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Found 34 of ph data with Target = 'DNA ligase 1'
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM22981(Glycosyl Ureides, 3a | ethyl 3-[(3aS,6R,6aS)-6-(be...)
Affinity DataIC50:  2.72E+5nMpH: 8.0 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM22982(Glycosyl Ureides, 3b | ethyl 3-[(3aS,6R,6aS)-6-(be...)
Affinity DataIC50:  1.27E+5nMpH: 8.0 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM22983(ethyl 3-[({3-[({1-[(3aR,6S,6aR)-6-(benzyloxy)-2,2-...)
Affinity DataIC50:  2.93E+5nMpH: 8.0 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM22986(18-[6-(piperidin-1-yl)hexyl]-8-thia-18-azatetracyc...)
Affinity DataIC50:  2.12E+5nMpH: 8.0 T: 2°CAssay Description:The assay was performed using a 40-bp double-stranded DNA substrate carrying a single-strand nick between bases 22 and 23. The reaction products were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23055(alpha-ketooxazole, 5aa | methyl 2-{7-oxo-7-[5-(pyr...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/mole IC50:  0.400nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23053(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-[3-(trifluo...)
Affinity DataKi:  1nM ΔG°:  -50.9kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23057(alpha-ketooxazole, 5cc | methyl 4-{7-oxo-7-[5-(pyr...)
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/mole IC50:  0.240nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23045(7-(2-fluorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  1.70nM ΔG°:  -49.6kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23056(alpha-ketooxazole, 5bb | methyl 3-{7-oxo-7-[5-(pyr...)
Affinity DataKi:  1.90nM ΔG°:  -49.3kJ/mole IC50:  0.400nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23046(7-(3-fluorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  2.20nM ΔG°:  -48.9kJ/mole IC50:  10nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23043(alpha-ketooxazole, 5o | tert-butyl N-(3-{7-oxo-7-[...)
Affinity DataKi:  2.40nM ΔG°:  -48.7kJ/molepH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23039(7-(3-methoxyphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  2.5nM ΔG°:  -48.6kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23050(7-[4-(methylsulfanyl)phenyl]-1-[5-(pyridin-2-yl)-1...)
Affinity DataKi:  2.5nM ΔG°:  -48.6kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23030(7-(naphthalen-1-yl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  2.60nM ΔG°:  -48.5kJ/mole IC50:  10nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23037(7-(4-methylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  2.80nM ΔG°:  -48.3kJ/mole IC50:  40nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23034(7-(2-methylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23042(7-(4-aminophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Affinity DataKi:  3nM ΔG°:  -48.2kJ/mole IC50:  4nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23047(7-(4-fluorophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  3.20nM ΔG°:  -48.0kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23036(7-(3-methylphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-...)
Affinity DataKi:  3.30nM ΔG°:  -47.9kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23048(7-[2-(methylsulfanyl)phenyl]-1-[5-(pyridin-2-yl)-1...)
Affinity DataKi:  3.30nM ΔG°:  -47.9kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23052(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-[2-(trifluo...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23054(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-[4-(trifluo...)
Affinity DataKi:  4nM ΔG°:  -47.5kJ/mole IC50:  9nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23049(7-[3-(methylsulfanyl)phenyl]-1-[5-(pyridin-2-yl)-1...)
Affinity DataKi:  4.20nM ΔG°:  -47.3kJ/mole IC50:  10nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23027(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-(thiophen-2...)
Affinity DataKi:  4.30nM ΔG°:  -47.3kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23029(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-(thiophen-3...)
Affinity DataKi:  5.10nM ΔG°:  -46.9kJ/mole IC50:  40nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23044(alpha-ketooxazole, 5p | tert-butyl N-(4-{7-oxo-7-[...)
Affinity DataKi:  5.60nM ΔG°:  -46.6kJ/molepH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23038(7-(2-methoxyphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  5.80nM ΔG°:  -46.5kJ/mole IC50:  10nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23040(7-(4-methoxyphenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  6.20nM ΔG°:  -46.4kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23051(7-(4-nitrophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Affinity DataKi:  6.5nM ΔG°:  -46.3kJ/mole IC50:  0.5nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23031(7-(naphthalen-2-yl)-1-[5-(pyridin-2-yl)-1,3-oxazol...)
Affinity DataKi:  11nM ΔG°:  -45.0kJ/mole IC50:  40nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23041(7-(3-aminophenyl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2...)
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23033(1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]-7-(pyridin-3-...)
Affinity DataKi:  32nM ΔG°:  -42.3kJ/mole IC50:  20nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23032(7-(pyridin-2-yl)-1-[5-(pyridin-2-yl)-1,3-oxazol-2-...)
Affinity DataKi:  120nM ΔG°:  -39.1kJ/mole IC50:  30nMpH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase 1(Homo sapiens (Human))
India Central Drug Research Institute

LigandPNGBDBM23035(2-{7-oxo-7-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepty...)
Affinity DataKi: >600nM ΔG°: >-35.2kJ/molepH: 9.0 T: 2°CAssay Description:The inhibition assays were performed by incubating enzyme, 14C-labeled oleamide in reaction buffer at room temperature in the presence of three diffe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed