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Compile Data Set for Download or QSAR

Found 174 hits of ph data with Target = 'Insulin-like growth factor 1 receptor (964-1370)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184355
PNG
(US9150578, I-003)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCO)n4)nc-23)nn1C
Show InChI InChI=1S/C25H25N9O/c1-32-15-19(14-27-32)16-3-5-17(6-4-16)24-22-20(30-33(24)2)8-7-18-13-26-25(29-23(18)22)28-21-9-10-34(31-21)11-12-35/h3-6,9-10,13-15,35H,7-8,11-12H2,1-2H3,(H,26,28,29,31)
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n/an/a 0.230n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184356
PNG
(US9150578, I-004)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCCO)n4)nc-23)nn1C
Show InChI InChI=1S/C26H27N9O/c1-33-16-20(15-28-33)17-4-6-18(7-5-17)25-23-21(31-34(25)2)9-8-19-14-27-26(30-24(19)23)29-22-10-12-35(32-22)11-3-13-36/h4-7,10,12,14-16,36H,3,8-9,11,13H2,1-2H3,(H,27,29,30,32)
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n/an/a 0.160n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184357
PNG
(US9150578, I-005)
Show SMILES CN(C)C(=O)Cn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C27H28N10O/c1-34(2)23(38)16-37-15-21(13-30-37)31-27-28-11-19-9-10-22-24(25(19)32-27)26(36(4)33-22)18-7-5-17(6-8-18)20-12-29-35(3)14-20/h5-8,11-15H,9-10,16H2,1-4H3,(H,28,31,32)
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n/an/a 0.100n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184358
PNG
(US9150578, I-006)
Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(C)n4)nc-23)nn1C
Show InChI InChI=1S/C26H27N9/c1-16(2)35-15-20(14-28-35)17-5-7-18(8-6-17)25-23-21(31-34(25)4)10-9-19-13-27-26(30-24(19)23)29-22-11-12-33(3)32-22/h5-8,11-16H,9-10H2,1-4H3,(H,27,29,30,32)
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n/an/a 0.880n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184359
PNG
(US9150578, I-007)
Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cc(C)n(C)n4)nc-23)nn1C
Show InChI InChI=1S/C27H29N9/c1-16(2)36-15-21(14-29-36)18-6-8-19(9-7-18)26-24-22(32-35(26)5)11-10-20-13-28-27(31-25(20)24)30-23-12-17(3)34(4)33-23/h6-9,12-16H,10-11H2,1-5H3,(H,28,30,31,33)
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n/an/a 3n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184360
PNG
(US9150578, I-008)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C26H27N9O/c1-33-16-20(15-28-33)17-4-6-18(7-5-17)25-23-21(31-34(25)2)9-8-19-14-27-26(30-24(19)23)29-22-10-11-35(32-22)12-13-36-3/h4-7,10-11,14-16H,8-9,12-13H2,1-3H3,(H,27,29,30,32)
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n/an/a 0.760n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184361
PNG
(US9150578, I-009)
Show SMILES CN(C)C(=O)Cn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)n1
Show InChI InChI=1S/C27H28N10O/c1-34(2)23(38)16-37-12-11-22(33-37)30-27-28-13-19-9-10-21-24(25(19)31-27)26(36(4)32-21)18-7-5-17(6-8-18)20-14-29-35(3)15-20/h5-8,11-15H,9-10,16H2,1-4H3,(H,28,30,31,33)
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n/an/a 0.510n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184362
PNG
(US9150578, I-010)
Show SMILES Cn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C24H23N9/c1-31-13-18(11-26-31)15-4-6-16(7-5-15)23-21-20(30-33(23)3)9-8-17-10-25-24(29-22(17)21)28-19-12-27-32(2)14-19/h4-7,10-14H,8-9H2,1-3H3,(H,25,28,29)
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n/an/a 0.260n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184363
PNG
(US9150578, I-011)
Show SMILES Cc1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)nn1C
