BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 28 hits of ph data with Target = 'Intestinal alkaline phosphatase (IAP)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50150071
PNG
(CHEMBL3774946)
Show SMILES OC(Cn1ccsc1=N)c1cc2ccccc2o1
Show InChI InChI=1S/C13H12N2O2S/c14-13-15(5-6-18-13)8-10(16)12-7-9-3-1-2-4-11(9)17-12/h1-7,10,14,16H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a7.8n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 7.8 followed by subs...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223073
PNG
((E)-N'-(4'-Fluorobenzylidene)isonicotinohy...)
Show SMILES Fc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C13H10FN3O/c14-12-3-1-10(2-4-12)9-16-17-13(18)11-5-7-15-8-6-11/h1-9H,(H,17,18)/b16-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.75E+4n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223074
PNG
((E)-N'-(4'-Methoxybenzylidene)isonicotinoh...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C14H13N3O2/c1-19-13-4-2-11(3-5-13)10-16-17-14(18)12-6-8-15-9-7-12/h2-10H,1H3,(H,17,18)/b16-10+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.74E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223075
PNG
((E)-N'-(2'-hydroxybenzylidene)isonicotinoh...)
Show SMILES Oc1ccccc1\C=N\NC(=O)c1ccncc1
Show InChI InChI=1S/C13H11N3O2/c17-12-4-2-1-3-11(12)9-15-16-13(18)10-5-7-14-8-6-10/h1-9,17H,(H,16,18)/b15-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.44E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223076
PNG
((E)-N'-(3'-Nitrobenzylidene)isonicotinohyd...)
Show SMILES [O-][N+](=O)c1cccc(\C=N\NC(=O)c2ccncc2)c1
Show InChI InChI=1S/C13H10N4O3/c18-13(11-4-6-14-7-5-11)16-15-9-10-2-1-3-12(8-10)17(19)20/h1-9H,(H,16,18)/b15-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 7.34E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223077
PNG
((E)-N'-(4'-Hydroxy-3-methoxybenzylidene)is...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccncc2)ccc1O
Show InChI InChI=1S/C14H13N3O3/c1-20-13-8-10(2-3-12(13)18)9-16-17-14(19)11-4-6-15-7-5-11/h2-9,18H,1H3,(H,17,19)/b16-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.92E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223078
PNG
((E)-N'-(Pyridin-4'-ylmethylene)isonicotino...)
Show SMILES O=C(N\N=C\c1ccncc1)c1ccncc1
Show InChI InChI=1S/C12H10N4O/c17-12(11-3-7-14-8-4-11)16-15-9-10-1-5-13-6-2-10/h1-9H,(H,16,17)/b15-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.46E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223079
PNG
((E)-N'-(Pyridin-3'-ylmethylene)isonicotino...)
Show SMILES O=C(N\N=C\c1cccnc1)c1ccncc1
Show InChI InChI=1S/C12H10N4O/c17-12(11-3-6-13-7-4-11)16-15-9-10-2-1-5-14-8-10/h1-9H,(H,16,17)/b15-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.46E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223080
PNG
((E)-N'-(1-(3-(4-fluorophenyl)-5-phenyl-4,5-dih...)
Show SMILES C\C(=N/NC(=O)c1ccncc1)N1N=C(CC1c1ccccc1)c1ccc(F)cc1
Show InChI InChI=1S/C23H20FN5O/c1-16(26-27-23(30)19-11-13-25-14-12-19)29-22(18-5-3-2-4-6-18)15-21(28-29)17-7-9-20(24)10-8-17/h2-14,22H,15H2,1H3,(H,27,30)/b26-16+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.98E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM18073
PNG
((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...)
Show SMILES N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 8.02E+4n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222179
PNG
(6-(Dimethylamino)-3-phenyl-2,3-dihydronaphtho[1,8-...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1ccccc1
Show InChI InChI=1S/C19H18N2O2S/c1-21(2)16-12-11-15-18-14(16)9-6-10-17(18)24(22,23)20-19(15)13-7-4-3-5-8-13/h3-12,19-20H,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.12E+3n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222185
PNG
(6-(Dimethylamino)-3-(3',5'-dichloro-2-hydr...)
Show SMILES CN(C)c1ccc2C(NS(=O)(=O)c3cccc1c23)c1cc(Cl)cc(Cl)c1O
Show InChI InChI=1S/C19H16Cl2N2O3S/c1-23(2)15-7-6-12-17-11(15)4-3-5-16(17)27(25,26)22-18(12)13-8-10(20)9-14(21)19(13)24/h3-9,18,22,24H,1-2H3
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 380n/an/an/an/a9.837



University of Karachi



Assay Description
Alkaline phosphatase (b-TNAP, c-IAP purchased from Calzyme Laboratories, Inc. USA) inhibition assay of different cyclic sulfonamides was performed us...


