BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 83 hits of ph data with Target = 'Kinesin Spindle Protein Eg5'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23772
PNG
((2R)-2-amino-3-[(triphenylmethyl)sulfanyl]propanoi...)
Show SMILES N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccccc1)C(O)=O
Show InChI InChI=1S/C22H21NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-15,20H,16,23H2,(H,24,25)/t20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

PDB
Article
PubMed
50 -41.3n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23777
PNG
((2R)-2-amino-3-[(2-methyl-1,1-diphenylpropyl)sulfa...)
Show SMILES CC(C)C(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H23NO2S/c1-14(2)19(15-9-5-3-6-10-15,16-11-7-4-8-12-16)23-13-17(20)18(21)22/h3-12,14,17H,13,20H2,1-2H3,(H,21,22)/t17-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
150 -38.6n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23778
PNG
((2R)-2-amino-3-[(cyclohexyldiphenylmethyl)sulfanyl...)
Show SMILES N[C@@H](CSC(C1CCCCC1)(c1ccccc1)c1ccccc1)C(O)=O
Show InChI InChI=1S/C22H27NO2S/c23-20(21(24)25)16-26-22(17-10-4-1-5-11-17,18-12-6-2-7-13-18)19-14-8-3-9-15-19/h1-2,4-7,10-13,19-20H,3,8-9,14-16,23H2,(H,24,25)/t20-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
175 -38.2n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23776
PNG
((2R)-2-amino-3-[(1,1-diphenylpentyl)sulfanyl]propa...)
Show SMILES CCCCC(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H25NO2S/c1-2-3-14-20(16-10-6-4-7-11-16,17-12-8-5-9-13-17)24-15-18(21)19(22)23/h4-13,18H,2-3,14-15,21H2,1H3,(H,22,23)/t18-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
175 -38.2n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23781
PNG
((2R)-2-amino-3-[(2H-1,3-benzodioxol-5-yldiphenylme...)
Show SMILES N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccc2OCOc2c1)C(O)=O
Show InChI InChI=1S/C23H21NO4S/c24-19(22(25)26)14-29-23(16-7-3-1-4-8-16,17-9-5-2-6-10-17)18-11-12-20-21(13-18)28-15-27-20/h1-13,19H,14-15,24H2,(H,25,26)/t19-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
200 -37.9n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23780
PNG
((2R)-2-amino-3-[(naphthalen-2-yldiphenylmethyl)sul...)
Show SMILES N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1ccc2ccccc2c1)C(O)=O
Show InChI InChI=1S/C26H23NO2S/c27-24(25(28)29)18-30-26(21-11-3-1-4-12-21,22-13-5-2-6-14-22)23-16-15-19-9-7-8-10-20(19)17-23/h1-17,24H,18,27H2,(H,28,29)/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
200 -37.9n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23775
PNG
((2R)-2-amino-3-[(1,1-diphenylpropyl)sulfanyl]propa...)
Show SMILES CCC(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C18H21NO2S/c1-2-18(14-9-5-3-6-10-14,15-11-7-4-8-12-15)22-13-16(19)17(20)21/h3-12,16H,2,13,19H2,1H3,(H,20,21)/t16-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
450 -35.9n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23774
PNG
((2R)-2-amino-3-[(1,1-diphenylethyl)sulfanyl]propan...)
Show SMILES CC(SC[C@H](N)C(O)=O)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H19NO2S/c1-17(13-8-4-2-5-9-13,14-10-6-3-7-11-14)21-12-15(18)16(19)20/h2-11,15H,12,18H2,1H3,(H,19,20)/t15-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.50E+3 -31.7n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23779
PNG
((2R)-2-amino-3-[(naphthalen-1-yldiphenylmethyl)sul...)
Show SMILES N[C@@H](CSC(c1ccccc1)(c1ccccc1)c1cccc2ccccc12)C(O)=O
Show InChI InChI=1S/C26H23NO2S/c27-24(25(28)29)18-30-26(20-12-3-1-4-13-20,21-14-5-2-6-15-21)23-17-9-11-19-10-7-8-16-22(19)23/h1-17,24H,18,27H2,(H,28,29)/t24-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.00E+3 -30.5n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23799
PNG
(2-amino-3-methyl-3-[(triphenylmethyl)sulfanyl]buta...)
Show SMILES CC(C)(SC(c1ccccc1)(c1ccccc1)c1ccccc1)C(N)C(O)=O
Show InChI InChI=1S/C24H25NO2S/c1-23(2,21(25)22(26)27)28-24(18-12-6-3-7-13-18,19-14-8-4-9-15-19)20-16-10-5-11-17-20/h3-17,21H,25H2,1-2H3,(H,26,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.23E+3 -29.8n/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23791
PNG
(Triphenylmethyl-containing compound, 20 | tripheny...)
Show SMILES SC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H16S/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,20H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23792
PNG
(Triphenylmethyl-containing compound, 21 | [(ethyls...)
Show SMILES CCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20S/c1-2-22-21(18-12-6-3-7-13-18,19-14-8-4-9-15-19)20-16-10-5-11-17-20/h3-17H,2H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23793
PNG
(Triphenylmethyl-containing compound, 22 | [(benzyl...)
