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Compile Data Set for Download or QSAR

Found 148 hits of ph data with Target = 'High affinity nerve growth factor receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24694
PNG
(4-aminopyrazolylpyrimidine analogue, 5 | 5-bromo-4...)
Show SMILES Cc1cc(CNc2ncc(Br)c(Nc3cc(n[nH]3)C3CC3)n2)on1
Show InChI InChI=1S/C15H16BrN7O/c1-8-4-10(24-23-8)6-17-15-18-7-11(16)14(20-15)19-13-5-12(21-22-13)9-2-3-9/h4-5,7,9H,2-3,6H2,1H3,(H3,17,18,19,20,21,22)
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Article
PubMed
n/an/a 270n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24924
PNG
(5-(carbamoylamino)-3-[(5S)-6,7,8,9-tetrahydro-5H-b...)
Show SMILES NC(=O)Nc1snc(S[C@H]2CCCCc3ccccc23)c1C(N)=O
Show InChI InChI=1S/C16H18N4O2S2/c17-13(21)12-14(19-16(18)22)24-20-15(12)23-11-8-4-2-6-9-5-1-3-7-10(9)11/h1,3,5,7,11H,2,4,6,8H2,(H2,17,21)(H3,18,19,22)/t11-/m0/s1
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Article
PubMed
n/an/a 91n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24696
PNG
(4-aminopyrazolylpyrimidine analogue, 10b | 5-bromo...)
Show SMILES COc1cccc(CNc2ncc(Br)c(Nc3cc(n[nH]3)C3CC3)n2)c1
Show InChI InChI=1S/C18H19BrN6O/c1-26-13-4-2-3-11(7-13)9-20-18-21-10-14(19)17(23-18)22-16-8-15(24-25-16)12-5-6-12/h2-4,7-8,10,12H,5-6,9H2,1H3,(H3,20,21,22,23,24,25)
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Article
PubMed
n/an/a 720n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24697
PNG
(4-aminopyrazolylpyrimidine analogue, 10c | 5-bromo...)
Show SMILES Clc1ccccc1CNc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1
Show InChI InChI=1S/C17H16BrClN6/c18-12-9-21-17(20-8-11-3-1-2-4-13(11)19)23-16(12)22-15-7-14(24-25-15)10-5-6-10/h1-4,7,9-10H,5-6,8H2,(H3,20,21,22,23,24,25)
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Article
PubMed
n/an/a 1.17E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24698
PNG
(4-aminopyrazolylpyrimidine analogue, 10d | 5-bromo...)
Show SMILES COc1ccccc1CNc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1
Show InChI InChI=1S/C18H19BrN6O/c1-26-15-5-3-2-4-12(15)9-20-18-21-10-13(19)17(23-18)22-16-8-14(24-25-16)11-6-7-11/h2-5,8,10-11H,6-7,9H2,1H3,(H3,20,21,22,23,24,25)
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Article
PubMed
n/an/a 120n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24699
PNG
(4-aminopyrazolylpyrimidine analogue, 10e | 5-bromo...)
Show SMILES Fc1ccc(CNc2ncc(Br)c(Nc3cc(n[nH]3)C3CC3)n2)cc1
Show InChI InChI=1S/C17H16BrFN6/c18-13-9-21-17(20-8-10-1-5-12(19)6-2-10)23-16(13)22-15-7-14(24-25-15)11-3-4-11/h1-2,5-7,9,11H,3-4,8H2,(H3,20,21,22,23,24,25)
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Article
PubMed
n/an/a 100n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24700
PNG
(4-aminopyrazolylpyrimidine analogue, 10f | 5-bromo...)
Show SMILES Clc1ccc(CNc2ncc(Br)c(Nc3cc(n[nH]3)C3CC3)n2)cc1
Show InChI InChI=1S/C17H16BrClN6/c18-13-9-21-17(20-8-10-1-5-12(19)6-2-10)23-16(13)22-15-7-14(24-25-15)11-3-4-11/h1-2,5-7,9,11H,3-4,8H2,(H3,20,21,22,23,24,25)
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Article
PubMed
n/an/a 360n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24701
PNG
(4-aminopyrazolylpyrimidine analogue, 10g | 5-bromo...)
Show SMILES C[C@H](Nc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1)c1ccccc1
Show InChI InChI=1S/C18H19BrN6/c1-11(12-5-3-2-4-6-12)21-18-20-10-14(19)17(23-18)22-16-9-15(24-25-16)13-7-8-13/h2-6,9-11,13H,7-8H2,1H3,(H3,20,21,22,23,24,25)/t11-/m0/s1
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Article
PubMed
n/an/a 100n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24702
PNG
(4-aminopyrazolylpyrimidine analogue, 10h | 5-bromo...)
Show SMILES C[C@@H](Nc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1)c1ccccc1
Show InChI InChI=1S/C18H19BrN6/c1-11(12-5-3-2-4-6-12)21-18-20-10-14(19)17(23-18)22-16-9-15(24-25-16)13-7-8-13/h2-6,9-11,13H,7-8H2,1H3,(H3,20,21,22,23,24,25)/t11-/m1/s1
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Article
PubMed
n/an/a 650n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24703
PNG
((2S)-2-({5-bromo-4-[(5-cyclopropyl-1H-pyrazol-3-yl...)
Show SMILES OC[C@@H](Nc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1)c1ccccc1
Show InChI InChI=1S/C18H19BrN6O/c19-13-9-20-18(21-15(10-26)11-4-2-1-3-5-11)23-17(13)22-16-8-14(24-25-16)12-6-7-12/h1-5,8-9,12,15,26H,6-7,10H2,(H3,20,21,22,23,24,25)/t15-/m1/s1
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Article
PubMed
n/an/a 1.90E+3n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24704
PNG
((2R)-2-({5-bromo-4-[(5-cyclopropyl-1H-pyrazol-3-yl...)
Show SMILES OC[C@H](Nc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1)c1ccccc1
Show InChI InChI=1S/C18H19BrN6O/c19-13-9-20-18(21-15(10-26)11-4-2-1-3-5-11)23-17(13)22-16-8-14(24-25-16)12-6-7-12/h1-5,8-9,12,15,26H,6-7,10H2,(H3,20,21,22,23,24,25)/t15-/m0/s1
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PubMed
n/an/a 120n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24705
PNG
(4-aminopyrazolylpyrimidine analogue, 10k | 5-bromo...)
Show SMILES C[C@H](Nc1ncc(Br)c(Nc2cc(n[nH]2)C2CC2)n1)c1ccc(F)cc1
Show InChI InChI=1S/C18H18BrFN6/c1-10(11-4-6-13(20)7-5-11)22-18-21-9-14(19)17(24-18)23-16-8-15(25-26-16)12-2-3-12/h4-10,12H,2-3H2,1H3,(H3,21,22,23,24,25,26)/t10-/m0/s1
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PubMed
n/an/a 6n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24706
PNG
((2R)-2-({5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-y...)
Show SMILES OC[C@H](Nc1ncc(Cl)c(Nc2cc(n[nH]2)C2CC2)n1)c1ccc(F)cc1
Show InChI InChI=1S/C18H18ClFN6O/c19-13-8-21-18(22-15(9-27)11-3-5-12(20)6-4-11)24-17(13)23-16-7-14(25-26-16)10-1-2-10/h3-8,10,15,27H,1-2,9H2,(H3,21,22,23,24,25,26)/t15-/m0/s1
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PubMed
n/an/a 10n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24707
PNG
((3S)-3-({5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-y...)
Show SMILES CN(C)C(=O)C[C@H](Nc1ncc(Cl)c(Nc2cc(n[nH]2)C2CC2)n1)c1ccc(F)cc1
Show InChI InChI=1S/C21H23ClFN7O/c1-30(2)19(31)10-16(12-5-7-14(23)8-6-12)25-21-24-11-15(22)20(27-21)26-18-9-17(28-29-18)13-3-4-13/h5-9,11,13,16H,3-4,10H2,1-2H3,(H3,24,25,26,27,28,29)/t16-/m0/s1
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Article
PubMed
n/an/a 13n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24708
PNG
((3S)-3-({5-chloro-4-[(5-cyclopropyl-1H-pyrazol-3-y...)
Show SMILES CNC(=O)C[C@H](Nc1ncc(Cl)c(Nc2cc(n[nH]2)C2CC2)n1)c1ccc(F)cc1
Show InChI InChI=1S/C20H21ClFN7O/c1-23-18(30)9-15(11-4-6-13(22)7-5-11)25-20-24-10-14(21)19(27-20)26-17-8-16(28-29-17)12-2-3-12/h4-8,10,12,15H,2-3,9H2,1H3,(H,23,30)(H3,24,25,26,27,28,29)/t15-/m0/s1
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PubMed
n/an/a 15n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24898
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-[(methylcar...)
Show SMILES CNC(=O)Nc1snc(SCc2ccc(Cl)cc2)c1C(N)=O
Show InChI InChI=1S/C13H13ClN4O2S2/c1-16-13(20)17-11-9(10(15)19)12(18-22-11)21-6-7-2-4-8(14)5-3-7/h2-5H,6H2,1H3,(H2,15,19)(H2,16,17,20)
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PubMed
n/an/a 7n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24899
PNG
(3-{[1-(4-chlorophenyl)ethyl]sulfanyl}-5-[(methylca...)
Show SMILES CNC(=O)Nc1snc(SC(C)c2ccc(Cl)cc2)c1C(N)=O
Show InChI InChI=1S/C14H15ClN4O2S2/c1-7(8-3-5-9(15)6-4-8)22-13-10(11(16)20)12(23-19-13)18-14(21)17-2/h3-7H,1-2H3,(H2,16,20)(H2,17,18,21)
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PubMed
n/an/a 3n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24900
PNG
(3-{[1-(4-chlorophenyl)propyl]sulfanyl}-5-[(methylc...)
Show SMILES CCC(Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H17ClN4O2S2/c1-3-10(8-4-6-9(16)7-5-8)23-14-11(12(17)21)13(24-20-14)19-15(22)18-2/h4-7,10H,3H2,1-2H3,(H2,17,21)(H2,18,19,22)
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PubMed
n/an/a 9n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24901
PNG
(3-{[(1R)-1-(4-chlorophenyl)propyl]sulfanyl}-5-[(me...)
Show SMILES CC[C@@H](Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H17ClN4O2S2/c1-3-10(8-4-6-9(16)7-5-8)23-14-11(12(17)21)13(24-20-14)19-15(22)18-2/h4-7,10H,3H2,1-2H3,(H2,17,21)(H2,18,19,22)/t10-/m1/s1
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PubMed
n/an/a 4n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24902
PNG
(3-{[(1S)-1-(4-chlorophenyl)propyl]sulfanyl}-5-[(me...)
Show SMILES CC[C@H](Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C15H17ClN4O2S2/c1-3-10(8-4-6-9(16)7-5-8)23-14-11(12(17)21)13(24-20-14)19-15(22)18-2/h4-7,10H,3H2,1-2H3,(H2,17,21)(H2,18,19,22)/t10-/m0/s1
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n/an/a 52n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24903
PNG
(3-{[1-(4-chlorophenyl)-2-methylpropyl]sulfanyl}-5-...)
Show SMILES CNC(=O)Nc1snc(SC(C(C)C)c2ccc(Cl)cc2)c1C(N)=O
Show InChI InChI=1S/C16H19ClN4O2S2/c1-8(2)12(9-4-6-10(17)7-5-9)24-15-11(13(18)22)14(25-21-15)20-16(23)19-3/h4-8,12H,1-3H3,(H2,18,22)(H2,19,20,23)
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n/an/a 16n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24904
PNG
(3-{[1-(4-chlorophenyl)butyl]sulfanyl}-5-[(methylca...)
Show SMILES CCCC(Sc1nsc(NC(=O)NC)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H19ClN4O2S2/c1-3-4-11(9-5-7-10(17)8-6-9)24-15-12(13(18)22)14(25-21-15)20-16(23)19-2/h5-8,11H,3-4H2,1-2H3,(H2,18,22)(H2,19,20,23)
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n/an/a 35n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24905
PNG
(3-{[1-(4-chlorophenyl)-2,2,2-trifluoroethyl]sulfan...)
Show SMILES CNC(=O)Nc1snc(SC(c2ccc(Cl)cc2)C(F)(F)F)c1C(N)=O
Show InChI InChI=1S/C14H12ClF3N4O2S2/c1-20-13(24)21-11-8(10(19)23)12(22-26-11)25-9(14(16,17)18)6-2-4-7(15)5-3-6/h2-5,9H,1H3,(H2,19,23)(H2,20,21,24)
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n/an/a 110n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24906
PNG
(3-{[(4-chlorophenyl)(phenyl)methyl]sulfanyl}-5-[(m...)
