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Compile Data Set for Download or QSAR

Found 47 hits of ph data with Target = 'Lck'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lck


(Mus musculus)
BDBM13217
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C19H25N3O3S/c1-10-8-11(2)14(12(3)9-10)21-16(23)15-13(4)20-17(26-15)22-18(24)25-19(5,6)7/h8-9H,1-7H3,(H,21,23)(H,20,22,24)
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PubMed
n/an/a 3.00E+3n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13218
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C17H20ClN3O3S/c1-9-7-6-8-11(18)12(9)20-14(22)13-10(2)19-15(25-13)21-16(23)24-17(3,4)5/h6-8H,1-5H3,(H,20,22)(H,19,21,23)
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PubMed
n/an/a 9.60E+3n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13224
PNG
(2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...)
Show SMILES Cc1nc(NC(=O)c2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H21N3O2S/c1-12-10-13(2)17(14(3)11-12)23-20(26)18-15(4)22-21(27-18)24-19(25)16-8-6-5-7-9-16/h5-11H,1-4H3,(H,23,26)(H,22,24,25)
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n/an/a 320n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13219
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H23N3O3S/c1-10-8-7-9-11(2)13(10)20-15(22)14-12(3)19-16(25-14)21-17(23)24-18(4,5)6/h7-9H,1-6H3,(H,20,22)(H,19,21,23)
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PubMed
n/an/a 7.50E+3n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13220
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C
Show InChI InChI=1S/C18H22BrN3O3S/c1-9-7-12(19)8-10(2)13(9)21-15(23)14-11(3)20-16(26-14)22-17(24)25-18(4,5)6/h7-8H,1-6H3,(H,21,23)(H,20,22,24)
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n/an/a 2.40E+3n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13225
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-phe...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H19N3O3S/c1-10-12(13(20)18-11-8-6-5-7-9-11)23-14(17-10)19-15(21)22-16(2,3)4/h5-9H,1-4H3,(H,18,20)(H,17,19,21)
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n/an/an/an/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13226
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1ccccc1C
Show InChI InChI=1S/C17H21N3O3S/c1-10-8-6-7-9-12(10)19-14(21)13-11(2)18-15(24-13)20-16(22)23-17(3,4)5/h6-9H,1-5H3,(H,19,21)(H,18,20,22)
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PubMed
n/an/a 4.57E+4n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13227
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES CC(C)c1cccc(C)c1NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C20H27N3O3S/c1-11(2)14-10-8-9-12(3)15(14)22-17(24)16-13(4)21-18(27-16)23-19(25)26-20(5,6)7/h8-11H,1-7H3,(H,22,24)(H,21,23,25)
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PubMed
n/an/a 4.03E+4n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13228
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES COc1cccc(C)c1NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C18H23N3O4S/c1-10-8-7-9-12(24-6)13(10)20-15(22)14-11(2)19-16(26-14)21-17(23)25-18(3,4)5/h7-9H,1-6H3,(H,20,22)(H,19,21,23)
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PubMed
n/an/a 2.43E+4n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13229
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1ccc(C)cc1C
Show InChI InChI=1S/C18H23N3O3S/c1-10-7-8-13(11(2)9-10)20-15(22)14-12(3)19-16(25-14)21-17(23)24-18(4,5)6/h7-9H,1-6H3,(H,20,22)(H,19,21,23)
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n/an/a 2.74E+4n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13222
PNG
(2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...)
Show SMILES COC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19N3O3S/c1-8-6-9(2)12(10(3)7-8)18-14(20)13-11(4)17-15(23-13)19-16(21)22-5/h6-7H,1-5H3,(H,18,20)(H,17,19,21)
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n/an/a 720n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13230
PNG
(2-[[(Benzyloxy)carbonyl]-amino]-4-methyl-N-(2,4,6-...)
Show SMILES Cc1nc(NC(=O)OCc2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C22H23N3O3S/c1-13-10-14(2)18(15(3)11-13)24-20(26)19-16(4)23-21(29-19)25-22(27)28-12-17-8-6-5-7-9-17/h5-11H,12H2,1-4H3,(H,24,26)(H,23,25,27)
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PubMed
n/an/a 3.33E+4n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM13223
PNG
(2-acetamido-4-methyl-N-(2,4,6-trimethylphenyl)-1,3...)
Show SMILES CC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19N3O2S/c1-8-6-9(2)13(10(3)7-8)19-15(21)14-11(4)17-16(22-14)18-12(5)20/h6-7H,1-5H3,(H,19,21)(H,17,18,20)
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n/an/a 510n/an/an/an/a7.022



Bristol-Myers Squibb Company



Assay Description
IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...