Show InChI InChI=1S/C25H25N9/c1-15-11-21(31-33(15)3)28-25-26-12-18-9-10-20-22(23(18)29-25)24(34(4)30-20)17-7-5-16(6-8-17)19-13-27-32(2)14-19/h5-8,11-14H,9-10H2,1-4H3,(H,26,28,29,31)
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n/an/a 0.270n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184364
PNG
(US9150578, I-012)
Show SMILES Cn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C25H25N9/c1-32-10-9-22(31-32)28-25-26-13-18-7-8-20-23(24(18)29-25)21(34(3)30-20)12-16-5-4-6-17(11-16)19-14-27-33(2)15-19/h4-6,9-11,13-15H,7-8,12H2,1-3H3,(H,26,28,29,31)
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n/an/a 0.360n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184365
PNG
(US9150578, I-013)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)cn1
Show InChI InChI=1S/C31H34N10O/c1-20(42)40-11-9-26(10-12-40)41-19-25(17-34-41)35-31-32-15-23-7-8-27-29(30(23)36-31)28(39(3)37-27)14-21-5-4-6-22(13-21)24-16-33-38(2)18-24/h4-6,13,15-19,26H,7-12,14H2,1-3H3,(H,32,35,36)
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n/an/a 0.390n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184366
PNG
(US9150578, I-014)
Show SMILES CN(C)C(=O)Cn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C28H30N10O/c1-35(2)25(39)17-38-11-10-24(34-38)31-28-29-14-20-8-9-22-26(27(20)32-28)23(37(4)33-22)13-18-6-5-7-19(12-18)21-15-30-36(3)16-21/h5-7,10-12,14-16H,8-9,13,17H2,1-4H3,(H,29,31,32,34)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184367
PNG
(US9150578, I-015)
Show SMILES CN(C)CCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C28H32N10/c1-35(2)12-13-38-11-10-25(34-38)31-28-29-16-21-8-9-23-26(27(21)32-28)24(37(4)33-23)15-19-6-5-7-20(14-19)22-17-30-36(3)18-22/h5-7,10-11,14,16-18H,8-9,12-13,15H2,1-4H3,(H,29,31,32,34)
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n/an/a 0.160n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184368
PNG
(US9150578, I-016)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C27H29N9O/c1-34-17-21(16-29-34)19-6-4-5-18(13-19)14-23-25-22(32-35(23)2)8-7-20-15-28-27(31-26(20)25)30-24-9-10-36(33-24)11-12-37-3/h4-6,9-10,13,15-17H,7-8,11-12,14H2,1-3H3,(H,28,30,31,33)
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n/an/a 0.360n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184369
PNG
(US9150578, I-017)
Show SMILES CN(C)CCn1cc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)cn1
Show InChI InChI=1S/C28H32N10/c1-35(2)10-11-38-18-23(16-31-38)32-28-29-14-21-8-9-24-26(27(21)33-28)25(37(4)34-24)13-19-6-5-7-20(12-19)22-15-30-36(3)17-22/h5-7,12,14-18H,8-11,13H2,1-4H3,(H,29,32,33)
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n/an/a 0.460n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184370
PNG
(US9150578, I-018)
Show SMILES Cn1cc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)cn1
Show InChI InChI=1S/C25H25N9/c1-32-14-19(12-27-32)17-6-4-5-16(9-17)10-22-23-21(31-34(22)3)8-7-18-11-26-25(30-24(18)23)29-20-13-28-33(2)15-20/h4-6,9,11-15H,7-8,10H2,1-3H3,(H,26,29,30)
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n/an/a 0.230n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184371
PNG
(US9150578, I-019)
Show SMILES Cc1cc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)nn1C
Show InChI InChI=1S/C26H27N9/c1-16-10-23(32-34(16)3)29-26-27-13-19-8-9-21-24(25(19)30-26)22(35(4)31-21)12-17-6-5-7-18(11-17)20-14-28-33(2)15-20/h5-7,10-11,13-15H,8-9,12H2,1-4H3,(H,27,29,30,32)
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n/an/a 0.870n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184372
PNG
(US9150578, I-020)
Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(CCN(C)C)c4)nc-23)nn1C
Show InChI InChI=1S/C29H34N10/c1-19(2)39-17-23(15-32-39)20-6-8-21(9-7-20)28-26-25(35-37(28)5)11-10-22-14-30-29(34-27(22)26)33-24-16-31-38(18-24)13-12-36(3)4/h6-9,14-19H,10-13H2,1-5H3,(H,30,33,34)
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n/an/a 0.210n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184373
PNG
(US9150578, I-021)
Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C29H34N10/c1-19(2)39-18-23(17-31-39)20-6-8-21(9-7-20)28-26-24(34-37(28)5)11-10-22-16-30-29(33-27(22)26)32-25-12-13-38(35-25)15-14-36(3)4/h6-9,12-13,16-19H,10-11,14-15H2,1-5H3,(H,30,32,33,35)
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n/an/a 0.120n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184374
PNG
(US9150578, I-022)
Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(c4)C4CCN(CC4)C(C)=O)nc-23)nn1C
Show InChI InChI=1S/C32H36N10O/c1-20(2)41-18-25(16-34-41)22-5-7-23(8-6-22)31-29-28(38-39(31)4)10-9-24-15-33-32(37-30(24)29)36-26-17-35-42(19-26)27-11-13-40(14-12-27)21(3)43/h5-8,15-20,27H,9-14H2,1-4H3,(H,33,36,37)
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n/an/a 0.170n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184375
PNG
(US9150578, I-023)
Show SMILES CC(C)n1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(CCN5CCOCC5)c4)nc-23)nn1C
Show InChI InChI=1S/C31H36N10O/c1-21(2)41-19-25(17-34-41)22-4-6-23(7-5-22)30-28-27(37-38(30)3)9-8-24-16-32-31(36-29(24)28)35-26-18-33-40(20-26)11-10-39-12-14-42-15-13-39/h4-7,16-21H,8-15H2,1-3H3,(H,32,35,36)
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n/an/a 0.420n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184376
PNG
(US9150578, I-024)
Show SMILES CCn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C25H25N9/c1-4-34-15-20(13-28-34)29-25-26-11-18-9-10-21-22(23(18)30-25)24(33(3)31-21)17-7-5-16(6-8-17)19-12-27-32(2)14-19/h5-8,11-15H,4,9-10H2,1-3H3,(H,26,29,30)
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n/an/a 0.160n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184377
PNG
(US9150578, I-025)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(CCN5CCOCC5)c4)nc-23)nn1C
Show InChI InChI=1S/C29H32N10O/c1-36-18-23(16-31-36)20-3-5-21(6-4-20)28-26-25(35-37(28)2)8-7-22-15-30-29(34-27(22)26)33-24-17-32-39(19-24)10-9-38-11-13-40-14-12-38/h3-6,15-19H,7-14H2,1-2H3,(H,30,33,34)
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n/an/a 0.380n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184378
PNG
(US9150578, I-026)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4cnn(Cc5ccncc5)c4)nc-23)nn1C
Show InChI InChI=1S/C29H26N10/c1-37-17-23(14-32-37)20-3-5-21(6-4-20)28-26-25(36-38(28)2)8-7-22-13-31-29(35-27(22)26)34-24-15-33-39(18-24)16-19-9-11-30-12-10-19/h3-6,9-15,17-18H,7-8,16H2,1-2H3,(H,31,34,35)
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n/an/a 0.280n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184379
PNG
(US9150578, I-027)
Show SMILES COCCn1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(c2)C(C)C)cn1
Show InChI InChI=1S/C28H31N9O/c1-18(2)37-16-22(14-31-37)19-5-7-20(8-6-19)27-25-24(34-35(27)3)10-9-21-13-29-28(33-26(21)25)32-23-15-30-36(17-23)11-12-38-4/h5-8,13-18H,9-12H2,1-4H3,(H,29,32,33)
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n/an/a 0.280n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184380
PNG
(US9150578, I-028)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CC(C)(C)O)n4)nc-23)nn1C
Show InChI InChI=1S/C27H29N9O/c1-27(2,37)16-36-12-11-22(33-36)30-26-28-13-19-9-10-21-23(24(19)31-26)25(35(4)32-21)18-7-5-17(6-8-18)20-14-29-34(3)15-20/h5-8,11-15,37H,9-10,16H2,1-4H3,(H,28,30,31,33)
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n/an/a 0.910n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184381
PNG
(US9150578, I-029)
