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Compile Data Set for Download or QSAR

Found 14 hits of ph data with Target = 'Hyaluronidase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hyaluronidase


(Homo sapiens (Human))
BDBM81867
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(Cn2cc(C(=O)NCc3ccc(Cl)cc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H18ClFN2O/c24-18-9-5-16(6-10-18)13-26-23(28)21-15-27(22-4-2-1-3-20(21)22)14-17-7-11-19(25)12-8-17/h1-12,15H,13-14H2,(H,26,28)
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n/an/a 7.29E+4n/an/an/an/a3.537



TBA



Assay Description
Morgan-elson assay were used to test inhibitors at pH of 3.5.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81866
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(Cn2cc(C(=O)NCc3ccccc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H19FN2O/c24-19-12-10-18(11-13-19)15-26-16-21(20-8-4-5-9-22(20)26)23(27)25-14-17-6-2-1-3-7-17/h1-13,16H,14-15H2,(H,25,27)
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n/an/a 6.16E+4n/an/an/an/a3.537



TBA



Assay Description
Morgan-elson assay were used to test inhibitors at pH of 3.5.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81861
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Clc1ccc(CNC(=O)c2cc3ccccc3n2Cc2ccccc2)cc1
Show InChI InChI=1S/C23H19ClN2O/c24-20-12-10-17(11-13-20)15-25-23(27)22-14-19-8-4-5-9-21(19)26(22)16-18-6-2-1-3-7-18/h1-14H,15-16H2,(H,25,27)
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n/an/a 6.43E+4n/an/an/an/a3.537



TBA



Assay Description
Morgan-elson assay were used to test inhibitors at pH of 3.5.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81860
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES O=C(NCc1ccccc1)c1cc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C23H20N2O/c26-23(24-16-18-9-3-1-4-10-18)22-15-20-13-7-8-14-21(20)25(22)17-19-11-5-2-6-12-19/h1-15H,16-17H2,(H,24,26)
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n/an/a 7.82E+4n/an/an/an/a3.537



TBA



Assay Description
Morgan-elson assay were used to test inhibitors at pH of 3.5.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81868
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(CNC(=O)c2cn(Cc3ccc(F)cc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H18F2N2O/c24-18-9-5-16(6-10-18)13-26-23(28)21-15-27(22-4-2-1-3-20(21)22)14-17-7-11-19(25)12-8-17/h1-12,15H,13-14H2,(H,26,28)
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n/an/a 5.67E+4n/an/an/an/a3.537



TBA



Assay Description
Morgan-elson assay were used to test inhibitors at pH of 3.5.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81865
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(CNC(=O)c2cc3ccccc3n2Cc2ccc(F)cc2)cc1
Show InChI InChI=1S/C23H18F2N2O/c24-19-9-5-16(6-10-19)14-26-23(28)22-13-18-3-1-2-4-21(18)27(22)15-17-7-11-20(25)12-8-17/h1-13H,14-15H2,(H,26,28)
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n/an/a 2.99E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81867
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(Cn2cc(C(=O)NCc3ccc(Cl)cc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H18ClFN2O/c24-18-9-5-16(6-10-18)13-26-23(28)21-15-27(22-4-2-1-3-20(21)22)14-17-7-11-19(25)12-8-17/h1-12,15H,13-14H2,(H,26,28)
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n/an/a 3.37E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81868
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(CNC(=O)c2cn(Cc3ccc(F)cc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H18F2N2O/c24-18-9-5-16(6-10-18)13-26-23(28)21-15-27(22-4-2-1-3-20(21)22)14-17-7-11-19(25)12-8-17/h1-12,15H,13-14H2,(H,26,28)
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n/an/a 2.57E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81864
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(Cn2c(cc3ccccc23)C(=O)NCc2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C23H18ClFN2O/c24-19-9-5-16(6-10-19)14-26-23(28)22-13-18-3-1-2-4-21(18)27(22)15-17-7-11-20(25)12-8-17/h1-13H,14-15H2,(H,26,28)
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n/an/a 3.30E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81863
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(Cn2c(cc3ccccc23)C(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C23H19FN2O/c24-20-12-10-18(11-13-20)16-26-21-9-5-4-8-19(21)14-22(26)23(27)25-15-17-6-2-1-3-7-17/h1-14H,15-16H2,(H,25,27)
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n/an/a 4.11E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81862
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(CNC(=O)c2cc3ccccc3n2Cc2ccccc2)cc1
Show InChI InChI=1S/C23H19FN2O/c24-20-12-10-17(11-13-20)15-25-23(27)22-14-19-8-4-5-9-21(19)26(22)16-18-6-2-1-3-7-18/h1-14H,15-16H2,(H,25,27)
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n/an/a 2.72E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81861
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Clc1ccc(CNC(=O)c2cc3ccccc3n2Cc2ccccc2)cc1
Show InChI InChI=1S/C23H19ClN2O/c24-20-12-10-17(11-13-20)15-25-23(27)22-14-19-8-4-5-9-21(19)26(22)16-18-6-2-1-3-7-18/h1-14H,15-16H2,(H,25,27)
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n/an/a 3.32E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81860
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES O=C(NCc1ccccc1)c1cc2ccccc2n1Cc1ccccc1
Show InChI InChI=1S/C23H20N2O/c26-23(24-16-18-9-3-1-4-10-18)22-15-20-13-7-8-14-21(20)25(22)17-19-11-5-2-6-12-19/h1-15H,16-17H2,(H,24,26)
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n/an/a 4.03E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair
Hyaluronidase


(Homo sapiens (Human))
BDBM81866
PNG
(N-Substituted indole-2- and 3-carboxamide derivati...)
Show SMILES Fc1ccc(Cn2cc(C(=O)NCc3ccccc3)c3ccccc23)cc1
Show InChI InChI=1S/C23H19FN2O/c24-19-12-10-18(11-13-19)15-26-16-21(20-8-4-5-9-22(20)26)23(27)25-14-17-6-2-1-3-7-17/h1-13,16H,14-15H2,(H,25,27)
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n/an/a 3.30E+4n/an/an/an/a7.037



TBA



Assay Description
Stains-all assay were used to test inhibitors at pH of 7.


Chem Biol Drug Des 70: 547-51 (2007)


Article DOI: 10.1111/j.1747-0285.2007.00590.x
BindingDB Entry DOI: 10.7270/Q2FB51F7
More data for this
Ligand-Target Pair