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Compile Data Set for Download or QSAR

Found 508 hits of ph data with Target = 'Cyclin-dependent kinase 4'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112460
PNG
(US8623885, 1)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CNCCc4n3)nc12
Show InChI InChI=1S/C24H27N7/c1-15-2-5-17(6-3-15)31-21-14-26-10-8-18(21)19-13-27-24(30-23(19)31)29-22-7-4-16-12-25-11-9-20(16)28-22/h4,7-8,10,13-15,17,25H,2-3,5-6,9,11-12H2,1H3,(H,27,28,29,30)/t15-,17-
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n/an/a 2.10n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112461
PNG
(US8623885, 2)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(C)=O)nc12
Show InChI InChI=1S/C26H29N7O/c1-16-3-6-19(7-4-16)33-23-14-27-11-9-20(23)21-13-28-26(31-25(21)33)30-24-8-5-18-15-32(17(2)34)12-10-22(18)29-24/h5,8-9,11,13-14,16,19H,3-4,6-7,10,12,15H2,1-2H3,(H,28,29,30,31)/t16-,19-
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n/an/a 4.5n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112462
PNG
(US8623885, 3)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCO)CCc4n3)nc12
Show InChI InChI=1S/C26H31N7O/c1-17-2-5-19(6-3-17)33-23-15-27-10-8-20(23)21-14-28-26(31-25(21)33)30-24-7-4-18-16-32(12-13-34)11-9-22(18)29-24/h4,7-8,10,14-15,17,19,34H,2-3,5-6,9,11-13,16H2,1H3,(H,28,29,30,31)/t17-,19-
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n/an/a 2.60n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112463
PNG
(US8623885, 4)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCCO)CCc4n3)nc12
Show InChI InChI=1S/C27H33N7O/c1-18-3-6-20(7-4-18)34-24-16-28-11-9-21(24)22-15-29-27(32-26(22)34)31-25-8-5-19-17-33(12-2-14-35)13-10-23(19)30-25/h5,8-9,11,15-16,18,20,35H,2-4,6-7,10,12-14,17H2,1H3,(H,29,30,31,32)/t18-,20-
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Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112464
PNG
(US8623885, 5)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(=O)CO)nc12
Show InChI InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)/t16-,18-
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n/an/a 2.40n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112465
PNG
(US8623885, 6)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCc4n3)C(=O)C(O)=O)nc12
Show InChI InChI=1S/C26H27N7O3/c1-15-2-5-17(6-3-15)33-21-13-27-10-8-18(21)19-12-28-26(31-23(19)33)30-22-7-4-16-14-32(24(34)25(35)36)11-9-20(16)29-22/h4,7-8,10,12-13,15,17H,2-3,5-6,9,11,14H2,1H3,(H,35,36)(H,28,29,30,31)/t15-,17-
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n/an/a 120n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112466
PNG
(US8623885, 7)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCC(F)(F)F)CCc4n3)nc12
Show InChI InChI=1S/C27H30F3N7/c1-17-2-5-19(6-3-17)37-23-15-31-11-8-20(23)21-14-32-26(35-25(21)37)34-24-7-4-18-16-36(12-9-22(18)33-24)13-10-27(28,29)30/h4,7-8,11,14-15,17,19H,2-3,5-6,9-10,12-13,16H2,1H3,(H,32,33,34,35)/t17-,19-
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n/an/a 52.4n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112467
PNG
(US8623885, 8)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCS(C)(=O)=O)CCc4n3)nc12
Show InChI InChI=1S/C27H33N7O2S/c1-18-3-6-20(7-4-18)34-24-16-28-11-9-21(24)22-15-29-27(32-26(22)34)31-25-8-5-19-17-33(12-10-23(19)30-25)13-14-37(2,35)36/h5,8-9,11,15-16,18,20H,3-4,6-7,10,12-14,17H2,1-2H3,(H,29,30,31,32)/t18-,20-
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Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112468
PNG
(US8623885, 9)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCF)CCc4n3)nc12
Show InChI InChI=1S/C26H30FN7/c1-17-2-5-19(6-3-17)34-23-15-28-11-8-20(23)21-14-29-26(32-25(21)34)31-24-7-4-18-16-33(13-10-27)12-9-22(18)30-24/h4,7-8,11,14-15,17,19H,2-3,5-6,9-10,12-13,16H2,1H3,(H,29,30,31,32)/t17-,19-
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n/an/a 72.8n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112469
PNG
(US8623885, 10)
Show SMILES COCCN1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1
Show InChI InChI=1S/C27H33N7O/c1-18-3-6-20(7-4-18)34-24-16-28-11-9-21(24)22-15-29-27(32-26(22)34)31-25-8-5-19-17-33(13-14-35-2)12-10-23(19)30-25/h5,8-9,11,15-16,18,20H,3-4,6-7,10,12-14,17H2,1-2H3,(H,29,30,31,32)/t18-,20-
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n/an/a 10.5n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112470
PNG
(US8623885, 11)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3cc4CNCCc4cn3)nc12
Show InChI InChI=1S/C24H27N7/c1-15-2-4-18(5-3-15)31-21-14-26-9-7-19(21)20-13-28-24(30-23(20)31)29-22-10-17-11-25-8-6-16(17)12-27-22/h7,9-10,12-15,18,25H,2-6,8,11H2,1H3,(H,27,28,29,30)/t15-,18-
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n/an/a 257n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112471
PNG
(US8623885, 12)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3cc4CN(CCO)CCc4cn3)nc12
Show InChI InChI=1S/C26H31N7O/c1-17-2-4-20(5-3-17)33-23-15-27-8-6-21(23)22-14-29-26(31-25(22)33)30-24-12-19-16-32(10-11-34)9-7-18(19)13-28-24/h6,8,12-15,17,20,34H,2-5,7,9-11,16H2,1H3,(H,28,29,30,31)/t17-,20-
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n/an/a 18.4n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112472
PNG
(US8623885, 13)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CNCC(C)c4n3)nc12
Show InChI InChI=1S/C25H29N7/c1-15-3-6-18(7-4-15)32-21-14-26-10-9-19(21)20-13-28-25(31-24(20)32)30-22-8-5-17-12-27-11-16(2)23(17)29-22/h5,8-10,13-16,18,27H,3-4,6-7,11-12H2,1-2H3,(H,28,29,30,31)/t15-,16?,18-
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n/an/a 31.3n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112473
PNG
(US8623885, 14)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CC(C)c4n3)C(C)=O)nc12
Show InChI InChI=1S/C27H31N7O/c1-16-4-7-20(8-5-16)34-23-13-28-11-10-21(23)22-12-29-27(32-26(22)34)31-24-9-6-19-15-33(18(3)35)14-17(2)25(19)30-24/h6,9-13,16-17,20H,4-5,7-8,14-15H2,1-3H3,(H,29,30,31,32)/t16-,17?,20-
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Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112474
PNG
(US8623885, 15)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCO)CC(C)c4n3)nc12
Show InChI InChI=1S/C27H33N7O/c1-17-3-6-20(7-4-17)34-23-14-28-10-9-21(23)22-13-29-27(32-26(22)34)31-24-8-5-19-16-33(11-12-35)15-18(2)25(19)30-24/h5,8-10,13-14,17-18,20,35H,3-4,6-7,11-12,15-16H2,1-2H3,(H,29,30,31,32)/t17-,18?,20-
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Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112475
PNG
(US8623885, 16)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CNCC(O)c4n3)nc12
Show InChI InChI=1S/C24H27N7O/c1-14-2-5-16(6-3-14)31-19-12-25-9-8-17(19)18-11-27-24(30-23(18)31)29-21-7-4-15-10-26-13-20(32)22(15)28-21/h4,7-9,11-12,14,16,20,26,32H,2-3,5-6,10,13H2,1H3,(H,27,28,29,30)/t14-,16-,20?
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n/an/a 16.5n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112476
PNG
(US8623885, 17)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(CCO)CC(O)c4n3)nc12
Show InChI InChI=1S/C26H31N7O2/c1-16-2-5-18(6-3-16)33-21-13-27-9-8-19(21)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(10-11-34)15-22(35)24(17)29-23/h4,7-9,12-13,16,18,22,34-35H,2-3,5-6,10-11,14-15H2,1H3,(H,28,29,30,31)/t16-,18-,22?
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n/an/a 19.2n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112477
PNG
(US8623885, 18a)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(C[C@@H](C)c4n3)C(C)=O)nc12
Show InChI InChI=1S/C27H31N7O/c1-16-4-7-20(8-5-16)34-23-13-28-11-10-21(23)22-12-29-27(32-26(22)34)31-24-9-6-19-15-33(18(3)35)14-17(2)25(19)30-24/h6,9-13,16-17,20H,4-5,7-8,14-15H2,1-3H3,(H,29,30,31,32)/t16-,17-,20-/m1/s1
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n/an/a 18.8n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112497
PNG
(US8623885, 18b)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CN(C[C@H](C)c4n3)C(C)=O)nc12
Show InChI InChI=1S/C27H31N7O/c1-16-4-7-20(8-5-16)34-23-13-28-11-10-21(23)22-12-29-27(32-26(22)34)31-24-9-6-19-15-33(18(3)35)14-17(2)25(19)30-24/h6,9-13,16-17,20H,4-5,7-8,14-15H2,1-3H3,(H,29,30,31,32)/t16-,17-,20-/m0/s1
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n/an/a 463n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112478
PNG
(US8623885, 19)
Show SMILES COc1cc2c(cn1)n([C@H]1CC[C@H](C)CC1)c1nc(Nc3ccc4CNCCc4n3)ncc21
Show InChI InChI=1S/C25H29N7O/c1-15-3-6-17(7-4-15)32-21-14-27-23(33-2)11-18(21)19-13-28-25(31-24(19)32)30-22-8-5-16-12-26-10-9-20(16)29-22/h5,8,11,13-15,17,26H,3-4,6-7,9-10,12H2,1-2H3,(H,28,29,30,31)/t15-,17-
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n/an/a 1.79E+3n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112479
PNG
(US8623885, 20)
Show SMILES COc1cc2c(cn1)n([C@H]1CC[C@H](C)CC1)c1nc(Nc3ccc4CN(CCc4n3)C(=O)CO)ncc21
Show InChI InChI=1S/C27H31N7O3/c1-16-3-6-18(7-4-16)34-22-13-28-24(37-2)11-19(22)20-12-29-27(32-26(20)34)31-23-8-5-17-14-33(25(36)15-35)10-9-21(17)30-23/h5,8,11-13,16,18,35H,3-4,6-7,9-10,14-15H2,1-2H3,(H,29,30,31,32)/t16-,18-
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n/an/a 847n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112481
PNG
(US8623885, 22)
Show SMILES OCC(=O)N1CCc2nc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)ccc2C1
Show InChI InChI=1S/C24H25N7O2/c32-14-22(33)30-10-8-19-15(13-30)5-6-21(27-19)28-24-26-11-18-17-7-9-25-12-20(17)31(23(18)29-24)16-3-1-2-4-16/h5-7,9,11-12,16,32H,1-4,8,10,13-14H2,(H,26,27,28,29)
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n/an/a 36n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112482
PNG
(US8623885, 23)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CCNCc4n3)nc12
Show InChI InChI=1S/C24H27N7/c1-15-2-5-17(6-3-15)31-21-14-26-11-9-18(21)19-12-27-24(30-23(19)31)29-22-7-4-16-8-10-25-13-20(16)28-22/h4,7,9,11-12,14-15,17,25H,2-3,5-6,8,10,13H2,1H3,(H,27,28,29,30)/t15-,17-
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n/an/a 8.60n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112483
PNG
(US8623885, 24)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3cc4CCNCc4cn3)nc12
Show InChI InChI=1S/C24H27N7/c1-15-2-4-18(5-3-15)31-21-14-26-9-7-19(21)20-13-28-24(30-23(20)31)29-22-10-16-6-8-25-11-17(16)12-27-22/h7,9-10,12-15,18,25H,2-6,8,11H2,1H3,(H,27,28,29,30)/t15-,18-
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n/an/a 4.70n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112489
PNG
(US8623885, 30)
Show SMILES C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc4CCN(Cc4n3)C(=O)CO)nc12
Show InChI InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-9-11-32(24(35)15-34)14-21(17)29-23/h4,7-8,10,12-13,16,18,34H,2-3,5-6,9,11,14-15H2,1H3,(H,28,29,30,31)/t16-,18-
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n/an/a 6.30n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM112496
PNG
(US8623885, 37)
Show SMILES CCN(CC)CC(=O)N1CCc2nc(Nc3ncc4c5ccncc5n([C@H]5CC[C@H](C)CC5)c4n3)ccc2C1
Show InChI InChI=1S/C30H38N8O/c1-4-36(5-2)19-28(39)37-15-13-25-21(18-37)8-11-27(33-25)34-30-32-16-24-23-12-14-31-17-26(23)38(29(24)35-30)22-9-6-20(3)7-10-22/h8,11-12,14,16-17,20,22H,4-7,9-10,13,15,18-19H2,1-3H3,(H,32,33,34,35)/t20-,22-
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n/an/a 3n/an/an/an/a7.4n/a



Amgen Inc.

US Patent


Assay Description
The CDK4 and CDK1 inhibitory activity of the CDK4/6-FLT3 inhibitors was determined with a filtration kinase assay. The compounds, kinase and substrat...


US Patent US8623885 (2014)


BindingDB Entry DOI: 10.7270/Q2DZ06Z1
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM50001584
PNG
(CHEMBL3237442 | US8841312, 1)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H26N8/c1-2-4-16(3-1)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-21-6-5-17(13-26-21)30-11-9-24-10-12-30/h5-8,13-16,24H,1-4,9-12H2,(H,26,27,28,29)
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n/an/a 3.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132260
PNG
(US8841312, 2)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1
Show InChI InChI=1S/C24H28N8/c1-30-10-12-31(13-11-30)18-6-7-22(26-14-18)28-24-27-15-20-19-8-9-25-16-21(19)32(23(20)29-24)17-4-2-3-5-17/h6-9,14-17H,2-5,10-13H2,1H3,(H,26,27,28,29)
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n/an/a 13n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132261
PNG
(US8841312, 3)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-4-19(3-1)31-22-16-26-10-9-20(22)21-15-27-24(29-23(21)31)28-17-5-7-18(8-6-17)30-13-11-25-12-14-30/h5-10,15-16,19,25H,1-4,11-14H2,(H,27,28,29)
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n/an/a 0.450n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132262
PNG
(US8841312, 4)
Show SMILES C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C23H27N9/c1-15-14-31(11-10-25-15)21-7-6-20(29-30-21)27-23-26-12-18-17-8-9-24-13-19(17)32(22(18)28-23)16-4-2-3-5-16/h6-9,12-13,15-16,25H,2-5,10-11,14H2,1H3,(H,26,27,28,29)/t15-/m1/s1
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n/an/a 3.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132263
PNG
(US8841312, 5)
Show SMILES Cc1cc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)cnc1N1CCNCC1
Show InChI InChI=1S/C24H28N8/c1-16-12-17(13-27-22(16)31-10-8-25-9-11-31)29-24-28-14-20-19-6-7-26-15-21(19)32(23(20)30-24)18-4-2-3-5-18/h6-7,12-15,18,25H,2-5,8-11H2,1H3,(H,28,29,30)
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n/an/a 0.910n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132264
PNG
(US8841312, 6)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCNCC3)nc12
Show InChI InChI=1S/C22H25N9/c1-2-4-15(3-1)31-18-14-24-8-7-16(18)17-13-25-22(27-21(17)31)26-19-5-6-20(29-28-19)30-11-9-23-10-12-30/h5-8,13-15,23H,1-4,9-12H2,(H,25,26,27,28)
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n/an/a 1.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132265
PNG
(US8841312, 7)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nc3)N3CCNCC3)nc12
Show InChI InChI=1S/C23H26N8/c1-2-4-17(3-1)31-20-15-25-8-7-18(20)19-14-27-23(29-22(19)31)28-16-5-6-21(26-13-16)30-11-9-24-10-12-30/h5-8,13-15,17,24H,1-4,9-12H2,(H,27,28,29)
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n/an/a 1.40n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132266
PNG
(US8841312, 8)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3cnc(nc3)N3CCNCC3)nc12
Show InChI InChI=1S/C22H25N9/c1-2-4-16(3-1)31-19-14-24-6-5-17(19)18-13-25-21(29-20(18)31)28-15-11-26-22(27-12-15)30-9-7-23-8-10-30/h5-6,11-14,16,23H,1-4,7-10H2,(H,25,28,29)
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n/an/a 0.130n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132267
PNG
(US8841312, 9)
Show SMILES C[C@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C23H27N9/c1-15-14-31(11-10-25-15)21-7-6-20(29-30-21)27-23-26-12-18-17-8-9-24-13-19(17)32(22(18)28-23)16-4-2-3-5-16/h6-9,12-13,15-16,25H,2-5,10-11,14H2,1H3,(H,26,27,28,29)/t15-/m0/s1
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n/an/a 3.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132268
PNG
(US8841312, 10)
Show SMILES CC1(C)CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C24H29N9/c1-24(2)15-32(12-11-27-24)21-8-7-20(30-31-21)28-23-26-13-18-17-9-10-25-14-19(17)33(22(18)29-23)16-5-3-4-6-16/h7-10,13-14,16,27H,3-6,11-12,15H2,1-2H3,(H,26,28,29,30)
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n/an/a 2.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132269
PNG
(US8841312, 11)
Show SMILES NC1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C24H28N8/c25-16-8-11-31(12-9-16)18-5-6-22(27-13-18)29-24-28-14-20-19-7-10-26-15-21(19)32(23(20)30-24)17-3-1-2-4-17/h5-7,10,13-17H,1-4,8-9,11-12,25H2,(H,27,28,29,30)
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n/an/a 3.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132270
PNG
(US8841312, 12)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nc1
Show InChI InChI=1S/C26H32N8/c1-32(2)18-10-13-33(14-11-18)20-7-8-24(28-15-20)30-26-29-16-22-21-9-12-27-17-23(21)34(25(22)31-26)19-5-3-4-6-19/h7-9,12,15-19H,3-6,10-11,13-14H2,1-2H3,(H,28,29,30,31)
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n/an/a 9.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132271
PNG
(US8841312, 13)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1
Show InChI InChI=1S/C25H31N9/c1-32(2)17-10-13-33(14-11-17)23-8-7-22(30-31-23)28-25-27-15-20-19-9-12-26-16-21(19)34(24(20)29-25)18-5-3-4-6-18/h7-9,12,15-18H,3-6,10-11,13-14H2,1-2H3,(H,27,28,29,30)
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n/an/a 1n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132272
PNG
(US8841312, 14)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(-c2ccccc2)c2cnccc32)nc1
Show InChI InChI=1S/C24H22N8/c1-2-4-17(5-3-1)32-21-16-26-9-8-19(21)20-15-28-24(30-23(20)32)29-22-7-6-18(14-27-22)31-12-10-25-11-13-31/h1-9,14-16,25H,10-13H2,(H,27,28,29,30)
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n/an/a 2.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132273
PNG
(US8841312, 15)
Show SMILES Fc1ccc(cc1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H21FN8/c25-16-1-3-17(4-2-16)33-21-15-27-8-7-19(21)20-14-29-24(31-23(20)33)30-22-6-5-18(13-28-22)32-11-9-26-10-12-32/h1-8,13-15,26H,9-12H2,(H,28,29,30,31)
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n/an/a 7.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132274
PNG
(US8841312, 16)
Show SMILES COc1ccc(cc1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H24N8O/c1-34-19-5-2-17(3-6-19)33-22-16-27-9-8-20(22)21-15-29-25(31-24(21)33)30-23-7-4-18(14-28-23)32-12-10-26-11-13-32/h2-9,14-16,26H,10-13H2,1H3,(H,28,29,30,31)
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n/an/a 10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132275
PNG
(US8841312, 17)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(-c2ccccc2)c2cnccc32)cc1
Show InChI InChI=1S/C25H23N7/c1-2-4-20(5-3-1)32-23-17-27-11-10-21(23)22-16-28-25(30-24(22)32)29-18-6-8-19(9-7-18)31-14-12-26-13-15-31/h1-11,16-17,26H,12-15H2,(H,28,29,30)
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n/an/a 0.320n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132276
PNG
(US8841312, 18)
Show SMILES O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1
Show InChI InChI=1S/C22H24N8O/c31-15-8-10-29(13-15)20-6-5-19(27-28-20)25-22-24-11-17-16-7-9-23-12-18(16)30(21(17)26-22)14-3-1-2-4-14/h5-7,9,11-12,14-15,31H,1-4,8,10,13H2,(H,24,25,26,27)/t15-/m1/s1
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n/an/a 1.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132277
PNG
(US8841312, 19)
Show SMILES O[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2cnccc32)nn1
Show InChI InChI=1S/C22H24N8O/c31-15-8-10-29(13-15)20-6-5-19(27-28-20)25-22-24-11-17-16-7-9-23-12-18(16)30(21(17)26-22)14-3-1-2-4-14/h5-7,9,11-12,14-15,31H,1-4,8,10,13H2,(H,24,25,26,27)/t15-/m0/s1
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n/an/a 4n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132278
PNG
(US8841312, 20)
Show SMILES C1CN(CCN1)c1ccc(Nc2ncc3c(n2)n(C2CCOCC2)c2cnccc32)nc1
Show InChI InChI=1S/C23H26N8O/c1-2-21(26-13-17(1)30-9-7-24-8-10-30)28-23-27-14-19-18-3-6-25-15-20(18)31(22(19)29-23)16-4-11-32-12-5-16/h1-3,6,13-16,24H,4-5,7-12H2,(H,26,27,28,29)
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n/an/a 8.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132279
PNG
(US8841312, 21)
Show SMILES C1CCC(CC1)n1c2ccccc2c2cnc(Nc3ccc(cc3)N3CCNCC3)nc12
Show InChI InChI=1S/C26H30N6/c1-2-6-21(7-3-1)32-24-9-5-4-8-22(24)23-18-28-26(30-25(23)32)29-19-10-12-20(13-11-19)31-16-14-27-15-17-31/h4-5,8-13,18,21,27H,1-3,6-7,14-17H2,(H,28,29,30)
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n/an/a 1n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132280
PNG
(US8841312, 22)
Show SMILES C1CCC(CC1)n1c2ccccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H29N7/c1-2-6-18(7-3-1)32-22-9-5-4-8-20(22)21-17-28-25(30-24(21)32)29-23-11-10-19(16-27-23)31-14-12-26-13-15-31/h4-5,8-11,16-18,26H,1-3,6-7,12-15H2,(H,27,28,29,30)
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n/an/a 1.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM50001536
PNG
(CHEMBL3237451 | US8841312, 23)
Show SMILES C1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C24H28N8/c1-2-4-17(5-3-1)32-21-16-26-9-8-19(21)20-15-28-24(30-23(20)32)29-22-7-6-18(14-27-22)31-12-10-25-11-13-31/h6-9,14-17,25H,1-5,10-13H2,(H,27,28,29,30)
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n/an/a 11n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 4


(Homo sapiens (human))
BDBM132281
PNG
(US8841312, 24)
Show SMILES C1CC2CC1CC2n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C25H28N8/c1-2-17-11-16(1)12-21(17)33-22-15-27-6-5-19(22)20-14-29-25(31-24(20)33)30-23-4-3-18(13-28-23)32-9-7-26-8-10-32/h3-6,13-17,21,26H,1-2,7-12H2,(H,28,29,30,31)
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n/an/a 0.940n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
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