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Compile Data Set for Download or QSAR

Found 246 hits of ph data with Target = 'Glycogen synthase kinase-3'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8336
PNG
(N-[5-(pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-...)
Show SMILES O=C(Nc1n[nH]c2nnc(cc12)-c1cccnc1)C1CC1
Show InChI InChI=1S/C14H12N6O/c21-14(8-3-4-8)16-12-10-6-11(9-2-1-5-15-7-9)17-19-13(10)20-18-12/h1-2,5-8H,3-4H2,(H2,16,18,19,20,21)
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PubMed
0.0800 -57.1n/an/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8337
PNG
(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Show SMILES Fc1cccc(c1F)-c1cc2c(NC(=O)C3CCCC3)n[nH]c2nn1
Show InChI InChI=1S/C17H15F2N5O/c18-12-7-3-6-10(14(12)19)13-8-11-15(22-24-16(11)23-21-13)20-17(25)9-4-1-2-5-9/h3,6-9H,1-2,4-5H2,(H2,20,22,23,24,25)
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0.110 -56.3n/an/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8339
PNG
(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Show SMILES CCN1CCC(CC(=O)Nc2n[nH]c3nnc(cc23)-c2cccc(F)c2F)CC1
Show InChI InChI=1S/C20H22F2N6O/c1-2-28-8-6-12(7-9-28)10-17(29)23-19-14-11-16(24-26-20(14)27-25-19)13-4-3-5-15(21)18(13)22/h3-5,11-12H,2,6-10H2,1H3,(H2,23,25,26,27,29)
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0.190 -54.9n/an/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8338
PNG
(N-[5-(2,3-difluorophenyl)-1H-pyrazolo[3,4-c]pyrida...)
Show SMILES CCN1CCC(CC1)C(=O)Nc1n[nH]c2nnc(cc12)-c1cccc(F)c1F
Show InChI InChI=1S/C19H20F2N6O/c1-2-27-8-6-11(7-9-27)19(28)22-17-13-10-15(23-25-18(13)26-24-17)12-4-3-5-14(20)16(12)21/h3-5,10-11H,2,6-9H2,1H3,(H2,22,24,25,26,28)
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0.950 -51.0n/an/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 1581-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00135-5
BindingDB Entry DOI: 10.7270/Q2BK19JV
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8296
PNG
(3-(2,4-dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-...)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2ccc(Cl)cc2Cl)c2ccccc12
Show InChI InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
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PubMed
9.10 -45.4 34.3n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
In vitro kinase inhibition assay using purified GSK-3 alpha from insect cells, was incubated at room temperature with substrate, and test compounds i...


Chem Biol 7: 793-803 (2000)


Article DOI: 10.1021/jm701185v
BindingDB Entry DOI: 10.7270/Q2M32T0X
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8297
PNG
(3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophen...)
Show SMILES Oc1ccc(NC2=C(C(=O)NC2=O)c2ccccc2N(=O)=O)cc1Cl
Show InChI InChI=1S/C16H10ClN3O5/c17-10-7-8(5-6-12(10)21)18-14-13(15(22)19-16(14)23)9-3-1-2-4-11(9)20(24)25/h1-7,21H,(H2,18,19,22,23)
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PubMed
30.8 -42.4 77.5n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
In vitro kinase inhibition assay using purified GSK-3 alpha from insect cells, was incubated at room temperature with substrate, and test compounds i...


Chem Biol 7: 793-803 (2000)


Article DOI: 10.1021/jm701185v
BindingDB Entry DOI: 10.7270/Q2M32T0X
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8345
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 9 | N-[6-(...)
Show SMILES COc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C17H16N4O2/c1-23-12-4-2-3-11(9-12)14-8-7-13-15(18-14)20-21-16(13)19-17(22)10-5-6-10/h2-4,7-10H,5-6H2,1H3,(H2,18,19,20,21,22)
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n/an/a 125n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8346
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 10 | N-[6-...)
Show SMILES Oc1ccccc1-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C16H14N4O2/c21-13-4-2-1-3-10(13)12-8-7-11-14(17-12)19-20-15(11)18-16(22)9-5-6-9/h1-4,7-9,21H,5-6H2,(H2,17,18,19,20,22)
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n/an/a 36n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8347
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 11 | N-[6-...)
Show SMILES COc1ccccc1-c1ccc2c(NC(=O)C3CC3)n[nH]c2n1
Show InChI InChI=1S/C17H16N4O2/c1-23-14-5-3-2-4-11(14)13-9-8-12-15(18-13)20-21-16(12)19-17(22)10-6-7-10/h2-5,8-10H,6-7H2,1H3,(H2,18,19,20,21,22)
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n/an/a 1.59E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8348
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 12 | CHEMB...)
Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1-c1ccccc1
Show InChI InChI=1S/C22H18N4O2/c27-16-10-8-14(9-11-16)19-17(13-4-2-1-3-5-13)12-18-20(23-19)25-26-21(18)24-22(28)15-6-7-15/h1-5,8-12,15,27H,6-7H2,(H2,23,24,25,26,28)
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n/an/a 24n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8349
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 13 | CHEMB...)
Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1Br
Show InChI InChI=1S/C16H13BrN4O2/c17-12-7-11-14(18-13(12)8-3-5-10(22)6-4-8)20-21-15(11)19-16(23)9-1-2-9/h3-7,9,22H,1-2H2,(H2,18,19,20,21,23)
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n/an/a 0.800n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8350
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 14 | N-[5-...)
Show SMILES Oc1ccc(cc1)-c1nc2[nH]nc(NC(=O)C3CC3)c2cc1Cl
Show InChI InChI=1S/C16H13ClN4O2/c17-12-7-11-14(18-13(12)8-3-5-10(22)6-4-8)20-21-15(11)19-16(23)9-1-2-9/h3-7,9,22H,1-2H2,(H2,18,19,20,21,23)
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n/an/a 1n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8351
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 15 | N-[6-...)
Show SMILES Cc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccc(O)cc1
Show InChI InChI=1S/C17H16N4O2/c1-9-8-13-15(18-14(9)10-4-6-12(22)7-5-10)20-21-16(13)19-17(23)11-2-3-11/h4-8,11,22H,2-3H2,1H3,(H2,18,19,20,21,23)
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n/an/a 6n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8352
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 16 | N-{5,...)
Show SMILES O=C(Nc1n[nH]c2nc(-c3ccccc3)c(cc12)-c1ccccc1)C1CC1
Show InChI InChI=1S/C22H18N4O/c27-22(16-11-12-16)24-21-18-13-17(14-7-3-1-4-8-14)19(23-20(18)25-26-21)15-9-5-2-6-10-15/h1-10,13,16H,11-12H2,(H2,23,24,25,26,27)
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n/an/a 415n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8353
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 17 | CHEMB...)
Show SMILES Brc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccccc1
Show InChI InChI=1S/C16H13BrN4O/c17-12-8-11-14(18-13(12)9-4-2-1-3-5-9)20-21-15(11)19-16(22)10-6-7-10/h1-5,8,10H,6-7H2,(H2,18,19,20,21,22)
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n/an/a 75n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8354
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 18 | N-{5-...)
Show SMILES Clc1cc2c(NC(=O)C3CC3)n[nH]c2nc1-c1ccccc1
Show InChI InChI=1S/C16H13ClN4O/c17-12-8-11-14(18-13(12)9-4-2-1-3-5-9)20-21-15(11)19-16(22)10-6-7-10/h1-5,8,10H,6-7H2,(H2,18,19,20,21,22)
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n/an/a 234n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8355
PNG
(6-aryl-pyrazolo[3,4-b]pyridine analogue 19 | N-{5-...)
Show SMILES O=C(Nc1n[nH]c2nc(-c3ccccc3)c(cc12)C#N)C1CC1
Show InChI InChI=1S/C17H13N5O/c18-9-12-8-13-15(19-14(12)10-4-2-1-3-5-10)21-22-16(13)20-17(23)11-6-7-11/h1-5,8,11H,6-7H2,(H2,19,20,21,22,23)
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n/an/a 87n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3055-7 (2003)


Article DOI: 10.1016/s0960-894x(03)00645-0
BindingDB Entry DOI: 10.7270/Q26T0JVK
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8372
PNG
(N-[6-(quinolin-6-yl)-1H-indazol-3-yl]cyclopropanec...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc2ncccc2c1)C1CC1
Show InChI InChI=1S/C20H16N4O/c25-20(12-3-4-12)22-19-16-7-5-14(11-18(16)23-24-19)13-6-8-17-15(10-13)2-1-9-21-17/h1-2,5-12H,3-4H2,(H2,22,23,24,25)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8373
PNG
(N-[6-(4-sulfamoylphenyl)-1H-indazol-3-yl]cycloprop...)
Show SMILES NS(=O)(=O)c1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H16N4O3S/c18-25(23,24)13-6-3-10(4-7-13)12-5-8-14-15(9-12)20-21-16(14)19-17(22)11-1-2-11/h3-9,11H,1-2H2,(H2,18,23,24)(H2,19,20,21,22)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8374
PNG
(CHEMBL407113 | N-[6-(3-sulfamoylphenyl)-1H-indazol...)
Show SMILES NS(=O)(=O)c1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H16N4O3S/c18-25(23,24)13-3-1-2-11(8-13)12-6-7-14-15(9-12)20-21-16(14)19-17(22)10-4-5-10/h1-3,6-10H,4-5H2,(H2,18,23,24)(H2,19,20,21,22)
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n/an/a 481n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8375
PNG
(N-[6-(3-methanesulfonamidophenyl)-1H-indazol-3-yl]...)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C18H18N4O3S/c1-26(24,25)22-14-4-2-3-12(9-14)13-7-8-15-16(10-13)20-21-17(15)19-18(23)11-5-6-11/h2-4,7-11,22H,5-6H2,1H3,(H2,19,20,21,23)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8376
PNG
(N-[6-(4-methanesulfonamidophenyl)-1H-indazol-3-yl]...)
Show SMILES CS(=O)(=O)Nc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C18H18N4O3S/c1-26(24,25)22-14-7-4-11(5-8-14)13-6-9-15-16(10-13)20-21-17(15)19-18(23)12-2-3-12/h4-10,12,22H,2-3H2,1H3,(H2,19,20,21,23)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8377
PNG
(N-[6-(6-oxo-1,6-dihydropyridin-3-yl)-1H-indazol-3-...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc(=O)[nH]c1)C1CC1
Show InChI InChI=1S/C16H14N4O2/c21-14-6-4-11(8-17-14)10-3-5-12-13(7-10)19-20-15(12)18-16(22)9-1-2-9/h3-9H,1-2H2,(H,17,21)(H2,18,19,20,22)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8378
PNG
(N-[6-(2-fluorophenyl)-1H-indazol-3-yl]cyclopropane...)
Show SMILES Fc1ccccc1-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H14FN3O/c18-14-4-2-1-3-12(14)11-7-8-13-15(9-11)20-21-16(13)19-17(22)10-5-6-10/h1-4,7-10H,5-6H2,(H2,19,20,21,22)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8379
PNG
(N-[6-(2,5-difluorophenyl)-1H-indazol-3-yl]cyclopro...)
Show SMILES Fc1ccc(F)c(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H13F2N3O/c18-11-4-6-14(19)13(8-11)10-3-5-12-15(7-10)21-22-16(12)20-17(23)9-1-2-9/h3-9H,1-2H2,(H2,20,21,22,23)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8380
PNG
(N-[6-(3,4-difluorophenyl)-1H-indazol-3-yl]cyclopro...)
Show SMILES Fc1ccc(cc1F)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H13F2N3O/c18-13-6-4-10(7-14(13)19)11-3-5-12-15(8-11)21-22-16(12)20-17(23)9-1-2-9/h3-9H,1-2H2,(H2,20,21,22,23)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8381
PNG
(N-[6-(2,3-difluorophenyl)-1H-indazol-3-yl]cyclopro...)
Show SMILES Fc1cccc(-c2ccc3c(NC(=O)C4CC4)n[nH]c3c2)c1F
Show InChI InChI=1S/C17H13F2N3O/c18-13-3-1-2-11(15(13)19)10-6-7-12-14(8-10)21-22-16(12)20-17(23)9-4-5-9/h1-3,6-9H,4-5H2,(H2,20,21,22,23)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8382
PNG
(CHEMBL261660 | N-[6-(3-fluorophenyl)-1H-indazol-3-...)
Show SMILES Fc1cccc(c1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-2-11(8-13)12-6-7-14-15(9-12)20-21-16(14)19-17(22)10-4-5-10/h1-3,6-10H,4-5H2,(H2,19,20,21,22)
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n/an/a 828n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8383
PNG
(N-[6-(4-fluorophenyl)-1H-indazol-3-yl]cyclopropane...)
Show SMILES Fc1ccc(cc1)-c1ccc2c(NC(=O)C3CC3)n[nH]c2c1
Show InChI InChI=1S/C17H14FN3O/c18-13-6-3-10(4-7-13)12-5-8-14-15(9-12)20-21-16(14)19-17(22)11-1-2-11/h3-9,11H,1-2H2,(H2,19,20,21,22)
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n/an/a>1.00E+3n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8384
PNG
(CHEMBL260929 | N-[6-(1H-pyrrol-2-yl)-1H-indazol-3-...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccc[nH]1)C1CC1
Show InChI InChI=1S/C15H14N4O/c20-15(9-3-4-9)17-14-11-6-5-10(8-13(11)18-19-14)12-2-1-7-16-12/h1-2,5-9,16H,3-4H2,(H2,17,18,19,20)
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n/an/a 320n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8385
PNG
(CHEMBL421207 | N-[6-(furan-2-yl)-1H-indazol-3-yl]c...)
Show SMILES O=C(Nc1n[nH]c2cc(ccc12)-c1ccco1)C1CC1
Show InChI InChI=1S/C15H13N3O2/c19-15(9-3-4-9)16-14-11-6-5-10(8-12(11)17-18-14)13-2-1-7-20-13/h1-2,5-9H,3-4H2,(H2,16,17,18,19)
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n/an/a 50n/an/an/an/a7.022