J Med Chem 49: 6819-32 (2006)


Article DOI: 10.1021/jm060727j
BindingDB Entry DOI: 10.7270/Q2QN6501
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM25191
PNG
(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1csc(C=O)n1
Show InChI InChI=1S/C20H15N3O2S/c1-12-2-4-14(25)9-17(12)22-16-6-7-21-18-8-13(3-5-15(16)18)19-11-26-20(10-24)23-19/h2-11,25H,1H3,(H,21,22)
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20 -43.5 59n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 18: 318-23 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.076
BindingDB Entry DOI: 10.7270/Q2KP80G3
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM25979
PNG
(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)cc1N1CCN(C)CC1
Show InChI InChI=1S/C29H31N5O3/c1-19-5-6-23(29-32-31-20(2)37-29)17-25(19)21-7-9-22(10-8-21)28(35)30-24-11-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,30,35)
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2.80E+3 -31.4 8.40E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 18: 318-23 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.076
BindingDB Entry DOI: 10.7270/Q2KP80G3
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM25980
PNG
(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C24H18N4O2/c1-15-6-7-20(24-28-27-16(2)30-24)13-22(15)18-8-10-19(11-9-18)23(29)26-21-5-3-4-17(12-21)14-25/h3-13H,1-2H3,(H,26,29)
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>5.40E+3>-29.8>1.60E+4n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 18: 318-23 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.076
BindingDB Entry DOI: 10.7270/Q2KP80G3
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM25981
PNG
(BMCL18324 Compound 17 | CHEMBL273158 | N-(cyclopro...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C21H21N3O2/c1-13-3-6-18(21-24-23-14(2)26-21)11-19(13)16-7-9-17(10-8-16)20(25)22-12-15-4-5-15/h3,6-11,15H,4-5,12H2,1-2H3,(H,22,25)
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>5.40E+3>-29.8>1.60E+4n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 18: 318-23 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.076
BindingDB Entry DOI: 10.7270/Q2KP80G3
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26148
PNG
(2,4-dianilino pyrimidine, 5 | 3-({4-[(3-hydroxy-4-...)
Show SMILES Cc1ccc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)cc1O
Show InChI InChI=1S/C18H17N5O2/c1-11-5-6-14(10-15(11)24)21-16-7-8-20-18(23-16)22-13-4-2-3-12(9-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)
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n/an/a 190n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26146
PNG
(2,4-dianilino pyrimidine, 3 | 3-({4-[(3-hydroxyphe...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc(O)c3)n2)c1
Show InChI InChI=1S/C17H15N5O2/c18-16(24)11-3-1-4-12(9-11)21-17-19-8-7-15(22-17)20-13-5-2-6-14(23)10-13/h1-10,23H,(H2,18,24)(H2,19,20,21,22)
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n/an/a 130n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26150
PNG
(2,4-dianilino pyrimidine, 7 | 3-[(4-{[5-hydroxy-2-...)
Show SMILES CC(C)c1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C20H21N5O2/c1-12(2)16-7-6-15(26)11-17(16)24-18-8-9-22-20(25-18)23-14-5-3-4-13(10-14)19(21)27/h3-12,26H,1-2H3,(H2,21,27)(H2,22,23,24,25)
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n/an/a 880n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26151
PNG
(2,4-dianilino pyrimidine, 8 | 3-({4-[(2-methylphen...)
Show SMILES Cc1ccccc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H17N5O/c1-12-5-2-3-8-15(12)22-16-9-10-20-18(23-16)21-14-7-4-6-13(11-14)17(19)24/h2-11H,1H3,(H2,19,24)(H2,20,21,22,23)
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n/an/a 89n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26152
PNG
(2,4-dianilino pyrimidine, 9 | 3-({4-[(4-hydroxy-2-...)
Show SMILES Cc1cc(O)ccc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H17N5O2/c1-11-9-14(24)5-6-15(11)22-16-7-8-20-18(23-16)21-13-4-2-3-12(10-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)
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n/an/a 40n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26153
PNG
(2,4-dianilino pyrimidine, 10 | 3-({4-[(2-hydroxy-6...)
Show SMILES Cc1cccc(O)c1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H17N5O2/c1-11-4-2-7-14(24)16(11)22-15-8-9-20-18(23-15)21-13-6-3-5-12(10-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)
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n/an/a 100n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26154
PNG
(2,4-dianilino pyrimidine, 11 | 3-({4-[(5-fluoro-2-...)
