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Found 16 hits of ph data with Target = 'Collagenase (ChC)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11725
PNG
(2-{[(2-chlorophenyl)methyl](1,1,2,2,3,3,4,4,5,5,6,...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C18H11ClF17NO4S/c1-7(10(38)39)37(6-8-4-2-3-5-9(8)19)42(40,41)18(35,36)16(30,31)14(26,27)12(22,23)11(20,21)13(24,25)15(28,29)17(32,33)34/h2-5,7H,6H2,1H3,(H,38,39)
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PubMed
1.50E+3 -33.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11724
PNG
(2-{[(2-chlorophenyl)methyl](1,1,2,2,3,3,4,4,4-nona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C14H11ClF9NO4S/c1-7(10(26)27)25(6-8-4-2-3-5-9(8)15)30(28,29)14(23,24)12(18,19)11(16,17)13(20,21)22/h2-5,7H,6H2,1H3,(H,26,27)
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PubMed
3.00E+3 -31.5n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11722
PNG
(2-{[(2-chlorophenyl)methyl](trifluoromethane)sulfo...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C11H11ClF3NO4S/c1-7(10(17)18)16(21(19,20)11(13,14)15)6-8-4-2-3-5-9(8)12/h2-5,7H,6H2,1H3,(H,17,18)
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PubMed
3.30E+3 -31.3n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11736
PNG
(2-{[(2-chlorophenyl)methyl](2-nitrobenzene)sulfona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccccc1[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C16H15ClN2O6S/c1-11(16(20)21)18(10-12-6-2-3-7-13(12)17)26(24,25)15-9-5-4-8-14(15)19(22)23/h2-9,11H,10H2,1H3,(H,20,21)
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PubMed
4.90E+3 -30.3n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11735
PNG
(2-{[(2-chlorophenyl)methyl](3-nitrobenzene)sulfona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C16H15ClN2O6S/c1-11(16(20)21)18(10-12-5-2-3-8-15(12)17)26(24,25)14-7-4-6-13(9-14)19(22)23/h2-9,11H,10H2,1H3,(H,20,21)
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5.00E+3 -30.3n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11734
PNG
(2-{[(2-chlorophenyl)methyl](4-nitrobenzene)sulfona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(cc1)[N+]([O-])=O)C(O)=O
Show InChI InChI=1S/C16H15ClN2O6S/c1-11(16(20)21)18(10-12-4-2-3-5-15(12)17)26(24,25)14-8-6-13(7-9-14)19(22)23/h2-9,11H,10H2,1H3,(H,20,21)
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PubMed
5.10E+3 -30.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11723
PNG
(2-{[(2-chlorophenyl)methyl](trichloromethane)sulfo...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)C(Cl)(Cl)Cl)C(O)=O
Show InChI InChI=1S/C11H11Cl4NO4S/c1-7(10(17)18)16(21(19,20)11(13,14)15)6-8-4-2-3-5-9(8)12/h2-5,7H,6H2,1H3,(H,17,18)
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PubMed
5.20E+3 -30.2n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11731
PNG
(2-[(4-bromobenzene)[(2-chlorophenyl)methyl]sulfona...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(Br)cc1)C(O)=O
Show InChI InChI=1S/C16H15BrClNO4S/c1-11(16(20)21)19(10-12-4-2-3-5-15(12)18)24(22,23)14-8-6-13(17)7-9-14/h2-9,11H,10H2,1H3,(H,20,21)
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PubMed
1.00E+4 -28.5n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11732
PNG
(2-{[(2-chlorophenyl)methyl](4-iodobenzene)sulfonam...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(I)cc1)C(O)=O
Show InChI InChI=1S/C16H15ClINO4S/c1-11(16(20)21)19(10-12-4-2-3-5-15(12)17)24(22,23)14-8-6-13(18)7-9-14/h2-9,11H,10H2,1H3,(H,20,21)
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PubMed
1.00E+4 -28.5n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11729
PNG
(2-{[(2-chlorophenyl)methyl](4-fluorobenzene)sulfon...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(F)cc1)C(O)=O
Show InChI InChI=1S/C16H15ClFNO4S/c1-11(16(20)21)19(10-12-4-2-3-5-15(12)17)24(22,23)14-8-6-13(18)7-9-14/h2-9,11H,10H2,1H3,(H,20,21)
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PubMed
1.20E+4 -28.1n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11730
PNG
(2-[(4-chlorobenzene)[(2-chlorophenyl)methyl]sulfon...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(Cl)cc1)C(O)=O
Show InChI InChI=1S/C16H15Cl2NO4S/c1-11(16(20)21)19(10-12-4-2-3-5-15(12)18)24(22,23)14-8-6-13(17)7-9-14/h2-9,11H,10H2,1H3,(H,20,21)
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PubMed
1.30E+4 -27.9n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11728
PNG
(2-{[(2-chlorophenyl)methyl](phenylmethane)sulfonam...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C17H18ClNO4S/c1-13(17(20)21)19(11-15-9-5-6-10-16(15)18)24(22,23)12-14-7-3-2-4-8-14/h2-10,13H,11-12H2,1H3,(H,20,21)
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1.60E+4 -27.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11733
PNG
(2-{[(2-chlorophenyl)methyl](4-methylbenzene)sulfon...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccc(C)cc1)C(O)=O
Show InChI InChI=1S/C17H18ClNO4S/c1-12-7-9-15(10-8-12)24(22,23)19(13(2)17(20)21)11-14-5-3-4-6-16(14)18/h3-10,13H,11H2,1-2H3,(H,20,21)
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PubMed
1.80E+4 -27.1n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11721
PNG
(2-{[(2-chlorophenyl)methyl](methane)sulfonamido}pr...)
Show SMILES CC(N(Cc1ccccc1Cl)S(C)(=O)=O)C(O)=O
Show InChI InChI=1S/C11H14ClNO4S/c1-8(11(14)15)13(18(2,16)17)7-9-5-3-4-6-10(9)12/h3-6,8H,7H2,1-2H3,(H,14,15)
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PubMed
2.10E+4 -26.7n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11727
PNG
(2-{benzene[(2-chlorophenyl)methyl]sulfonamido}prop...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)c1ccccc1)C(O)=O
Show InChI InChI=1S/C16H16ClNO4S/c1-12(16(19)20)18(11-13-7-5-6-10-15(13)17)23(21,22)14-8-3-2-4-9-14/h2-10,12H,11H2,1H3,(H,19,20)
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PubMed
2.40E+4 -26.4n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair
Collagenase (ChC)


(Clostridium histolyticum)
BDBM11726
PNG
(2-{[(2-chlorophenyl)methyl](dimethylsulfamoyl)amin...)
Show SMILES CC(N(Cc1ccccc1Cl)S(=O)(=O)N(C)C)C(O)=O
Show InChI InChI=1S/C12H17ClN2O4S/c1-9(12(16)17)15(20(18,19)14(2)3)8-10-6-4-5-7-11(10)13/h4-7,9H,8H2,1-3H3,(H,16,17)
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4.00E+4 -25.1n/an/an/an/an/a7.525



Universita degli Studi di Firenze



Assay Description
The rate of hydrolysis was determined from the change in absorbance at 324 nm using an extinction coefficient, 24700 M-1 cm-1 for FALGPA. Initial vel...


Bioorg Med Chem 8: 637-45 (2000)


Article DOI: 10.1016/j.chembiol.2007.09.006
BindingDB Entry DOI: 10.7270/Q2542KT3
More data for this
Ligand-Target Pair