Show SMILES CNC(=O)Nc1snc(SC(c2ccccc2)c2ccc(Cl)cc2)c1C(N)=O
Show InChI InChI=1S/C19H17ClN4O2S2/c1-22-19(26)23-17-14(16(21)25)18(24-28-17)27-15(11-5-3-2-4-6-11)12-7-9-13(20)10-8-12/h2-10,15H,1H3,(H2,21,25)(H2,22,23,26)
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n/an/a 2.60E+3n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24907
PNG
(1-(3-{[(4-chlorophenyl)methyl]sulfanyl}-4-cyano-1,...)
Show SMILES CNC(=O)Nc1snc(SCc2ccc(Cl)cc2)c1C#N
Show InChI InChI=1S/C13H11ClN4OS2/c1-16-13(19)17-11-10(6-15)12(18-21-11)20-7-8-2-4-9(14)5-3-8/h2-5H,7H2,1H3,(H2,16,17,19)
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n/an/a>5.00E+3n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24908
PNG
(5-amino-3-{[(4-chlorophenyl)methyl]sulfanyl}-1,2-t...)
Show SMILES NC(=O)c1c(N)snc1SCc1ccc(Cl)cc1
Show InChI InChI=1S/C11H10ClN3OS2/c12-7-3-1-6(2-4-7)5-17-11-8(9(13)16)10(14)18-15-11/h1-4H,5,14H2,(H2,13,16)
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n/an/a>5.00E+3n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24909
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-2-...)
Show SMILES NC(=O)c1c(SCc2ccc(Cl)cc2)nsc1Nc1ccccn1
Show InChI InChI=1S/C16H13ClN4OS2/c17-11-6-4-10(5-7-11)9-23-16-13(14(18)22)15(24-21-16)20-12-3-1-2-8-19-12/h1-8H,9H2,(H2,18,22)(H,19,20)
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n/an/a 33n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24910
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-3-...)
Show SMILES NC(=O)c1c(SCc2ccc(Cl)cc2)nsc1Nc1cccnc1
Show InChI InChI=1S/C16H13ClN4OS2/c17-11-5-3-10(4-6-11)9-23-16-13(14(18)22)15(24-21-16)20-12-2-1-7-19-8-12/h1-8,20H,9H2,(H2,18,22)
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n/an/a 19n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24911
PNG
(3-{[1-(4-chlorophenyl)ethyl]sulfanyl}-5-(pyridin-3...)
Show SMILES CC(Sc1nsc(Nc2cccnc2)c1C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C17H15ClN4OS2/c1-10(11-4-6-12(18)7-5-11)24-17-14(15(19)23)16(25-22-17)21-13-3-2-8-20-9-13/h2-10,21H,1H3,(H2,19,23)
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n/an/a 29n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24912
PNG
(3-[(cyclohexylmethyl)sulfanyl]-5-(pyridin-3-ylamin...)
Show SMILES NC(=O)c1c(SCC2CCCCC2)nsc1Nc1cccnc1
Show InChI InChI=1S/C16H20N4OS2/c17-14(21)13-15(19-12-7-4-8-18-9-12)23-20-16(13)22-10-11-5-2-1-3-6-11/h4,7-9,11,19H,1-3,5-6,10H2,(H2,17,21)
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n/an/a 610n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24913
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES NC(=O)c1c(SCc2ccc(Cl)cc2)nsc1Nc1ccncc1
Show InChI InChI=1S/C16H13ClN4OS2/c17-11-3-1-10(2-4-11)9-23-16-13(14(18)22)15(24-21-16)20-12-5-7-19-8-6-12/h1-8H,9H2,(H2,18,22)(H,19,20)
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n/an/a 45n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24914
PNG
(3-{[(2-chlorophenyl)methyl]sulfanyl}-5-(pyridin-4-...)
Show SMILES NC(=O)c1c(SCc2ccccc2Cl)nsc1Nc1ccncc1
Show InChI InChI=1S/C16H13ClN4OS2/c17-12-4-2-1-3-10(12)9-23-16-13(14(18)22)15(24-21-16)20-11-5-7-19-8-6-11/h1-8H,9H2,(H2,18,22)(H,19,20)
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n/an/a 28n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24915
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-(pyrimidin-...)
Show SMILES NC(=O)c1c(SCc2ccc(Cl)cc2)nsc1Nc1ccncn1
Show InChI InChI=1S/C15H12ClN5OS2/c16-10-3-1-9(2-4-10)7-23-15-12(13(17)22)14(24-21-15)20-11-5-6-18-8-19-11/h1-6,8H,7H2,(H2,17,22)(H,18,19,20)
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n/an/a 47n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24916
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-[(6-methoxy...)
Show SMILES COc1ccc(Nc2snc(SCc3ccc(Cl)cc3)c2C(N)=O)cn1
Show InChI InChI=1S/C17H15ClN4O2S2/c1-24-13-7-6-12(8-20-13)21-16-14(15(19)23)17(22-26-16)25-9-10-2-4-11(18)5-3-10/h2-8,21H,9H2,1H3,(H2,19,23)
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n/an/a 179n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24917
PNG
(3-{[(4-chlorophenyl)methyl]sulfanyl}-5-[(6-oxo-1,6...)
Show SMILES NC(=O)c1c(SCc2ccc(Cl)cc2)nsc1Nc1ccc(=O)[nH]c1
Show InChI InChI=1S/C16H13ClN4O2S2/c17-10-3-1-9(2-4-10)8-24-16-13(14(18)23)15(25-21-16)20-11-5-6-12(22)19-7-11/h1-7,20H,8H2,(H2,18,23)(H,19,22)
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n/an/a 84n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24918
PNG
(5-(carbamoylamino)-3-[(5-chloro-2,3-dihydro-1H-ind...)
Show SMILES NC(=O)Nc1snc(SC2CCc3cc(Cl)ccc23)c1C(N)=O
Show InChI InChI=1S/C14H13ClN4O2S2/c15-7-2-3-8-6(5-7)1-4-9(8)22-13-10(11(16)20)12(23-19-13)18-14(17)21/h2-3,5,9H,1,4H2,(H2,16,20)(H3,17,18,21)
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n/an/a 10n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24919
PNG
(3-[(5-chloro-2,3-dihydro-1H-inden-1-yl)sulfanyl]-5...)
Show SMILES CNC(=O)Nc1snc(SC2CCc3cc(Cl)ccc23)c1C(N)=O
Show InChI InChI=1S/C15H15ClN4O2S2/c1-18-15(22)19-13-11(12(17)21)14(20-24-13)23-10-5-2-7-6-8(16)3-4-9(7)10/h3-4,6,10H,2,5H2,1H3,(H2,17,21)(H2,18,19,22)
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n/an/a 8n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24920
PNG
(5-(carbamoylamino)-3-(1,2,3,4-tetrahydronaphthalen...)
Show SMILES NC(=O)Nc1snc(SC2CCCc3ccccc23)c1C(N)=O
Show InChI InChI=1S/C15H16N4O2S2/c16-12(20)11-13(18-15(17)21)23-19-14(11)22-10-7-3-5-8-4-1-2-6-9(8)10/h1-2,4,6,10H,3,5,7H2,(H2,16,20)(H3,17,18,21)
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n/an/a 105n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24921
PNG
(5-[(methylcarbamoyl)amino]-3-(1,2,3,4-tetrahydrona...)
Show SMILES CNC(=O)Nc1snc(SC2CCCc3ccccc23)c1C(N)=O
Show InChI InChI=1S/C16H18N4O2S2/c1-18-16(22)19-14-12(13(17)21)15(20-24-14)23-11-8-4-6-9-5-2-3-7-10(9)11/h2-3,5,7,11H,4,6,8H2,1H3,(H2,17,21)(H2,18,19,22)
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n/an/a 111n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24922
PNG
(5-(carbamoylamino)-3-{6,7,8,9-tetrahydro-5H-benzo[...)
Show SMILES NC(=O)Nc1snc(SC2CCCCc3ccccc23)c1C(N)=O
Show InChI InChI=1S/C16H18N4O2S2/c17-13(21)12-14(19-16(18)22)24-20-15(12)23-11-8-4-2-6-9-5-1-3-7-10(9)11/h1,3,5,7,11H,2,4,6,8H2,(H2,17,21)(H3,18,19,22)
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n/an/a<1n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24923
PNG
(5-(carbamoylamino)-3-[(5R)-6,7,8,9-tetrahydro-5H-b...)
Show SMILES NC(=O)Nc1snc(S[C@@H]2CCCCc3ccccc23)c1C(N)=O
Show InChI InChI=1S/C16H18N4O2S2/c17-13(21)12-14(19-16(18)22)24-20-15(12)23-11-8-4-2-6-9-5-1-3-7-10(9)11/h1,3,5,7,11H,2,4,6,8H2,(H2,17,21)(H3,18,19,22)/t11-/m1/s1
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n/an/a<1n/an/an/an/a7.422