Show SMILES Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN5CCOCC5)n4)nc-23)nn1C
Show InChI InChI=1S/C29H32N10O/c1-36-19-23(18-31-36)20-3-5-21(6-4-20)28-26-24(34-37(28)2)8-7-22-17-30-29(33-27(22)26)32-25-9-10-39(35-25)12-11-38-13-15-40-16-14-38/h3-6,9-10,17-19H,7-8,11-16H2,1-2H3,(H,30,32,33,35)
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n/an/a 0.170n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184382
PNG
(US9150578, I-030)
Show SMILES COCCN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccc(cc3)-c3cnn(C)c3)n2)CC1
Show InChI InChI=1S/C32H39N11O/c1-39-22-26(21-34-39)23-4-6-24(7-5-23)31-29-27(37-40(31)2)9-8-25-20-33-32(36-30(25)29)35-28-10-11-43(38-28)17-16-41-12-14-42(15-13-41)18-19-44-3/h4-7,10-11,20-22H,8-9,12-19H2,1-3H3,(H,33,35,36,38)
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n/an/a 0.100n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184383
PNG
(US9150578, I-031)
Show SMILES CN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(c5-c4n3)-c3ccc(cc3)-c3cnn(C)c3)n2)CC1
Show InChI InChI=1S/C30H35N11/c1-37-12-14-40(15-13-37)16-17-41-11-10-26(36-41)33-30-31-18-23-8-9-25-27(28(23)34-30)29(39(3)35-25)22-6-4-21(5-7-22)24-19-32-38(2)20-24/h4-7,10-11,18-20H,8-9,12-17H2,1-3H3,(H,31,33,34,36)
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n/an/a 0.0500n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184384
PNG
(US9150578, I-032)
Show SMILES Cn1cc(cn1)-c1cccc(Cc2c-3c(CCc4cnc(Nc5ccn(CCN6CCOCC6)n5)nc-34)nn2C)c1
Show InChI InChI=1S/C30H34N10O/c1-37-20-24(19-32-37)22-5-3-4-21(16-22)17-26-28-25(35-38(26)2)7-6-23-18-31-30(34-29(23)28)33-27-8-9-40(36-27)11-10-39-12-14-41-15-13-39/h3-5,8-9,16,18-20H,6-7,10-15,17H2,1-2H3,(H,31,33,34,36)
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n/an/a 0.210n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184385
PNG
(US9150578, I-033)
Show SMILES COCCN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(Cc6cccc(c6)-c6cnn(C)c6)c5-c4n3)n2)CC1
Show InChI InChI=1S/C33H41N11O/c1-40-23-27(22-35-40)25-6-4-5-24(19-25)20-29-31-28(38-41(29)2)8-7-26-21-34-33(37-32(26)31)36-30-9-10-44(39-30)16-15-42-11-13-43(14-12-42)17-18-45-3/h4-6,9-10,19,21-23H,7-8,11-18,20H2,1-3H3,(H,34,36,37,39)
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n/an/a 0.240n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184386
PNG
(US9150578, I-034)
Show SMILES CN1CCN(CCn2ccc(Nc3ncc4CCc5nn(C)c(Cc6cccc(c6)-c6cnn(C)c6)c5-c4n3)n2)CC1
Show InChI InChI=1S/C31H37N11/c1-38-11-13-41(14-12-38)15-16-42-10-9-28(37-42)34-31-32-19-24-7-8-26-29(30(24)35-31)27(40(3)36-26)18-22-5-4-6-23(17-22)25-20-33-39(2)21-25/h4-6,9-10,17,19-21H,7-8,11-16,18H2,1-3H3,(H,32,34,35,37)
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n/an/a 0.170n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184387
PNG
(US9150578, I-035)
Show SMILES Cn1cc(cn1)-c1cccc(Cc2c-3c(CCc4cnc(Nc5ccn(CCCN6CCCC6)n5)nc-34)nn2C)c1
Show InChI InChI=1S/C31H36N10/c1-38-21-25(20-33-38)23-8-5-7-22(17-23)18-27-29-26(36-39(27)2)10-9-24-19-32-31(35-30(24)29)34-28-11-16-41(37-28)15-6-14-40-12-3-4-13-40/h5,7-8,11,16-17,19-21H,3-4,6,9-10,12-15,18H2,1-2H3,(H,32,34,35,37)
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n/an/a 0.0800n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184388
PNG
(US9150578, I-036)
Show SMILES COCCCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C28H31N9O/c1-35-18-22(17-30-35)20-7-4-6-19(14-20)15-24-26-23(33-36(24)2)9-8-21-16-29-28(32-27(21)26)31-25-10-12-37(34-25)11-5-13-38-3/h4,6-7,10,12,14,16-18H,5,8-9,11,13,15H2,1-3H3,(H,29,31,32,34)
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n/an/a 0.370n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184389
PNG
(US9150578, I-037)
