BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 821 hits of ph data with Target = 'Cereblon/Histone deacetylase 6'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM24622
PNG
(3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoy...)
Show SMILES CN(C)Cc1c(oc2ccccc12)C(=O)NCCOc1ccc(cc1)C(=O)NO
Show InChI InChI=1S/C21H23N3O5/c1-24(2)13-17-16-5-3-4-6-18(16)29-19(17)21(26)22-11-12-28-15-9-7-14(8-10-15)20(25)23-27/h3-10,27H,11-13H2,1-2H3,(H,22,26)(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
17 -43.9n/an/an/an/an/a7.422



Celera Genomics



Assay Description
HDAC activity was measured using a continuous trypsin-coupled assay. For inhibitor characterization, measurements were done using 96-well assay plat...


Mol Cancer Ther 5: 1309-17 (2006)


Article DOI: 10.1158/1535-7163.MCT-05-0442
BindingDB Entry DOI: 10.7270/Q2DF6PJJ
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM19149
PNG
(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccccc1
Show InChI InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

DrugBank
Article
PubMed
21 -43.4n/an/an/an/an/a7.422



University of Notre Dame



Assay Description
To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...


J Med Chem 51: 2898-906 (2008)


Article DOI: 10.1021/jm7015254
BindingDB Entry DOI: 10.7270/Q2NC5ZG2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM22450
PNG
(N-hydroxy-N -(4-{(2R,4S,6R)-4-phenyl-6-[(pyridin-4...)
Show SMILES ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)[C@H]1O[C@@H](CSc2ccncc2)C[C@H](O1)c1ccccc1
Show InChI InChI=1S/C30H35N3O5S/c34-28(10-6-1-2-7-11-29(35)33-36)32-24-14-12-23(13-15-24)30-37-25(21-39-26-16-18-31-19-17-26)20-27(38-30)22-8-4-3-5-9-22/h3-5,8-9,12-19,25,27,30,36H,1-2,6-7,10-11,20-21H2,(H,32,34)(H,33,35)/t25-,27+,30+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
28 -42.7n/an/an/an/an/a7.422



University of Notre Dame



Assay Description
To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...


J Med Chem 51: 2898-906 (2008)


Article DOI: 10.1021/jm7015254
BindingDB Entry DOI: 10.7270/Q2NC5ZG2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM22449
PNG
(CHEMBL356769 | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-...)
Show SMILES OCc1ccc(cc1)[C@@H]1C[C@H](CSc2nc(c(o2)-c2ccccc2)-c2ccccc2)O[C@@H](O1)c1ccc(NC(=O)CCCCCCC(=O)NO)cc1
Show InChI InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
142 -38.7n/an/an/an/an/a7.422



University of Notre Dame



Assay Description
To assess the effect of test compounds on histone deacetylase enzyme function in Vitro, a fluorometric assay was performed using HDAC, which incubate...


J Med Chem 51: 2898-906 (2008)