GlaxoSmithKline



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 13: 3059-62 (2003)


Article DOI: 10.1016/s0960-894x(03)00646-2
BindingDB Entry DOI: 10.7270/Q2348HKS
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8541
PNG
(N-[2-(2-fluorophenyl)ethyl]-2-[4-({[5-(pyridin-4-y...)
Show SMILES Fc1ccccc1CCNC(=O)Cc1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C24H21FN4O2S/c25-21-4-2-1-3-19(21)11-14-27-22(30)15-17-5-7-18(8-6-17)16-32-24-29-28-23(31-24)20-9-12-26-13-10-20/h1-10,12-13H,11,14-16H2,(H,27,30)
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n/an/a 1.20E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8542
PNG
(2-[4-({[5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)9-11-1-3-12(4-2-11)10-22-16-19-18-15(23-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,20,21)
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n/an/a 1.10E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8543
PNG
(2-[4-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulf...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H13N3O3S/c20-14(21)9-11-1-3-12(4-2-11)10-23-16-19-18-15(22-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,20,21)
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n/an/a 8.00E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8544
PNG
(2-[4-({[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc([nH]2)-c2ccncc2)cc1
Show InChI InChI=1S/C16H14N4O2S/c21-14(22)9-11-1-3-12(4-2-11)10-23-16-18-15(19-20-16)13-5-7-17-8-6-13/h1-8H,9-10H2,(H,21,22)(H,18,19,20)
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n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8545
PNG
(2-[4-({[5-(pyridin-3-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2cccnc2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)8-11-3-5-12(6-4-11)10-22-16-19-18-15(23-16)13-2-1-7-17-9-13/h1-7,9H,8,10H2,(H,20,21)
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n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8546
PNG
(2-[4-({[5-(pyridin-2-yl)-1,3,4-thiadiazol-2-yl]sul...)
Show SMILES OC(=O)Cc1ccc(CSc2nnc(s2)-c2ccccn2)cc1
Show InChI InChI=1S/C16H13N3O2S2/c20-14(21)9-11-4-6-12(7-5-11)10-22-16-19-18-15(23-16)13-3-1-2-8-17-13/h1-8H,9-10H2,(H,20,21)
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n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8547
PNG
(4-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfany...)
Show SMILES OC(=O)c1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C15H11N3O3S/c19-14(20)12-3-1-10(2-4-12)9-22-15-18-17-13(21-15)11-5-7-16-8-6-11/h1-8H,9H2,(H,19,20)
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n/an/a 2.90E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8548
PNG
(2-(benzylsulfanyl)-5-(pyridin-4-yl)-1,3,4-oxadiazo...)
Show SMILES C(Sc1nnc(o1)-c1ccncc1)c1ccccc1
Show InChI InChI=1S/C14H11N3OS/c1-2-4-11(5-3-1)10-19-14-17-16-13(18-14)12-6-8-15-9-7-12/h1-9H,10H2
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n/an/a 6.70E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8549
PNG
(2-[(2-phenylethyl)sulfanyl]-5-(pyridin-4-yl)-1,3,4...)
Show SMILES C(Cc1ccccc1)Sc1nnc(o1)-c1ccncc1
Show InChI InChI=1S/C15H13N3OS/c1-2-4-12(5-3-1)8-11-20-15-18-17-14(19-15)13-6-9-16-10-7-13/h1-7,9-10H,8,11H2
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n/an/a 2.90E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8550
PNG
(2-{[(3-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Clc1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10ClN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
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n/an/a 820n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8551
PNG
(2-{[(2-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Clc1ccccc1CSc1nnc(o1)-c1ccncc1
Show InChI InChI=1S/C14H10ClN3OS/c15-12-4-2-1-3-11(12)9-20-14-18-17-13(19-14)10-5-7-16-8-6-10/h1-8H,9H2
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n/an/a 1.20E+4n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8552
PNG
(2-{[(3-iodophenyl)methyl]sulfanyl}-5-(pyridin-4-yl...)
Show SMILES Ic1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10IN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
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n/an/a 390n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8553
PNG
(2-{[(4-iodophenyl)methyl]sulfanyl}-5-(pyridin-4-yl...)
Show SMILES Ic1ccc(CSc2nnc(o2)-c2ccncc2)cc1
Show InChI InChI=1S/C14H10IN3OS/c15-12-3-1-10(2-4-12)9-20-14-18-17-13(19-14)11-5-7-16-8-6-11/h1-8H,9H2
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n/an/a 1.98E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8554
PNG
(2-{[(3-fluorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES Fc1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C14H10FN3OS/c15-12-3-1-2-10(8-12)9-20-14-18-17-13(19-14)11-4-6-16-7-5-11/h1-8H,9H2
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n/an/a 1.40E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8555
PNG
(methyl 3-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]...)
Show SMILES COC(=O)c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C16H13N3O3S/c1-21-15(20)13-4-2-3-11(9-13)10-23-16-19-18-14(22-16)12-5-7-17-8-6-12/h2-9H,10H2,1H3
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n/an/a 1.10E+3n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8556
PNG
(3-({[5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl]sulfany...)
Show SMILES OC(=O)c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C15H11N3O3S/c19-14(20)12-3-1-2-10(8-12)9-22-15-18-17-13(21-15)11-4-6-16-7-5-11/h1-8H,9H2,(H,19,20)
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n/an/a 2.35E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8557
PNG
(2-({[3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]methy...)
Show SMILES Cc1nc(no1)-c1cccc(CSc2nnc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C17H13N5O2S/c1-11-19-15(22-24-11)14-4-2-3-12(9-14)10-25-17-21-20-16(23-17)13-5-7-18-8-6-13/h2-9H,10H2,1H3
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n/an/a>2.50E+5n/an/an/an/a7.022



Novo Nordisk A/S



Assay Description
In vitro kinase assay using purified enzyme, was incubated at room temperature with substrate, and test compounds in the presence of 100 uM ATP/ [gam...


Bioorg Med Chem Lett 12: 1525-8 (2002)


Article DOI: 10.1016/s0960-894x(02)00169-5
BindingDB Entry DOI: 10.7270/Q2251GDH
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8218
PNG
(3-phenyl-4-(phenylamino)-2,5-dihydro-1H-pyrrole-2,...)
Show SMILES O=C1NC(=O)C(=C1Nc1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H12N2O2/c19-15-13(11-7-3-1-4-8-11)14(16(20)18-15)17-12-9-5-2-6-10-12/h1-10H,(H2,17,18,19,20)
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n/an/a 529n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (human))
BDBM8219
PNG
(3-(2-chlorophenyl)-4-(phenylamino)-2,5-dihydro-1H-...)
Show SMILES Clc1ccccc1C1=C(Nc2ccccc2)C(=O)NC1=O
Show InChI InChI=1S/C16H11ClN2O2/c17-12-9-5-4-8-11(12)13-14(16(21)19-15(13)20)18-10-6-2-1-3-7-10/h1-9H,(H2,18,19,20,21)
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n/an/a 216n/an/an/an/a7.022



SmithKline Beecham Pharmaceuticals



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 10 uM ATP/ [gamma-33P] ATP. Aft...


Bioorg Med Chem Lett 11: 635-9 (2001)


Article DOI: 10.1016/s0960-894x(00)00721-6
BindingDB Entry DOI: 10.7270/Q2QV3JRC
More data for this
Ligand-Target Pair
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