Show SMILES Cn1cc(cn1)-c1cccc(Cc2c-3c(CCc4cnc(Nc5ccn(CCCn6ccnc6)n5)nc-34)nn2C)c1
Show InChI InChI=1S/C30H31N11/c1-38-19-24(18-33-38)22-6-3-5-21(15-22)16-26-28-25(36-39(26)2)8-7-23-17-32-30(35-29(23)28)34-27-9-13-41(37-27)12-4-11-40-14-10-31-20-40/h3,5-6,9-10,13-15,17-20H,4,7-8,11-12,16H2,1-2H3,(H,32,34,35,37)
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n/an/a 0.230n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184390
PNG
(US9150578, I-038)
Show SMILES CCS(=O)(=O)CCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C28H31N9O2S/c1-4-40(38,39)13-12-37-11-10-25(34-37)31-28-29-16-21-8-9-23-26(27(21)32-28)24(36(3)33-23)15-19-6-5-7-20(14-19)22-17-30-35(2)18-22/h5-7,10-11,14,16-18H,4,8-9,12-13,15H2,1-3H3,(H,29,31,32,34)
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n/an/a 0.220n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184391
PNG
(US9150578, I-039)
Show SMILES CN(C)C(=O)CCCn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C30H34N10O/c1-37(2)27(41)9-6-13-40-14-12-26(36-40)33-30-31-17-22-10-11-24-28(29(22)34-30)25(39(4)35-24)16-20-7-5-8-21(15-20)23-18-32-38(3)19-23/h5,7-8,12,14-15,17-19H,6,9-11,13,16H2,1-4H3,(H,31,33,34,36)
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n/an/a 0.800n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184392
PNG
(US9150578, I-040)
Show SMILES CN(C)CCNC(=O)Cn1ccc(Nc2ncc3CCc4nn(C)c(Cc5cccc(c5)-c5cnn(C)c5)c4-c3n2)n1
Show InChI InChI=1S/C30H35N11O/c1-38(2)13-11-31-27(42)19-41-12-10-26(37-41)34-30-32-16-22-8-9-24-28(29(22)35-30)25(40(4)36-24)15-20-6-5-7-21(14-20)23-17-33-39(3)18-23/h5-7,10,12,14,16-18H,8-9,11,13,15,19H2,1-4H3,(H,31,42)(H,32,34,35,37)
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n/an/a 0.570n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184393
PNG
(US9150578, I-041)
Show SMILES Cn1cc(cn1)-c1cccc(Cc2c-3c(CCc4cnc(Nc5ccn(CC(=O)N6CCOCC6)n5)nc-34)nn2C)c1
Show InChI InChI=1S/C30H32N10O2/c1-37-18-23(17-32-37)21-5-3-4-20(14-21)15-25-28-24(35-38(25)2)7-6-22-16-31-30(34-29(22)28)33-26-8-9-40(36-26)19-27(41)39-10-12-42-13-11-39/h3-5,8-9,14,16-18H,6-7,10-13,15,19H2,1-2H3,(H,31,33,34,36)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184417
PNG
(US9150578, I-051 | US9150578, I-075)
Show SMILES CC(=O)N1CCC(CC1)n1cc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(C)c2)cn1
Show InChI InChI=1S/C30H32N10O/c1-19(41)39-12-10-25(11-13-39)40-18-24(16-33-40)34-30-31-14-22-8-9-26-27(28(22)35-30)29(38(3)36-26)21-6-4-20(5-7-21)23-15-32-37(2)17-23/h4-7,14-18,25H,8-13H2,1-3H3,(H,31,34,35)
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n/an/a 0.210n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184419
PNG
(US9150578, I-053)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CC(=O)N(C)C)c2)n1
Show InChI InChI=1S/C28H30N10O/c1-5-37-13-12-23(34-37)31-28-29-14-20-10-11-22-25(26(20)32-28)27(36(4)33-22)19-8-6-18(7-9-19)21-15-30-38(16-21)17-24(39)35(2)3/h6-9,12-16H,5,10-11,17H2,1-4H3,(H,29,31,32,34)
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n/an/a 0.210n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184420
PNG
(US9150578, I-054)
Show SMILES COCCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(c2)C(C)C)n1
Show InChI InChI=1S/C28H31N9O/c1-18(2)37-17-22(16-30-37)19-5-7-20(8-6-19)27-25-23(33-35(27)3)10-9-21-15-29-28(32-26(21)25)31-24-11-12-36(34-24)13-14-38-4/h5-8,11-12,15-18H,9-10,13-14H2,1-4H3,(H,29,31,32,34)
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n/an/a 0.190n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184421
PNG
(US9150578, I-055)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CC(C)C)c2)n1