Article DOI: 10.1021/jm7015254
BindingDB Entry DOI: 10.7270/Q2NC5ZG2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109949
PNG
(US8609678, 4-(diphenylamino)-N-(7-(hydroxyamino)-7...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H29N3O3/c30-25(28-32)15-9-1-2-10-20-27-26(31)21-16-18-24(19-17-21)29(22-11-5-3-6-12-22)23-13-7-4-8-14-23/h3-8,11-14,16-19,32H,1-2,9-10,15,20H2,(H,27,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 18n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109950
PNG
(US8609678, 4-(dipyrimidin-2-ylamino)-N-(7-(hydroxy...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1ncccn1)c1ncccn1
Show InChI InChI=1S/C22H25N7O3/c30-19(28-32)7-3-1-2-4-12-23-20(31)17-8-10-18(11-9-17)29(21-24-13-5-14-25-21)22-26-15-6-16-27-22/h5-6,8-11,13-16,32H,1-4,7,12H2,(H,23,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 174n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109951
PNG
(US8609678, 4-(bis(4-methoxyphenyl)amino)-N-(7-(hyd...)
Show SMILES COc1ccc(cc1)N(c1ccc(OC)cc1)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C28H33N3O5/c1-35-25-16-12-23(13-17-25)31(24-14-18-26(36-2)19-15-24)22-10-8-21(9-11-22)28(33)29-20-6-4-3-5-7-27(32)30-34/h8-19,34H,3-7,20H2,1-2H3,(H,29,33)(H,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 200n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109952
PNG
(US8609678, 4-((2,6-dichlorophenyl)(methyl)amino)-N...)
Show SMILES CN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C21H25Cl2N3O3/c1-26(20-17(22)7-6-8-18(20)23)16-12-10-15(11-13-16)21(28)24-14-5-3-2-4-9-19(27)25-29/h6-8,10-13,29H,2-5,9,14H2,1H3,(H,24,28)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109953
PNG
(US8609678, 4-(dipyrimidin-2-ylamino)-N-(8-(hydroxy...)
Show SMILES ONC(=O)CCCCCCCNC(=O)c1ccc(cc1)N(c1ncccn1)c1ncccn1
Show InChI InChI=1S/C23H27N7O3/c31-20(29-33)8-4-2-1-3-5-13-24-21(32)18-9-11-19(12-10-18)30(22-25-14-6-15-26-22)23-27-16-7-17-28-23/h6-7,9-12,14-17,33H,1-5,8,13H2,(H,24,32)(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109954
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(met...)
Show SMILES CN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C22H26F3N3O3/c1-28(19-9-6-5-8-18(19)22(23,24)25)17-13-11-16(12-14-17)21(30)26-15-7-3-2-4-10-20(29)27-31/h5-6,8-9,11-14,31H,2-4,7,10,15H2,1H3,(H,26,30)(H,27,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109955
PNG
(US8609678, 4-((2,6-diisopropylphenyl)(methyl)amino...)
Show SMILES CC(C)c1cccc(C(C)C)c1N(C)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C27H39N3O3/c1-19(2)23-11-10-12-24(20(3)4)26(23)30(5)22-16-14-21(15-17-22)27(32)28-18-9-7-6-8-13-25(31)29-33/h10-12,14-17,19-20,33H,6-9,13,18H2,1-5H3,(H,28,32)(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 45n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109956
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-2-(met...)
Show SMILES CN(c1ccccc1)c1ncc(cn1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C19H25N5O3/c1-24(16-9-5-4-6-10-16)19-21-13-15(14-22-19)18(26)20-12-8-3-2-7-11-17(25)23-27/h4-6,9-10,13-14,27H,2-3,7-8,11-12H2,1H3,(H,20,26)(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109957
PNG
(US8609678, 4-(2,6-diisopropylphenylamino)-N-(7-(hy...)