Show SMILES C(SC(c1ccccc1)(c1ccccc1)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H22S/c1-5-13-22(14-6-1)21-27-26(23-15-7-2-8-16-23,24-17-9-3-10-18-24)25-19-11-4-12-20-25/h1-20H,21H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23794
PNG
(1-[(triphenylmethyl)sulfanyl]ethan-1-one | Triphen...)
Show SMILES CC(=O)SC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H18OS/c1-17(22)23-21(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23795
PNG
(Triphenylmethyl-containing compound, 24 | {[(2-chl...)
Show SMILES ClCCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H19ClS/c22-16-17-23-21(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15H,16-17H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23796
PNG
(4-[(triphenylmethyl)sulfanyl]butan-2-one | Triphen...)
Show SMILES CC(=O)CCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H22OS/c1-19(24)17-18-25-23(20-11-5-2-6-12-20,21-13-7-3-8-14-21)22-15-9-4-10-16-22/h2-16H,17-18H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23797
PNG
(2-[(triphenylmethyl)sulfanyl]ethan-1-ol | Tripheny...)
Show SMILES OCCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20OS/c22-16-17-23-21(18-10-4-1-5-11-18,19-12-6-2-7-13-19)20-14-8-3-9-15-20/h1-15,22H,16-17H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23798
PNG
(1-methyl-2-[(triphenylmethyl)sulfanyl]benzene | Tr...)
Show SMILES Cc1ccccc1SC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H22S/c1-21-13-11-12-20-25(21)27-26(22-14-5-2-6-15-22,23-16-7-3-8-17-23)24-18-9-4-10-19-24/h2-20H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23800
PNG
(Triphenylmethyl-containing compound, 29 | methyl 2...)
Show SMILES COC(=O)CSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C22H20O2S/c1-24-21(23)17-25-22(18-11-5-2-6-12-18,19-13-7-3-8-14-19)20-15-9-4-10-16-20/h2-16H,17H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23790
PNG
(4-(triphenylmethyl)aniline | Triphenylmethyl-conta...)
Show SMILES Nc1ccc(cc1)C(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C25H21N/c26-24-18-16-23(17-19-24)25(20-10-4-1-5-11-20,21-12-6-2-7-13-21)22-14-8-3-9-15-22/h1-19H,26H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23789
PNG
(2-methyl-4,4,4-triphenylbutan-2-ol | Triphenylmeth...)
Show SMILES CC(C)(O)CC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H24O/c1-22(2,24)18-23(19-12-6-3-7-13-19,20-14-8-4-9-15-20)21-16-10-5-11-17-21/h3-17,24H,18H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23788
PNG
((1,1-diphenylpropyl)benzene | Triphenylmethyl-cont...)
Show SMILES CCC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H20/c1-2-21(18-12-6-3-7-13-18,19-14-8-4-9-15-19)20-16-10-5-11-17-20/h3-17H,2H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23787
PNG
((1,1-diphenylethyl)benzene | Triphenylmethyl-conta...)
Show SMILES CC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H18/c1-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19/h2-16H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23786
PNG
(Triphenylmethyl-containing compound, 15 | tripheny...)
Show SMILES NC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H17N/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H,20H2
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23785
PNG
((methoxydiphenylmethyl)benzene | Triphenylmethyl-c...)
Show SMILES COC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H18O/c1-21-20(17-11-5-2-6-12-17,18-13-7-3-8-14-18)19-15-9-4-10-16-19/h2-16H,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23784
PNG
(CHEMBL118166 | Triphenylmethyl-containing compound...)
Show SMILES OC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H16O/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,20H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23783
PNG
((bromodiphenylmethyl)benzene | Triphenylmethyl-con...)
Show SMILES BrC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H15Br/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23782
PNG
((chlorodiphenylmethyl)benzene | Triphenylmethyl-co...)
Show SMILES ClC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C19H15Cl/c20-19(16-10-4-1-5-11-16,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15H
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23801
PNG
(Triphenylmethyl-containing compound, 30 | methyl 3...)
Show SMILES COC(=O)CCSC(c1ccccc1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C23H22O2S/c1-25-22(24)17-18-26-23(19-11-5-2-6-12-19,20-13-7-3-8-14-20)21-15-9-4-10-16-21/h2-16H,17-18H2,1H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM23773
PNG
((2R)-2-amino-3-[(diphenylmethyl)sulfanyl]propanoic...)
Show SMILES N[C@@H](CSC(c1ccccc1)c1ccccc1)C(O)=O
Show InChI InChI=1S/C16H17NO2S/c17-14(16(18)19)11-20-15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14-15H,11,17H2,(H,18,19)/t14-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/an/an/an/an/a6.922



Institut de Biologie Structurale



Assay Description
The microtubule-activated ATPase rates were measured using the pyruvate kinase/lactate dehydrogenase-linked assay. To optimize the signal for basal E...


J Med Chem 51: 1115-25 (2008)


Article DOI: 10.1021/jm070606z
BindingDB Entry DOI: 10.7270/Q2DJ5CXD
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24105
PNG
(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoli...)
Show SMILES Cc1ccc2C(CNCc2c1C)c1ccccc1
Show InChI InChI=1S/C17H19N/c1-12-8-9-15-16(13(12)2)10-18-11-17(15)14-6-4-3-5-7-14/h3-9,17-18H,10-11H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.33E+3n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24106
PNG
(2,7,8-trimethyl-4-phenyl-1,2,3,4-tetrahydroisoquin...)
Show SMILES CN1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C18H21N/c1-13-9-10-16-17(14(13)2)11-19(3)12-18(16)15-7-5-4-6-8-15/h4-10,18H,11-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.84E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24107
PNG
(2-ethyl-7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydrois...)
Show SMILES CCN1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C19H23N/c1-4-20-12-18-15(3)14(2)10-11-17(18)19(13-20)16-8-6-5-7-9-16/h5-11,19H,4,12-13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.52E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24108
PNG
(7,8-dimethyl-4-phenyl-2-(propan-2-yl)-1,2,3,4-tetr...)
Show SMILES CC(C)N1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C20H25N/c1-14(2)21-12-19-16(4)15(3)10-11-18(19)20(13-21)17-8-6-5-7-9-17/h5-11,14,20H,12-13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.10E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24109
PNG
(7,8-dimethyl-4-phenyl-2-(2-phenylethyl)-1,2,3,4-te...)
Show SMILES Cc1ccc2C(CN(CCc3ccccc3)Cc2c1C)c1ccccc1
Show InChI InChI=1S/C25H27N/c1-19-13-14-23-24(20(19)2)17-26(16-15-21-9-5-3-6-10-21)18-25(23)22-11-7-4-8-12-22/h3-14,25H,15-18H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24110
PNG
(2-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquin...)
Show SMILES Cc1ccc2C(CN(CCN)Cc2c1C)c1ccccc1
Show InChI InChI=1S/C19H24N2/c1-14-8-9-17-18(15(14)2)12-21(11-10-20)13-19(17)16-6-4-3-5-7-16/h3-9,19H,10-13,20H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.27E+3n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24111
PNG
(3-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquin...)
Show SMILES Cc1ccc2C(CN(CCCN)Cc2c1C)c1ccccc1
Show InChI InChI=1S/C20H26N2/c1-15-9-10-18-19(16(15)2)13-22(12-6-11-21)14-20(18)17-7-4-3-5-8-17/h3-5,7-10,20H,6,11-14,21H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 3.06E+3n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24112
PNG
(4-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquin...)
Show SMILES Cc1ccc2C(CN(CCCCN)Cc2c1C)c1ccccc1
Show InChI InChI=1S/C21H28N2/c1-16-10-11-19-20(17(16)2)14-23(13-7-6-12-22)15-21(19)18-8-4-3-5-9-18/h3-5,8-11,21H,6-7,12-15,22H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 4.65E+3n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24113
PNG
(7,8-dimethyl-4-phenyl-2-[2-(1H-pyrrol-1-yl)ethyl]-...)
Show SMILES Cc1ccc2C(CN(CCn3cccc3)Cc2c1C)c1ccccc1
Show InChI InChI=1S/C23H26N2/c1-18-10-11-21-22(19(18)2)16-25(15-14-24-12-6-7-13-24)17-23(21)20-8-4-3-5-9-20/h3-13,23H,14-17H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.50E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24114
PNG
([3-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoqui...)
Show SMILES CN(C)CCCN1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C22H30N2/c1-17-11-12-20-21(18(17)2)15-24(14-8-13-23(3)4)16-22(20)19-9-6-5-7-10-19/h5-7,9-12,22H,8,13-16H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.88E+3n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24115
PNG
([4-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoqui...)
Show SMILES CN(C)CCCCN1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C23H32N2/c1-18-12-13-21-22(19(18)2)16-25(15-9-8-14-24(3)4)17-23(21)20-10-6-5-7-11-20/h5-7,10-13,23H,8-9,14-17H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 5.36E+3n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24116
PNG
(1-(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquin...)
Show SMILES CC(=O)N1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C19H21NO/c1-13-9-10-17-18(14(13)2)11-20(15(3)21)12-19(17)16-7-5-4-6-8-16/h4-10,19H,11-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.79E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24117
PNG
(2-benzoyl-7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydro...)
Show SMILES Cc1ccc2C(CN(Cc2c1C)C(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H23NO/c1-17-13-14-21-22(18(17)2)15-25(24(26)20-11-7-4-8-12-20)16-23(21)19-9-5-3-6-10-19/h3-14,23H,15-16H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.64E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24118
PNG
(2-methanesulfonyl-7,8-dimethyl-4-phenyl-1,2,3,4-te...)
Show SMILES Cc1ccc2C(CN(Cc2c1C)S(C)(=O)=O)c1ccccc1
Show InChI InChI=1S/C18H21NO2S/c1-13-9-10-16-17(14(13)2)11-19(22(3,20)21)12-18(16)15-7-5-4-6-8-15/h4-10,18H,11-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>2.50E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24119
PNG
(methyl 7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroiso...)
Show SMILES COC(=O)N1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C19H21NO2/c1-13-9-10-16-17(14(13)2)11-20(19(21)22-3)12-18(16)15-7-5-4-6-8-15/h4-10,18H,11-12H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.44E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24120
PNG
(ethyl 7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoq...)
Show SMILES CCOC(=O)N1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C20H23NO2/c1-4-23-20(22)21-12-18-15(3)14(2)10-11-17(18)19(13-21)16-8-6-5-7-9-16/h5-11,19H,4,12-13H2,1-3H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24121
PNG
(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoquinoli...)
Show SMILES Cc1ccc2C(CN(Cc2c1C)C(N)=O)c1ccccc1
Show InChI InChI=1S/C18H20N2O/c1-12-8-9-15-16(13(12)2)10-20(18(19)21)11-17(15)14-6-4-3-5-7-14/h3-9,17H,10-11H2,1-2H3,(H2,19,21)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24122
PNG
(N,7,8-trimethyl-4-phenyl-1,2,3,4-tetrahydroisoquin...)
Show SMILES CNC(=O)N1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C19H22N2O/c1-13-9-10-16-17(14(13)2)11-21(19(22)20-3)12-18(16)15-7-5-4-6-8-15/h4-10,18H,11-12H2,1-3H3,(H,20,22)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a>2.50E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24123
PNG
(N,N,7,8-tetramethyl-4-phenyl-1,2,3,4-tetrahydroiso...)
Show SMILES CN(C)C(=O)N1CC(c2ccccc2)c2ccc(C)c(C)c2C1
Show InChI InChI=1S/C20H24N2O/c1-14-10-11-17-18(15(14)2)12-22(20(23)21(3)4)13-19(17)16-8-6-5-7-9-16/h5-11,19H,12-13H2,1-4H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.75E+3n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Kinesin Spindle Protein Eg5


(Homo sapiens)
BDBM24124
PNG
(4-[(7,8-dimethyl-4-phenyl-1,2,3,4-tetrahydroisoqui...)
Show SMILES Cc1ccc2C(CN(Cc2c1C)C(=O)N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C22H26N2O2/c1-16-8-9-19-20(17(16)2)14-24(22(25)23-10-12-26-13-11-23)15-21(19)18-6-4-3-5-7-18/h3-9,21H,10-15H2,1-2H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 2.23E+4n/an/an/an/a7.023



Bristol-Myers Squibb Company



Assay Description
ATPase assays with Eg5 motor domain protein were performed using Kinase-Glo Luminescent Kit as described by the manufacturer (Promega).


Bioorg Med Chem Lett 16: 2095-100 (2006)


Article DOI: 10.1016/j.bmcl.2006.01.056
BindingDB Entry DOI: 10.7270/Q2VM49KF
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 83 total )  |  Next  |  Last  >>
Jump to: