDBM31989
PNG
(Dipeptidyl nitrile inhibitor, 22)
Show SMILES Cc1cc(C(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)NCC#N)c(C)s1
Show InChI InChI=1S/C18H18ClN3O2S/c1-11-8-15(12(2)25-11)17(23)22-16(18(24)21-7-6-20)10-13-4-3-5-14(19)9-13/h3-5,8-9,16H,7,10H2,1-2H3,(H,21,24)(H,22,23)/t16-/m0/s1
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PubMed
n/an/a 79n/an/an/an/a7.037



AstraZeneca



Assay Description
IC50 values for inhibition of Cathepsins were determined from dose dependent inhibition of cleavage of fluorogenic, AMC-tagged, peptide substrates.


Bioorg Med Chem Lett 19: 4280-3 (2009)


Article DOI: 10.1016/j.bmcl.2009.05.071
BindingDB Entry DOI: 10.7270/Q2TT4PBM
More data for this
Ligand-Target Pair
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