Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM50355501![]() (INCB-018424 | RUXOLITINIB | RUXOLITINIB PHOSPHATE ...) | PDB GoogleScholar | Purchase CHEBI DrugBank PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 200 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM50021655![]() (DECERNOTINIB | US10112907, Example 00017 | VRT-831...) | PDB GoogleScholar | Purchase PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 10 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM50332294![]() (CHEMBL1287853 | N-tert-butyl-3-(5-methyl-2-(4-(2-(...) | PDB GoogleScholar | Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents | US Patent | n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM50311017![]() (CHEMBL1078178 | Momelotinib | N-(cyanomethyl)-4-(2...) | PDB GoogleScholar | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | US Patent | n/a | n/a | 210 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM294911![]() (US10112907, Example 00020) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM294912![]() (US10112907, Example 00021) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM50193995![]() (3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...) | PDB GoogleScholar | Purchase CHEBI CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars | PDB US Patent | n/a | n/a | 20 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM147692![]() (US10112907, Example 00025 | US8962608, 28-1) | PDB GoogleScholar | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM294915![]() (US10112907, Example 00026) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM294916![]() (US10112907, Example 00027 | US10206907, Compound 1...) | PDB GoogleScholar | PC cid PC sid UniChem | US Patent | n/a | n/a | 380 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM103727![]() (US10112907, Example 00033 | US10206907, Compound 2...) | PDB GoogleScholar | Purchase PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 9.40E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM50021656![]() (BARICITINIB | INCB-028050 | LY-3009104 | US1011290...) | PDB GoogleScholar | Purchase PC cid PC sid PDB UniChem | US Patent | n/a | n/a | 250 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 811-1124) (Homo sapiens (Human)) | BDBM50402074![]() (CHEMBL2206059 | US10112907, Example 00024) | PDB GoogleScholar | CHEMBL MMDB PC cid PC sid PDB UniChem Similars | US Patent | n/a | n/a | 950 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Novartis AG US Patent | Assay Description A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for recombinant human Jak1 (aa 866-1154), Jak2 (aa808-1132), J... | US Patent US10112907 (2018) BindingDB Entry DOI: 10.7270/Q2FX7CHW | |||||||||||
More data for this Ligand-Target Pair |