Show InChI InChI=1S/C28H31N9/c1-5-36-13-12-24(34-36)31-28-29-14-21-10-11-23-25(26(21)32-28)27(35(4)33-23)20-8-6-19(7-9-20)22-15-30-37(17-22)16-18(2)3/h6-9,12-15,17-18H,5,10-11,16H2,1-4H3,(H,29,31,32,34)
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n/an/a 2n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184422
PNG
(US9150578, I-056)
Show SMILES CCCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CC)n4)nc-23)nn1C
Show InChI InChI=1S/C27H29N9/c1-4-13-36-17-21(16-29-36)18-6-8-19(9-7-18)26-24-22(32-34(26)3)11-10-20-15-28-27(31-25(20)24)30-23-12-14-35(5-2)33-23/h6-9,12,14-17H,4-5,10-11,13H2,1-3H3,(H,28,30,31,33)
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n/an/a 1n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184423
PNG
(US9150578, I-057)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(Cc3ccccc3)c2)n1
Show InChI InChI=1S/C31H29N9/c1-3-39-16-15-27(37-39)34-31-32-17-24-13-14-26-28(29(24)35-31)30(38(2)36-26)23-11-9-22(10-12-23)25-18-33-40(20-25)19-21-7-5-4-6-8-21/h4-12,15-18,20H,3,13-14,19H2,1-2H3,(H,32,34,35,37)
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n/an/a 0.550n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184424
PNG
(US9150578, I-058)
Show SMILES CCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C28H32N10/c1-5-37-18-22(17-30-37)19-6-8-20(9-7-19)27-25-23(33-36(27)4)11-10-21-16-29-28(32-26(21)25)31-24-12-13-38(34-24)15-14-35(2)3/h6-9,12-13,16-18H,5,10-11,14-15H2,1-4H3,(H,29,31,32,34)
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n/an/a 0.180n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184425
PNG
(US9150578, I-059)
Show SMILES COCCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C29H34N10O/c1-36(2)13-14-38-12-11-25(35-38)32-29-30-17-22-9-10-24-26(27(22)33-29)28(37(3)34-24)21-7-5-20(6-8-21)23-18-31-39(19-23)15-16-40-4/h5-8,11-12,17-19H,9-10,13-16H2,1-4H3,(H,30,32,33,35)
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n/an/a 0.130n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184426
PNG
(US9150578, I-060)
Show SMILES CC(C)Cn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C30H36N10/c1-20(2)18-40-19-24(17-32-40)21-6-8-22(9-7-21)29-27-25(35-38(29)5)11-10-23-16-31-30(34-28(23)27)33-26-12-13-39(36-26)15-14-37(3)4/h6-9,12-13,16-17,19-20H,10-11,14-15,18H2,1-5H3,(H,31,33,34,36)
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n/an/a 0.310n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184427
PNG
(US9150578, I-061)
Show SMILES CCCn1cc(cn1)-c1ccc(cc1)-c1c-2c(CCc3cnc(Nc4ccn(CCN(C)C)n4)nc-23)nn1C
Show InChI InChI=1S/C29H34N10/c1-5-13-39-19-23(18-31-39)20-6-8-21(9-7-20)28-26-24(34-37(28)4)11-10-22-17-30-29(33-27(22)26)32-25-12-14-38(35-25)16-15-36(2)3/h6-9,12,14,17-19H,5,10-11,13,15-16H2,1-4H3,(H,30,32,33,35)
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n/an/a 0.150n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
Insulin-like growth factor 1 receptor (964-1370)


(Homo sapiens (Human))
BDBM184428
PNG
(US9150578, I-062)
Show SMILES CCn1ccc(Nc2ncc3CCc4nn(C)c(c4-c3n2)-c2ccc(cc2)-c2cnn(CCN(C)C)c2)n1
Show InChI InChI=1S/C28H32N10/c1-5-37-13-12-24(34-37)31-28-29-16-21-10-11-23-25(26(21)32-28)27(36(4)33-23)20-8-6-19(7-9-20)22-17-30-38(18-22)15-14-35(2)3/h6-9,12-13,16-18H,5,10-11,14-15H2,1-4H3,(H,29,31,32,34)
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n/an/a 0.130n/an/an/an/a7.4n/a



Boehringer Ingelheim International GmbH

US Patent


Assay Description
The kinase activity is measured by DELFIA.RTM. assay (dissociation-enhanced lanthanide fluorescence immunoassay, Perkin Elmer). The cytoplasmic kinas...


US Patent US9150578 (2015)


BindingDB Entry DOI: 10.7270/Q2BK1B4W
More data for this
Ligand-Target Pair
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