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Compile Data Set for Download or QSAR

Found 97 hits of ph data with Target = 'Glycogen Phosphorylase (PYGL)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35338
PNG
(indole-2-carboxamide derivative, 3)
Show SMILES OC1CCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc12
Show InChI InChI=1S/C18H15ClN2O2/c19-12-2-5-15-11(7-12)9-16(21-15)18(23)20-13-3-4-14-10(8-13)1-6-17(14)22/h2-5,7-9,17,21-22H,1,6H2,(H,20,23)
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n/an/a 440n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35640
PNG
(5-chloroindolecarboxamide, 15b)
Show SMILES OCC(O)c1cnc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)s1
Show InChI InChI=1S/C14H12ClN3O3S/c15-8-1-2-9-7(3-8)4-10(17-9)13(21)18-14-16-5-12(22-14)11(20)6-19/h1-5,11,17,19-20H,6H2,(H,16,18,21)
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n/an/a 3.10E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35340
PNG
(indole-2-carboxamide derivative, 5c)
Show SMILES OC1CCCCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc12
Show InChI InChI=1S/C20H19ClN2O2/c21-14-5-8-17-13(9-14)11-18(23-17)20(25)22-15-6-7-16-12(10-15)3-1-2-4-19(16)24/h5-11,19,23-24H,1-4H2,(H,22,25)
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n/an/a 1.20E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35341
PNG
(indole-2-carboxamide derivative, 7)
Show SMILES Oc1cccc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc12
Show InChI InChI=1S/C19H13ClN2O2/c20-13-4-7-16-12(8-13)10-17(22-16)19(24)21-14-5-6-15-11(9-14)2-1-3-18(15)23/h1-10,22-23H,(H,21,24)
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n/an/a 900n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35342
PNG
(cis-isomers | indole-2-carboxamide derivative, 9a)
Show SMILES O[C@@H]1CCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc2[C@@H]1O
Show InChI InChI=1S/C19H17ClN2O3/c20-12-2-5-15-11(7-12)9-16(22-15)19(25)21-13-3-4-14-10(8-13)1-6-17(23)18(14)24/h2-5,7-9,17-18,22-24H,1,6H2,(H,21,25)/t17-,18+/m1/s1
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n/an/a 8.50E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35343
PNG
(indole-2-carboxamide derivative, 9b | trans-isomer...)
Show SMILES O[C@H]1CCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc2[C@@H]1O
Show InChI InChI=1S/C19H17ClN2O3/c20-12-2-5-15-11(7-12)9-16(22-15)19(25)21-13-3-4-14-10(8-13)1-6-17(23)18(14)24/h2-5,7-9,17-18,22-24H,1,6H2,(H,21,25)/t17-,18-/m0/s1
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n/an/a 800n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35344
PNG
(indole-2-carboxamide derivative, 12)
Show SMILES CC1(C)CCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc2C1O
Show InChI InChI=1S/C21H21ClN2O2/c1-21(2)8-7-12-10-15(4-5-16(12)19(21)25)23-20(26)18-11-13-9-14(22)3-6-17(13)24-18/h3-6,9-11,19,24-25H,7-8H2,1-2H3,(H,23,26)
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n/an/a>1.00E+4n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35345
PNG
(indole-2-carboxamide derivative, 15)
Show SMILES OC1c2ccc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)cc2CCC1(F)F
Show InChI InChI=1S/C19H15ClF2N2O2/c20-12-1-4-15-11(7-12)9-16(24-15)18(26)23-13-2-3-14-10(8-13)5-6-19(21,22)17(14)25/h1-4,7-9,17,24-25H,5-6H2,(H,23,26)
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n/an/a 68n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35346
PNG
((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Show SMILES OC1CCN(CC1)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C23H23ClFN3O3/c24-16-3-6-19-15(12-16)13-20(26-19)22(30)27-21(11-14-1-4-17(25)5-2-14)23(31)28-9-7-18(29)8-10-28/h1-6,12-13,18,21,26,29H,7-11H2,(H,27,30)/t21-/m0/s1
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n/an/a 920n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35350
PNG
(indole-2-carboxamide derivative, 25d)
Show SMILES OC1c2ccc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)c(F)c2CCC1(F)F
Show InChI InChI=1S/C19H14ClF3N2O2/c20-10-1-3-13-9(7-10)8-15(24-13)18(27)25-14-4-2-12-11(16(14)21)5-6-19(22,23)17(12)26/h1-4,7-8,17,24,26H,5-6H2,(H,25,27)
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n/an/a 48n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35351
PNG
(indole-2-carboxamide derivative, 25e)
Show SMILES OC1c2cc(F)c(NC(=O)c3cc4cc(Cl)ccc4[nH]3)c(F)c2CCC1(F)F
Show InChI InChI=1S/C19H13ClF4N2O2/c20-9-1-2-13-8(5-9)6-14(25-13)18(28)26-16-12(21)7-11-10(15(16)22)3-4-19(23,24)17(11)27/h1-2,5-7,17,25,27H,3-4H2,(H,26,28)
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n/an/a 36n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35352
PNG
(indole-2-carboxamide derivative, 25e (S-isomer))
Show SMILES O[C@H]1c2cc(F)c(NC(=O)c3cc4cc(Cl)ccc4[nH]3)c(F)c2CCC1(F)F
Show InChI InChI=1S/C19H13ClF4N2O2/c20-9-1-2-13-8(5-9)6-14(25-13)18(28)26-16-12(21)7-11-10(15(16)22)3-4-19(23,24)17(11)27/h1-2,5-7,17,25,27H,3-4H2,(H,26,28)/t17-/m0/s1
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n/an/a 160n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35353
PNG
(indole-2-carboxamide derivative, 25e (R-isomer))
Show SMILES O[C@@H]1c2cc(F)c(NC(=O)c3cc4cc(Cl)ccc4[nH]3)c(F)c2CCC1(F)F
Show InChI InChI=1S/C19H13ClF4N2O2/c20-9-1-2-13-8(5-9)6-14(25-13)18(28)26-16-12(21)7-11-10(15(16)22)3-4-19(23,24)17(11)27/h1-2,5-7,17,25,27H,3-4H2,(H,26,28)/t17-/m1/s1
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n/an/a 20n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35347
PNG
(indole-2-carboxamide derivative, 25a)
Show SMILES COc1cc2C(O)C(F)(F)CCc2cc1NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C20H17ClF2N2O3/c1-28-17-9-13-10(4-5-20(22,23)18(13)26)7-15(17)25-19(27)16-8-11-6-12(21)2-3-14(11)24-16/h2-3,6-9,18,24,26H,4-5H2,1H3,(H,25,27)
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n/an/a 810n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35348
PNG
(indole-2-carboxamide derivative, 25b)
Show SMILES COc1c(NC(=O)c2cc3cc(Cl)ccc3[nH]2)ccc2C(O)C(F)(F)CCc12
Show InChI InChI=1S/C20H17ClF2N2O3/c1-28-17-12-6-7-20(22,23)18(26)13(12)3-5-15(17)25-19(27)16-9-10-8-11(21)2-4-14(10)24-16/h2-5,8-9,18,24,26H,6-7H2,1H3,(H,25,27)
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n/an/a 590n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35349
PNG
(indole-2-carboxamide derivative, 25c)
Show SMILES OC1c2cc(F)c(NC(=O)c3cc4cc(Cl)ccc4[nH]3)cc2CCC1(F)F
Show InChI InChI=1S/C19H14ClF3N2O2/c20-11-1-2-14-10(5-11)7-16(24-14)18(27)25-15-6-9-3-4-19(22,23)17(26)12(9)8-13(15)21/h1-2,5-8,17,24,26H,3-4H2,(H,25,27)
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n/an/a 63n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35617
PNG
(5-chloroindolecarboxamide, 2a)
Show SMILES OCc1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C16H13ClN2O2/c17-12-3-6-14-11(7-12)8-15(19-14)16(21)18-13-4-1-10(9-20)2-5-13/h1-8,19-20H,9H2,(H,18,21)
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n/an/a 1.60E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35618
PNG
(5-chloroindolecarboxamide, 2b)
Show SMILES OCCc1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C17H15ClN2O2/c18-13-3-6-15-12(9-13)10-16(20-15)17(22)19-14-4-1-11(2-5-14)7-8-21/h1-6,9-10,20-21H,7-8H2,(H,19,22)
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n/an/a 1.20E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35619
PNG
(5-chloroindolecarboxamide, 2c)
Show SMILES OCCCc1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C18H17ClN2O2/c19-14-5-8-16-13(10-14)11-17(21-16)18(23)20-15-6-3-12(4-7-15)2-1-9-22/h3-8,10-11,21-22H,1-2,9H2,(H,20,23)
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n/an/a>1.00E+4n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35623
PNG
(5-chloroindolecarboxamide, 2g)