Pfizer



Assay Description
The kinase domain of the human TrkA receptor in phosphorylation buffer with 0.5 uM ATP is incubated in plates coated with PGT substrate. Compounds ar...


Bioorg Med Chem Lett 16: 3444-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.003
BindingDB Entry DOI: 10.7270/Q26Q1VH5
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM24695
PNG
(2-N-benzyl-5-bromo-4-N-(5-cyclopropyl-1H-pyrazol-3...)
Show SMILES Brc1cnc(NCc2ccccc2)nc1Nc1cc(n[nH]1)C1CC1
Show InChI InChI=1S/C17H17BrN6/c18-13-10-20-17(19-9-11-4-2-1-3-5-11)22-16(13)21-15-8-14(23-24-15)12-6-7-12/h1-5,8,10,12H,6-7,9H2,(H3,19,20,21,22,23,24)
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n/an/a 750n/an/an/an/a7.422



AstraZeneca



Assay Description
TrkA kinase activity was determined by measuring the kinase ability to phosphorylate synthetic tyrosine residues within a generic polypeptide substra...


J Med Chem 51: 4672-84 (2008)


Article DOI: 10.1021/jm800343j
BindingDB Entry DOI: 10.7270/Q2RN365V
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM31545
PNG
(Milciclib | pyrazolo[4,3-h]quinazoline-3-carboxami...)
Show SMILES CNC(=O)c1nn(C)c-2c1C(C)(C)Cc1cnc(Nc3ccc(cc3)N3CCN(C)CC3)nc-21
Show InChI InChI=1S/C25H32N8O/c1-25(2)14-16-15-27-24(29-20(16)22-19(25)21(23(34)26-3)30-32(22)5)28-17-6-8-18(9-7-17)33-12-10-31(4)11-13-33/h6-9,15H,10-14H2,1-5H3,(H,26,34)(H,27,28,29)
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n/an/a 53n/an/an/an/a7.523



Nerviano Medical Sciences Srl



Assay Description
The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...


J Med Chem 52: 5152-63 (2009)


Article DOI: 10.1021/jm9006559
BindingDB Entry DOI: 10.7270/Q2JH3JJP
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM136584
PNG
(US10047097, 1 | US8865698, 1 | US9676783, 1)
Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H20F2N6O2/c21-12-3-4-15(22)14(8-12)17-2-1-6-27(17)18-5-7-28-19(25-18)16(9-23-28)24-20(30)26-10-13(29)11-26/h3-5,7-9,13,17,29H,1-2,6,10-11H2,(H,24,30)/t17-/m1/s1
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n/an/a 20.7n/an/an/an/a7.5n/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8865698 (2014)


