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Compile Data Set for Download or QSAR

Found 105 hits of ph data with Target = 'Cyclin-Dependent Kinase 5 (CDK5)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7462
PNG
(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Show SMILES Oc1ccc(cc1)-c1oc2cc(O)cc(O)c2c(=O)c1O
Show InChI InChI=1S/C15H10O6/c16-8-3-1-7(2-4-8)15-14(20)13(19)12-10(18)5-9(17)6-11(12)21-15/h1-6,16-18,20H
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Article
PubMed
n/an/a 5.10E+4n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM5655
PNG
(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Show SMILES CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
Show InChI InChI=1S/C21H20ClNO5/c1-23-7-6-12(17(27)10-23)19-14(24)8-15(25)20-16(26)9-18(28-21(19)20)11-4-2-3-5-13(11)22/h2-5,8-9,12,17,24-25,27H,6-7,10H2,1H3/t12-,17+/m0/s1
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n/an/a 170n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7457
PNG
(2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O6/c16-8-2-3-9-12(6-8)21-15(14(20)13(9)19)7-1-4-10(17)11(18)5-7/h1-6,16-18,20H
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n/an/a 570n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7458
PNG
(5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one...)
Show SMILES Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
Show InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
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PubMed
n/an/a 1.60E+3n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7459
PNG
(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccc(O)c(O)c1
Show InChI InChI=1S/C15H10O6/c16-8-4-11(19)15-12(20)6-13(21-14(15)5-8)7-1-2-9(17)10(18)3-7/h1-6,16-19H
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n/an/a 3.80E+3n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7460
PNG
(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)
Show SMILES Oc1cc(O)c2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Show InChI InChI=1S/C15H10O7/c16-7-4-10(19)12-11(5-7)22-15(14(21)13(12)20)6-1-2-8(17)9(18)3-6/h1-5,16-19,21H
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n/an/a 2.30E+4n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7461
PNG
(5,7-dihydroxy-2-phenyl-4H-chromen-4-one | 5,7-dihy...)
Show SMILES Oc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
Show InChI InChI=1S/C15H10O4/c16-10-6-11(17)15-12(18)8-13(19-14(15)7-10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 3.10E+3n/an/an/an/a7.030



Lawrence Berkeley National Laboratory



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


J Med Chem 48: 737-43 (2005)


Article DOI: 10.1021/jm049353p
BindingDB Entry DOI: 10.7270/Q2M61HG4
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7453
PNG
(1-aza-9-oxafluorene deriv. 7b | 4-methoxy-3-phenyl...)
Show SMILES COc1cnc2oc3ccc(O)cc3c2c1-c1ccccc1
Show InChI InChI=1S/C18H13NO3/c1-21-15-10-19-18-17(16(15)11-5-3-2-4-6-11)13-9-12(20)7-8-14(13)22-18/h2-10,20H,1H3
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n/an/a 6.30E+3n/an/an/an/a7.230



Martin-Luther-University Halle-Wittenberg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 15: 823-5 (2005)


Article DOI: 10.1016/j.bmcl.2004.10.091
BindingDB Entry DOI: 10.7270/Q2QZ2853
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7454
PNG
(1-aza-9-oxafluorene deriv. 7c | 4-ethoxy-3-phenyl-...)
Show SMILES CCOc1cnc2oc3ccc(O)cc3c2c1-c1ccccc1
Show InChI InChI=1S/C19H15NO3/c1-2-22-16-11-20-19-18(17(16)12-6-4-3-5-7-12)14-10-13(21)8-9-15(14)23-19/h3-11,21H,2H2,1H3
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n/an/a 5.90E+3n/an/an/an/a7.230



Martin-Luther-University Halle-Wittenberg



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 15: 823-5 (2005)


Article DOI: 10.1016/j.bmcl.2004.10.091
BindingDB Entry DOI: 10.7270/Q2QZ2853
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10841
PNG
(4-(6-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2cc(Br)ccc12
Show InChI InChI=1S/C12H9BrN4/c13-7-1-2-8-9(6-16-11(8)5-7)10-3-4-15-12(14)17-10/h1-6,16H,(H2,14,15,17)
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n/an/a 5.50E+3n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Bioorg Med Chem Lett 14: 1703-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2BZ648W
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10840
PNG
(4-(5-bromo-1H-indol-3-yl)pyrimidin-2-amine | Merid...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2ccc(Br)cc12
Show InChI InChI=1S/C12H9BrN4/c13-7-1-2-10-8(5-7)9(6-16-10)11-3-4-15-12(14)17-11/h1-6,16H,(H2,14,15,17)
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n/an/a 6.00E+3n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Bioorg Med Chem Lett 14: 1703-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2BZ648W
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7491
PNG
((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Show SMILES NC1=NC(=O)C(N1)=C1CCNC(=O)c2[nH]c(Br)cc12
Show InChI InChI=1S/C11H10BrN5O2/c12-6-3-5-4(7-10(19)17-11(13)16-7)1-2-14-9(18)8(5)15-6/h3,15H,1-2H2,(H,14,18)(H3,13,16,17,19)
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n/an/a 28n/an/an/an/a7.230



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7492
PNG
(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Show SMILES Ic1ccc2NC(=O)C(c2c1)c1[nH]c2ccccc2c1N=O
Show InChI InChI=1S/C16H10IN3O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)15-14(20-22)9-3-1-2-4-11(9)18-15/h1-7,13,18H,(H,19,21)
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n/an/a 20n/an/an/an/a7.230



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7370
PNG
(6-(4-chlorophenyl)-7-(propan-2-yl)-5H-pyrrolo[2,3-...)
Show SMILES CC(C)c1c([nH]c2nccnc12)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H14ClN3/c1-9(2)12-13(10-3-5-11(16)6-4-10)19-15-14(12)17-7-8-18-15/h3-9H,1-2H3,(H,18,19)
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n/an/a 1.30E+4n/an/an/an/a7.230



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7266
PNG
(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
Show InChI InChI=1S/C16H11BrN2O/c17-9-5-6-14-11(7-9)12-8-15(20)18-13-4-2-1-3-10(13)16(12)19-14/h1-7,19H,8H2,(H,18,20)
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n/an/a 850n/an/an/an/a7.230



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7336
PNG
(13-bromo-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6}...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccsc-34)c2c1
Show InChI InChI=1S/C14H9BrN2OS/c15-7-1-2-10-8(5-7)9-6-12(18)16-11-3-4-19-14(11)13(9)17-10/h1-5,17H,6H2,(H,16,18)
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n/an/a 4.00E+3n/an/an/an/a7.230



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7496
PNG
(14-bromo-6,8,18-triazatetracyclo[9.7.0.0^{2,7}.0^{...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ncccc-34)c2c1
Show InChI InChI=1S/C15H10BrN3O/c16-8-3-4-12-10(6-8)11-7-13(20)19-15-9(14(11)18-12)2-1-5-17-15/h1-6,18H,7H2,(H,17,19,20)
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n/an/a 1.20E+4n/an/an/an/a7.230



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7497
PNG
(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Show SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4cccnc-34)c2c1
Show InChI InChI=1S/C15H10BrN3O/c16-8-3-4-11-9(6-8)10-7-13(20)18-12-2-1-5-17-15(12)14(10)19-11/h1-6,19H,7H2,(H,18,20)
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n/an/a 4.20E+3n/an/an/an/a7.230



Technische Universitat Braunschweig



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem Lett 14: 413-6 (2004)


Article DOI: 10.1016/j.bmcl.2003.10.062
BindingDB Entry DOI: 10.7270/Q2BR8QDD
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7533
PNG
((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
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n/an/a 200n/an/an/an/a7.230



Chinese Academy of Sciences



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


J Biol Chem 280: 31220-9 (2005)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2Q81B9F
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10909
PNG
((2R)-2-({6-[benzyl(methyl)amino]-9-(propan-2-yl)-9...)
Show SMILES CC[C@H](CO)Nc1nc(N(C)Cc2ccccc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C20H28N6O/c1-5-16(12-27)22-20-23-18(25(4)11-15-9-7-6-8-10-15)17-19(24-20)26(13-21-17)14(2)3/h6-10,13-14,16,27H,5,11-12H2,1-4H3,(H,22,23,24)/t16-/m1/s1
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n/an/a 4.50E+4n/an/an/an/a7.230



Chinese Academy of Sciences



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


J Biol Chem 280: 31220-9 (2005)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2Q81B9F
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10910
PNG
((2R)-2-{[6-(benzyloxy)-9-(propan-2-yl)-9H-purin-2-...)
Show SMILES CC[C@H](CO)Nc1nc(OCc2ccccc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H25N5O2/c1-4-15(10-25)21-19-22-17-16(20-12-24(17)13(2)3)18(23-19)26-11-14-8-6-5-7-9-14/h5-9,12-13,15,25H,4,10-11H2,1-3H3,(H,21,22,23)/t15-/m1/s1
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n/an/a 2.00E+5n/an/an/an/a7.230