Show SMILES CC(C)c1cccc(C(C)C)c1Nc1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C26H37N3O3/c1-18(2)22-10-9-11-23(19(3)4)25(22)28-21-15-13-20(14-16-21)26(31)27-17-8-6-5-7-12-24(30)29-32/h9-11,13-16,18-19,28,32H,5-8,12,17H2,1-4H3,(H,27,31)(H,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 20n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109958
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-2-((2-...)
Show SMILES CC(C)c1ccccc1N(C)c1ncc(cn1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C22H31N5O3/c1-16(2)18-10-7-8-11-19(18)27(3)22-24-14-17(15-25-22)21(29)23-13-9-5-4-6-12-20(28)26-30/h7-8,10-11,14-16,30H,4-6,9,12-13H2,1-3H3,(H,23,29)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109959
PNG
(US8609678, 4-(2,6-dimethylphenylamino)-N-(7-(hydro...)
Show SMILES Cc1cccc(C)c1Nc1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C22H29N3O3/c1-16-8-7-9-17(2)21(16)24-19-13-11-18(12-14-19)22(27)23-15-6-4-3-5-10-20(26)25-28/h7-9,11-14,24,28H,3-6,10,15H2,1-2H3,(H,23,27)(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109960
PNG
(US8609678, 4-(ethyl(2-(trifluoromethyl)phenyl)amin...)
Show SMILES CCN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C23H28F3N3O3/c1-2-29(20-10-7-6-9-19(20)23(24,25)26)18-14-12-17(13-15-18)22(31)27-16-8-4-3-5-11-21(30)28-32/h6-7,9-10,12-15,32H,2-5,8,11,16H2,1H3,(H,27,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109961
PNG
(US8609678, 4-(diphenylamino)-N-(7-(hydroxyamino)-7...)
Show SMILES CN(CCCCCCC(=O)NO)C(=O)c1ccc(cc1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C27H31N3O3/c1-29(21-11-3-2-10-16-26(31)28-33)27(32)22-17-19-25(20-18-22)30(23-12-6-4-7-13-23)24-14-8-5-9-15-24/h4-9,12-15,17-20,33H,2-3,10-11,16,21H2,1H3,(H,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 82n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109962
PNG
(US8609678, 4-(dipyrimidin-2-ylamino)-N-(7-(hydroxy...)
Show SMILES CN(CCCCCCC(=O)NO)C(=O)c1ccc(cc1)N(c1ncccn1)c1ncccn1
Show InChI InChI=1S/C23H27N7O3/c1-29(17-5-3-2-4-8-20(31)28-33)21(32)18-9-11-19(12-10-18)30(22-24-13-6-14-25-22)23-26-15-7-16-27-23/h6-7,9-16,33H,2-5,8,17H2,1H3,(H,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 198n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109963
PNG
(US8609678, 4-((2,6-dichlorophenyl)(ethyl)amino)-N-...)
Show SMILES CCN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C22H27Cl2N3O3/c1-2-27(21-18(23)8-7-9-19(21)24)17-13-11-16(12-14-17)22(29)25-15-6-4-3-5-10-20(28)26-30/h7-9,11-14,30H,2-6,10,15H2,1H3,(H,25,29)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 8n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109964
PNG
(US8609678, 4-(2,6-dichlorophenylamino)-N-(7-(hydro...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(Nc2c(Cl)cccc2Cl)cc1
Show InChI InChI=1S/C20H23Cl2N3O3/c21-16-6-5-7-17(22)19(16)24-15-11-9-14(10-12-15)20(27)23-13-4-2-1-3-8-18(26)25-28/h5-7,9-12,24,28H,1-4,8,13H2,(H,23,27)(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109965
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(phe...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1ccccc1)c1ncccn1
Show InChI InChI=1S/C24H27N5O3/c30-22(28-32)11-6-1-2-7-16-25-23(31)19-12-14-21(15-13-19)29(20-9-4-3-5-10-20)24-26-17-8-18-27-24/h3-5,8-10,12-15,17-18,32H,1-2,6-7,11,16H2,(H,25,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109966
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-2-((2-...)
Show SMILES CC(C)c1ccccc1N(C)c1ncc(cn1)C(=O)N(C)CCCCCCC(=O)NO
