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Found 42 hits of ph data with Target = 'Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101897
PNG
(US8530490, 167)
Show SMILES O=c1ccn(COCCCC2(CC2)NS(=O)(=O)c2cccc(OCC3CC3)c2)c(=O)[nH]1
Show InChI InChI=1S/C21H27N3O6S/c25-19-7-11-24(20(26)22-19)15-29-12-2-8-21(9-10-21)23-31(27,28)18-4-1-3-17(13-18)30-14-16-5-6-16/h1,3-4,7,11,13,16,23H,2,5-6,8-10,12,14-15H2,(H,22,25,26)
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n/an/a 130n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101909
PNG
(US8530490, 1)
Show SMILES O=c1ccn(COCCCS(=O)(=O)NCc2cccc(OCC3CC3)c2)c(=O)[nH]1
Show InChI InChI=1S/C19H25N3O6S/c23-18-7-8-22(19(24)21-18)14-27-9-2-10-29(25,26)20-12-16-3-1-4-17(11-16)28-13-15-5-6-15/h1,3-4,7-8,11,15,20H,2,5-6,9-10,12-14H2,(H,21,23,24)
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n/an/a 330n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM139105
PNG
(US8883759, 19)
Show SMILES CC[C@@H](NS(=O)(=O)CCCn1ccc(=O)[nH]c1=O)c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C20H27N3O5S/c1-2-18(16-5-3-6-17(13-16)28-14-15-7-8-15)22-29(26,27)12-4-10-23-11-9-19(24)21-20(23)25/h3,5-6,9,11,13,15,18,22H,2,4,7-8,10,12,14H2,1H3,(H,21,24,25)/t18-/m1/s1
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n/an/a 610n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101763
PNG
(CHEMBL2057909 | US8530490, 23)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C20H27N3O6S/c1-15(17-4-2-5-18(12-17)29-13-16-6-7-16)22-30(26,27)11-3-10-28-14-23-9-8-19(24)21-20(23)25/h2,4-5,8-9,12,15-16,22H,3,6-7,10-11,13-14H2,1H3,(H,21,24,25)/t15-/m1/s1
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n/an/a 50n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101809
PNG
(US8530490, 69)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OCC=C)c1
Show InChI InChI=1S/C19H25N3O6S/c1-3-10-28-17-7-4-6-16(13-17)15(2)21-29(25,26)12-5-11-27-14-22-9-8-18(23)20-19(22)24/h3-4,6-9,13,15,21H,1,5,10-12,14H2,2H3,(H,20,23,24)/t15-/m1/s1
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n/an/a 740n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101808
PNG
(US8530490, 68)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1ccc(F)c(OCC(F)F)c1
Show InChI InChI=1S/C18H22F3N3O6S/c1-12(13-3-4-14(19)15(9-13)30-10-16(20)21)23-31(27,28)8-2-7-29-11-24-6-5-17(25)22-18(24)26/h3-6,9,12,16,23H,2,7-8,10-11H2,1H3,(H,22,25,26)/t12-/m1/s1
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n/an/a 110n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101794
PNG
(US8530490, 54)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1ccc(F)c(OCC(F)(F)F)c1
Show InChI InChI=1S/C18H21F4N3O6S/c1-12(13-3-4-14(19)15(9-13)31-10-18(20,21)22)24-32(28,29)8-2-7-30-11-25-6-5-16(26)23-17(25)27/h3-6,9,12,24H,2,7-8,10-11H2,1H3,(H,23,26,27)/t12-/m1/s1
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n/an/a 230n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101787
PNG
(US8530490, 47)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OC2CCOCC2)c1
Show InChI InChI=1S/C21H29N3O7S/c1-16(17-4-2-5-19(14-17)31-18-7-11-29-12-8-18)23-32(27,28)13-3-10-30-15-24-9-6-20(25)22-21(24)26/h2,4-6,9,14,16,18,23H,3,7-8,10-13,15H2,1H3,(H,22,25,26)/t16-/m1/s1
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n/an/a 210n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101801
PNG
(US8530490, 61)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OCC(F)F)c1
Show InChI InChI=1S/C18H23F2N3O6S/c1-13(14-4-2-5-15(10-14)29-11-16(19)20)22-30(26,27)9-3-8-28-12-23-7-6-17(24)21-18(23)25/h2,4-7,10,13,16,22H,3,8-9,11-12H2,1H3,(H,21,24,25)/t13-/m1/s1
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n/an/a 140n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101799
PNG
(US8530490, 59)
Show SMILES CC[C@H](C)COc1cccc(c1)[C@@H](C)NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C21H31N3O6S/c1-4-16(2)14-30-19-8-5-7-18(13-19)17(3)23-31(27,28)12-6-11-29-15-24-10-9-20(25)22-21(24)26/h5,7-10,13,16-17,23H,4,6,11-12,14-15H2,1-3H3,(H,22,25,26)/t16-,17+/m0/s1
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n/an/a 720n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101798
