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Compile Data Set for Download or QSAR

Found 38 hits of ph data with Target = 'Kallikrein-1 (KLK1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162367
PNG
(US9687479, 4 3-(5-[(5-chlorothiophen-2-yl)methyl]a...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccoc2)-c2ccc[nH]c2=O)s1
Show InChI InChI=1S/C18H13ClN4O3S/c19-15-4-3-12(27-15)9-21-16-8-14(13-2-1-6-20-17(13)24)22-23(16)18(25)11-5-7-26-10-11/h1-8,10,21H,9H2,(H,20,24)
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US Patent
n/an/a 5.50E+4n/an/an/an/a7.537



VERSEON CORPORATION

US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM164185
PNG
(US9687479, 402 N-benzyl-1-[(furan-3-yl)carbonyl]-3...)
Show SMILES O=C(c1ccoc1)n1nc(nc1NCc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C19H15N5O2/c25-18(16-8-11-26-13-16)24-19(21-12-14-4-2-1-3-5-14)22-17(23-24)15-6-9-20-10-7-15/h1-11,13H,12H2,(H,21,22,23)
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n/an/a>1.00E+5n/an/an/an/a7.537



VERSEON CORPORATION

US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162371
PNG
(US9687479, 25 3-(5-[(5-chlorothiophen-2-yl)methyl]...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccoc2)-c2cccn(Cc3ccccn3)c2=O)s1
Show InChI InChI=1S/C24H18ClN5O3S/c25-21-7-6-18(34-21)13-27-22-12-20(28-30(22)23(31)16-8-11-33-15-16)19-5-3-10-29(24(19)32)14-17-4-1-2-9-26-17/h1-12,15,27H,13-14H2
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n/an/a 5.50E+4n/an/an/an/a7.537



VERSEON CORPORATION

US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162372
PNG
(US9687479, 26 3-(5-[(5-chlorothiophen-2-yl)methyl]...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccoc2)-c2cccn(Cc3ccco3)c2=O)s1
Show InChI InChI=1S/C23H17ClN4O4S/c24-20-6-5-17(33-20)12-25-21-11-19(26-28(21)22(29)15-7-10-31-14-15)18-4-1-8-27(23(18)30)13-16-3-2-9-32-16/h1-11,14,25H,12-13H2
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n/an/a 5.50E+4n/an/an/an/a7.537



VERSEON CORPORATION

US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162579
PNG
(US9687479, 59 2-[3-(5-[(5-chlorothiophen-2-yl)meth...)
Show SMILES OC(=O)n1cccc(-c2cc(NCc3ccc(Cl)s3)nn2)c1=O
Show InChI InChI=1S/C14H10ClN4O3S/c15-11-4-3-8(23-11)7-16-12-6-10(17-18-12)9-2-1-5-19(13(9)20)14(21)22/h1-6H,7H2,(H,16,18)(H,21,22)
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162601
PNG
(US9687479, 81 3-(5-[(5-chlorothiophen-2-yl)methyl]...)
Show SMILES CC(C)(C)C(=O)n1nc(cc1NCc1ccc(Cl)s1)-c1cccn(Cc2cccnn2)c1=O
Show InChI InChI=1S/C23H23ClN6O2S/c1-23(2,3)22(32)30-20(25-13-16-8-9-19(24)33-16)12-18(28-30)17-7-5-11-29(21(17)31)14-15-6-4-10-26-27-15/h4-12,25H,13-14H2,1-3H3
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n/an/a>1.00E+5n/an/an/an/a7.537



VERSEON CORPORATION

US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162633
PNG
(US9687479, 113 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2cccc3OCCOc23)-c2cccn(Cc3ccccn3)c2=O)s1
Show InChI InChI=1S/C28H22ClN5O4S/c29-24-10-9-19(39-24)16-31-25-15-22(20-7-4-12-33(27(20)35)17-18-5-1-2-11-30-18)32-34(25)28(36)21-6-3-8-23-26(21)38-14-13-37-23/h1-12,15,31H,13-14,16-17H2
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n/an/a 5.50E+4n/an/an/an/a7.537



VERSEON CORPORATION

US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162646
PNG
(US9687479, 126 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Show SMILES COc1ccc(C(=O)n2nc(cc2NCc2ccc(Cl)s2)-c2cccn(Cc3cccnc3)c2=O)c(OC)c1
Show InChI InChI=1S/C28H24ClN5O4S/c1-37-19-7-9-22(24(13-19)38-2)28(36)34-26(31-16-20-8-10-25(29)39-20)14-23(32-34)21-6-4-12-33(27(21)35)17-18-5-3-11-30-15-18/h3-15,31H,16-17H2,1-2H3
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n/an/a>1.00E+5n/an/an/an/a7.537



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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162652
PNG
(US9687479, 132 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Show SMILES COc1ccccc1C(=O)n1nc(cc1NCc1ccc(Cl)s1)-c1cccnc1=O
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n/an/a>1.00E+5n/an/an/an/a7.537



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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162658
PNG
(US9687479, 138 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Show SMILES COc1ccccc1C(=O)n1nc(cc1NCc1ccc(Cl)s1)-c1cccn(Cc2cccnn2)c1=O
Show InChI InChI=1S/C26H21ClN6O3S/c1-36-22-9-3-2-7-20(22)26(35)33-24(28-15-18-10-11-23(27)37-18)14-21(31-33)19-8-5-13-32(25(19)34)16-17-6-4-12-29-30-17/h2-14,28H,15-16H2,1H3
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162665
PNG
(US9687479, 145 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Show SMILES COc1ccccc1C(=O)n1nc(cc1NCc1ccc(Cl)s1)-c1cccn(CC(=O)N2CCOCC2)c1=O
Show InChI InChI=1S/C27H26ClN5O5S/c1-37-22-7-3-2-5-20(22)27(36)33-24(29-16-18-8-9-23(28)39-18)15-21(30-33)19-6-4-10-32(26(19)35)17-25(34)31-11-13-38-14-12-31/h2-10,15,29H,11-14,16-17H2,1H3
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162669
PNG
(US9687479, 149 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Show SMILES COCCn1cccc(-c2cc(NCc3ccc(Cl)s3)n(n2)C(=O)C2(C)CCOCC2)c1=O
Show InChI InChI=1S/C23H27ClN4O4S/c1-23(7-11-32-12-8-23)22(30)28-20(25-15-16-5-6-19(24)33-16)14-18(26-28)17-4-3-9-27(21(17)29)10-13-31-2/h3-6,9,14,25H,7-8,10-13,15H2,1-2H3
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163297
PNG
(US9687479, 213 3-(5-[(5-chlorothiophen-2-yl)methyl...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccc(cc2)N2CCOCC2)-c2cccn(Cc3cccnc3)c2=O)s1
Show InChI InChI=1S/C30H27ClN6O3S/c31-27-10-9-24(41-27)19-33-28-17-26(25-4-2-12-36(30(25)39)20-21-3-1-11-32-18-21)34-37(28)29(38)22-5-7-23(8-6-22)35-13-15-40-16-14-35/h1-12,17-18,33H,13-16,19-20H2
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163338
PNG
(US9687479, 242 3-1-[(2-chlorophenyl)carbonyl]-5-[(...)
Show SMILES COCCn1cccc(-c2cc(NCc3ccc(Cl)s3)n(n2)C(=O)c2ccccc2Cl)c1=O
Show InChI InChI=1S/C23H20Cl2N4O3S/c1-32-12-11-28-10-4-6-17(22(28)30)19-13-21(26-14-15-8-9-20(25)33-15)29(27-19)23(31)16-5-2-3-7-18(16)24/h2-10,13,26H,11-12,14H2,1H3
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VERSEON CORPORATION

US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163346
PNG
(US9687479, 247 3-1-[(2-chlorophenyl)carbonyl]-5-[(...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccccc2Cl)-c2cccn(Cc3cccnc3)c2=O)s1
Show InChI InChI=1S/C26H19Cl2N5O2S/c27-21-8-2-1-6-19(21)26(35)33-24(30-15-18-9-10-23(28)36-18)13-22(31-33)20-7-4-12-32(25(20)34)16-17-5-3-11-29-14-17/h1-14,30H,15-16H2
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163348
PNG
(US9687479, 248 3-1-[(2-chlorophenyl)carbonyl]-5-[(...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccccc2Cl)-c2cccn(Cc3ccncc3)c2=O)s1
Show InChI InChI=1S/C26H19Cl2N5O2S/c27-21-6-2-1-4-19(21)26(35)33-24(30-15-18-7-8-23(28)36-18)14-22(31-33)20-5-3-13-32(25(20)34)16-17-9-11-29-12-10-17/h1-14,30H,15-16H2
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163403
PNG
(US9687479, 276 1-[(2-aminophenyl)carbonyl]-N-[(5-c...)
Show SMILES Nc1ccccc1C(=O)n1nc(c(F)c1NCc1ccc(Cl)s1)-c1ncccc1F
Show InChI InChI=1S/C20H14ClF2N5OS/c21-15-8-7-11(30-15)10-26-19-16(23)18(17-13(22)5-3-9-25-17)27-28(19)20(29)12-4-1-2-6-14(12)24/h1-9,26H,10,24H2
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163404
PNG
(US9687479, 277 1-[(2-aminophenyl)carbonyl]-N-[(5-c...)
Show SMILES Nc1ccccc1C(=O)n1nc(c(F)c1NCc1ccc(Cl)s1)-c1ccco1
Show InChI InChI=1S/C19H14ClFN4O2S/c20-15-8-7-11(28-15)10-23-18-16(21)17(14-6-3-9-27-14)24-25(18)19(26)12-4-1-2-5-13(12)22/h1-9,23H,10,22H2
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163414
PNG
(US9687479, 282 2-(5-[(5-chlorothiophen-2-yl)methyl...)
Show SMILES COc1ccccc1C(=O)n1nc(cc1NCc1ccc(Cl)s1)C1CCCCC1O
Show InChI InChI=1S/C22H24ClN3O3S/c1-29-19-9-5-3-7-16(19)22(28)26-21(24-13-14-10-11-20(23)30-14)12-17(25-26)15-6-2-4-8-18(15)27/h3,5,7,9-12,15,18,24,27H,2,4,6,8,13H2,1H3
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163407
PNG
(US9687479, 278 1-[(2-methoxyphenyl)carbonyl]-3-(py...)
Show SMILES COc1ccccc1C(=O)n1nc(cc1NCc1ccc(Cl)s1)-c1ccccn1
Show InChI InChI=1S/C21H17ClN4O2S/c1-28-18-8-3-2-6-15(18)21(27)26-20(24-13-14-9-10-19(22)29-14)12-17(25-26)16-7-4-5-11-23-16/h2-12,24H,13H2,1H3
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163425
PNG
(US9687479, 292 N-[(5-chlorothiophen-2-yl)methyl]-3...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccoc2)-c2cccnn2)s1
Show InChI InChI=1S/C17H12ClN5O2S/c18-15-4-3-12(26-15)9-19-16-8-14(13-2-1-6-20-21-13)22-23(16)17(24)11-5-7-25-10-11/h1-8,10,19H,9H2
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163421
PNG
(US9687479, 288 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Show SMILES Clc1ccc(CNc2cc(nn2C(=O)c2ccoc2)-c2ccccn2)s1
Show InChI InChI=1S/C18H13ClN4O2S/c19-16-5-4-13(26-16)10-21-17-9-15(14-3-1-2-7-20-14)22-23(17)18(24)12-6-8-25-11-12/h1-9,11,21H,10H2
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163427
PNG
(US9687479, 294 N-[(5-chlorothiophen-2-yl)methyl]-4...)
Show SMILES Fc1c(NCc2ccc(Cl)s2)n(nc1C1CCOCC1)C(=O)c1ccoc1
Show InChI InChI=1S/C18H17ClFN3O3S/c19-14-2-1-13(27-14)9-21-17-15(20)16(11-3-6-25-7-4-11)22-23(17)18(24)12-5-8-26-10-12/h1-2,5,8,10-11,21H,3-4,6-7,9H2
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163475
PNG
(US9687479, 15 1-[(2-methoxyphenyl)carbonyl]-5-(met...)
Show SMILES COc1ccccc1C(=O)n1nc(nc1SC)-c1cccs1
Show InChI InChI=1S/C15H13N3O2S2/c1-20-11-7-4-3-6-10(11)14(19)18-15(21-2)16-13(17-18)12-8-5-9-22-12/h3-9H,1-2H3
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163478
PNG
(US9687479, 18 N-benzyl-1-[(2-methoxyphenyl)carbony...)
Show SMILES COc1ccccc1C(=O)n1nc(nc1NCc1ccccc1)-c1ncccn1
Show InChI InChI=1S/C21H18N6O2/c1-29-17-11-6-5-10-16(17)20(28)27-21(24-14-15-8-3-2-4-9-15)25-19(26-27)18-22-12-7-13-23-18/h2-13H,14H2,1H3,(H,24,25,26)
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163508
PNG
(US9687479, 22 N-[(5-chlorothiophen-2-yl)methyl]-1-...)
Show SMILES COc1ccccc1C(=O)n1nc(nc1NCc1ccc(Cl)s1)-c1ccccn1
Show InChI InChI=1S/C20H16ClN5O2S/c1-28-16-8-3-2-6-14(16)19(27)26-20(23-12-13-9-10-17(21)29-13)24-18(25-26)15-7-4-5-11-22-15/h2-11H,12H2,1H3,(H,23,24,25)
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163544
PNG
(US9687479, 323 1-(5-[(4-methoxyphenyl)methyl]amino...)
Show SMILES COc1ccc(CNc2nc(nn2C(=O)CCc2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C24H23N5O2/c1-31-20-13-10-19(11-14-20)17-26-24-27-23(21-9-5-6-16-25-21)28-29(24)22(30)15-12-18-7-3-2-4-8-18/h2-11,13-14,16H,12,15,17H2,1H3,(H,26,27,28)
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163554
PNG
(US9687479, 332 1-[(2-methoxyphenyl)carbonyl]-3-(py...)
Show SMILES COc1ccccc1C(=O)n1nc(nc1NCc1nccs1)-c1ccccn1
Show InChI InChI=1S/C19H16N6O2S/c1-27-15-8-3-2-6-13(15)18(26)25-19(22-12-16-21-10-11-28-16)23-17(24-25)14-7-4-5-9-20-14/h2-11H,12H2,1H3,(H,22,23,24)
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163592
PNG
(US9687479, 358 1-benzoyl-N-[(4-fluorophenyl)methyl...)
Show SMILES Fc1ccc(CNc2nc(nn2C(=O)c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C21H16FN5O/c22-17-11-9-15(10-12-17)14-24-21-25-19(18-8-4-5-13-23-18)26-27(21)20(28)16-6-2-1-3-7-16/h1-13H,14H2,(H,24,25,26)
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163595
PNG
(US9687479, 360 1-benzoyl-N-[(4-methoxyphenyl)methy...)
Show SMILES COc1ccc(CNc2nc(nn2C(=O)c2ccccc2)-c2ccccn2)cc1
Show InChI InChI=1S/C22H19N5O2/c1-29-18-12-10-16(11-13-18)15-24-22-25-20(19-9-5-6-14-23-19)26-27(22)21(28)17-7-3-2-4-8-17/h2-14H,15H2,1H3,(H,24,25,26)
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163596
PNG
(US9687479, 361 1-benzoyl-N-[(4-methoxyphenyl)methy...)
Show SMILES COc1ccc(CNc2nc(nn2C(=O)c2ccccc2)-c2cccnc2)cc1
Show InChI InChI=1S/C22H19N5O2/c1-29-19-11-9-16(10-12-19)14-24-22-25-20(18-8-5-13-23-15-18)26-27(22)21(28)17-6-3-2-4-7-17/h2-13,15H,14H2,1H3,(H,24,25,26)
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163597
PNG
(US9687479, 362 1-benzoyl-N-benzyl-3-(pyridin-2-yl)...)
Show SMILES O=C(c1ccccc1)n1nc(nc1NCc1ccccc1)-c1ccccn1
Show InChI InChI=1S/C21H17N5O/c27-20(17-11-5-2-6-12-17)26-21(23-15-16-9-3-1-4-10-16)24-19(25-26)18-13-7-8-14-22-18/h1-14H,15H2,(H,23,24,25)
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163601
PNG
(US9687479, 366 3-1-[(2-methoxyphenyl)carbonyl]-5-(...)
Show SMILES COc1ccccc1C(=O)n1nc(nc1SC)-c1cccnc1
Show InChI InChI=1S/C16H14N4O2S/c1-22-13-8-4-3-7-12(13)15(21)20-16(23-2)18-14(19-20)11-6-5-9-17-10-11/h3-10H,1-2H3
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM164104
PNG
(US9687479, 384 N-[(5-chlorothiophen-2-yl)methyl]-1...)
Show SMILES COc1ccc(C(=O)n2nc(nc2NCc2ccc(Cl)s2)C2CCOCC2)c(OC)c1
Show InChI InChI=1S/C21H23ClN4O4S/c1-28-14-3-5-16(17(11-14)29-2)20(27)26-21(23-12-15-4-6-18(22)31-15)24-19(25-26)13-7-9-30-10-8-13/h3-6,11,13H,7-10,12H2,1-2H3,(H,23,24,25)
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM164103
PNG
(US9687479, 383 N-[(5-chlorofuran-2-yl)methyl]-1-[(...)
Show SMILES COc1ccccc1C(=O)n1nc(nc1NCc1ccc(Cl)s1)-c1ccccc1
Show InChI InChI=1S/C21H17ClN4O2S/c1-28-17-10-6-5-9-16(17)20(27)26-21(23-13-15-11-12-18(22)29-15)24-19(25-26)14-7-3-2-4-8-14/h2-12H,13H2,1H3,(H,23,24,25)
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US Patent


Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM163508
PNG
(US9687479, 22 N-[(5-chlorothiophen-2-yl)methyl]-1-...)
Show SMILES COc1ccccc1C(=O)n1nc(nc1NCc1ccc(Cl)s1)-c1ccccn1
Show InChI InChI=1S/C20H16ClN5O2S/c1-28-16-8-3-2-6-14(16)19(27)26-20(23-12-13-9-10-17(21)29-13)24-18(25-26)15-7-4-5-11-22-15/h2-11H,12H2,1H3,(H,23,24,25)
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM164176
PNG
(US9687479, 393 N-[(5-chlorothiophen-2-yl)methyl]-3...)
Show SMILES COc1ccccc1C(=O)n1nc(nc1NCc1ccc(Cl)s1)-c1ccc(cc1)N(C)C
Show InChI InChI=1S/C23H22ClN5O2S/c1-28(2)16-10-8-15(9-11-16)21-26-23(25-14-17-12-13-20(24)32-17)29(27-21)22(30)18-6-4-5-7-19(18)31-3/h4-13H,14H2,1-3H3,(H,25,26,27)
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair
Kallikrein-1 (KLK1)


(Homo sapiens (Human))
BDBM162370
PNG
(US9687479, 23 3-(5-[(5-chlorothiophen-2-yl)methyl]...)
Show SMILES Cn1cccc(-c2cc(NCc3ccc(Cl)s3)n(n2)C(=O)c2ccoc2)c1=O
Show InChI InChI=1S/C19H15ClN4O3S/c1-23-7-2-3-14(19(23)26)15-9-17(21-10-13-4-5-16(20)28-13)24(22-15)18(25)12-6-8-27-11-12/h2-9,11,21H,10H2,1H3
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Assay Description
Recombinant human tissue kallikrein (KLK1) was obtained from R&D Systems. Pro-Phe-Arg-AMC (I-1295) substrate was obtained from Bachem. KLK1 enzyme is...


US Patent US9687479 (2017)


BindingDB Entry DOI: 10.7270/Q2N29V4R
More data for this
Ligand-Target Pair