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Compile Data Set for Download or QSAR

Found 464 hits of ph data with Target = 'Gag-Pol polyprotein'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM22664
PNG
(2-[1-(dimethylamino)ethyl]-N-[(4-fluorophenyl)meth...)
Show SMILES CC(N(C)C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)[nH]1
Show InChI InChI=1S/C16H19FN4O3/c1-9(21(2)3)14-19-12(13(22)16(24)20-14)15(23)18-8-10-4-6-11(17)7-5-10/h4-7,9,22H,8H2,1-3H3,(H,18,23)(H,19,20,24)
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n/an/a 80n/an/an/an/a7.837



IRBM-MRL



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 49: 6646-9 (2006)


Article DOI: 10.1021/jm060854f
BindingDB Entry DOI: 10.7270/Q23F4MX3
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM22719
PNG
(2-[(dimethylamino)methyl]-N-[(4-fluorophenyl)methy...)
Show SMILES CN(C)Cc1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)[nH]1
Show InChI InChI=1S/C15H17FN4O3/c1-20(2)8-11-18-12(13(21)15(23)19-11)14(22)17-7-9-3-5-10(16)6-4-9/h3-6,21H,7-8H2,1-2H3,(H,17,22)(H,18,19,23)
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n/an/a 200n/an/an/an/a7.837



IRBM-MRL



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 49: 6646-9 (2006)


Article DOI: 10.1021/jm060854f
BindingDB Entry DOI: 10.7270/Q23F4MX3
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM22720
PNG
(2-[2-(dimethylamino)propan-2-yl]-N-[(4-fluoropheny...)
Show SMILES CN(C)C(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)[nH]1
Show InChI InChI=1S/C17H21FN4O3/c1-17(2,22(3)4)16-20-12(13(23)15(25)21-16)14(24)19-9-10-5-7-11(18)8-6-10/h5-8,23H,9H2,1-4H3,(H,19,24)(H,20,21,25)
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n/an/a 50n/an/an/an/a7.837



IRBM-MRL



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 49: 6646-9 (2006)


Article DOI: 10.1021/jm060854f
BindingDB Entry DOI: 10.7270/Q23F4MX3
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM22609
PNG
(JMC496646 Compound 14 | N-[(4-fluorophenyl)methyl]...)
Show SMILES CN1CCCCC1c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)[nH]1
Show InChI InChI=1S/C18H21FN4O3/c1-23-9-3-2-4-13(23)16-21-14(15(24)18(26)22-16)17(25)20-10-11-5-7-12(19)8-6-11/h5-8,13,24H,2-4,9-10H2,1H3,(H,20,25)(H,21,22,26)
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n/an/a 200n/an/an/an/a7.837



IRBM-MRL



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 49: 6646-9 (2006)


Article DOI: 10.1021/jm060854f
BindingDB Entry DOI: 10.7270/Q23F4MX3
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM22611
PNG
(JMC496646 Compound 16 | N-Me-pyrimidone deriv., 11...)
Show SMILES CN1CCCCC1c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C19H23FN4O3/c1-23-10-4-3-5-14(23)17-22-15(16(25)19(27)24(17)2)18(26)21-11-12-6-8-13(20)9-7-12/h6-9,14,25H,3-5,10-11H2,1-2H3,(H,21,26)
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n/an/a 210n/an/an/an/a7.837



IRBM-MRL



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 49: 6646-9 (2006)


Article DOI: 10.1021/jm060854f
BindingDB Entry DOI: 10.7270/Q23F4MX3
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM22628
PNG
(JMC51861 Compound 4 | N-Me-pyrimidone deriv., 27 |...)
Show SMILES CN1CCOCC1c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C18H21FN4O4/c1-22-7-8-27-10-13(22)16-21-14(15(24)18(26)23(16)2)17(25)20-9-11-3-5-12(19)6-4-11/h3-6,13,24H,7-10H2,1-2H3,(H,20,25)
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n/an/a 60n/an/an/an/a7.837



IRBM-MRL



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 49: 6646-9 (2006)


Article DOI: 10.1021/jm060854f
BindingDB Entry DOI: 10.7270/Q23F4MX3
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25328
PNG
(2-[2-(dimethylamino)propan-2-yl]-N-[(4-fluoropheny...)
Show SMILES CN(C)C(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C18H23FN4O3/c1-18(2,22(3)4)17-21-13(14(24)16(26)23(17)5)15(25)20-10-11-6-8-12(19)9-7-11/h6-9,24H,10H2,1-5H3,(H,20,25)
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n/an/a 230n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25329
PNG
(N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-[2...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)N1CCOCC1
Show InChI InChI=1S/C20H25FN4O4/c1-20(2,25-8-10-29-11-9-25)19-23-15(16(26)18(28)24(19)3)17(27)22-12-13-4-6-14(21)7-5-13/h4-7,26H,8-12H2,1-3H3,(H,22,27)
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n/an/a 3n/an/an/an/a7.837



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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25330
PNG
(2-[4-(dimethylamino)oxan-4-yl]-N-[(4-fluorophenyl)...)
Show SMILES CN(C)C1(CCOCC1)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C20H25FN4O4/c1-24(2)20(8-10-29-11-9-20)19-23-15(16(26)18(28)25(19)3)17(27)22-12-13-4-6-14(21)7-5-13/h4-7,26H,8-12H2,1-3H3,(H,22,27)
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n/an/a 2n/an/an/an/a7.837



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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25331
PNG
(2-(2-acetamidopropan-2-yl)-N-[(4-fluorophenyl)meth...)
Show SMILES CC(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C18H21FN4O4/c1-10(24)22-18(2,3)17-21-13(14(25)16(27)23(17)4)15(26)20-9-11-5-7-12(19)8-6-11/h5-8,25H,9H2,1-4H3,(H,20,26)(H,22,24)
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n/an/a 7n/an/an/an/a7.837



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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25332
PNG
(N-[(4-fluorophenyl)methyl]-5-hydroxy-2-(2-methanes...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NS(C)(=O)=O
Show InChI InChI=1S/C17H21FN4O5S/c1-17(2,21-28(4,26)27)16-20-12(13(23)15(25)22(16)3)14(24)19-9-10-5-7-11(18)8-6-10/h5-8,21,23H,9H2,1-4H3,(H,19,24)
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n/an/a 8n/an/an/an/a7.837



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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25333
PNG
(2-{2-[(dimethylcarbamoyl)amino]propan-2-yl}-N-[(4-...)
Show SMILES CN(C)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C19H24FN5O4/c1-19(2,23-18(29)24(3)4)17-22-13(14(26)16(28)25(17)5)15(27)21-10-11-6-8-12(20)9-7-11/h6-9,26H,10H2,1-5H3,(H,21,27)(H,23,29)
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n/an/a 18n/an/an/an/a7.837



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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25334
PNG
(2-{2-[(dimethylsulfamoyl)amino]propan-2-yl}-N-[(4-...)
Show SMILES CN(C)S(=O)(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C18H24FN5O5S/c1-18(2,22-30(28,29)23(3)4)17-21-13(14(25)16(27)24(17)5)15(26)20-10-11-6-8-12(19)9-7-11/h6-9,22,25H,10H2,1-5H3,(H,20,26)
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n/an/a 12n/an/an/an/a7.837



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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25335
PNG
(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Show SMILES CN(C)C(=O)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C20H24FN5O5/c1-20(2,24-16(29)18(31)25(3)4)19-23-13(14(27)17(30)26(19)5)15(28)22-10-11-6-8-12(21)9-7-11/h6-9,27H,10H2,1-5H3,(H,22,28)(H,24,29)
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n/an/a 10n/an/an/an/a7.837



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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25336
PNG
(N-methyl-pyrimidinone derivative, 12 | methyl 0-{[...)
Show SMILES COC(=O)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C19H21FN4O6/c1-19(2,23-15(27)17(29)30-4)18-22-12(13(25)16(28)24(18)3)14(26)21-9-10-5-7-11(20)8-6-10/h5-8,25H,9H2,1-4H3,(H,21,26)(H,23,27)
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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25337
PNG
(N-methyl-pyrimidinone derivative, 13 | {[2-(4-{[(4...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NC(=O)C(O)=O
Show InChI InChI=1S/C18H19FN4O6/c1-18(2,22-14(26)16(28)29)17-21-11(12(24)15(27)23(17)3)13(25)20-8-9-4-6-10(19)7-5-9/h4-7,24H,8H2,1-3H3,(H,20,25)(H,22,26)(H,28,29)
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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25338
PNG
(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Show SMILES CN(C)C(=O)C(=O)N(C)C(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C21H26FN5O5/c1-21(2,27(6)19(32)18(31)25(3)4)20-24-14(15(28)17(30)26(20)5)16(29)23-11-12-7-9-13(22)10-8-12/h7-10,28H,11H2,1-6H3,(H,23,29)
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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25339
PNG
(N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-{2...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NC(=O)C(=O)N1CCOCC1
Show InChI InChI=1S/C22H26FN5O6/c1-22(2,26-18(31)20(33)28-8-10-34-11-9-28)21-25-15(16(29)19(32)27(21)3)17(30)24-12-13-4-6-14(23)7-5-13/h4-7,29H,8-12H2,1-3H3,(H,24,30)(H,26,31)
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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25340
PNG
(N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-{2...)
Show SMILES CN1CCN(CC1)C(=O)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C23H29FN6O5/c1-23(2,27-19(33)21(35)30-11-9-28(3)10-12-30)22-26-16(17(31)20(34)29(22)4)18(32)25-13-14-5-7-15(24)8-6-14/h5-8,31H,9-13H2,1-4H3,(H,25,32)(H,27,33)
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n/an/a 26n/an/an/an/a7.837