Chinese Academy of Sciences



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


J Biol Chem 280: 31220-9 (2005)


Article DOI: 10.1074/jbc.M500805200
BindingDB Entry DOI: 10.7270/Q2Q81B9F
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7503
PNG
(2,6,9-Trisubstituted purine deriv. 3f | 2-Amino-6-...)
Show SMILES Nc1nc(Cl)c2ncn(C3CC=CC3)c2n1
Show InChI InChI=1S/C10H10ClN5/c11-8-7-9(15-10(12)14-8)16(5-13-7)6-3-1-2-4-6/h1-2,5-6H,3-4H2,(H2,12,14,15)
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n/an/a>1.00E+5n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem 7: 1281-93 (1999)


Article DOI: 10.1016/S0968-0896(99)00064-4
BindingDB Entry DOI: 10.7270/Q23776X6
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7504
PNG
(2,6,9-Trisubstituted purine deriv. 4b | 6-Chloro-2...)
Show SMILES CC(C)n1cnc2c(Cl)nc(I)nc12
Show InChI InChI=1S/C8H8ClIN4/c1-4(2)14-3-11-5-6(9)12-8(10)13-7(5)14/h3-4H,1-2H3
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n/an/a>1.00E+5n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem 7: 1281-93 (1999)


Article DOI: 10.1016/S0968-0896(99)00064-4
BindingDB Entry DOI: 10.7270/Q23776X6
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7505
PNG
(2,6,9-Trisubstituted purine deriv. 5a | 2-iodo-N,9...)
Show SMILES CN(CC=C)c1nc(I)nc2n(C)cnc12
Show InChI InChI=1S/C10H12IN5/c1-4-5-15(2)8-7-9(14-10(11)13-8)16(3)6-12-7/h4,6H,1,5H2,2-3H3
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n/an/a 4.00E+4n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem 7: 1281-93 (1999)


Article DOI: 10.1016/S0968-0896(99)00064-4
BindingDB Entry DOI: 10.7270/Q23776X6
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7506
PNG
(2,6,9-Trisubstituted purine deriv. 5b | 2-iodo-N-m...)
Show SMILES CC(C)n1cnc2c(nc(I)nc12)N(C)CC=C
Show InChI InChI=1S/C12H16IN5/c1-5-6-17(4)10-9-11(16-12(13)15-10)18(7-14-9)8(2)3/h5,7-8H,1,6H2,2-4H3
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n/an/a 1.40E+4n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem 7: 1281-93 (1999)


Article DOI: 10.1016/S0968-0896(99)00064-4
BindingDB Entry DOI: 10.7270/Q23776X6
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7507
PNG
(2,6,9-Trisubstituted purine deriv. 5c | CHEMBL1335...)
Show SMILES CC(C)n1cnc2c(NCc3ccccc3)nc(I)nc12
Show InChI InChI=1S/C15H16IN5/c1-10(2)21-9-18-12-13(19-15(16)20-14(12)21)17-8-11-6-4-3-5-7-11/h3-7,9-10H,8H2,1-2H3,(H,17,19,20)
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n/an/a 1.30E+4n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem 7: 1281-93 (1999)


Article DOI: 10.1016/S0968-0896(99)00064-4
BindingDB Entry DOI: 10.7270/Q23776X6
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7508
PNG
(2,6,9-Trisubstituted purine deriv. 5d | CHEMBL1329...)
Show SMILES Ic1nc(NCc2ccccc2)c2ncn(C3CCCC3)c2n1
Show InChI InChI=1S/C17H18IN5/c18-17-21-15(19-10-12-6-2-1-3-7-12)14-16(22-17)23(11-20-14)13-8-4-5-9-13/h1-3,6-7,11,13H,4-5,8-10H2,(H,19,21,22)
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n/an/a>1.00E+5n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem 7: 1281-93 (1999)


Article DOI: 10.1016/S0968-0896(99)00064-4
BindingDB Entry DOI: 10.7270/Q23776X6
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7509
PNG
(2,6,9-Trisubstituted purine deriv. 5e | CHEMBL3359...)
Show SMILES Ic1nc(NCc2ccccc2)c2ncn(C3CCCCC3)c2n1
Show InChI InChI=1S/C18H20IN5/c19-18-22-16(20-11-13-7-3-1-4-8-13)15-17(23-18)24(12-21-15)14-9-5-2-6-10-14/h1,3-4,7-8,12,14H,2,5-6,9-11H2,(H,20,22,23)
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n/an/a>1.00E+5n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem 7: 1281-93 (1999)