Bioorg Chem 71: 10-18 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.008
BindingDB Entry DOI: 10.7270/Q26Q1W36
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222258
PNG
((Z)-4-(2-((E)-4-(2-chlorophenyl)-1-morpholino-2-ox...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccccc2Cl)cc1
Show InChI InChI=1S/C20H21ClN4O4S/c21-18-4-2-1-3-15(18)5-10-19(26)20(25-11-13-29-14-12-25)24-23-16-6-8-17(9-7-16)30(22,27)28/h1-10,23H,11-14H2,(H2,22,27,28)/b10-5+,24-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 120n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222259
PNG
((Z)-4-(2-((E)-4-(2,4-dichlorophenyl)-1-morpholino-...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C20H20Cl2N4O4S/c21-15-3-1-14(18(22)13-15)2-8-19(27)20(26-9-11-30-12-10-26)25-24-16-4-6-17(7-5-16)31(23,28)29/h1-8,13,24H,9-12H2,(H2,23,28,29)/b8-2+,25-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 680n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222260
PNG
((Z)-4-(2-((E)-4-(3-methoxyphenyl)-1-morpholino-2-o...)
Show SMILES COc1cccc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)c1
Show InChI InChI=1S/C21H24N4O5S/c1-29-18-4-2-3-16(15-18)5-10-20(26)21(25-11-13-30-14-12-25)24-23-17-6-8-19(9-7-17)31(22,27)28/h2-10,15,23H,11-14H2,1H3,(H2,22,27,28)/b10-5+,24-21-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 990n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222261
PNG
((Z)-4-(2-((E)-4-(4-methoxyphenyl)-1-morpholino-2-o...)
Show SMILES COc1ccc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)cc1
Show InChI InChI=1S/C21H24N4O5S/c1-29-18-7-2-16(3-8-18)4-11-20(26)21(25-12-14-30-15-13-25)24-23-17-5-9-19(10-6-17)31(22,27)28/h2-11,23H,12-15H2,1H3,(H2,22,27,28)/b11-4+,24-21-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.71E+3n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222262
PNG
((Z)-4-(2-((E)-4-(3,4-dimethoxyphenyl)-1-morpholino...)
Show SMILES COc1ccc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)cc1OC
Show InChI InChI=1S/C22H26N4O6S/c1-30-20-10-4-16(15-21(20)31-2)3-9-19(27)22(26-11-13-32-14-12-26)25-24-17-5-7-18(8-6-17)33(23,28)29/h3-10,15,24H,11-14H2,1-2H3,(H2,23,28,29)/b9-3+,25-22-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 350n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222263
PNG
((Z)-4-(2-((E)-1-morpholino-2-oxo-4-(3,4,5-Trimetho...)
Show SMILES COc1cc(\C=C\C(=O)C(=N\Nc2ccc(cc2)S(N)(=O)=O)\N2CCOCC2)cc(OC)c1OC
Show InChI InChI=1S/C23H28N4O7S/c1-31-20-14-16(15-21(32-2)22(20)33-3)4-9-19(28)23(27-10-12-34-13-11-27)26-25-17-5-7-18(8-6-17)35(24,29)30/h4-9,14-15,25H,10-13H2,1-3H3,(H2,24,29,30)/b9-4+,26-23-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.57E+3n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222264
PNG
((Z)-4-(2-((E)-4-(2-fluorophenyl)-1-morpholino-2-ox...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccccc2F)cc1
Show InChI InChI=1S/C20H21FN4O4S/c21-18-4-2-1-3-15(18)5-10-19(26)20(25-11-13-29-14-12-25)24-23-16-6-8-17(9-7-16)30(22,27)28/h1-10,23H,11-14H2,(H2,22,27,28)/b10-5+,24-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 440n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222265
PNG
((Z)-4-(2-((E)-4-(3-fluorophenyl)-1-morpholino-2-ox...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2cccc(F)c2)cc1
Show InChI InChI=1S/C20H21FN4O4S/c21-16-3-1-2-15(14-16)4-9-19(26)20(25-10-12-29-13-11-25)24-23-17-5-7-18(8-6-17)30(22,27)28/h1-9,14,23H,10-13H2,(H2,22,27,28)/b9-4+,24-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 730n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222266
PNG
((Z)-4-(2-((E)-4-(2-bromophenyl)-1-morpholino-2-oxo...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2ccccc2Br)cc1
Show InChI InChI=1S/C20H21BrN4O4S/c21-18-4-2-1-3-15(18)5-10-19(26)20(25-11-13-29-14-12-25)24-23-16-6-8-17(9-7-16)30(22,27)28/h1-10,23H,11-14H2,(H2,22,27,28)/b10-5+,24-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.21E+3n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM222267
PNG
((Z)-4-(2-((E)-1-morpholino-4-(3-Nitrophenyl)-2-oxo...)
Show SMILES NS(=O)(=O)c1ccc(N\N=C(/N2CCOCC2)C(=O)\C=C\c2cccc(c2)[N+]([O-])=O)cc1
Show InChI InChI=1S/C20H21N5O6S/c21-32(29,30)18-7-5-16(6-8-18)22-23-20(24-10-12-31-13-11-24)19(26)9-4-15-2-1-3-17(14-15)25(27)28/h1-9,14,22H,10-13H2,(H2,21,29,30)/b9-4+,23-20-
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 740n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM18073
PNG
((2S)-2-amino-3-phenylpropanoic acid | CHEMBL301523...)
Show SMILES N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C9H11NO2/c10-8(9(11)12)6-7-4-2-1-3-5-7/h1-5,8H,6,10H2,(H,11,12)/t8-/m0/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
UniChem