PNG
(US8530490, 58)
Show SMILES CC(C)COc1cccc(c1)[C@@H](C)NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C20H29N3O6S/c1-15(2)13-29-18-7-4-6-17(12-18)16(3)22-30(26,27)11-5-10-28-14-23-9-8-19(24)21-20(23)25/h4,6-9,12,15-16,22H,5,10-11,13-14H2,1-3H3,(H,21,24,25)/t16-/m1/s1
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n/an/a 310n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101793
PNG
(US8530490, 53)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OCC(F)(F)F)c1
Show InChI InChI=1S/C18H22F3N3O6S/c1-13(14-4-2-5-15(10-14)30-11-18(19,20)21)23-31(27,28)9-3-8-29-12-24-7-6-16(25)22-17(24)26/h2,4-7,10,13,23H,3,8-9,11-12H2,1H3,(H,22,25,26)/t13-/m1/s1
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n/an/a 230n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101764
PNG
(US8530490, 24)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1ccc(F)c(OC2CCCC2)c1
Show InChI InChI=1S/C21H28FN3O6S/c1-15(16-7-8-18(22)19(13-16)31-17-5-2-3-6-17)24-32(28,29)12-4-11-30-14-25-10-9-20(26)23-21(25)27/h7-10,13,15,17,24H,2-6,11-12,14H2,1H3,(H,23,26,27)/t15-/m1/s1
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n/an/a 40n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101762
PNG
(US8530490, 22)
Show SMILES CC[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1ccc(F)c(OCC2CC2)c1
Show InChI InChI=1S/C21H28FN3O6S/c1-2-18(16-6-7-17(22)19(12-16)31-13-15-4-5-15)24-32(28,29)11-3-10-30-14-25-9-8-20(26)23-21(25)27/h6-9,12,15,18,24H,2-5,10-11,13-14H2,1H3,(H,23,26,27)/t18-/m1/s1
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n/an/a 30n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101761
PNG
(US8530490, 21)
Show SMILES O=c1ccn(COCCCS(=O)(=O)NCc2cccc(OC3CCCC3)c2)c(=O)[nH]1
Show InChI InChI=1S/C20H27N3O6S/c24-19-9-10-23(20(25)22-19)15-28-11-4-12-30(26,27)21-14-16-5-3-8-18(13-16)29-17-6-1-2-7-17/h3,5,8-10,13,17,21H,1-2,4,6-7,11-12,14-15H2,(H,22,24,25)
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n/an/a 270n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101751
PNG
(US8530490, 11)
Show SMILES CC(NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OCC2CC2)c1
Show InChI InChI=1S/C20H27N3O6S/c1-15(17-4-2-5-18(12-17)29-13-16-6-7-16)22-30(26,27)11-3-10-28-14-23-9-8-19(24)21-20(23)25/h2,4-5,8-9,12,15-16,22H,3,6-7,10-11,13-14H2,1H3,(H,21,24,25)
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n/an/a 490n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101748
PNG
(CHEMBL2057911 | US8530490, 8)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1ccc(F)c(OCC2CC2)c1
Show InChI InChI=1S/C20H26FN3O6S/c1-14(16-5-6-17(21)18(11-16)30-12-15-3-4-15)23-31(27,28)10-2-9-29-13-24-8-7-19(25)22-20(24)26/h5-8,11,14-15,23H,2-4,9-10,12-13H2,1H3,(H,22,25,26)/t14-/m1/s1
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n/an/a 90n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101747
PNG
(US8530490, 7)
Show SMILES Fc1ccc(CNS(=O)(=O)CCCOCn2ccc(=O)[nH]c2=O)cc1OCC1CC1
Show InChI InChI=1S/C19H24FN3O6S/c20-16-5-4-15(10-17(16)29-12-14-2-3-14)11-21-30(26,27)9-1-8-28-13-23-7-6-18(24)22-19(23)25/h4-7,10,14,21H,1-3,8-9,11-13H2,(H,22,24,25)
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n/an/a 640n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101746
PNG
(US8530490, 397 | US8530490, 6)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OC2CCOC2)c1
Show InChI InChI=1S/C20H27N3O7S/c1-15(16-4-2-5-17(12-16)30-18-7-10-28-13-18)22-31(26,27)11-3-9-29-14-23-8-6-19(24)21-20(23)25/h2,4-6,8,12,15,18,22H,3,7,9-11,13-14H2,1H3,(H,21,24,25)/t15-,18?/m1/s1
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n/an/a 460n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM101745
PNG
(US8530490, 5)
Show SMILES C[C@@H](NS(=O)(=O)CCCOCn1ccc(=O)[nH]c1=O)c1cccc(OC2CCCC2)c1
Show InChI InChI=1S/C21H29N3O6S/c1-16(17-6-4-9-19(14-17)30-18-7-2-3-8-18)23-31(27,28)13-5-12-29-15-24-11-10-20(25)22-21(24)26/h4,6,9-11,14,16,18,23H,2-3,5,7-8,12-13,15H2,1H3,(H,22,25,26)/t16-/m1/s1
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US Patent
n/an/a 60n/an/an/an/a7.437