Show SMILES OCC(CO)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C18H17ClN2O3/c19-14-3-6-16-12(7-14)8-17(21-16)18(24)20-15-4-1-11(2-5-15)13(9-22)10-23/h1-8,13,21-23H,9-10H2,(H,20,24)
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n/an/a 5.80E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35624
PNG
(5-chloroindolecarboxamide, 2h)
Show SMILES COCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C18H17ClN2O3/c1-24-10-17(22)11-2-5-14(6-3-11)20-18(23)16-9-12-8-13(19)4-7-15(12)21-16/h2-9,17,21-22H,10H2,1H3,(H,20,23)
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n/an/a 3.60E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35625
PNG
(5-chloroindolecarboxamide, 2i)
Show SMILES CC(C)(O)C(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C19H19ClN2O3/c1-19(2,25)17(23)11-3-6-14(7-4-11)21-18(24)16-10-12-9-13(20)5-8-15(12)22-16/h3-10,17,22-23,25H,1-2H3,(H,21,24)
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n/an/a>1.00E+4n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35346
PNG
((S)-5-chloro-N-(3-(4-fluorophenyl)-1-(4-hydroxypip...)
Show SMILES OC1CCN(CC1)C(=O)[C@H](Cc1ccc(F)cc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C23H23ClFN3O3/c24-16-3-6-19-15(12-16)13-20(26-19)22(30)27-21(11-14-1-4-17(25)5-2-14)23(31)28-9-7-18(29)8-10-28/h1-6,12-13,18,21,26,29H,7-11H2,(H,27,30)/t21-/m0/s1
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n/an/a 920n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35626
PNG
(5-chloroindolecarboxamide, 9a)
Show SMILES Cc1cc(ccc1NC(=O)c1cc2cc(Cl)ccc2[nH]1)C(O)CO
Show InChI InChI=1S/C18H17ClN2O3/c1-10-6-11(17(23)9-22)2-4-14(10)21-18(24)16-8-12-7-13(19)3-5-15(12)20-16/h2-8,17,20,22-23H,9H2,1H3,(H,21,24)
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n/an/a 2.60E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35627
PNG
(5-chloroindolecarboxamide, 9b)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c(F)c1
Show InChI InChI=1S/C17H14ClFN2O3/c18-11-2-4-13-10(5-11)7-15(20-13)17(24)21-14-3-1-9(6-12(14)19)16(23)8-22/h1-7,16,20,22-23H,8H2,(H,21,24)
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n/an/a 3.20E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35628
PNG
(5-chloroindolecarboxamide, 9c)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c(Cl)c1
Show InChI InChI=1S/C17H14Cl2N2O3/c18-11-2-4-13-10(5-11)7-15(20-13)17(24)21-14-3-1-9(6-12(14)19)16(23)8-22/h1-7,16,20,22-23H,8H2,(H,21,24)
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n/an/a 420n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35629
PNG
(5-chloroindolecarboxamide, 9d)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c(c1)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N2O3/c19-11-2-4-13-10(5-11)7-15(23-13)17(27)24-14-3-1-9(16(26)8-25)6-12(14)18(20,21)22/h1-7,16,23,25-26H,8H2,(H,24,27)
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n/an/a 1.10E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35620
PNG
(5-chloroindolecarboxamide, 2d)
Show SMILES OCCc1ccccc1NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C17H15ClN2O2/c18-13-5-6-15-12(9-13)10-16(19-15)17(22)20-14-4-2-1-3-11(14)7-8-21/h1-6,9-10,19,21H,7-8H2,(H,20,22)
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n/an/a>1.00E+4n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35621
PNG
(5-chloroindolecarboxamide, 2e)
Show SMILES OCCc1cccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)c1
Show InChI InChI=1S/C17H15ClN2O2/c18-13-4-5-15-12(9-13)10-16(20-15)17(22)19-14-3-1-2-11(8-14)6-7-21/h1-5,8-10,20-21H,6-7H2,(H,19,22)
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n/an/a 6.20E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35622
PNG
(5-chloroindolecarboxamide, 2f)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1
Show InChI InChI=1S/C17H15ClN2O3/c18-12-3-6-14-11(7-12)8-15(20-14)17(23)19-13-4-1-10(2-5-13)16(22)9-21/h1-8,16,20-22H,9H2,(H,19,23)
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n/an/a 900n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35630
PNG
(5-chloroindolecarboxamide, 9e)
Show SMILES COc1cc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)ccc1C(O)CO
Show InChI InChI=1S/C18H17ClN2O4/c1-25-17-8-12(3-4-13(17)16(23)9-22)20-18(24)15-7-10-6-11(19)2-5-14(10)21-15/h2-8,16,21-23H,9H2,1H3,(H,20,24)
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n/an/a 2.50E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35631
PNG
(5-chloroindolecarboxamide, 9f)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1-c1ccccc1
Show InChI InChI=1S/C23H19ClN2O3/c24-16-6-9-20-15(10-16)11-21(26-20)23(29)25-17-7-8-18(22(28)13-27)19(12-17)14-4-2-1-3-5-14/h1-12,22,26-28H,13H2,(H,25,29)
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n/an/a 7.40E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35632
PNG
(5-chloroindolecarboxamide, 9g)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1F
Show InChI InChI=1S/C17H14ClFN2O3/c18-10-1-4-14-9(5-10)6-15(21-14)17(24)20-11-2-3-12(13(19)7-11)16(23)8-22/h1-7,16,21-23H,8H2,(H,20,24)
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n/an/a 3.30E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35633
PNG
(5-chloroindolecarboxamide, 9h)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N2O3/c19-10-1-4-14-9(5-10)6-15(24-14)17(27)23-11-2-3-12(16(26)8-25)13(7-11)18(20,21)22/h1-7,16,24-26H,8H2,(H,23,27)
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n/an/a 340n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35634
PNG
(5-chloroindolecarboxamide, 9i)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cc1[N+]([O-])=O
Show InChI InChI=1S/C17H14ClN3O5/c18-10-1-4-13-9(5-10)6-14(20-13)17(24)19-11-2-3-12(16(23)8-22)15(7-11)21(25)26/h1-7,16,20,22-23H,8H2,(H,19,24)
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n/an/a 2.10E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35635
PNG
(5-chloroindolecarboxamide, 9j)
Show SMILES Nc1cc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)ccc1C(O)CO
Show InChI InChI=1S/C17H16ClN3O3/c18-10-1-4-14-9(5-10)6-15(21-14)17(24)20-11-2-3-12(13(19)7-11)16(23)8-22/h1-7,16,21-23H,8,19H2,(H,20,24)
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n/an/a 1.70E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35636
PNG
(5-chloroindolecarboxamide, 13a)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)nc1
Show InChI InChI=1S/C16H14ClN3O3/c17-11-2-3-12-10(5-11)6-13(19-12)16(23)20-15-4-1-9(7-18-15)14(22)8-21/h1-7,14,19,21-22H,8H2,(H,18,20,23)
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n/an/a 250n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35637
PNG
(5-chloroindolecarboxamide, 13b)
Show SMILES OCC(O)c1ccc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cn1
Show InChI InChI=1S/C16H14ClN3O3/c17-10-1-3-12-9(5-10)6-14(20-12)16(23)19-11-2-4-13(18-7-11)15(22)8-21/h1-7,15,20-22H,8H2,(H,19,23)
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n/an/a 4.40E+3n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35638
PNG
(5-chloroindolecarboxamide, 13c)
Show SMILES OCC(O)c1cnc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)cn1
Show InChI InChI=1S/C15H13ClN4O3/c16-9-1-2-10-8(3-9)4-11(19-10)15(23)20-14-6-17-12(5-18-14)13(22)7-21/h1-6,13,19,21-22H,7H2,(H,18,20,23)
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n/an/a 440n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35639
PNG
(5-chloroindolecarboxamide, 15a)
Show SMILES OCC(O)c1csc(NC(=O)c2cc3cc(Cl)ccc3[nH]2)n1
Show InChI InChI=1S/C14H12ClN3O3S/c15-8-1-2-9-7(3-8)4-10(16-9)13(21)18-14-17-11(6-22-14)12(20)5-19/h1-4,6,12,16,19-20H,5H2,(H,17,18,21)
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n/an/a>1.00E+4n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 5452-64 (2008)


