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Compile Data Set for Download or QSAR

Found 267 hits of ph data with Target = 'Cyclin-dependent kinase 6'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132418
PNG
(US8841312, 165)
Show SMILES O[C@H]1CCN(Cc2csc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)n2)C1
Show InChI InChI=1S/C22H25N7OS/c30-16-6-8-28(12-16)11-14-13-31-22(25-14)27-21-24-9-18-17-5-7-23-10-19(17)29(20(18)26-21)15-3-1-2-4-15/h5,7,9-10,13,15-16,30H,1-4,6,8,11-12H2,(H,24,25,26,27)/t16-/m0/s1
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n/an/a 17n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132420
PNG
(US8841312, 167)
Show SMILES FC(F)(F)C1CN(CCN1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C24H25F3N8/c25-24(26,27)20-14-34(10-9-29-20)16-5-6-21(30-11-16)32-23-31-12-18-17-7-8-28-13-19(17)35(22(18)33-23)15-3-1-2-4-15/h5-8,11-13,15,20,29H,1-4,9-10,14H2,(H,30,31,32,33)
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n/an/a 21n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132421
PNG
(US8841312, 168)
Show SMILES C1CCC(C1)n1c2cnsc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C21H24N8S/c1-2-4-14(3-1)29-17-13-25-30-19(17)16-12-24-21(27-20(16)29)26-18-6-5-15(11-23-18)28-9-7-22-8-10-28/h5-6,11-14,22H,1-4,7-10H2,(H,23,24,26,27)
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n/an/a 1.00E+4n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132422
PNG
(US8841312, 169)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(CC4CC4)c3n2)nn1
Show InChI InChI=1S/C24H28FN9/c1-32(2)16-8-11-33(12-9-16)20-6-5-19(30-31-20)28-24-27-13-18-17-7-10-26-22(25)21(17)34(23(18)29-24)14-15-3-4-15/h5-7,10,13,15-16H,3-4,8-9,11-12,14H2,1-2H3,(H,27,28,29,30)
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n/an/a 150n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132434
PNG
(US8841312, 181)
Show SMILES O[C@H]1CCN(Cc2csc(Nc3ncc4c5ccnc(F)c5n(C5CCCC5)c4n3)n2)C1
Show InChI InChI=1S/C22H24FN7OS/c23-19-18-16(5-7-24-19)17-9-25-21(27-20(17)30(18)14-3-1-2-4-14)28-22-26-13(12-32-22)10-29-8-6-15(31)11-29/h5,7,9,12,14-15,31H,1-4,6,8,10-11H2,(H,25,26,27,28)/t15-/m0/s1
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n/an/a 26n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132435
PNG
(US8841312, 182)
Show SMILES COc1ccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c2n1
Show InChI InChI=1S/C24H28N8O/c1-33-21-9-7-18-19-15-27-24(30-23(19)32(22(18)29-21)16-4-2-3-5-16)28-20-8-6-17(14-26-20)31-12-10-25-11-13-31/h6-9,14-16,25H,2-5,10-13H2,1H3,(H,26,27,28,30)
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n/an/a 16n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132436
PNG
(US8841312, 183)
Show SMILES Oc1ccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c2n1
Show InChI InChI=1S/C23H26N8O/c32-20-8-6-17-18-14-26-23(29-22(18)31(21(17)28-20)15-3-1-2-4-15)27-19-7-5-16(13-25-19)30-11-9-24-10-12-30/h5-8,13-15,24H,1-4,9-12H2,(H,28,32)(H,25,26,27,29)
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n/an/a 104n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132437
PNG
(US8841312, 184)
Show SMILES Cn1c2n(C3CCCC3)c3nc(Nc4ccc(cn4)N4CCNCC4)ncc3c2ccc1=O
Show InChI InChI=1S/C24H28N8O/c1-30-21(33)9-7-18-19-15-27-24(29-22(19)32(23(18)30)16-4-2-3-5-16)28-20-8-6-17(14-26-20)31-12-10-25-11-13-31/h6-9,14-16,25H,2-5,10-13H2,1H3,(H,26,27,28,29)
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n/an/a 31n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132438