Similars

Article
PubMed
n/an/a 8.02E+4n/an/an/an/a9.837



COMSATS Institute of Information Technology



Assay Description
Alkaline phosphatase assay was optimized and performed in the same way as previously reported method with slight modifications [Sergienko et al., Nat...


Bioorg Chem 70: 229-236 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.003
BindingDB Entry DOI: 10.7270/Q2K07334
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223071
PNG
((E)-N'-(4'-Chlorobenzylidene)isonicotinohy...)
Show SMILES Clc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C13H10ClN3O/c14-12-3-1-10(2-4-12)9-16-17-13(18)11-5-7-15-8-6-11/h1-9H,(H,17,18)/b16-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 670n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM223072
PNG
((E)-N'-(4'-Bromobenzylidene)isonicotinohyd...)
Show SMILES Brc1ccc(\C=N\NC(=O)c2ccncc2)cc1
Show InChI InChI=1S/C13H10BrN3O/c14-12-3-1-10(2-4-12)9-16-17-13(18)11-5-7-15-8-6-11/h1-9H,(H,17,18)/b16-9+
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 9.72E+3n/an/an/an/a9.837



Quaid-I-Azam University



Assay Description
The assay conditions were optimized with some changes in formerly reported spectrophotometric method. The composition of assay buffer of pH 9.8 was a...


Chem Biol Drug Des 89: 365-370 (2017)


Article DOI: 10.1111/cbdd.12861
BindingDB Entry DOI: 10.7270/Q2F47N10
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50150070
PNG
(CHEMBL3774470)
Show SMILES C1C(N=C2SC=CN12)c1cc2ccccc2o1
Show InChI InChI=1S/C13H10N2OS/c1-2-4-11-9(3-1)7-12(16-11)10-8-15-5-6-17-13(15)14-10/h1-7,10H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a10.4n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50150089
PNG
(CHEMBL3774723)
Show SMILES N=c1sccn1CC(=O)c1cc2ccccc2o1
Show InChI InChI=1S/C13H10N2O2S/c14-13-15(5-6-18-13)8-10(16)12-7-9-3-1-2-4-11(9)17-12/h1-7,14H,8H2
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a10.4n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair
Intestinal alkaline phosphatase (IAP)


(Bos taurus (Cattle))
BDBM50241179
PNG
((S)-6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b]thiaz...)
Show SMILES C1CN2C[C@@H](N=C2S1)c1ccccc1
Show InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10/h1-5,10H,6-8H2/t10-/m1/s1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
DrugBank
KEGG
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a>4.00E+5n/an/an/an/a10.4n/a



Universit£ de Lyon

Curated by ChEMBL


Assay Description
Inhibition of bovine intestinal alkaline phosphatase using para-nitrophenylphosphate as substrate preincubated for 10 mins at pH 10.4 followed by sub...


Bioorg Med Chem Lett 26: 1457-9 (2016)


Article DOI: 10.1016/j.bmcl.2016.01.061
BindingDB Entry DOI: 10.7270/Q23N2572
More data for this
Ligand-Target Pair