Article DOI: 10.1016/j.bmc.2008.04.010
BindingDB Entry DOI: 10.7270/Q2J101H2
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM35339
PNG
(indole-2-carboxamide derivative, 5b)
Show SMILES OC1CCCc2cc(NC(=O)c3cc4cc(Cl)ccc4[nH]3)ccc12
Show InChI InChI=1S/C19H17ClN2O2/c20-13-4-7-16-12(8-13)10-17(22-16)19(24)21-14-5-6-15-11(9-14)2-1-3-18(15)23/h4-10,18,22-23H,1-3H2,(H,21,24)
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n/an/a 320n/an/an/an/a6.822



Astellas Pharma Inc.



Assay Description
The activity of recombinant human liver GPa in the forward direction was measured by monitoring the production of NADPH. Enzyme activity was assayed...


Bioorg Med Chem 16: 10001-12 (2008)


Article DOI: 10.1016/j.bmc.2008.10.021
BindingDB Entry DOI: 10.7270/Q2K072MF
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24361
PNG
(2,3-dichloro-N-(2-oxo-1,2,3,4-tetrahydroquinolin-3...)
Show SMILES Clc1sc2cc([nH]c2c1Cl)C(=O)NC1Cc2ccccc2NC1=O
Show InChI InChI=1S/C16H11Cl2N3O2S/c17-12-13-11(24-14(12)18)6-10(19-13)16(23)21-9-5-7-3-1-2-4-8(7)20-15(9)22/h1-4,6,9,19H,5H2,(H,20,22)(H,21,23)
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n/an/a 132n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24363
PNG
(2-chloro-N-(2-oxo-1,2,3,4-tetrahydroquinolin-3-yl)...)
Show SMILES Clc1cc2cc([nH]c2s1)C(=O)NC1Cc2ccccc2NC1=O
Show InChI InChI=1S/C16H12ClN3O2S/c17-13-7-9-6-12(20-16(9)23-13)15(22)19-11-5-8-3-1-2-4-10(8)18-14(11)21/h1-4,6-7,11,20H,5H2,(H,18,21)(H,19,22)
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n/an/a 41n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24364
PNG
(2-chloro-N-(1-methyl-2-oxo-1,2,3,4-tetrahydroquino...)
Show SMILES CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)sc2[nH]1
Show InChI InChI=1S/C17H14ClN3O2S/c1-21-13-5-3-2-4-9(13)6-12(17(21)23)19-15(22)11-7-10-8-14(18)24-16(10)20-11/h2-5,7-8,12,20H,6H2,1H3,(H,19,22)
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n/an/a 223n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24365
PNG
(2-chloro-N-[1-(2-methoxyethyl)-2-oxo-1,2,3,4-tetra...)
Show SMILES COCCN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)sc2[nH]1
Show InChI InChI=1S/C19H18ClN3O3S/c1-26-7-6-23-15-5-3-2-4-11(15)8-14(19(23)25)21-17(24)13-9-12-10-16(20)27-18(12)22-13/h2-5,9-10,14,22H,6-8H2,1H3,(H,21,24)
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n/an/a 50n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24366
PNG
(2-chloro-N-{1-[2-(methylsulfanyl)ethyl]-2-oxo-1,2,...)
Show SMILES CSCCN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)sc2[nH]1
Show InChI InChI=1S/C19H18ClN3O2S2/c1-26-7-6-23-15-5-3-2-4-11(15)8-14(19(23)25)21-17(24)13-9-12-10-16(20)27-18(12)22-13/h2-5,9-10,14,22H,6-8H2,1H3,(H,21,24)
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n/an/a 163n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24367
PNG
(2-chloro-N-[1-(2-methanesulfinylethyl)-2-oxo-1,2,3...)
Show SMILES CS(=O)CCN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)sc2[nH]1
Show InChI InChI=1S/C19H18ClN3O3S2/c1-28(26)7-6-23-15-5-3-2-4-11(15)8-14(19(23)25)21-17(24)13-9-12-10-16(20)27-18(12)22-13/h2-5,9-10,14,22H,6-8H2,1H3,(H,21,24)
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n/an/a 48n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24368
PNG
(2-chloro-N-[1-(2-methanesulfonylethyl)-2-oxo-1,2,3...)
Show SMILES CS(=O)(=O)CCN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)sc2[nH]1
Show InChI InChI=1S/C19H18ClN3O4S2/c1-29(26,27)7-6-23-15-5-3-2-4-11(15)8-14(19(23)25)21-17(24)13-9-12-10-16(20)28-18(12)22-13/h2-5,9-10,14,22H,6-8H2,1H3,(H,21,24)
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n/an/a 63n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24369
PNG
(2-chloro-N-[2-oxo-1-(2-oxobutyl)-1,2,3,4-tetrahydr...)
Show SMILES CCC(=O)CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2cc(Cl)sc2[nH]1
Show InChI InChI=1S/C20H18ClN3O3S/c1-2-13(25)10-24-16-6-4-3-5-11(16)7-15(20(24)27)22-18(26)14-8-12-9-17(21)28-19(12)23-14/h3-6,8-9,15,23H,2,7,10H2,1H3,(H,22,26)
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n/an/a 84n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
Glycogen Phosphorylase (PYGL)


(Homo sapiens (human))
BDBM24370
PNG
(2-[3-({2,3-dichloro-4H-thieno[3,2-b]pyrrole-5-}ami...)
Show SMILES OC(=O)CN1C(=O)C(Cc2ccccc12)NC(=O)c1cc2sc(Cl)c(Cl)c2[nH]1
Show InChI InChI=1S/C18H13Cl2N3O4S/c19-14-15-12(28-16(14)20)6-9(21-15)17(26)22-10-5-8-3-1-2-4-11(8)23(18(10)27)7-13(24)25/h1-4,6,10,21H,5,7H2,(H,22,26)(H,24,25)
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n/an/a 63n/an/an/an/a7.222



AstraZeneca



Assay Description
The inhibitory activity of the test compounds against human recombinant glycogen phosphorylase a (GPa) was monitored using 96-well microplate format....


Bioorg Med Chem Lett 17: 394-9 (2007)


Article DOI: 10.1016/j.bmcl.2006.10.037
BindingDB Entry DOI: 10.7270/Q2TM78DM
More data for this
Ligand-Target Pair
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