BindingDB Entry DOI: 10.7270/Q2B856TM
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM136585
PNG
(US10047097, 2 | US8865698, 2 | US9676783, 2)
Show SMILES CN(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C19H20F2N6O/c1-25(2)19(28)23-15-11-22-27-9-7-17(24-18(15)27)26-8-3-4-16(26)13-10-12(20)5-6-14(13)21/h5-7,9-11,16H,3-4,8H2,1-2H3,(H,23,28)/t16-/m1/s1
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n/an/a 15.8n/an/an/an/a7.5n/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8865698 (2014)


BindingDB Entry DOI: 10.7270/Q2B856TM
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM136586
PNG
(US10047097, 3 | US8865698, 3 | US9676783, 3)
Show SMILES CC(C)(C)NC(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C21H24F2N6O/c1-21(2,3)27-20(30)25-16-12-24-29-10-8-18(26-19(16)29)28-9-4-5-17(28)14-11-13(22)6-7-15(14)23/h6-8,10-12,17H,4-5,9H2,1-3H3,(H2,25,27,30)/t17-/m1/s1
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n/an/a 22.2n/an/an/an/a7.5n/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8865698 (2014)


BindingDB Entry DOI: 10.7270/Q2B856TM
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM136587
PNG
(US10047097, 4 | US8865698, 4 | US9676783, 4)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(NC(=O)Nc3ccccc3)c2n1
Show InChI InChI=1S/C23H20F2N6O/c24-15-8-9-18(25)17(13-15)20-7-4-11-30(20)21-10-12-31-22(29-21)19(14-26-31)28-23(32)27-16-5-2-1-3-6-16/h1-3,5-6,8-10,12-14,20H,4,7,11H2,(H2,27,28,32)/t20-/m1/s1
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n/an/a 5n/an/an/an/a7.5n/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8865698 (2014)


BindingDB Entry DOI: 10.7270/Q2B856TM
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM136588
PNG
(US10047097, 5 | US8865698, 5 | US9676783, 5)
Show SMILES CC(C)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1S/C20H21F2N5O/c1-12(2)20(28)24-16-11-23-27-9-7-18(25-19(16)27)26-8-3-4-17(26)14-10-13(21)5-6-15(14)22/h5-7,9-12,17H,3-4,8H2,1-2H3,(H,24,28)/t17-/m1/s1
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n/an/a 12.1n/an/an/an/a7.5n/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8865698 (2014)


BindingDB Entry DOI: 10.7270/Q2B856TM
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM136589
PNG
(US8865698, 6 | US9676783, 6)
Show SMILES Cn1nc(ccc1=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1S/C22H20FN7O2/c1-28-20(31)8-7-16(27-28)22(32)25-17-13-24-30-11-9-19(26-21(17)30)29-10-3-6-18(29)14-4-2-5-15(23)12-14/h2,4-5,7-9,11-13,18H,3,6,10H2,1H3,(H,25,32)/t18-/m1/s1
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n/an/a 19.2n/an/an/an/a7.5n/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8865698 (2014)


BindingDB Entry DOI: 10.7270/Q2B856TM
More data for this
Ligand-Target Pair
High affinity nerve growth factor receptor


(Homo Sapiens)
BDBM136590
PNG
(US10047097, 7 | US8865698, 7 | US9676783, 7)
Show SMILES OC1CN(C1)C(=O)Nc1cnn2ccc(nc12)N1CC(F)(F)C[C@@H]1c1cccc(F)c1
Show InChI InChI=1S/C20H19F3N6O2/c21-13-3-1-2-12(6-13)16-7-20(22,23)11-28(16)17-4-5-29-18(26-17)15(8-24-29)25-19(31)27-9-14(30)10-27/h1-6,8,14,16,30H,7,9-11H2,(H,25,31)/t16-/m1/s1
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n/an/a 77.5n/an/an/an/a7.5n/a



Array BioPharma Inc.

US Patent


Assay Description
An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...


US Patent US8865698 (2014)


BindingDB Entry DOI: 10.7270/Q2B856TM
More data for this
Ligand-Target Pair
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