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Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25341
PNG
(N-methyl-pyrimidinone derivative, 17 | N-{2-[5-hyd...)
Show SMILES CNC(=O)c1nc(n(C)c(=O)c1O)C(C)(C)NC(=O)C(=O)N(C)C
Show InChI InChI=1S/C14H21N5O5/c1-14(2,17-10(22)12(24)18(4)5)13-16-7(9(21)15-3)8(20)11(23)19(13)6/h20H,1-6H3,(H,15,21)(H,17,22)
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Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25342
PNG
(N-methyl-pyrimidinone derivative, 18)
Show SMILES COc1cccc(CNC(=O)c2nc(n(C)c(=O)c2O)C(C)(C)NC(=O)C(=O)N(C)C)c1OC
Show InChI InChI=1S/C22H29N5O7/c1-22(2,25-18(30)20(32)26(3)4)21-24-14(15(28)19(31)27(21)5)17(29)23-11-12-9-8-10-13(33-6)16(12)34-7/h8-10,28H,11H2,1-7H3,(H,23,29)(H,25,30)
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n/an/a 21n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25343
PNG
(N-[2-(4-{[(4-fluoro-2-methanesulfonylphenyl)methyl...)
Show SMILES CN(C)C(=O)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2S(C)(=O)=O)c(O)c(=O)n1C
Show InChI InChI=1S/C21H26FN5O7S/c1-21(2,25-17(30)19(32)26(3)4)20-24-14(15(28)18(31)27(20)5)16(29)23-10-11-7-8-12(22)9-13(11)35(6,33)34/h7-9,28H,10H2,1-6H3,(H,23,29)(H,25,30)
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n/an/a 4n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25344
PNG
(N-[2-(4-{[(3-chloro-4-fluorophenyl)methyl]carbamoy...)
Show SMILES CN(C)C(=O)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)c(Cl)c2)c(O)c(=O)n1C
Show InChI InChI=1S/C20H23ClFN5O5/c1-20(2,25-16(30)18(32)26(3)4)19-24-13(14(28)17(31)27(19)5)15(29)23-9-10-6-7-12(22)11(21)8-10/h6-8,28H,9H2,1-5H3,(H,23,29)(H,25,30)
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n/an/a 9n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25345
PNG
(N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-6-ox...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NC(=O)c1ccccn1
Show InChI InChI=1S/C22H22FN5O4/c1-22(2,27-18(30)15-6-4-5-11-24-15)21-26-16(17(29)20(32)28(21)3)19(31)25-12-13-7-9-14(23)10-8-13/h4-11,29H,12H2,1-3H3,(H,25,31)(H,27,30)
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n/an/a 20n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25346
PNG
(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NC(=O)c1cccnn1
Show InChI InChI=1S/C21H21FN6O4/c1-21(2,26-17(30)14-5-4-10-24-27-14)20-25-15(16(29)19(32)28(20)3)18(31)23-11-12-6-8-13(22)9-7-12/h4-10,29H,11H2,1-3H3,(H,23,31)(H,26,30)
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n/an/a 15n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25347
PNG
(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NC(=O)c1ncccn1
Show InChI InChI=1S/C21H21FN6O4/c1-21(2,27-18(31)16-23-9-4-10-24-16)20-26-14(15(29)19(32)28(20)3)17(30)25-11-12-5-7-13(22)8-6-12/h4-10,29H,11H2,1-3H3,(H,25,30)(H,27,31)
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n/an/a 7n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25348
PNG
(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NC(=O)c1cnco1
Show InChI InChI=1S/C20H20FN5O5/c1-20(2,25-16(28)13-9-22-10-31-13)19-24-14(15(27)18(30)26(19)3)17(29)23-8-11-4-6-12(21)7-5-11/h4-7,9-10,27H,8H2,1-3H3,(H,23,29)(H,25,28)
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n/an/a 7n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25349
PNG
(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NC(=O)c1cscn1
Show InChI InChI=1S/C20H20FN5O4S/c1-20(2,25-16(28)13-9-31-10-23-13)19-24-14(15(27)18(30)26(19)3)17(29)22-8-11-4-6-12(21)7-5-11/h4-7,9-10,27H,8H2,1-3H3,(H,22,29)(H,25,28)
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n/an/a 8n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25350
PNG
(N-[(4-fluorophenyl)methyl]-5-hydroxy-2-[2-(1H-imid...)
Show SMILES Cn1c(nc(C(=O)NCc2ccc(F)cc2)c(O)c1=O)C(C)(C)NC(=O)c1cnc[nH]1
Show InChI InChI=1S/C20H21FN6O4/c1-20(2,26-16(29)13-9-22-10-24-13)19-25-14(15(28)18(31)27(19)3)17(30)23-8-11-4-6-12(21)7-5-11/h4-7,9-10,28H,8H2,1-3H3,(H,22,24)(H,23,30)(H,26,29)
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n/an/a 6n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25351
PNG
(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Show SMILES Cc1nnc(o1)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C20H21FN6O5/c1-10-25-26-17(32-10)16(30)24-20(2,3)19-23-13(14(28)18(31)27(19)4)15(29)22-9-11-5-7-12(21)8-6-11/h5-8,28H,9H2,1-4H3,(H,22,29)(H,24,30)
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n/an/a 15n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM25352
PNG
(N-[(4-fluorophenyl)methyl]-5-hydroxy-1-methyl-2-{2...)
Show SMILES Cc1nnc([nH]1)C(=O)NC(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C
Show InChI InChI=1S/C20H22FN7O4/c1-10-23-15(27-26-10)17(31)25-20(2,3)19-24-13(14(29)18(32)28(19)4)16(30)22-9-11-5-7-12(21)8-6-11/h5-8,29H,9H2,1-4H3,(H,22,30)(H,25,31)(H,23,26,27)
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n/an/a 4n/an/an/an/a7.837



Merck Research Laboratories



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 51: 5843-55 (2008)


Article DOI: 10.1021/jm800245z
BindingDB Entry DOI: 10.7270/Q2QJ7FMR
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM231619
PNG
(GSK5750)
Show SMILES On1c2ncccc2c(NCc2cc3ccccc3s2)nc1=O
Show InChI InChI=1S/C16H12N4O2S/c21-16-19-14(12-5-3-7-17-15(12)20(16)22)18-9-11-8-10-4-1-2-6-13(10)23-11/h1-8,22H,9H2,(H,18,19,21)
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n/an/a 330n/an/an/an/a7.837



McGill University



Assay Description
To compare activity and inhibition of E. coli RNase H with HIV-1 RNase H, theconcentration of the E. coli was adjusted to the efficiency of 500 nM HI...


J Biol Chem 289: 16270-7 (2014)


Article DOI: 10.1074/jbc.M114.569707
BindingDB Entry DOI: 10.7270/Q2MW2G0Q
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM33411
PNG
(β-Thujaplicinol | hydroxytropolone, 3)
Show SMILES CC(C)c1ccc(O)c(=O)c(O)c1
Show InChI InChI=1S/C10H12O3/c1-6(2)7-3-4-8(11)10(13)9(12)5-7/h3-6H,1-2H3,(H2,11,12,13)
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n/an/a 3.80E+3n/an/an/an/a7.837



McGill University



Assay Description
To compare activity and inhibition of E. coli RNase H with HIV-1 RNase H, theconcentration of the E. coli was adjusted to the efficiency of 500 nM HI...


J Biol Chem 289: 16270-7 (2014)


Article DOI: 10.1074/jbc.M114.569707
BindingDB Entry DOI: 10.7270/Q2MW2G0Q
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237341
PNG
(3-(Benzo[d]thiazol-2-yl)-2-(2,6-difluorophenyl)thi...)
Show SMILES Fc1cccc(F)c1C1SCC(=O)N1c1nc2ccccc2s1
Show InChI InChI=1S/C16H10F2N2OS2/c17-9-4-3-5-10(18)14(9)15-20(13(21)8-22-15)16-19-11-6-1-2-7-12(11)23-16/h1-7,15H,8H2
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Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237342
PNG
(3-(Benzo[d]thiazol-2-yl)-2-(2-chloro-6-fluoropheny...)
Show SMILES Fc1cccc(Cl)c1C1SCC(=O)N1c1nc2ccccc2s1
Show InChI InChI=1S/C16H10ClFN2OS2/c17-9-4-3-5-10(18)14(9)15-20(13(21)8-22-15)16-19-11-6-1-2-7-12(11)23-16/h1-7,15H,8H2
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Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237343
PNG
(3-(6-Chlorobenzo[d]thiazol-2-yl)-2-(2,6-dichloroph...)
Show SMILES Clc1ccc2nc(sc2c1)N1C(SCC1=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H9Cl3N2OS2/c17-8-4-5-11-12(6-8)24-16(20-11)21-13(22)7-23-15(21)14-9(18)2-1-3-10(14)19/h1-6,15H,7H2
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Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237344
PNG
(3-(6-Chlorobenzo[d]thiazol-2-yl)-2-(2-chloro-6-flu...)
Show SMILES Fc1cccc(Cl)c1C1SCC(=O)N1c1nc2ccc(Cl)cc2s1
Show InChI InChI=1S/C16H9Cl2FN2OS2/c17-8-4-5-11-12(6-8)24-16(20-11)21-13(22)7-23-15(21)14-9(18)2-1-3-10(14)19/h1-6,15H,7H2
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Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237345
PNG
(3-(4-Chlorobenzo[d]thiazol-2-yl)-2-(2,6-dichloroph...)
Show SMILES Clc1cccc(Cl)c1C1SCC(=O)N1c1nc2c(Cl)cccc2s1
Show InChI InChI=1S/C16H9Cl3N2OS2/c17-8-3-1-4-9(18)13(8)15-21(12(22)7-23-15)16-20-14-10(19)5-2-6-11(14)24-16/h1-6,15H,7H2
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Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237346
PNG
(3-(4-Chlorobenzo[d]thiazol-2-yl)-2-(2-chloro-6-flu...)
Show SMILES Fc1cccc(Cl)c1C1SCC(=O)N1c1nc2c(Cl)cccc2s1
Show InChI InChI=1S/C16H9Cl2FN2OS2/c17-8-3-1-5-10(19)13(8)15-21(12(22)7-23-15)16-20-14-9(18)4-2-6-11(14)24-16/h1-6,15H,7H2
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Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237347
PNG
(3-(4-Chlorobenzo[d]thiazol-2-yl)-2-(2,6-difluoroph...)
Show SMILES Fc1cccc(F)c1C1SCC(=O)N1c1nc2c(Cl)cccc2s1
Show InChI InChI=1S/C16H9ClF2N2OS2/c17-8-3-1-6-11-14(8)20-16(24-11)21-12(22)7-23-15(21)13-9(18)4-2-5-10(13)19/h1-6,15H,7H2
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Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237348
PNG
(3-(6-Fluorobenzo[d]thiazol-2-yl)-2-(2,6-dichloroph...)
Show SMILES Fc1ccc2nc(sc2c1)N1C(SCC1=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H9Cl2FN2OS2/c17-9-2-1-3-10(18)14(9)15-21(13(22)7-23-15)16-20-11-5-4-8(19)6-12(11)24-16/h1-6,15H,7H2
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n/an/a 250n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237349
PNG
(3-(6-Methoxybenzo[d]thiazol-2-yl)-2-(2,6-dichlorop...)
Show SMILES COc1ccc2nc(sc2c1)N1C(SCC1=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H12Cl2N2O2S2/c1-23-9-5-6-12-13(7-9)25-17(20-12)21-14(22)8-24-16(21)15-10(18)3-2-4-11(15)19/h2-7,16H,8H2,1H3
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n/an/a>4.00E+4n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237350
PNG
(3-(6-Methoxybenzo[d]thiazol-2-yl)-2-(2-chloro-6-fl...)
Show SMILES COc1ccc2nc(sc2c1)N1C(SCC1=O)c1c(F)cccc1Cl
Show InChI InChI=1S/C17H12ClFN2O2S2/c1-23-9-5-6-12-13(7-9)25-17(20-12)21-14(22)8-24-16(21)15-10(18)3-2-4-11(15)19/h2-7,16H,8H2,1H3
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n/an/a>4.00E+4n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237351
PNG
(3-(6-Methoxybenzo[d]thiazol-2-yl)-2-(2,6-difluorop...)
Show SMILES COc1ccc2nc(sc2c1)N1C(SCC1=O)c1c(F)cccc1F
Show InChI InChI=1S/C17H12F2N2O2S2/c1-23-9-5-6-12-13(7-9)25-17(20-12)21-14(22)8-24-16(21)15-10(18)3-2-4-11(15)19/h2-7,16H,8H2,1H3
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n/an/a>4.00E+4n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237352
PNG
(3-(4-Methoxybenzo[d]thiazol-2-yl)-2-(2,6-dichlorop...)
Show SMILES COc1cccc2sc(nc12)N1C(SCC1=O)c1c(Cl)cccc1Cl
Show InChI InChI=1S/C17H12Cl2N2O2S2/c1-23-11-6-3-7-12-15(11)20-17(25-12)21-13(22)8-24-16(21)14-9(18)4-2-5-10(14)19/h2-7,16H,8H2,1H3
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n/an/a 3.00E+3n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237353
PNG
(3-(4-Methoxybenzo[d]thiazol-2-yl)-2-(2-chloro-6-fl...)
Show SMILES COc1cccc2sc(nc12)N1C(SCC1=O)c1c(F)cccc1Cl
Show InChI InChI=1S/C17H12ClFN2O2S2/c1-23-11-6-3-7-12-15(11)20-17(25-12)21-13(22)8-24-16(21)14-9(18)4-2-5-10(14)19/h2-7,16H,8H2,1H3
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n/an/a>4.00E+4n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237354
PNG
(3-(6-Ethoxybenzo[d]thiazol-2-yl)-2-(2-chloro-6-flu...)
Show SMILES CCOc1ccc2nc(sc2c1)N1C(SCC1=O)c1c(F)cccc1Cl
Show InChI InChI=1S/C18H14ClFN2O2S2/c1-2-24-10-6-7-13-14(8-10)26-18(21-13)22-15(23)9-25-17(22)16-11(19)4-3-5-12(16)20/h3-8,17H,2,9H2,1H3
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n/an/a 3.40E+3n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM237355
PNG
(3-(6-Ethoxybenzo[d]thiazol-2-yl)-2-(2,6-difluoroph...)
Show SMILES CCOc1ccc2nc(sc2c1)N1C(SCC1=O)c1c(F)cccc1F
Show InChI InChI=1S/C18H14F2N2O2S2/c1-2-24-10-6-7-13-14(8-10)26-18(21-13)22-15(23)9-25-17(22)16-11(19)4-3-5-12(16)20/h3-8,17H,2,9H2,1H3
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n/an/a>4.00E+4n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM1434
PNG
(11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...)
Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12
Show InChI InChI=1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
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n/an/a 300n/an/an/an/a7.837