Taiho Pharmaceutical Co., Ltd.

US Patent


Assay Description
The inhibitory activity of these compounds of the present invention against human dUTPase was determined by measuring the production of [5-3H]deoxyur...


US Patent US8883759 (2014)


BindingDB Entry DOI: 10.7270/Q27943CK
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173548
PNG
(CHEMBL373232 | Phosphoric acid 5-(2,4-dioxo-3,4-di...)
Show SMILES OC1CC(OC1COP(=O)(Oc1ccccc1)Oc1ccccc1)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C21H21N2O8P/c24-17-13-20(23-12-11-19(25)22-21(23)26)29-18(17)14-28-32(27,30-15-7-3-1-4-8-15)31-16-9-5-2-6-10-16/h1-12,17-18,20,24H,13-14H2,(H,22,25,26)
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1.35E+5 -22.1n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173546
PNG
(1-(5-Trityloxymethyl-2,5-dihydro-furan-2-yl)-1H-py...)
Show SMILES O=c1ccn(C2OC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)C=C2)c(=O)[nH]1
Show InChI InChI=1S/C28H24N2O4/c31-25-18-19-30(27(32)29-25)26-17-16-24(34-26)20-33-28(21-10-4-1-5-11-21,22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-19,24,26H,20H2,(H,29,31,32)
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1.56E+5 -21.7n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM91592
PNG
(dUTPase inhibitor, 3)
Show SMILES O=C(OCC1OC(C=C1)n1ccc(=O)[nH]c1=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H24N2O5/c23-16-3-4-22(19(25)21-16)17-2-1-15(27-17)11-26-18(24)20-8-12-5-13(9-20)7-14(6-12)10-20/h1-4,12-15,17H,5-11H2,(H,21,23,25)
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2.98E+5 -20.1n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173554
PNG
(CHEMBL194480 | Hexadecanoic acid 5-(2,4-dioxo-3,4-...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OCC1OC(C=C1)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C25H40N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(29)31-20-21-16-17-23(32-21)27-19-18-22(28)26-25(27)30/h16-19,21,23H,2-15,20H2,1H3,(H,26,28,30)
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3.50E+5 -19.7n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM91592
PNG
(dUTPase inhibitor, 3)
Show SMILES O=C(OCC1OC(C=C1)n1ccc(=O)[nH]c1=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H24N2O5/c23-16-3-4-22(19(25)21-16)17-2-1-15(27-17)11-26-18(24)20-8-12-5-13(9-20)7-14(6-12)10-20/h1-4,12-15,17H,5-11H2,(H,21,23,25)
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5.47E+5 -18.6n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173530
PNG
(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydr...)
Show SMILES CC(C)(C)[Si](OCC1OC(CC1O)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H30N2O5Si/c1-25(2,3)33(18-10-6-4-7-11-18,19-12-8-5-9-13-19)31-17-21-20(28)16-23(32-21)27-15-14-22(29)26-24(27)30/h4-15,20-21,23,28H,16-17H2,1-3H3,(H,26,29,30)
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8.05E+5 -17.7n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173532
PNG
(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluo...)
Show SMILES CC(C)(C)[Si](OCC1OC(CC1F)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H29FN2O4Si/c1-25(2,3)33(18-10-6-4-7-11-18,19-12-8-5-9-13-19)31-17-21-20(26)16-23(32-21)28-15-14-22(29)27-24(28)30/h4-15,20-21,23H,16-17H2,1-3H3,(H,27,29,30)
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8.07E+5 -17.7n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173531
PNG
(1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...)
Show SMILES OC1CC(OC1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C27H26N2O5Si/c30-23-18-26(29-17-16-25(31)28-27(29)32)34-24(23)19-33-35(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-17,23-24,26,30H,18-19H2,(H,28,31,32)
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9.08E+5 -17.4n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173548
PNG
(CHEMBL373232 | Phosphoric acid 5-(2,4-dioxo-3,4-di...)
Show SMILES OC1CC(OC1COP(=O)(Oc1ccccc1)Oc1ccccc1)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C21H21N2O8P/c24-17-13-20(23-12-11-19(25)22-21(23)26)29-18(17)14-28-32(27,30-15-7-3-1-4-8-15)31-16-9-5-2-6-10-16/h1-12,17-18,20,24H,13-14H2,(H,22,25,26)
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1.00E+6 -17.1n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173540
PNG
(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-di...)
Show SMILES CC(C)(C)[Si](OCC1OC(C=C1)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H28N2O4Si/c1-25(2,3)32(20-10-6-4-7-11-20,21-12-8-5-9-13-21)30-18-19-14-15-23(31-19)27-17-16-22(28)26-24(27)29/h4-17,19,23H,18H2,1-3H3,(H,26,28,29)
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>1.00E+6>-17.1n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173567
PNG
(1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-fluo...)
Show SMILES CC(C)(C)[Si](C)(C)OCC1OC(CC1F)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H25FN2O4Si/c1-15(2,3)23(4,5)21-9-11-10(16)8-13(22-11)18-7-6-12(19)17-14(18)20/h6-7,10-11,13H,8-9H2,1-5H3,(H,17,19,20)
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>1.00E+6>-17.1n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173566
PNG
(1-(4-Hydroxy-5-triisopropylsilanyloxymethyl-tetrah...)
Show SMILES CC(C)[Si](OCC1OC(CC1O)n1ccc(=O)[nH]c1=O)(C(C)C)C(C)C
Show InChI InChI=1S/C18H32N2O5Si/c1-11(2)26(12(3)4,13(5)6)24-10-15-14(21)9-17(25-15)20-8-7-16(22)19-18(20)23/h7-8,11-15,17,21H,9-10H2,1-6H3,(H,19,22,23)
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1.00E+6 -17.1n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Homo sapiens (Human))
BDBM50173576
PNG
(1-[5-(Benzylamino-methyl)-4-hydroxy-tetrahydro-fur...)
Show SMILES OC1CC(OC1CNCc1ccccc1)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C16H19N3O4/c20-12-8-15(19-7-6-14(21)18-16(19)22)23-13(12)10-17-9-11-4-2-1-3-5-11/h1-7,12-13,15,17,20H,8-10H2,(H,18,21,22)
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1.00E+6 -17.1n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173546
PNG
(1-(5-Trityloxymethyl-2,5-dihydro-furan-2-yl)-1H-py...)
Show SMILES O=c1ccn(C2OC(COC(c3ccccc3)(c3ccccc3)c3ccccc3)C=C2)c(=O)[nH]1
Show InChI InChI=1S/C28H24N2O4/c31-25-18-19-30(27(32)29-25)26-17-16-24(34-26)20-33-28(21-10-4-1-5-11-21,22-12-6-2-7-13-22)23-14-8-3-9-15-23/h1-19,24,26H,20H2,(H,29,31,32)
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1.00E+6 -17.1n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173567
PNG
(1-[5-(tert-Butyl-dimethyl-silanyloxymethyl)-4-fluo...)
Show SMILES CC(C)(C)[Si](C)(C)OCC1OC(CC1F)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C15H25FN2O4Si/c1-15(2,3)23(4,5)21-9-11-10(16)8-13(22-11)18-7-6-12(19)17-14(18)20/h6-7,10-11,13H,8-9H2,1-5H3,(H,17,19,20)
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1.00E+9 0n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173532
PNG
