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Compile Data Set for Download or QSAR

Found 4 hits of ph data with Target = 'HIV-1 Reverse Transcriptase Mutant (P236L)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase Mutant (P236L)


(Human immunodeficiency virus type 1)
BDBM2314
PNG
(1,5-Diphenyl-3-(2-hydroxyethyl)-4-ethylpyrazole | ...)
Show SMILES CCc1c(CCO)nn(c1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H20N2O/c1-2-17-18(13-14-22)20-21(16-11-7-4-8-12-16)19(17)15-9-5-3-6-10-15/h3-12,22H,2,13-14H2,1H3
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 650n/an/an/an/a8.328



Upjohn



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 43: 1034-40 (2000)


Article DOI: 10.1021/jm990383f
BindingDB Entry DOI: 10.7270/Q2HD7SVS
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (P236L)


(Human immunodeficiency virus type 1)
BDBM2311
PNG
(1,5-Diphenyl-3-methylpyrazole (DPP) analogue | 2-(...)
Show SMILES Cc1nn(c(c1CC#N)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C18H15N3/c1-14-17(12-13-19)18(15-8-4-2-5-9-15)21(20-14)16-10-6-3-7-11-16/h2-11H,12H2,1H3
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.14E+3n/an/an/an/a8.328



Upjohn



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 43: 1034-40 (2000)


Article DOI: 10.1021/jm990383f
BindingDB Entry DOI: 10.7270/Q2HD7SVS
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (P236L)


(Human immunodeficiency virus type 1)
BDBM2313
PNG
(1,5-Diphenyl-3-methyl-4-propargylpyrazole | 1,5-Di...)
Show SMILES Cc1nn(c(c1CC#C)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C19H16N2/c1-3-10-18-15(2)20-21(17-13-8-5-9-14-17)19(18)16-11-6-4-7-12-16/h1,4-9,11-14H,10H2,2H3
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.54E+3n/an/an/an/a8.328



Upjohn



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 43: 1034-40 (2000)


Article DOI: 10.1021/jm990383f
BindingDB Entry DOI: 10.7270/Q2HD7SVS
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase Mutant (P236L)


(Human immunodeficiency virus type 1)
BDBM2312
PNG
(1,5-Diphenyl-3-methyl-4-ethylpyrazole | 1,5-Diphen...)
Show SMILES CCc1c(C)nn(c1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C18H18N2/c1-3-17-14(2)19-20(16-12-8-5-9-13-16)18(17)15-10-6-4-7-11-15/h4-13H,3H2,1-2H3
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 520n/an/an/an/a8.328



Upjohn



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.


J Med Chem 43: 1034-40 (2000)


Article DOI: 10.1021/jm990383f
BindingDB Entry DOI: 10.7270/Q2HD7SVS
More data for this
Ligand-Target Pair