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Compile Data Set for Download or QSAR

Found 69 hits of ph data with Target = 'JAK2 (aa 831-1132)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264177
PNG
((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264178
PNG
((2R)-2-[(3R)-3,4- dimethylpiperazin-1-yl]-N- (3-{5...)
Show SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12
PDB

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n/an/a 1.28E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264179
PNG
((2R)-N-(3-{5-fluoro-2- [(3-methoxy-1-methyl- 1H-py...)
Show SMILES COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F
PDB

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n/an/a 2.68E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264180
PNG
((2R)-2-(4-ethylpiperazin- 1-yl)-N-(3-{5-fluoro-2- ...)
Show SMILES CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1F
PDB

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n/an/a 6.57E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264181
PNG
((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Show SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12
PDB

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n/an/a 1.04E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264182
PNG
((2R)-2-[(2R)-3,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Show SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12
PDB

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n/an/a 9.62E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264183
PNG
((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Show SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264184
PNG
((2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{5...)
Show SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264185
PNG
((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12
PDB

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US Patent
n/an/a 2.36E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264186
PNG
((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264187
PNG
((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264188
PNG
((2S)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)C[C@@H]3C)cccc12
PDB

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US Patent
n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264189
PNG
((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12
PDB

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PC cid
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US Patent
n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264190
PNG
((2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12
PDB

GoogleScholar
PC cid
PC sid
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US Patent
n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264191
PNG
((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12
PDB

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US Patent
n/an/a 2.26E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264192
PNG
((2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12
PDB

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PC cid
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US Patent
n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264193
PNG
((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12
PDB

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n/an/a 6.39E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264194
PNG
((2R)-2-[4-(2- hydroxyethyl)piperazin- 1-yl]-N-(3-{...)
Show SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCO)CC3)cccc12
PDB

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US Patent
n/an/a 2.53E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264195
PNG
((2R)-2-(4-ethylpiperazin- 1-yl)-N-(3- {2-[(3-metho...)
Show SMILES CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C
PDB

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n/an/a 6.24E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264196
PNG
((2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{...)
Show SMILES COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C
PDB

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US Patent
n/an/a 1.81E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264197
PNG
((2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12
PDB

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US Patent
n/an/a 1.73E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264198
PNG
((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264199
PNG
((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CC)CC3)cccc12
PDB

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n/an/a 1.72E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264200
PNG
((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(CCOC)CC3)cccc12
PDB

GoogleScholar
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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264201
PNG
((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264202
PNG
((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12
PDB

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PC cid
PC sid
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US Patent
n/an/a 2.57E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264203
PNG
((2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264204
PNG
((2R)-N-(3-{5-Fluoro- 2-[(3-methoxy-1- methyl-1H-py...)
Show SMILES COc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a 6.62E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264205
PNG
((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12
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n/an/a 1.67E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264206
PNG
((2R)-2-[4-(2- methoxyethyl)piperazin- 1-yl]-N-(3-{...)
Show SMILES COCCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264207
PNG
((2R)-2-(4- ethylpiperidin-1-yl)-N-(3- {2-[(3-metho...)
Show SMILES CCN1CCN(CC1)[C@H](C)C(=O)Nc1cccc2c(c[nH]c12)-c1ccnc(Nc2cn(C)nc2OC)n1
PDB

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n/an/a 1.18E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264208
PNG
((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12
PDB

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n/an/a 2.04E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264209
PNG
((2R)-2-[(3R)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@H](C)C3)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264210
PNG
((2R)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)[C@@H](C)C3)cccc12
PDB

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n/an/a 1.98E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264211
PNG
((2S)-2-[(3S)-3,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)[C@@H](C)C3)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264212
PNG
((2R)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...)
Show SMILES COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a>1.47E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264213
PNG
((2S)-N-(3-{2-[(3- methoxy-1-methyl- 1H-pyrazol-4-y...)
Show SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264214
PNG
((2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)
Show SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a 5.37E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264215
PNG
((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a 1.70E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264216
PNG
((2R)-N-(3-{5-chloro- 2-[(3-methoxy-1- methyl-1H-py...)
Show SMILES COc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a 1.76E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264217
PNG
((2R)-N-(3-{5-bromo- 2-[(3-methoxy-1- methyl-1H-pyr...)
Show SMILES COc1nn(C)cc1Nc1ncc(Br)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a 1.58E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264218
PNG
((2R)-2-[(2R)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)
Show SMILES COc1nn(C)cc1Nc1ncc(C)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@H]3C)cccc12
PDB

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n/an/a 6.48E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264219
PNG
((2R)-N-(3-{2-[(3- ethoxy-1-methyl-1H- pyrazol-4-yl...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(F)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a 2.55E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264220
PNG
((2R)-N-(3-{5-chloro- 2-[(3-ethoxy-1- methyl-1H-pyr...)
Show SMILES CCOc1nn(C)cc1Nc1ncc(Cl)c(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)CC3)cccc12
PDB

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n/an/a 8.93E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264221
PNG
((2R)-N-(3-{2-[(1,3- dimethyl-1H-pyrazol- 4-yl)amin...)
Show SMILES C[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C
PDB

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n/an/a 2.58E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264222
PNG
((2S)-N-(3-{2- [(1,3-dimethyl-1H- pyrazol-4-yl)amin...)
Show SMILES C[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2C)ncc1C
PDB

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n/an/a 2.11E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264223
PNG
((2S)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)
Show SMILES CC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C
PDB

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n/an/a 2.11E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264224
PNG
((2R)-N-(3-{2-[(3- Methoxy-1-methyl- 1H-pyrazol-4-y...)
Show SMILES CC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C
PDB

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n/an/a 1.95E+3n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264225
PNG
((2R)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)
Show SMILES COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C
PDB

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n/an/a 790n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
JAK2 (aa 831-1132)


(Homo sapiens (Human))
BDBM264226
PNG
((2S)-3-methoxy-N- (3-{2-[(3-methoxy- 1-methyl-1H-p...)
Show SMILES COC[C@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cn(C)nc2OC)ncc1C
PDB

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n/an/a>3.00E+4n/an/an/an/a7.3n/a



AstraZeneca AB

US Patent


Assay Description
Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...


US Patent US9714236 (2017)


BindingDB Entry DOI: 10.7270/Q2VQ34PC
More data for this
Ligand-Target Pair
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