BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 19 hits of ph data with Target = 'Dual specificity protein phosphatase (VHR)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84495
PNG
(CHEMBL1945189 | Roseophilin, 1)
Show SMILES COc1cc(oc1C1=c2[nH]c3=CCCCCCCC[C@@H]1[C@@H](C(C)C)c2c3)-c1[nH]ccc1Cl
Show InChI InChI=1S/C27H31ClN2O2/c1-16(2)23-18-11-9-7-5-4-6-8-10-17-14-19(23)25(30-17)24(18)27-22(31-3)15-21(32-27)26-20(28)12-13-29-26/h10,12-16,18,23H,4-9,11H2,1-3H3/b17-10?,26-21-,27-24-/t18-,23-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.20E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84512
PNG
(Acyclic analogue, 18)
Show SMILES COC1=CC(=O)N\C1=C/c1ccc(CCCC\C=C\CCCCC(O)=O)[nH]1
Show InChI InChI=1S/C21H28N2O4/c1-27-19-15-20(24)23-18(19)14-17-13-12-16(22-17)10-8-6-4-2-3-5-7-9-11-21(25)26/h2-3,12-15,22H,4-11H2,1H3,(H,23,24)(H,25,26)/b3-2+,18-14-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84496
PNG
(Roseophilin, 2)
Show SMILES COc1cc(oc1C1=c2[nH]c3=CCCCCCCC[C@H]1[C@H](C(C)C)c2c3)-c1[nH]ccc1Cl
Show InChI InChI=1S/C27H31ClN2O2/c1-16(2)23-18-11-9-7-5-4-6-8-10-17-14-19(23)25(30-17)24(18)27-22(31-3)15-21(32-27)26-20(28)12-13-29-26/h10,12-16,18,23H,4-9,11H2,1-3H3/b17-10?,26-21-,27-24-/t18-,23-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 6.00E+3n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84497
PNG
(Roseophilin analogue, 3)
Show SMILES CC(C)[C@@H]1[C@H]2CCCCCCCC=c3cc1c([nH]3)=C2c1ccc(o1)-c1ccc[nH]1
Show InChI InChI=1S/C26H30N2O/c1-17(2)24-19-11-8-6-4-3-5-7-10-18-16-20(24)26(28-18)25(19)23-14-13-22(29-23)21-12-9-15-27-21/h9-10,12-17,19,24H,3-8,11H2,1-2H3/b18-10?,22-21-,25-23-/t19-,24-/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.50E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84498
PNG
(3-chloro-2-(5-{1-[(2Z)-2H-pyrrol-2-ylidene]ethyl}f...)
Show SMILES C\C(=C1/C=CC=N1)c1ccc(o1)-c1[nH]ccc1Cl
Show InChI InChI=1S/C14H11ClN2O/c1-9(11-3-2-7-16-11)12-4-5-13(18-12)14-10(15)6-8-17-14/h2-8,17H,1H3/b11-9-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.00E+3n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84499
PNG
(2-(5-{1-[(2Z)-2H-pyrrol-2-ylidene]ethyl}furan-2-yl...)
Show SMILES C\C(=C1/C=CC=N1)c1ccc(o1)-c1ccc[nH]1
Show InChI InChI=1S/C14H12N2O/c1-10(11-4-2-8-15-11)13-6-7-14(17-13)12-5-3-9-16-12/h2-9,16H,1H3/b11-10-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.90E+3n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84500
PNG
(Nonylprodigiosin, 6)
Show SMILES CCC1=CC2=N\C1=C/c1ccc(CCCCCCCCCc3ccc2[nH]3)[nH]1
Show InChI InChI=1S/C24H29N3/c1-2-18-16-24-22-15-14-20(26-22)11-9-7-5-3-4-6-8-10-19-12-13-21(25-19)17-23(18)27-24/h12-17H,2-11H2,1H3/b21-17-,24-22-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.10E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84501
PNG
(Cyclic analogue, 7)
Show SMILES COC1=CC2=N\C1=C/c1ccc(CCCC\C=C\CCCc3ccc2o3)[nH]1
Show InChI InChI=1S/C23H26N2O2/c1-26-23-16-21-22-14-13-19(27-22)10-8-6-4-2-3-5-7-9-17-11-12-18(24-17)15-20(23)25-21/h2,4,11-16,24H,3,5-10H2,1H3/b4-2+,20-15-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.80E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84502
PNG
(Cyclic analogue, 8)
Show SMILES COC1=CC2=N\C1=C/c1ccc(CCCC\C=C\CCCCCCCCCCc3ccc2o3)[nH]1
Show InChI InChI=1S/C30H40N2O2/c1-33-30-23-28-29-21-20-26(34-29)17-15-13-11-9-7-5-3-2-4-6-8-10-12-14-16-24-18-19-25(31-24)22-27(30)32-28/h6,8,18-23,31H,2-5,7,9-17H2,1H3/b8-6+,27-22-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.10E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84503
PNG
(Cyclic analogue, 9)
Show SMILES COC1=CC2=N\C1=C/c1ccc(CCCC\C=C\CCCc3cccc2c3)[nH]1
Show InChI InChI=1S/C25H28N2O/c1-28-25-18-23-20-12-9-11-19(16-20)10-7-5-3-2-4-6-8-13-21-14-15-22(26-21)17-24(25)27-23/h2-3,9,11-12,14-18,26H,4-8,10,13H2,1H3/b3-2+,24-17-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.00E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84504
PNG
(Acyclic analogue, 10)
Show SMILES COC1=CC(=N\C1=C/c1ccc(CCCCC=C)[nH]1)c1ccc(CCCC=C)[nH]1
Show InChI InChI=1S/C25H29N3O/c1-4-6-8-10-12-19-13-14-21(26-19)17-24-25(29-3)18-23(28-24)22-16-15-20(27-22)11-9-7-5-2/h4-5,13-18H,1-2,6-12H2,3H3/b21-17-,23-22-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84505
PNG
(Acyclic analogue, 11)
Show SMILES COC1=CC(=NC1=Cc1ccc(CCCCC=C)[nH]1)c1ccc([nH]1)C(=O)CCC=C
Show InChI InChI=1S/C25H27N3O2/c1-4-6-8-9-10-18-12-13-19(26-18)16-23-25(30-3)17-22(28-23)20-14-15-21(27-20)24(29)11-7-5-2/h4-5,12-17H,1-2,6-11H2,3H3/b19-16?,22-20-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84506
PNG
(Acyclic analogue, 12)
Show SMILES COC1=CC(=N\C1=C/c1ccc(CCCCC=C)[nH]1)c1ccc([nH]1)C(\C)=C/CC=C
Show InChI InChI=1S/C26H29N3O/c1-5-7-9-10-12-20-13-14-21(27-20)17-25-26(30-4)18-24(29-25)23-16-15-22(28-23)19(3)11-8-6-2/h5-6,11,13-18H,1-2,7-10,12H2,3-4H3/b19-11-,21-17-,24-23-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 9.00E+3n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84507
PNG
(Acyclic analogue, 13)
Show SMILES COC1=CC(=N\C1=C/c1ccc(CCCCC=C)[nH]1)c1ccc[nH]1
Show InChI InChI=1S/C20H21N3O/c1-3-4-5-6-8-15-10-11-16(22-15)13-19-20(24-2)14-18(23-19)17-9-7-12-21-17/h3,7,9-14H,1,4-6,8H2,2H3/b16-13-,18-17-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84508
PNG
(Acyclic analogue, 14)
Show SMILES CCc1ccc(\C=C2/N=C(C=C2OC)c2ccc[nH]2)[nH]1
Show InChI InChI=1S/C16H15N3O/c1-3-11-6-7-12(18-11)9-15-16(20-2)10-14(19-15)13-5-4-8-17-13/h4-10H,3H2,1-2H3/b12-9-,14-13-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.10E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84509
PNG
(Acyclic analogue, 15)
Show SMILES COC1=CC(=N\C1=C/c1ccc(CCCCC=C)[nH]1)c1ccc(CCCC=C)s1
Show InChI InChI=1S/C25H30N2OS/c1-4-6-8-10-11-19-13-14-20(26-19)17-22-24(28-3)18-23(27-22)25-16-15-21(29-25)12-9-7-5-2/h4-5,13-18,26H,1-2,6-12H2,3H3/b22-17-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.90E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84511
PNG
(Acyclic analogue, 16)
Show SMILES COC1=CC(=O)N\C1=C/c1ccc(CCCCC=C)[nH]1
Show InChI InChI=1S/C16H20N2O2/c1-3-4-5-6-7-12-8-9-13(17-12)10-14-15(20-2)11-16(19)18-14/h3,8-11,17H,1,4-7H2,2H3,(H,18,19)/b14-10-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.00E+3n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM84510
PNG
(Acyclic analogue, 17)
Show SMILES CCc1ccc(\C=C2/NC(=O)C=C2OC)[nH]1
Show InChI InChI=1S/C12H14N2O2/c1-3-8-4-5-9(13-8)6-10-11(16-2)7-12(15)14-10/h4-7,13H,3H2,1-2H3,(H,14,15)/b10-6-
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>5.00E+4n/an/an/an/a6.537