Aristotle University of Thessaloniki



Assay Description
HIV-1 Reverse Transcriptase Activity was measured using the colorimetric photometric immunoassay kit provided by Roche. Estimation of RT activity is ...


J Enzyme Inhib Med Chem 28: 113-22 (2013)


Article DOI: 10.3109/14756366.2011.636362
BindingDB Entry DOI: 10.7270/Q2PR7TV6
More data for this
Ligand-Target Pair
Gag-Pol polyprotein


(Human immunodeficiency virus type 1 group M subtyp...)
BDBM22608
PNG
(N-[(4-fluorophenyl)methyl]-5,6-dihydroxy-2-(1-meth...)
Show SMILES CN1CCCC1c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)[nH]1
Show InChI InChI=1S/C17H19FN4O3/c1-22-8-2-3-12(22)15-20-13(14(23)17(25)21-15)16(24)19-9-10-4-6-11(18)7-5-10/h4-7,12,23H,2-3,8-9H2,1H3,(H,19,24)(H,20,21,25)
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n/an/a 120n/an/an/an/a7.837



IRBM-MRL



Assay Description
The microtiter plate assay for stand transfer was performed with an immobilized donor substrate and a target substrate biotinylated at the 3-prime en...


J Med Chem 50: 4953-75 (2007)


Article DOI: 10.1021/jm0704705
BindingDB Entry DOI: 10.7270/Q2BZ64BS
More data for this
Ligand-Target Pair
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