Show InChI InChI=1S/C23H33N5O3/c1-17(2)19-11-8-9-12-20(19)28(4)23-24-15-18(16-25-23)22(30)27(3)14-10-6-5-7-13-21(29)26-31/h8-9,11-12,15-17,31H,5-7,10,13-14H2,1-4H3,(H,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 50n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109967
PNG
(US8609678, 4-((2-chloro-6-methylphenyl)(methyl)ami...)
Show SMILES CN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1c(C)cccc1Cl
Show InChI InChI=1S/C22H28ClN3O3/c1-16-8-7-9-19(23)21(16)26(2)18-13-11-17(12-14-18)22(28)24-15-6-4-3-5-10-20(27)25-29/h7-9,11-14,29H,3-6,10,15H2,1-2H3,(H,24,28)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109968
PNG
(US8609678, 4-((2,6-difluorophenyl)(methyl)amino)-N...)
Show SMILES CN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1c(F)cccc1F
Show InChI InChI=1S/C21H25F2N3O3/c1-26(20-17(22)7-6-8-18(20)23)16-12-10-15(11-13-16)21(28)24-14-5-3-2-4-9-19(27)25-29/h6-8,10-13,29H,2-5,9,14H2,1H3,(H,24,28)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109969
PNG
(US8609678, 4-(ethyl(2-(trifluoromethyl)phenyl)amin...)
Show SMILES CCN(c1ccc(cc1)C(=O)N(C)CCCCCCC(=O)NO)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C24H30F3N3O3/c1-3-30(21-11-8-7-10-20(21)24(25,26)27)19-15-13-18(14-16-19)23(32)29(2)17-9-5-4-6-12-22(31)28-33/h7-8,10-11,13-16,33H,3-6,9,12,17H2,1-2H3,(H,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 6n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109970
PNG
(US8609678, 4-(2,6-difluorophenylamino)-N-(7-(hydro...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(Nc2c(F)cccc2F)cc1
Show InChI InChI=1S/C20H23F2N3O3/c21-16-6-5-7-17(22)19(16)24-15-11-9-14(10-12-15)20(27)23-13-4-2-1-3-8-18(26)25-28/h5-7,9-12,24,28H,1-4,8,13H2,(H,23,27)(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109971
PNG
(US8609678, 4-(bis(3-chlorophenyl)amino)-N-(7-(hydr...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1cccc(Cl)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C26H27Cl2N3O3/c27-20-7-5-9-23(17-20)31(24-10-6-8-21(28)18-24)22-14-12-19(13-15-22)26(33)29-16-4-2-1-3-11-25(32)30-34/h5-10,12-15,17-18,34H,1-4,11,16H2,(H,29,33)(H,30,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 858n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109968
PNG
(US8609678, 4-((2,6-difluorophenyl)(methyl)amino)-N...)
Show SMILES CN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1c(F)cccc1F
Show InChI InChI=1S/C21H25F2N3O3/c1-26(20-17(22)7-6-8-18(20)23)16-12-10-15(11-13-16)21(28)24-14-5-3-2-4-9-19(27)25-29/h6-8,10-13,29H,2-5,9,14H2,1H3,(H,24,28)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 121n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109973
PNG
(US8609678, 2-(2,6-dimethylphenylamino)-N-(7-(hydro...)
Show SMILES Cc1cccc(C)c1Nc1ncc(cn1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C20H27N5O3/c1-14-8-7-9-15(2)18(14)24-20-22-12-16(13-23-20)19(27)21-11-6-4-3-5-10-17(26)25-28/h7-9,12-13,28H,3-6,10-11H2,1-2H3,(H,21,27)(H,25,26)(H,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 33n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM50439674
PNG
(RICOLINOSTAT | US8609678, 2-(diphenylamino)-N-(7-(...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1cnc(nc1)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H27N5O3/c30-22(28-32)15-9-1-2-10-16-25-23(31)19-17-26-24(27-18-19)29(20-11-5-3-6-12-20)21-13-7-4-8-14-21/h3-8,11-14,17-18,32H,1-2,9-10,15-16H2,(H,25,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem

Similars

US Patent
n/an/a 10n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109974
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(met...)
Show SMILES CN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1cnccn1
Show InChI InChI=1S/C19H25N5O3/c1-24(17-14-20-12-13-21-17)16-9-7-15(8-10-16)19(26)22-11-5-3-2-4-6-18(25)23-27/h7-10,12-14,27H,2-6,11H2,1H3,(H,22,26)(H,23,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 21n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109975
PNG
(US8609678, 4-(2,6-dimethylphenylamino)-N-(7-(hydro...)
Show SMILES CN(CCCCCCC(=O)NO)C(=O)c1ccc(Nc2c(C)cccc2C)cc1
Show InChI InChI=1S/C23H31N3O3/c1-17-9-8-10-18(2)22(17)24-20-14-12-19(13-15-20)23(28)26(3)16-7-5-4-6-11-21(27)25-29/h8-10,12-15,24,29H,4-7,11,16H2,1-3H3,(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109976
PNG
(US8609678, 4-(ethyl(pyrazin-2-yl)amino)-N-(7-(hydr...)
Show SMILES CCN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1cnccn1
Show InChI InChI=1S/C20H27N5O3/c1-2-25(18-15-21-13-14-22-18)17-10-8-16(9-11-17)20(27)23-12-6-4-3-5-7-19(26)24-28/h8-11,13-15,28H,2-7,12H2,1H3,(H,23,27)(H,24,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109977
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(1-m...)
Show SMILES Cn1c(Nc2ccc(cc2)C(=O)NCCCCCCC(=O)NO)nc2ccccc12
Show InChI InChI=1S/C22H27N5O3/c1-27-19-9-6-5-8-18(19)25-22(27)24-17-13-11-16(12-14-17)21(29)23-15-7-3-2-4-10-20(28)26-30/h5-6,8-9,11-14,30H,2-4,7,10,15H2,1H3,(H,23,29)(H,24,25)(H,26,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109978
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(phe...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1ccccc1)c1cncnc1
Show InChI InChI=1S/C24H27N5O3/c30-23(28-32)10-6-1-2-7-15-27-24(31)19-11-13-21(14-12-19)29(20-8-4-3-5-9-20)22-16-25-18-26-17-22/h3-5,8-9,11-14,16-18,32H,1-2,6-7,10,15H2,(H,27,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109979
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(N-p...)
Show SMILES CC(=O)N(c1ccccc1)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C22H27N3O4/c1-17(26)25(19-9-5-4-6-10-19)20-14-12-18(13-15-20)22(28)23-16-8-3-2-7-11-21(27)24-29/h4-6,9-10,12-15,29H,2-3,7-8,11,16H2,1H3,(H,23,28)(H,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109980
PNG
(US8609678, 4-(benzo[d]oxazol-2-ylamino)-N-(7-(hydr...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(Nc2nc3ccccc3o2)cc1
Show InChI InChI=1S/C21H24N4O4/c26-19(25-28)9-3-1-2-6-14-22-20(27)15-10-12-16(13-11-15)23-21-24-17-7-4-5-8-18(17)29-21/h4-5,7-8,10-13,28H,1-3,6,9,14H2,(H,22,27)(H,23,24)(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 3n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109981
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(phe...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1ccccc1)c1cnccn1
Show InChI InChI=1S/C24H27N5O3/c30-23(28-32)10-6-1-2-7-15-27-24(31)19-11-13-21(14-12-19)29(20-8-4-3-5-9-20)22-18-25-16-17-26-22/h3-5,8-9,11-14,16-18,32H,1-2,6-7,10,15H2,(H,27,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109982
PNG
(US8609678, 2-(2,6-dimethylphenylamino)-N-(7-(hydro...)
Show SMILES CN(CCCCCCC(=O)NO)C(=O)c1cnc(Nc2c(C)cccc2C)nc1
Show InChI InChI=1S/C21H29N5O3/c1-15-9-8-10-16(2)19(15)24-21-22-13-17(14-23-21)20(28)26(3)12-7-5-4-6-11-18(27)25-29/h8-10,13-14,29H,4-7,11-12H2,1-3H3,(H,25,27)(H,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 33n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109983
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(phe...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1ccccc1)c1ccccn1
Show InChI InChI=1S/C25H28N4O3/c30-24(28-32)13-6-1-2-8-19-27-25(31)20-14-16-22(17-15-20)29(21-10-4-3-5-11-21)23-12-7-9-18-26-23/h3-5,7,9-12,14-18,32H,1-2,6,8,13,19H2,(H,27,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109984
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(N-p...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C26H29N3O5S/c30-25(28-32)15-9-1-2-10-20-27-26(31)21-16-18-23(19-17-21)29(22-11-5-3-6-12-22)35(33,34)24-13-7-4-8-14-24/h3-8,11-14,16-19,32H,1-2,9-10,15,20H2,(H,27,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 15n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109985
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-(phe...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(cc1)N(c1ccccc1)c1cccnc1
Show InChI InChI=1S/C25H28N4O3/c30-24(28-32)12-6-1-2-7-18-27-25(31)20-13-15-22(16-14-20)29(21-9-4-3-5-10-21)23-11-8-17-26-19-23/h3-5,8-11,13-17,19,32H,1-2,6-7,12,18H2,(H,27,31)(H,28,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 21n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109986
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-4-((3-...)
Show SMILES Cc1cccnc1N(c1ccccc1)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C26H30N4O3/c1-20-10-9-19-27-25(20)30(22-11-5-4-6-12-22)23-16-14-21(15-17-23)26(32)28-18-8-3-2-7-13-24(31)29-33/h4-6,9-12,14-17,19,33H,2-3,7-8,13,18H2,1H3,(H,28,32)(H,29,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 20n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109987
PNG
(US8609678, 4-(benzo[d]oxazol-2-yl(methyl)amino)-N-...)
Show SMILES CN(CCCCCCC(=O)NO)C(=O)c1ccc(cc1)N(C)c1nc2ccccc2o1
Show InChI InChI=1S/C23H28N4O4/c1-26(16-8-4-3-5-11-21(28)25-30)22(29)17-12-14-18(15-13-17)27(2)23-24-19-9-6-7-10-20(19)31-23/h6-7,9-10,12-15,30H,3-5,8,11,16H2,1-2H3,(H,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 107n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109988
PNG
(US8609678, 4-(benzo[d]oxazol-2-yl(methyl)amino)-N-...)
Show SMILES CN(c1nc2ccccc2o1)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO
Show InChI InChI=1S/C22H26N4O4/c1-26(22-24-18-8-5-6-9-19(18)30-22)17-13-11-16(12-14-17)21(28)23-15-7-3-2-4-10-20(27)25-29/h5-6,8-9,11-14,29H,2-4,7,10,15H2,1H3,(H,23,28)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 11n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109989
PNG
(US8609678, 4-((2-cyanophenyl)(methyl)amino)-N-(7-(...)
Show SMILES CN(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1ccccc1C#N
Show InChI InChI=1S/C22H26N4O3/c1-26(20-9-6-5-8-18(20)16-23)19-13-11-17(12-14-19)22(28)24-15-7-3-2-4-10-21(27)25-29/h5-6,8-9,11-14,29H,2-4,7,10,15H2,1H3,(H,24,28)(H,25,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109990
PNG
(US8609678, 4-(benzo[d]thiazol-2-ylamino)-N-(7-(hyd...)
Show SMILES ONC(=O)CCCCCCNC(=O)c1ccc(Nc2nc3ccccc3s2)cc1
Show InChI InChI=1S/C21H24N4O3S/c26-19(25-28)9-3-1-2-6-14-22-20(27)15-10-12-16(13-11-15)23-21-24-17-7-4-5-8-18(17)29-21/h4-5,7-8,10-13,28H,1-3,6,9,14H2,(H,22,27)(H,23,24)(H,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 12n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109991
PNG
(US8609678, 4-(N-(2,6-dimethylphenyl)acetamido)-N-(...)
Show SMILES CC(=O)N(c1ccc(cc1)C(=O)NCCCCCCC(=O)NO)c1c(C)cccc1C
Show InChI InChI=1S/C24H31N3O4/c1-17-9-8-10-18(2)23(17)27(19(3)28)21-14-12-20(13-15-21)24(30)25-16-7-5-4-6-11-22(29)26-31/h8-10,12-15,31H,4-7,11,16H2,1-3H3,(H,25,30)(H,26,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 22n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109992
PNG
(US8609678, N-(7-(hydroxyamino)-7-oxoheptyl)-N-meth...)
Show SMILES CN(CCCCCCC(=O)NO)C(=O)c1ccc(cc1)N(c1ccccc1)c1cccnc1
Show InChI InChI=1S/C26H30N4O3/c1-29(19-8-3-2-7-13-25(31)28-33)26(32)21-14-16-23(17-15-21)30(22-10-5-4-6-11-22)24-12-9-18-27-20-24/h4-6,9-12,14-18,20,33H,2-3,7-8,13,19H2,1H3,(H,28,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 64n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 6


(Homo sapiens (Human))
BDBM109993
PNG
(US8609678, 4-((2-cyanophenyl)(methyl)amino)-N-(7-(...)
Show SMILES CN(CCCCCCC(=O)NO)C(=O)c1ccc(cc1)N(C)c1ccccc1C#N
Show InChI InChI=1S/C23H28N4O3/c1-26(16-8-4-3-5-11-22(28)25-30)23(29)18-12-14-20(15-13-18)27(2)21-10-7-6-9-19(21)17-24/h6-7,9-10,12-15,30H,3-5,8,11,16H2,1-2H3,(H,25,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 35n/an/an/an/a7.4n/a



Acetylon Pharmaceuticals Inc

US Patent


Assay Description
Compounds for testing were diluted in DMSO to 50 fold the final concentration and a ten point three fold dilution series was made. The compounds were...


US Patent US8609678 (2013)


BindingDB Entry DOI: 10.7270/Q25M64BS
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 821 total )  |  Next  |  Last  >>
Jump to: