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Compile Data Set for Download or QSAR

Found 12 hits of ph data with Target = 'Cyclooxygenase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cyclooxygenase


(Homo sapiens (human))
BDBM22569
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@H](C)CO)c2c1
Show InChI InChI=1S/C22H23ClN2O4/c1-13(12-26)24-21(27)11-18-14(2)25(20-9-8-17(29-3)10-19(18)20)22(28)15-4-6-16(23)7-5-15/h4-10,13,26H,11-12H2,1-3H3,(H,24,27)/t13-/m1/s1
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Article
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n/an/a 170n/an/an/an/a8.037



Michigan State University



Assay Description
For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...


J Biol Chem 282: 28096-105 (2007)


Article DOI: 10.1074/jbc.M701335200
BindingDB Entry DOI: 10.7270/Q2R49P2D
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM22571
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@@H](C)CO)c2c1
Show InChI InChI=1S/C22H23ClN2O4/c1-13(12-26)24-21(27)11-18-14(2)25(20-9-8-17(29-3)10-19(18)20)22(28)15-4-6-16(23)7-5-15/h4-10,13,26H,11-12H2,1-3H3,(H,24,27)/t13-/m0/s1
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Article
PubMed
n/an/a 270n/an/an/an/a8.037



Michigan State University



Assay Description
For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...


J Biol Chem 282: 28096-105 (2007)


Article DOI: 10.1074/jbc.M701335200
BindingDB Entry DOI: 10.7270/Q2R49P2D
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM22572
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES CC[C@H](CO)NC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12
Show InChI InChI=1S/C23H25ClN2O4/c1-4-17(13-27)25-22(28)12-19-14(2)26(21-10-9-18(30-3)11-20(19)21)23(29)15-5-7-16(24)8-6-15/h5-11,17,27H,4,12-13H2,1-3H3,(H,25,28)/t17-/m1/s1
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n/an/a 100n/an/an/an/a8.037



Michigan State University



Assay Description
For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...


J Biol Chem 282: 28096-105 (2007)


Article DOI: 10.1074/jbc.M701335200
BindingDB Entry DOI: 10.7270/Q2R49P2D
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM22573
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES CC[C@@H](CO)NC(=O)Cc1c(C)n(C(=O)c2ccc(Cl)cc2)c2ccc(OC)cc12
Show InChI InChI=1S/C23H25ClN2O4/c1-4-17(13-27)25-22(28)12-19-14(2)26(21-10-9-18(30-3)11-20(19)21)23(29)15-5-7-16(24)8-6-15/h5-11,17,27H,4,12-13H2,1-3H3,(H,25,28)/t17-/m0/s1
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n/an/a 280n/an/an/an/a8.037



Michigan State University



Assay Description
For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...


J Biol Chem 282: 28096-105 (2007)


Article DOI: 10.1074/jbc.M701335200
BindingDB Entry DOI: 10.7270/Q2R49P2D
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM22574
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@@H](CO)CCSC)c2c1
Show InChI InChI=1S/C24H27ClN2O4S/c1-15-20(13-23(29)26-18(14-28)10-11-32-3)21-12-19(31-2)8-9-22(21)27(15)24(30)16-4-6-17(25)7-5-16/h4-9,12,18,28H,10-11,13-14H2,1-3H3,(H,26,29)/t18-/m1/s1
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n/an/a 250n/an/an/an/a8.037



Michigan State University



Assay Description
For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...


J Biol Chem 282: 28096-105 (2007)


Article DOI: 10.1074/jbc.M701335200
BindingDB Entry DOI: 10.7270/Q2R49P2D
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM11639
PNG
(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Show SMILES Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C17H14F3N3O2S/c1-11-2-4-12(5-3-11)15-10-16(17(18,19)20)22-23(15)13-6-8-14(9-7-13)26(21,24)25/h2-10H,1H3,(H2,21,24,25)
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Article
PubMed
n/an/a 70n/an/an/an/a8.037



University of Alberta



Assay Description
The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...


J Med Chem 49: 1668-83 (2006)


Article DOI: 10.1021/jm0510474
BindingDB Entry DOI: 10.7270/Q2DV1H5S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase


(Homo sapiens (human))
BDBM22576
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@@H](CO)c3ccccc3)c2c1
Show InChI InChI=1S/C27H25ClN2O4/c1-17-22(15-26(32)29-24(16-31)18-6-4-3-5-7-18)23-14-21(34-2)12-13-25(23)30(17)27(33)19-8-10-20(28)11-9-19/h3-14,24,31H,15-16H2,1-2H3,(H,29,32)/t24-/m0/s1
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n/an/a 440n/an/an/an/a8.037



Michigan State University



Assay Description
For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...


J Biol Chem 282: 28096-105 (2007)


Article DOI: 10.1074/jbc.M701335200
BindingDB Entry DOI: 10.7270/Q2R49P2D
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM22577
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@H](CO)c3ccccc3)c2c1
Show InChI InChI=1S/C27H25ClN2O4/c1-17-22(15-26(32)29-24(16-31)18-6-4-3-5-7-18)23-14-21(34-2)12-13-25(23)30(17)27(33)19-8-10-20(28)11-9-19/h3-14,24,31H,15-16H2,1-2H3,(H,29,32)/t24-/m1/s1
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n/an/a 85n/an/an/an/a8.037



Michigan State University



Assay Description
For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...


J Biol Chem 282: 28096-105 (2007)


Article DOI: 10.1074/jbc.M701335200
BindingDB Entry DOI: 10.7270/Q2R49P2D
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM22342
PNG
((5E)-5-[(3-chlorophenyl)methylidene]-2-(1,3-thiazo...)
Show SMILES Clc1cccc(C=C2SC(Nc3nccs3)=NC2=O)c1
Show InChI InChI=1S/C13H8ClN3OS2/c14-9-3-1-2-8(6-9)7-10-11(18)16-13(20-10)17-12-15-4-5-19-12/h1-7H,(H,15,16,17,18)
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n/an/a 2.62E+5n/an/an/an/a8.037



Aristotle University



Assay Description
The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The ass...


J Med Chem 51: 1601-9 (2008)


Article DOI: 10.1021/jm701496h
BindingDB Entry DOI: 10.7270/Q2JM27XJ
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM22360
PNG
(2-(acetyloxy)benzoate | 2-(acetyloxy)benzoic acid ...)
Show SMILES CC(=O)Oc1ccccc1C(O)=O
Show InChI InChI=1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
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n/an/a 2.40E+3n/an/an/an/a8.037



University of Alberta



Assay Description
The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...


J Med Chem 49: 1668-83 (2006)


Article DOI: 10.1021/jm0510474
BindingDB Entry DOI: 10.7270/Q2DV1H5S
More data for this
Ligand-Target Pair
Cyclooxygenase


(Homo sapiens (human))
BDBM22369
PNG
(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Show SMILES CS(=O)(=O)c1ccc(cc1)C1=C(C(=O)OC1)c1ccccc1
Show InChI InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
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n/an/a 500n/an/an/an/a8.037



University of Alberta



Assay Description
The COX enzyme activities were measured using the COX Inhibitor Screening Assay kit provided by Cayman (Cayman, Chemical Co., Ann Arbor, MI). The as...


J Med Chem 49: 1668-83 (2006)


Article DOI: 10.1021/jm0510474
BindingDB Entry DOI: 10.7270/Q2DV1H5S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Cyclooxygenase


(Homo sapiens (human))
BDBM22575
PNG
(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Show SMILES COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)N[C@H](CO)CCSC)c2c1
Show InChI InChI=1S/C24H27ClN2O4S/c1-15-20(13-23(29)26-18(14-28)10-11-32-3)21-12-19(31-2)8-9-22(21)27(15)24(30)16-4-6-17(25)7-5-16/h4-9,12,18,28H,10-11,13-14H2,1-3H3,(H,26,29)/t18-/m0/s1
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n/an/a 1.00E+3n/an/an/an/a8.037



Michigan State University



Assay Description
For the time-dependent inhibition studies, COX enzyme was incubated with test co mpounds for 20 min and then analyzed for remaining COX activity by t...


J Biol Chem 282: 28096-105 (2007)


Article DOI: 10.1074/jbc.M701335200
BindingDB Entry DOI: 10.7270/Q2R49P2D
More data for this
Ligand-Target Pair