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Compile Data Set for Download or QSAR

Found 16 hits of ph data with Target = 'Insulin receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens (human))
BDBM234389
PNG
(Mangiferin)
Show SMILES OC[C@H]1OC([C@H](O)[C@@H](O)[C@@H]1O)c1c(O)cc2oc3cc(O)c(O)cc3c(=O)c2c1O
Show InChI InChI=1S/C19H18O11/c20-4-11-15(25)17(27)18(28)19(30-11)12-8(23)3-10-13(16(12)26)14(24)5-1-6(21)7(22)2-9(5)29-10/h1-3,11,15,17-23,25-28H,4H2/t11-,15-,17+,18-,19?/m1/s1
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n/an/a>1.00E+4n/an/an/an/a7.0n/a



Gyeongsang National University



Assay Description
Inhibition of kinase activity against a variety of recombinant kinases [FLT3, FLT3 D835Y, anaplastic lymphoma kinase (ALK), insulin receptor, and epi...


J Enzyme Inhib Med Chem 26: 445-8 (2011)


Article DOI: 10.3109/14756366.2010.515215
BindingDB Entry DOI: 10.7270/Q2S46QTV
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM15012
PNG
(2,4-diethyl 3-ethyl-5-formyl-1H-pyrrole-2,4-dicarb...)
Show SMILES CCOC(=O)c1[nH]c(C=O)c(C(=O)OCC)c1CC
Show InChI InChI=1S/C13H17NO5/c1-4-8-10(12(16)18-5-2)9(7-15)14-11(8)13(17)19-6-3/h7,14H,4-6H2,1-3H3
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n/an/a 5.40E+3n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...


Biochemistry 44: 9430-40 (2005)


Article DOI: 10.1021/bi0500628
BindingDB Entry DOI: 10.7270/Q2BV7DV5
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM15013
PNG
(2,4-diethyl 5-(hydroxymethyl)-3-methyl-1H-pyrrole-...)
Show SMILES CCOC(=O)c1[nH]c(CO)c(C(=O)OCC)c1C
Show InChI InChI=1S/C12H17NO5/c1-4-17-11(15)9-7(3)10(12(16)18-5-2)13-8(9)6-14/h13-14H,4-6H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...


Biochemistry 44: 9430-40 (2005)


Article DOI: 10.1021/bi0500628
BindingDB Entry DOI: 10.7270/Q2BV7DV5
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM15014
PNG
(2-N,2-N,4-N,4-N-tetraethyl-5-formyl-3-methyl-1H-py...)
Show SMILES CCN(CC)C(=O)c1[nH]c(C=O)c(C(=O)N(CC)CC)c1C
Show InChI InChI=1S/C16H25N3O3/c1-6-18(7-2)15(21)13-11(5)14(17-12(13)10-20)16(22)19(8-3)9-4/h10,17H,6-9H2,1-5H3
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n/an/a>1.00E+5n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...


Biochemistry 44: 9430-40 (2005)


Article DOI: 10.1021/bi0500628
BindingDB Entry DOI: 10.7270/Q2BV7DV5
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM15015
PNG
(2-tert-Butyl 4-Ethyl 3-Ethyl-5-formyl-1H-pyrrole-2...)
Show SMILES CCOC(=O)c1c(CC)c([nH]c1C=O)C(=O)OC(C)(C)C
Show InChI InChI=1S/C15H21NO5/c1-6-9-11(13(18)20-7-2)10(8-17)16-12(9)14(19)21-15(3,4)5/h8,16H,6-7H2,1-5H3
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n/an/a 2.00E+3n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...


Biochemistry 44: 9430-40 (2005)


Article DOI: 10.1021/bi0500628
BindingDB Entry DOI: 10.7270/Q2BV7DV5
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM15016
PNG
(Ethyl 5-[(tert-Butylamino)carbonyl]-4-ethyl-2-form...)
Show SMILES CCOC(=O)c1c(CC)c([nH]c1C=O)C(=O)NC(C)(C)C
Show InChI InChI=1S/C15H22N2O4/c1-6-9-11(14(20)21-7-2)10(8-18)16-12(9)13(19)17-15(3,4)5/h8,16H,6-7H2,1-5H3,(H,17,19)
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n/an/a 1.70E+4n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...


Biochemistry 44: 9430-40 (2005)


Article DOI: 10.1021/bi0500628
BindingDB Entry DOI: 10.7270/Q2BV7DV5
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM15017
PNG
(2-tert-Butyl 4-Ethyl 3-Ethyl-5-formyl-1-methyl-1H-...)
Show SMILES CCOC(=O)c1c(CC)c(C(=O)OC(C)(C)C)n(C)c1C=O
Show InChI InChI=1S/C16H23NO5/c1-7-10-12(14(19)21-8-2)11(9-18)17(6)13(10)15(20)22-16(3,4)5/h9H,7-8H2,1-6H3
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n/an/a 1.20E+4n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...


Biochemistry 44: 9430-40 (2005)


Article DOI: 10.1021/bi0500628
BindingDB Entry DOI: 10.7270/Q2BV7DV5
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM2580
PNG
(K252a | methyl (15R,16S,18S)-16-hydroxy-15-methyl-...)
Show SMILES COC(=O)[C@]1(O)C[C@@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C27H21N3O5/c1-26-27(33,25(32)34-2)11-18(35-26)29-16-9-5-3-7-13(16)20-21-15(12-28-24(21)31)19-14-8-4-6-10-17(14)30(26)23(19)22(20)29/h3-10,18,33H,11-12H2,1-2H3,(H,28,31)/t18?,26-,27-/m1/s1
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n/an/a 210n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...


Biochemistry 44: 9430-40 (2005)


Article DOI: 10.1021/bi0500628
BindingDB Entry DOI: 10.7270/Q2BV7DV5
More data for this
Ligand-Target Pair
Insulin receptor


(Rattus norvegicus (rat))
BDBM2683
PNG
(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
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n/an/a>1.00E+5n/an/an/an/a7.423



Laboratoires Glaxo



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] lab...


J Biol Chem 266: 15771-81 (1991)


Article DOI: 10.1021/jm0508282
BindingDB Entry DOI: 10.7270/Q2FF3QJ4
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM15011
PNG
(2,4-diethyl 5-formyl-3-methyl-1H-pyrrole-2,4-dicar...)
Show SMILES CCOC(=O)c1[nH]c(C=O)c(C(=O)OCC)c1C
Show InChI InChI=1S/C12H15NO5/c1-4-17-11(15)9-7(3)10(12(16)18-5-2)13-8(9)6-14/h6,13H,4-5H2,1-3H3
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n/an/a 1.20E+4n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore...


Biochemistry 44: 9430-40 (2005)


Article DOI: 10.1021/bi0500628
BindingDB Entry DOI: 10.7270/Q2BV7DV5
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM84534
PNG
(Indirubin derivative, 20)
Show SMILES OS(=O)(=O)c1ccc2NC(=O)C(=C3Nc4ccccc4C3=O)c2c1
Show InChI InChI=1S/C16H10N2O5S/c19-15-9-3-1-2-4-11(9)17-14(15)13-10-7-8(24(21,22)23)5-6-12(10)18-16(13)20/h1-7,17H,(H,18,20)(H,21,22,23)
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n/an/a>1.00E+4n/an/an/an/a7.522



Schering AG



Assay Description
Inhibition assay using CDK and selective kinases such as gsk3, EGFR, c-Kit, InsR and KDR.


Chembiochem 6: 531-40 (2005)


Article DOI: 10.1002/cbic.200400108
BindingDB Entry DOI: 10.7270/Q2B56H8H
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM84553
PNG
(Indirubin derivative, 28a | Indirubin derivative, ...)
Show SMILES CN(C)CCN(C)S(=O)(=O)c1ccc2NC(=O)C(C3=Nc4ccccc4C3(C)O)c2c1
Show InChI InChI=1S/C22H26N4O4S/c1-22(28)16-7-5-6-8-18(16)23-20(22)19-15-13-14(9-10-17(15)24-21(19)27)31(29,30)26(4)12-11-25(2)3/h5-10,13,19,28H,11-12H2,1-4H3,(H,24,27)
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n/an/a>1.00E+4n/an/an/an/a7.522



Schering AG



Assay Description
Inhibition assay using CDK and selective kinases such as gsk3, EGFR, c-Kit, InsR and KDR.


Chembiochem 6: 531-40 (2005)


Article DOI: 10.1002/cbic.200400108
BindingDB Entry DOI: 10.7270/Q2B56H8H
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM84553
PNG
(Indirubin derivative, 28a | Indirubin derivative, ...)
Show SMILES CN(C)CCN(C)S(=O)(=O)c1ccc2NC(=O)C(C3=Nc4ccccc4C3(C)O)c2c1
Show InChI InChI=1S/C22H26N4O4S/c1-22(28)16-7-5-6-8-18(16)23-20(22)19-15-13-14(9-10-17(15)24-21(19)27)31(29,30)26(4)12-11-25(2)3/h5-10,13,19,28H,11-12H2,1-4H3,(H,24,27)
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n/an/a>1.00E+4n/an/an/an/a7.522



Schering AG



Assay Description
Inhibition assay using CDK and selective kinases such as gsk3, EGFR, c-Kit, InsR and KDR.


Chembiochem 6: 531-40 (2005)


Article DOI: 10.1002/cbic.200400108
BindingDB Entry DOI: 10.7270/Q2B56H8H
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM84555
PNG
(Indirubin derivative, 30a | Indirubin derivative, ...)
Show SMILES CN(C)CCN(C)S(=O)(=O)c1ccc2NC(=O)C(C3=Nc4ccccc4C3(O)CC=C)c2c1
Show InChI InChI=1S/C24H28N4O4S/c1-5-12-24(30)18-8-6-7-9-20(18)25-22(24)21-17-15-16(10-11-19(17)26-23(21)29)33(31,32)28(4)14-13-27(2)3/h5-11,15,21,30H,1,12-14H2,2-4H3,(H,26,29)
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n/an/a>1.00E+4n/an/an/an/a7.522



Schering AG



Assay Description
Inhibition assay using CDK and selective kinases such as gsk3, EGFR, c-Kit, InsR and KDR.


Chembiochem 6: 531-40 (2005)


Article DOI: 10.1002/cbic.200400108
BindingDB Entry DOI: 10.7270/Q2B56H8H
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM84555
PNG
(Indirubin derivative, 30a | Indirubin derivative, ...)
Show SMILES CN(C)CCN(C)S(=O)(=O)c1ccc2NC(=O)C(C3=Nc4ccccc4C3(O)CC=C)c2c1
Show InChI InChI=1S/C24H28N4O4S/c1-5-12-24(30)18-8-6-7-9-20(18)25-22(24)21-17-15-16(10-11-19(17)26-23(21)29)33(31,32)28(4)14-13-27(2)3/h5-11,15,21,30H,1,12-14H2,2-4H3,(H,26,29)
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Schering AG



Assay Description
Inhibition assay using CDK and selective kinases such as gsk3, EGFR, c-Kit, InsR and KDR.


Chembiochem 6: 531-40 (2005)


Article DOI: 10.1002/cbic.200400108
BindingDB Entry DOI: 10.7270/Q2B56H8H
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (human))
BDBM54680
PNG
((3Z)-5-bromanyl-3-(3-oxidanylidene-1H-indol-2-ylid...)
Show SMILES Brc1ccc2NC(=O)C(=C3Nc4ccccc4C3=O)c2c1
Show InChI InChI=1S/C16H9BrN2O2/c17-8-5-6-12-10(7-8)13(16(21)19-12)14-15(20)9-3-1-2-4-11(9)18-14/h1-7,18H,(H,19,21)
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n/an/a>1.00E+4n/an/an/an/a7.522



Schering AG



Assay Description
Inhibition assay using CDK and selective kinases such as gsk3, EGFR, c-Kit, InsR and KDR.


Chembiochem 6: 531-40 (2005)


Article DOI: 10.1002/cbic.200400108
BindingDB Entry DOI: 10.7270/Q2B56H8H
More data for this
Ligand-Target Pair