Max-Planck-Institut für Kohlenforschung



Assay Description
Enzyme concentrations were chose to yield absorption changes of 0.2 OD at 405 nm within 80 min for 4-nitrophenyl phosphate (pNPP) in the absence of i...


Chembiochem 5: 1575-9 (2004)


Article DOI: 10.1002/cbic.200400135
BindingDB Entry DOI: 10.7270/Q2QF8RCP
More data for this
Ligand-Target Pair
Dual specificity protein phosphatase (VHR)


(Homo sapiens (human))
BDBM26104
PNG
(5-{2-cyclohexyl-4-[4-fluoro-3-(trifluoromethyl)phe...)
Show SMILES OC(=O)c1cc(on1)-c1ccc(cc1C1CCCCC1)-c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1S/C23H19F4NO3/c24-19-9-7-15(11-18(19)23(25,26)27)14-6-8-16(21-12-20(22(29)30)28-31-21)17(10-14)13-4-2-1-3-5-13/h6-13H,1-5H2,(H,29,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
>5.00E+4>-24.3n/an/an/an/an/a7.422



University of California at Berkeley



Assay Description
The reaction was started by addition of pNPP substrate, and reaction progress was monitored at 405 nm. The initial rate data collected was used for d...


J Am Chem Soc 129: 9613-5 (2007)


Article DOI: 10.1021/ja0727520
BindingDB Entry DOI: 10.7270/Q2PG1Q2M
More data for this
Ligand-Target Pair