PNG
(US8841312, 185)
Show SMILES Cn1c2n(C3CCCC3)c3nc(Nc4ccc(cn4)N4CC[C@@H](O)C4)ncc3c2ccc1=O
Show InChI InChI=1S/C24H27N7O2/c1-29-21(33)9-7-18-19-13-26-24(28-22(19)31(23(18)29)15-4-2-3-5-15)27-20-8-6-16(12-25-20)30-11-10-17(32)14-30/h6-9,12-13,15,17,32H,2-5,10-11,14H2,1H3,(H,25,26,27,28)/t17-/m1/s1
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n/an/a 149n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132439
PNG
(US8841312, 186A)
Show SMILES O[C@@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(F)nccc32)nc1
Show InChI InChI=1S/C23H24FN7O/c24-21-20-17(7-9-25-21)18-12-27-23(29-22(18)31(20)14-3-1-2-4-14)28-19-6-5-15(11-26-19)30-10-8-16(32)13-30/h5-7,9,11-12,14,16,32H,1-4,8,10,13H2,(H,26,27,28,29)/t16-/m1/s1
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n/an/a 2n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132440
PNG
(US8841312, 186B)
Show SMILES O[C@H]1CCN(C1)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(F)nccc32)nc1
Show InChI InChI=1S/C23H24FN7O/c24-21-20-17(7-9-25-21)18-12-27-23(29-22(18)31(20)14-3-1-2-4-14)28-19-6-5-15(11-26-19)30-10-8-16(32)13-30/h5-7,9,11-12,14,16,32H,1-4,8,10,13H2,(H,26,27,28,29)/t16-/m0/s1
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n/an/a 4.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132441
PNG
(US8841312, 187)
Show SMILES OCC1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C25H28FN7O/c26-23-22-19(7-10-27-23)20-14-29-25(31-24(20)33(22)17-3-1-2-4-17)30-21-6-5-18(13-28-21)32-11-8-16(15-34)9-12-32/h5-7,10,13-14,16-17,34H,1-4,8-9,11-12,15H2,(H,28,29,30,31)
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n/an/a 2.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM50001532
PNG
(CHEMBL3237447 | US8841312, 188)
Show SMILES N#Cc1nccc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c12
Show InChI InChI=1S/C24H25N9/c25-13-20-22-18(7-8-27-20)19-15-29-24(31-23(19)33(22)16-3-1-2-4-16)30-21-6-5-17(14-28-21)32-11-9-26-10-12-32/h5-8,14-16,26H,1-4,9-12H2,(H,28,29,30,31)
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n/an/a 13.4n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132442
PNG
(US8841312, 189)
Show SMILES CC1CN(CC(C)N1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C25H29FN8/c1-15-13-33(14-16(2)30-15)18-7-8-21(28-11-18)31-25-29-12-20-19-9-10-27-23(26)22(19)34(24(20)32-25)17-5-3-4-6-17/h7-12,15-17,30H,3-6,13-14H2,1-2H3,(H,28,29,31,32)
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n/an/a 22n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132443
PNG
(US8841312, 190)
Show SMILES OCCC1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C26H30FN7O/c27-24-23-20(7-11-28-24)21-16-30-26(32-25(21)34(23)18-3-1-2-4-18)31-22-6-5-19(15-29-22)33-12-8-17(9-13-33)10-14-35/h5-7,11,15-18,35H,1-4,8-10,12-14H2,(H,29,30,31,32)
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n/an/a 7.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132444
PNG
(US8841312, 191)
Show SMILES OCCN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C25H30N8O/c34-14-13-31-9-11-32(12-10-31)19-5-6-23(27-15-19)29-25-28-16-21-20-7-8-26-17-22(20)33(24(21)30-25)18-3-1-2-4-18/h5-8,15-18,34H,1-4,9-14H2,(H,27,28,29,30)
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n/an/a 4.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM50001533
PNG
(CHEMBL3237448 | US8841312, 200)
Show SMILES C1CCC(C1)n1c2nnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C22H25N9/c1-2-4-15(3-1)31-20-18(17-7-8-26-29-21(17)31)14-25-22(28-20)27-19-6-5-16(13-24-19)30-11-9-23-10-12-30/h5-8,13-15,23H,1-4,9-12H2,(H,24,25,27,28)
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n/an/a 13n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132454
PNG
(US8841312, 202)
Show SMILES COc1cc2c3cnc(Nc4ccc(cn4)N4CCNCC4)nc3n(C3CCCC3)c2nn1
Show InChI InChI=1S/C23H27N9O/c1-33-20-12-17-18-14-26-23(27-19-7-6-16(13-25-19)31-10-8-24-9-11-31)28-21(18)32(22(17)30-29-20)15-4-2-3-5-15/h6-7,12-15,24H,2-5,8-11H2,1H3,(H,25,26,27,28)
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n/an/a 520n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM50001539
PNG
(CHEMBL3237704 | US8841312, 204)
Show SMILES CC1(C)CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)nc12
Show InChI InChI=1S/C26H32N8/c1-26(2)8-5-18(6-9-26)34-22-17-28-10-7-20(22)21-16-30-25(32-24(21)34)31-23-4-3-19(15-29-23)33-13-11-27-12-14-33/h3-4,7,10,15-18,27H,5-6,8-9,11-14H2,1-2H3,(H,29,30,31,32)
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n/an/a 1.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132463
PNG
(US8841312, 212)
Show SMILES C(N1CCNCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C24H28N8/c1-2-4-18(3-1)32-21-15-26-8-7-19(21)20-14-28-24(30-23(20)32)29-22-6-5-17(13-27-22)16-31-11-9-25-10-12-31/h5-8,13-15,18,25H,1-4,9-12,16H2,(H,27,28,29,30)
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n/an/a 33n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132464
PNG
(US8841312, 213)
Show SMILES Fc1nccc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c12
Show InChI InChI=1S/C24H27FN8/c25-22-21-18(7-8-27-22)19-14-29-24(31-23(19)33(21)17-3-1-2-4-17)30-20-6-5-16(13-28-20)15-32-11-9-26-10-12-32/h5-8,13-14,17,26H,1-4,9-12,15H2,(H,28,29,30,31)
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n/an/a 52n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132465
PNG
(US8841312, 214)
Show SMILES Oc1nccc2c3cnc(Nc4ccc(CN5CCNCC5)cn4)nc3n(C3CCCC3)c12
Show InChI InChI=1S/C24H28N8O/c33-23-21-18(7-8-26-23)19-14-28-24(30-22(19)32(21)17-3-1-2-4-17)29-20-6-5-16(13-27-20)15-31-11-9-25-10-12-31/h5-8,13-14,17,25H,1-4,9-12,15H2,(H,26,33)(H,27,28,29,30)
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n/an/a 21n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132466
PNG
(US8841312, 215)
Show SMILES OC1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1
Show InChI InChI=1S/C25H29N7O/c33-19-8-11-31(12-9-19)16-17-5-6-23(27-13-17)29-25-28-14-21-20-7-10-26-15-22(20)32(24(21)30-25)18-3-1-2-4-18/h5-7,10,13-15,18-19,33H,1-4,8-9,11-12,16H2,(H,27,28,29,30)
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n/an/a 8.20n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132467
PNG
(US8841312, 216)
Show SMILES OC1CCCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)C1
Show InChI InChI=1S/C25H29N7O/c33-19-6-3-11-31(16-19)15-17-7-8-23(27-12-17)29-25-28-13-21-20-9-10-26-14-22(20)32(24(21)30-25)18-4-1-2-5-18/h7-10,12-14,18-19,33H,1-6,11,15-16H2,(H,27,28,29,30)
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n/an/a 15n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132468
PNG
(US8841312, 217)
Show SMILES CCOC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C26H31N9O2/c1-2-37-24(36)17-33-11-13-34(14-12-33)23-8-7-22(31-32-23)29-26-28-15-20-19-9-10-27-16-21(19)35(25(20)30-26)18-5-3-4-6-18/h7-10,15-16,18H,2-6,11-14,17H2,1H3,(H,28,29,30,31)
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n/an/a 9.80n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132469
PNG
(US8841312, 218)
Show SMILES OC(=O)CN1CCN(CC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C24H27N9O2/c34-22(35)15-31-9-11-32(12-10-31)21-6-5-20(29-30-21)27-24-26-13-18-17-7-8-25-14-19(17)33(23(18)28-24)16-3-1-2-4-16/h5-8,13-14,16H,1-4,9-12,15H2,(H,34,35)(H,26,27,28,29)
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n/an/a 3.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132470
PNG
(US8841312, 219)
Show SMILES CCOC(=O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1
Show InChI InChI=1S/C28H34N8O2/c1-2-38-26(37)19-35-13-11-34(12-14-35)18-20-7-8-25(30-15-20)32-28-31-16-23-22-9-10-29-17-24(22)36(27(23)33-28)21-5-3-4-6-21/h7-10,15-17,21H,2-6,11-14,18-19H2,1H3,(H,30,31,32,33)
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n/an/a 11n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132471
PNG
(US8841312, 220)
Show SMILES OC(=O)CN1CCN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CC1
Show InChI InChI=1S/C26H30N8O2/c35-24(36)17-33-11-9-32(10-12-33)16-18-5-6-23(28-13-18)30-26-29-14-21-20-7-8-27-15-22(20)34(25(21)31-26)19-3-1-2-4-19/h5-8,13-15,19H,1-4,9-12,16-17H2,(H,35,36)(H,28,29,30,31)
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n/an/a 3.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132472
PNG
(US8841312, 221)
Show SMILES O=C(N1CCNCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C24H26N8O/c33-23(31-11-9-25-10-12-31)16-5-6-21(27-13-16)29-24-28-14-19-18-7-8-26-15-20(18)32(22(19)30-24)17-3-1-2-4-17/h5-8,13-15,17,25H,1-4,9-12H2,(H,27,28,29,30)
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Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132475
PNG
(US8841312, 224)
Show SMILES OC(=O)c1ccc(Nc2ncc3c(n2)n(C2CCCC2)c2c(O)nccc32)nc1
Show InChI InChI=1S/C20H18N6O3/c27-18-16-13(7-8-21-18)14-10-23-20(24-15-6-5-11(9-22-15)19(28)29)25-17(14)26(16)12-3-1-2-4-12/h5-10,12H,1-4H2,(H,21,27)(H,28,29)(H,22,23,24,25)
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n/an/a 860n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132476
PNG
(US8841312, 225)
Show SMILES O=C1CN(Cc2ccc(Nc3ncc4c5ccncc5n(C5CCCC5)c4n3)nc2)CCN1
Show InChI InChI=1S/C24H26N8O/c33-22-15-31(10-9-26-22)14-16-5-6-21(27-11-16)29-24-28-12-19-18-7-8-25-13-20(18)32(23(19)30-24)17-3-1-2-4-17/h5-8,11-13,17H,1-4,9-10,14-15H2,(H,26,33)(H,27,28,29,30)
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n/an/a 3n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132477
PNG
(US8841312, 226)
Show SMILES O=C1CNCCN1Cc1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C24H26N8O/c33-22-14-26-9-10-31(22)15-16-5-6-21(27-11-16)29-24-28-12-19-18-7-8-25-13-20(18)32(23(19)30-24)17-3-1-2-4-17/h5-8,11-13,17,26H,1-4,9-10,14-15H2,(H,27,28,29,30)
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n/an/a 2.70n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132478
PNG
(US8841312, 227)
Show SMILES O=S(=O)(N1CCNCC1)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C23H26N8O2S/c32-34(33,30-11-9-24-10-12-30)17-5-6-21(26-13-17)28-23-27-14-19-18-7-8-25-15-20(18)31(22(19)29-23)16-3-1-2-4-16/h5-8,13-16,24H,1-4,9-12H2,(H,26,27,28,29)
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n/an/a 3.10n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132479
PNG
(US8841312, 228)
Show SMILES Fc1nccc2c3cnc(Nc4ccc(cn4)S(=O)(=O)N4CCNCC4)nc3n(C3CCCC3)c12
Show InChI InChI=1S/C23H25FN8O2S/c24-21-20-17(7-8-26-21)18-14-28-23(30-22(18)32(20)15-3-1-2-4-15)29-19-6-5-16(13-27-19)35(33,34)31-11-9-25-10-12-31/h5-8,13-15,25H,1-4,9-12H2,(H,27,28,29,30)
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n/an/a 3.90n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132480
PNG
(US8841312, 229)
Show SMILES CN(C)C1CCN(CC1)S(=O)(=O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C26H32N8O2S/c1-32(2)18-10-13-33(14-11-18)37(35,36)20-7-8-24(28-15-20)30-26-29-16-22-21-9-12-27-17-23(21)34(25(22)31-26)19-5-3-4-6-19/h7-9,12,15-19H,3-6,10-11,13-14H2,1-2H3,(H,28,29,30,31)
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n/an/a 20.5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132481
PNG
(US8841312, 230)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(Nc2ncc3c4ccncc4n(C4CCCC4)c3n2)nc1
Show InChI InChI=1S/C27H32N8O/c1-33(2)19-10-13-34(14-11-19)26(36)18-7-8-24(29-15-18)31-27-30-16-22-21-9-12-28-17-23(21)35(25(22)32-27)20-5-3-4-6-20/h7-9,12,15-17,19-20H,3-6,10-11,13-14H2,1-2H3,(H,29,30,31,32)
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Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132484
PNG
(US8841312, 233)
Show SMILES C1CN(CCN1)c1ccc(Nc2cc3n(-c4ccccc4)c4cnccc4c3cn2)nc1
Show InChI InChI=1S/C25H23N7/c1-2-4-18(5-3-1)32-22-14-25(29-16-21(22)20-8-9-27-17-23(20)32)30-24-7-6-19(15-28-24)31-12-10-26-11-13-31/h1-9,14-17,26H,10-13H2,(H,28,29,30)
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n/an/a 12n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132485
PNG
(US8841312, 234)
Show SMILES FC(F)(F)c1cccc(c1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12
Show InChI InChI=1S/C26H22F3N7/c27-26(28,29)17-2-1-3-18(12-17)36-22-13-25(33-15-21(22)20-6-7-31-16-23(20)36)34-24-5-4-19(14-32-24)35-10-8-30-9-11-35/h1-7,12-16,30H,8-11H2,(H,32,33,34)
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n/an/a 26n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132486
PNG
(US8841312, 235)
Show SMILES C(c1ccsc1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12
Show InChI InChI=1S/C24H23N7S/c1-2-23(27-12-18(1)30-8-6-25-7-9-30)29-24-11-21-20(13-28-24)19-3-5-26-14-22(19)31(21)15-17-4-10-32-16-17/h1-5,10-14,16,25H,6-9,15H2,(H,27,28,29)
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n/an/a 257n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132487
PNG
(US8841312, 236)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12
Show InChI InChI=1S/C24H27N7/c1-2-4-17(3-1)31-21-13-24(28-15-20(21)19-7-8-26-16-22(19)31)29-23-6-5-18(14-27-23)30-11-9-25-10-12-30/h5-8,13-17,25H,1-4,9-12H2,(H,27,28,29)
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n/an/a 112n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132488
PNG
(US8841312, 237)
Show SMILES C(c1cccs1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12
Show InChI InChI=1S/C24H23N7S/c1-2-18(32-11-1)16-31-21-12-24(28-14-20(21)19-5-6-26-15-22(19)31)29-23-4-3-17(13-27-23)30-9-7-25-8-10-30/h1-6,11-15,25H,7-10,16H2,(H,27,28,29)
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n/an/a 131n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132489
PNG
(US8841312, 238)
Show SMILES OC(=O)Cc1ccc(cc1)-n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12
Show InChI InChI=1S/C27H25N7O2/c35-27(36)13-18-1-3-19(4-2-18)34-23-14-26(31-16-22(23)21-7-8-29-17-24(21)34)32-25-6-5-20(15-30-25)33-11-9-28-10-12-33/h1-8,14-17,28H,9-13H2,(H,35,36)(H,30,31,32)
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n/an/a 178n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132490
PNG
(US8841312, 239)
Show SMILES C1CC(CS1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12
Show InChI InChI=1S/C23H25N7S/c1-2-22(26-12-16(1)29-8-6-24-7-9-29)28-23-11-20-19(13-27-23)18-3-5-25-14-21(18)30(20)17-4-10-31-15-17/h1-3,5,11-14,17,24H,4,6-10,15H2,(H,26,27,28)
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n/an/a 17n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132491
PNG
(US8841312, 240)
Show SMILES C1CCC(CC1)n1c2cnccc2c2cnc(Nc3ccc(cn3)N3CCNCC3)cc12
Show InChI InChI=1S/C25H29N7/c1-2-4-18(5-3-1)32-22-14-25(29-16-21(22)20-8-9-27-17-23(20)32)30-24-7-6-19(15-28-24)31-12-10-26-11-13-31/h6-9,14-18,26H,1-5,10-13H2,(H,28,29,30)
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n/an/a 4.60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132503
PNG
(US8841312, 252)
Show SMILES CN(C)C1CCN(CC1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C25H30FN9/c1-33(2)16-10-13-34(14-11-16)21-8-7-20(31-32-21)29-25-28-15-19-18-9-12-27-23(26)22(18)35(24(19)30-25)17-5-3-4-6-17/h7-9,12,15-17H,3-6,10-11,13-14H2,1-2H3,(H,28,29,30,31)
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n/an/a 5n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132504
PNG
(US8841312, 253)
Show SMILES C[C@@H]1CN(CCN1)c1ccc(Nc2ncc3c4ccnc(F)c4n(C4CCCC4)c3n2)nn1
Show InChI InChI=1S/C23H26FN9/c1-14-13-32(11-10-25-14)19-7-6-18(30-31-19)28-23-27-12-17-16-8-9-26-21(24)20(16)33(22(17)29-23)15-4-2-3-5-15/h6-9,12,14-15,25H,2-5,10-11,13H2,1H3,(H,27,28,29,30)/t14-/m1/s1
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n/an/a 27n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132505
PNG
(US8841312, 254)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)N3CCC=CC3)nc12
Show InChI InChI=1S/C23H24N8/c1-4-12-30(13-5-1)21-9-8-20(28-29-21)26-23-25-14-18-17-10-11-24-15-19(17)31(22(18)27-23)16-6-2-3-7-16/h1,4,8-11,14-16H,2-3,5-7,12-13H2,(H,25,26,27,28)
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n/an/a 40n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132506
PNG
(US8841312, 255)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(nn3)C3=CCNCC3)nc12
Show InChI InChI=1S/C23H24N8/c1-2-4-16(3-1)31-20-14-25-12-9-17(20)18-13-26-23(28-22(18)31)27-21-6-5-19(29-30-21)15-7-10-24-11-8-15/h5-7,9,12-14,16,24H,1-4,8,10-11H2,(H,26,27,28,30)
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n/an/a 60n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132507
PNG
(US8841312, 256)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)C3=CCNCC3)nc12
Show InChI InChI=1S/C24H25N7/c1-2-4-18(3-1)31-21-15-26-12-9-19(21)20-14-28-24(30-23(20)31)29-22-6-5-17(13-27-22)16-7-10-25-11-8-16/h5-7,9,12-15,18,25H,1-4,8,10-11H2,(H,27,28,29,30)
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n/an/a 7n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 6


(Homo sapiens (human))
BDBM132508
PNG
(US8841312, 257)
Show SMILES C1CCC(C1)n1c2cnccc2c2cnc(Nc3ccc(cn3)C3CCNCC3)nc12
Show InChI InChI=1S/C24H27N7/c1-2-4-18(3-1)31-21-15-26-12-9-19(21)20-14-28-24(30-23(20)31)29-22-6-5-17(13-27-22)16-7-10-25-11-8-16/h5-6,9,12-16,18,25H,1-4,7-8,10-11H2,(H,27,28,29,30)
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n/an/a 5.30n/an/an/an/a7.437



Amgen Inc.

US Patent


Assay Description
The Cdk4 and Cdk6 inhibitory activity of the compounds is measured with a kinase inhibition assay using recombinant Cdk4/CyclinD1 or Cdk6/CyclinD3 pr...


US Patent US8841312 (2014)


BindingDB Entry DOI: 10.7270/Q2H41Q4H
More data for this
Ligand-Target Pair
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