(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-fluo...)
Show SMILES CC(C)(C)[Si](OCC1OC(CC1F)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H29FN2O4Si/c1-25(2,3)33(18-10-6-4-7-11-18,19-12-8-5-9-13-19)31-17-21-20(26)16-23(32-21)28-15-14-22(29)27-24(28)30/h4-15,20-21,23H,16-17H2,1-3H3,(H,27,29,30)
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1.00E+9 0n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173566
PNG
(1-(4-Hydroxy-5-triisopropylsilanyloxymethyl-tetrah...)
Show SMILES CC(C)[Si](OCC1OC(CC1O)n1ccc(=O)[nH]c1=O)(C(C)C)C(C)C
Show InChI InChI=1S/C18H32N2O5Si/c1-11(2)26(12(3)4,13(5)6)24-10-15-14(21)9-17(25-15)20-8-7-16(22)19-18(20)23/h7-8,11-15,17,21H,9-10H2,1-6H3,(H,19,22,23)
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1.00E+9 0n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173530
PNG
(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-hydr...)
Show SMILES CC(C)(C)[Si](OCC1OC(CC1O)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H30N2O5Si/c1-25(2,3)33(18-10-6-4-7-11-18,19-12-8-5-9-13-19)31-17-21-20(28)16-23(32-21)27-15-14-22(29)26-24(27)30/h4-15,20-21,23,28H,16-17H2,1-3H3,(H,26,29,30)
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1.00E+9 0n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173576
PNG
(1-[5-(Benzylamino-methyl)-4-hydroxy-tetrahydro-fur...)
Show SMILES OC1CC(OC1CNCc1ccccc1)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C16H19N3O4/c20-12-8-15(19-7-6-14(21)18-16(19)22)23-13(12)10-17-9-11-4-2-1-3-5-11/h1-7,12-13,15,17,20H,8-10H2,(H,18,21,22)
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1.00E+9 0n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173531
PNG
(1-(4-Hydroxy-5-triphenylsilanyloxymethyl-tetrahydr...)
Show SMILES OC1CC(OC1CO[Si](c1ccccc1)(c1ccccc1)c1ccccc1)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C27H26N2O5Si/c30-23-18-26(29-17-16-25(31)28-27(29)32)34-24(23)19-33-35(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-17,23-24,26,30H,18-19H2,(H,28,31,32)
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1.00E+9 0n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173540
PNG
(1-[5-(tert-Butyl-diphenyl-silanyloxymethyl)-2,5-di...)
Show SMILES CC(C)(C)[Si](OCC1OC(C=C1)n1ccc(=O)[nH]c1=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H28N2O4Si/c1-25(2,3)32(20-10-6-4-7-11-20,21-12-8-5-9-13-21)30-18-19-14-15-23(31-19)27-17-16-22(28)26-24(27)29/h4-17,19,23H,18H2,1-3H3,(H,26,28,29)
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1.00E+9 0n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase)


(Campylobacter jejuni)
BDBM50173554
PNG
(CHEMBL194480 | Hexadecanoic acid 5-(2,4-dioxo-3,4-...)
Show SMILES CCCCCCCCCCCCCCCC(=O)OCC1OC(C=C1)n1ccc(=O)[nH]c1=O
Show InChI InChI=1S/C25H40N2O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-24(29)31-20-21-16-17-23(32-21)27-19-18-22(28)26-25(27)30/h16-19,21,23H,2-15,20H2,1H3,(H,26,28,30)
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1.00E+9 0n/an/an/an/an/a8.025



Instituto de Parastiologia y Biomedicina "Lopez-Neyra"



Assay Description
Nucleotide hydrolysis was monitored by mixing enzyme and substrate with a rapid kinetic accessory (Hi-Tech Scientific) attached to a spectrophotomete...


J Enzyme Inhib Med Chem 24: 111-6 (2009)


Article DOI: 10.1080/14756360801915476
BindingDB Entry DOI: 10.7270/Q2JH3JST
More data for this
Ligand-Target Pair