Article DOI: 10.1016/S0968-0896(99)00064-4
BindingDB Entry DOI: 10.7270/Q23776X6
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7510
PNG
(2,6,9-Trisubstituted purine deriv. 5f | CHEMBL1334...)
Show SMILES Ic1nc(NCc2ccccc2)c2ncn(Cc3ccccc3)c2n1
Show InChI InChI=1S/C19H16IN5/c20-19-23-17(21-11-14-7-3-1-4-8-14)16-18(24-19)25(13-22-16)12-15-9-5-2-6-10-15/h1-10,13H,11-12H2,(H,21,23,24)
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n/an/a>1.00E+5n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...


Bioorg Med Chem 7: 1281-93 (1999)


Article DOI: 10.1016/S0968-0896(99)00064-4
BindingDB Entry DOI: 10.7270/Q23776X6
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10643
PNG
(2-arylpurine deriv. 8 | 4-{6-[(2-methoxyethyl)amin...)
Show SMILES COCCNc1nc(nc2n(cnc12)C(C)C)-c1ccc(C=O)cc1
Show InChI InChI=1S/C18H21N5O2/c1-12(2)23-11-20-15-17(19-8-9-25-3)21-16(22-18(15)23)14-6-4-13(10-24)5-7-14/h4-7,10-12H,8-9H2,1-3H3,(H,19,21,22)
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n/an/a 1.40E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10644
PNG
(1-(4-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Show SMILES COCCNc1nc(nc2n(cnc12)C(C)C)-c1ccc(cc1)C(C)=O
Show InChI InChI=1S/C19H23N5O2/c1-12(2)24-11-21-16-18(20-9-10-26-4)22-17(23-19(16)24)15-7-5-14(6-8-15)13(3)25/h5-8,11-12H,9-10H2,1-4H3,(H,20,22,23)
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n/an/a 2.80E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10645
PNG
(2-arylpurine deriv. 10 | N-(4-{6-[(2-methoxyethyl)...)
Show SMILES COCCNc1nc(nc2n(cnc12)C(C)C)-c1ccc(NS(C)(=O)=O)cc1
Show InChI InChI=1S/C18H24N6O3S/c1-12(2)24-11-20-15-17(19-9-10-27-3)21-16(22-18(15)24)13-5-7-14(8-6-13)23-28(4,25)26/h5-8,11-12,23H,9-10H2,1-4H3,(H,19,21,22)
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n/an/a 3.00E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10646
PNG
(2-arylpurine deriv. 11 | 4-{6-[(2-methoxyethyl)ami...)
Show SMILES CNC(=O)c1ccc(cc1)-c1nc(NCCOC)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H24N6O2/c1-12(2)25-11-22-15-17(21-9-10-27-4)23-16(24-18(15)25)13-5-7-14(8-6-13)19(26)20-3/h5-8,11-12H,9-10H2,1-4H3,(H,20,26)(H,21,23,24)
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n/an/a 1.80E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10647
PNG
(2-arylpurine deriv. 12 | N-(2-cyanoethyl)-4-{6-[(2...)
Show SMILES COCCNc1nc(nc2n(cnc12)C(C)C)-c1ccc(cc1)C(=O)NCCC#N
Show InChI InChI=1S/C21H25N7O2/c1-14(2)28-13-25-17-19(23-11-12-30-3)26-18(27-20(17)28)15-5-7-16(8-6-15)21(29)24-10-4-9-22/h5-8,13-14H,4,10-12H2,1-3H3,(H,24,29)(H,23,26,27)
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n/an/a 3.40E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10648
PNG
(2-arylpurine deriv. 13 | methyl N-(4-{6-[(2-methox...)
Show SMILES COCCNc1nc(nc2n(cnc12)C(C)C)-c1ccc(NC(=O)OC)cc1
Show InChI InChI=1S/C19H24N6O3/c1-12(2)25-11-21-15-17(20-9-10-27-3)23-16(24-18(15)25)13-5-7-14(8-6-13)22-19(26)28-4/h5-8,11-12H,9-10H2,1-4H3,(H,22,26)(H,20,23,24)
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n/an/a 4.00E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10649
PNG
(1-(5-{6-[(2-methoxyethyl)amino]-9-(propan-2-yl)-9H...)
Show SMILES COCCNc1nc(nc2n(cnc12)C(C)C)-c1ccc(s1)C(C)=O
Show InChI InChI=1S/C17H21N5O2S/c1-10(2)22-9-19-14-16(18-7-8-24-4)20-15(21-17(14)22)13-6-5-12(25-13)11(3)23/h5-6,9-10H,7-8H2,1-4H3,(H,18,20,21)
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n/an/a 4.90E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10650
PNG
(2-purine deriv. 15 | 5-{6-[(2-methoxyethyl)amino]-...)
Show SMILES COCCNc1nc(nc2n(cnc12)C(C)C)-c1ccc(s1)C#N
Show InChI InChI=1S/C16H18N6OS/c1-10(2)22-9-19-13-15(18-6-7-23-3)20-14(21-16(13)22)12-5-4-11(8-17)24-12/h4-5,9-10H,6-7H2,1-3H3,(H,18,20,21)
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n/an/a 2.20E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10651
PNG
(2-purine deriv. 17 | 4-(6-{[(4-methoxyphenyl)methy...)
Show SMILES COc1ccc(CNc2nc(nc3n(cnc23)C(C)C)-c2ccc(C=O)cc2)cc1
Show InChI InChI=1S/C23H23N5O2/c1-15(2)28-14-25-20-22(24-12-16-6-10-19(30-3)11-7-16)26-21(27-23(20)28)18-8-4-17(13-29)5-9-18/h4-11,13-15H,12H2,1-3H3,(H,24,26,27)
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n/an/a 1.30E+3n/an/an/an/a7.230



Institut Curie



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...


Bioorg Med Chem Lett 16: 3144-6 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.060
BindingDB Entry DOI: 10.7270/Q2862DPV
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM7533
PNG
((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
Show InChI InChI=1S/C19H26N6O/c1-4-15(11-26)22-19-23-17(20-10-14-8-6-5-7-9-14)16-18(24-19)25(12-21-16)13(2)3/h5-9,12-13,15,26H,4,10-11H2,1-3H3,(H2,20,22,23,24)/t15-/m1/s1
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Article
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n/an/a 160n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Bioorg Med Chem Lett 14: 1703-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2BZ648W
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10838
PNG
(3-(2-aminopyrimidin-4-yl)-1H-indol-4-ol | Meridian...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2cccc(O)c12
Show InChI InChI=1S/C12H10N4O/c13-12-14-5-4-8(16-12)7-6-15-9-2-1-3-10(17)11(7)9/h1-6,15,17H,(H2,13,14,16)
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n/an/a 3.00E+3n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Bioorg Med Chem Lett 14: 1703-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2BZ648W
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM10839
PNG
(3-(2-aminopyrimidin-4-yl)-6-bromo-1H-indol-4-ol | ...)
Show SMILES Nc1nccc(n1)-c1c[nH]c2cc(Br)cc(O)c12
Show InChI InChI=1S/C12H9BrN4O/c13-6-3-9-11(10(18)4-6)7(5-16-9)8-1-2-15-12(14)17-8/h1-5,16,18H,(H2,14,15,17)
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n/an/a 1.00E+3n/an/an/an/a7.230



CNRS



Assay Description
Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30°C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P ...


Bioorg Med Chem Lett 14: 1703-7 (2004)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2BZ648W
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM12100
PNG
(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Show SMILES CCCCNC(=O)N1Cc2n[nH]c(NC(=O)[C@@H](C)c3ccc4ccccc4c3)c2C1
Show InChI InChI=1S/C23H27N5O2/c1-3-4-11-24-23(30)28-13-19-20(14-28)26-27-21(19)25-22(29)15(2)17-10-9-16-7-5-6-8-18(16)12-17/h5-10,12,15H,3-4,11,13-14H2,1-2H3,(H,24,30)(H2,25,26,27,29)/t15-/m0/s1
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n/an/a 150n/an/an/an/a7.422



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


Bioorg Med Chem Lett 16: 1084-90 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.071
BindingDB Entry DOI: 10.7270/Q2PZ5725
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM12097
PNG
(3-Amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole 1...)
Show SMILES CCCCNC(=O)N1Cc2n[nH]c(NC(=O)Cc3ccc(cc3)N3CCCC3)c2C1
Show InChI InChI=1S/C22H30N6O2/c1-2-3-10-23-22(30)28-14-18-19(15-28)25-26-21(18)24-20(29)13-16-6-8-17(9-7-16)27-11-4-5-12-27/h6-9H,2-5,10-15H2,1H3,(H,23,30)(H2,24,25,26,29)
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n/an/a 280n/an/an/an/a7.422



Nerviano Medical Sciences



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...


Bioorg Med Chem Lett 16: 1084-90 (2006)


Article DOI: 10.1016/j.bmcl.2005.10.071
BindingDB Entry DOI: 10.7270/Q2PZ5725
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM31545
PNG
(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)
Show SMILES CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21
Show InChI InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)
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n/an/a 265n/an/an/an/a7.423



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM20816
PNG
(1-phenyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]urea...)
Show SMILES O=C(Nc1csc(n1)-c1ccncc1)Nc1ccccc1
Show InChI InChI=1S/C15H12N4OS/c20-15(17-12-4-2-1-3-5-12)19-13-10-21-14(18-13)11-6-8-16-9-7-11/h1-10H,(H2,17,19,20)
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n/an/a 2.99E+3n/an/an/an/a7.525



Amgen



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...


Bioorg Med Chem 15: 6574-95 (2007)


Article DOI: 10.1016/j.bmc.2007.07.005
BindingDB Entry DOI: 10.7270/Q2Z60MB9
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM20817
PNG
(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetr...)
Show SMILES O=c1[nH]c2ccccc2c(=O)n1-c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C16H10N4O2S/c21-15-11-3-1-2-4-12(11)18-16(22)20(15)13-9-23-14(19-13)10-5-7-17-8-6-10/h1-9H,(H,18,22)
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n/an/a>1.00E+4n/an/an/an/a7.525



Amgen



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...


Bioorg Med Chem 15: 6574-95 (2007)


Article DOI: 10.1016/j.bmc.2007.07.005
BindingDB Entry DOI: 10.7270/Q2Z60MB9
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM20818
PNG
(1-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-2,3-dihydro-...)
Show SMILES O=c1[nH]c2ccccc2n1-c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C15H10N4OS/c20-15-17-11-3-1-2-4-12(11)19(15)13-9-21-14(18-13)10-5-7-16-8-6-10/h1-9H,(H,17,20)
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n/an/a 1.16E+3n/an/an/an/a7.525



Amgen



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...


Bioorg Med Chem 15: 6574-95 (2007)


Article DOI: 10.1016/j.bmc.2007.07.005
BindingDB Entry DOI: 10.7270/Q2Z60MB9
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM20819
PNG
(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2,3,4-tetr...)
Show SMILES O=C1Nc2ccccc2CN1c1csc(n1)-c1ccncc1
Show InChI InChI=1S/C16H12N4OS/c21-16-18-13-4-2-1-3-12(13)9-20(16)14-10-22-15(19-14)11-5-7-17-8-6-11/h1-8,10H,9H2,(H,18,21)
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n/an/a 79n/an/an/an/a7.525



Amgen



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...


Bioorg Med Chem 15: 6574-95 (2007)


Article DOI: 10.1016/j.bmc.2007.07.005
BindingDB Entry DOI: 10.7270/Q2Z60MB9
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM20820
PNG
(3-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]-1,2,3,4-tetr...)
Show SMILES O=C1Nc2ccccc2CN1c1nc(cs1)-c1ccncc1
Show InChI InChI=1S/C16H12N4OS/c21-15-18-13-4-2-1-3-12(13)9-20(15)16-19-14(10-22-16)11-5-7-17-8-6-11/h1-8,10H,9H2,(H,18,21)
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n/an/a 77n/an/an/an/a7.525



Amgen



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...


Bioorg Med Chem 15: 6574-95 (2007)


Article DOI: 10.1016/j.bmc.2007.07.005
BindingDB Entry DOI: 10.7270/Q2Z60MB9
More data for this
Ligand-Target Pair
Cyclin-Dependent Kinase 5 (CDK5)


(Homo sapiens (human))
BDBM20821
PNG
(3-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]-1,2,3,4-...)
Show SMILES O=C1Nc2ccccc2CN1c1nc(no1)-c1ccncc1
Show InChI InChI=1S/C15H11N5O2/c21-14-17-12-4-2-1-3-11(12)9-20(14)15-18-13(19-22-15)10-5-7-16-8-6-10/h1-8H,9H2,(H,17,21)
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n/an/a>1.00E+4n/an/an/an/a7.525



Amgen



Assay Description
In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...


Bioorg Med Chem 15: 6574-95 (2007)


Article DOI: 10.1016/j.bmc.2007.07.005
BindingDB Entry DOI: 10.7270/Q2Z60MB9
More data for this
Ligand-Target Pair
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