Show SMILES Cc1ccc(F)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H16FN5O/c1-11-5-6-13(19)10-15(11)23-16-7-8-21-18(24-16)22-14-4-2-3-12(9-14)17(20)25/h2-10H,1H3,(H2,20,25)(H2,21,22,23,24)
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n/an/a 270n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26155
PNG
(2,4-dianilino pyrimidine, 12 | 3-({4-[(5-chloro-2-...)
Show SMILES Cc1ccc(Cl)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H16ClN5O/c1-11-5-6-13(19)10-15(11)23-16-7-8-21-18(24-16)22-14-4-2-3-12(9-14)17(20)25/h2-10H,1H3,(H2,20,25)(H2,21,22,23,24)
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n/an/a 380n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26156
PNG
(2,4-dianilino pyrimidine, 13 | 3-({4-[(5-methoxy-2...)
Show SMILES COc1ccc(C)c(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1
Show InChI InChI=1S/C19H19N5O2/c1-12-6-7-15(26-2)11-16(12)23-17-8-9-21-19(24-17)22-14-5-3-4-13(10-14)18(20)25/h3-11H,1-2H3,(H2,20,25)(H2,21,22,23,24)
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n/an/a 86n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26157
PNG
(2,4-dianilino pyrimidine, 14 | 3-({4-[(5-amino-2-m...)
Show SMILES Cc1ccc(N)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H18N6O/c1-11-5-6-13(19)10-15(11)23-16-7-8-21-18(24-16)22-14-4-2-3-12(9-14)17(20)25/h2-10H,19H2,1H3,(H2,20,25)(H2,21,22,23,24)
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n/an/a 97n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26158
PNG
(2,4-dianilino pyrimidine, 15 | 3-({2-[(3-carbamoyl...)
Show SMILES Cc1ccc(cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1)C(N)=O
Show InChI InChI=1S/C19H18N6O2/c1-11-5-6-13(18(21)27)10-15(11)24-16-7-8-22-19(25-16)23-14-4-2-3-12(9-14)17(20)26/h2-10H,1H3,(H2,20,26)(H2,21,27)(H2,22,23,24,25)
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n/an/a 1.30E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26159
PNG
(2,4-dianilino pyrimidine, 16 | 3-({2-[(3-carbamoyl...)
Show SMILES CN(C)C(=O)c1ccc(C)c(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1
Show InChI InChI=1S/C21H22N6O2/c1-13-7-8-15(20(29)27(2)3)12-17(13)25-18-9-10-23-21(26-18)24-16-6-4-5-14(11-16)19(22)28/h4-12H,1-3H3,(H2,22,28)(H2,23,24,25,26)
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n/an/a 9.30E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26160
PNG
(2,4-dianilino pyrimidine, 17 | 3-({4-[(5-methanesu...)
Show SMILES Cc1ccc(NS(C)(=O)=O)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C19H20N6O3S/c1-12-6-7-15(25-29(2,27)28)11-16(12)23-17-8-9-21-19(24-17)22-14-5-3-4-13(10-14)18(20)26/h3-11,25H,1-2H3,(H2,20,26)(H2,21,22,23,24)
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n/an/a 7.70E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26161
PNG
(2,4-dianilino pyrimidine, 18 | 3-[(4-{[5-(aminomet...)
Show SMILES Cc1ccc(CN)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C19H20N6O/c1-12-5-6-13(11-20)9-16(12)24-17-7-8-22-19(25-17)23-15-4-2-3-14(10-15)18(21)26/h2-10H,11,20H2,1H3,(H2,21,26)(H2,22,23,24,25)
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n/an/a 3.40E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26162
PNG
(2,4-dianilino pyrimidine, 19 | 3-({4-[(3-methoxyph...)
Show SMILES COc1cccc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1
Show InChI InChI=1S/C18H17N5O2/c1-25-15-7-3-6-14(11-15)21-16-8-9-20-18(23-16)22-13-5-2-4-12(10-13)17(19)24/h2-11H,1H3,(H2,19,24)(H2,20,21,22,23)
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n/an/a 2.70E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26163
PNG
(2,4-dianilino pyrimidine, 20 | 3-({4-[(3-fluorophe...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cccc(F)c3)n2)c1
Show InChI InChI=1S/C17H14FN5O/c18-12-4-2-6-14(10-12)21-15-7-8-20-17(23-15)22-13-5-1-3-11(9-13)16(19)24/h1-10H,(H2,19,24)(H2,20,21,22,23)
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n/an/a 3.30E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26164
PNG
(2,4-dianilino pyrimidine, 21 | 3-[(4-{[3-(N-methyl...)
Show SMILES CN(C(C)=O)c1cccc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1
Show InChI InChI=1S/C20H20N6O2/c1-13(27)26(2)17-8-4-7-16(12-17)23-18-9-10-22-20(25-18)24-15-6-3-5-14(11-15)19(21)28/h3-12H,1-2H3,(H2,21,28)(H2,22,23,24,25)
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n/an/a 1.80E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26165
PNG
(2,4-dianilino pyrimidine, 22 | 3-({4-[(2,4-difluor...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3ccc(F)cc3F)n2)c1
Show InChI InChI=1S/C17H13F2N5O/c18-11-4-5-14(13(19)9-11)23-15-6-7-21-17(24-15)22-12-3-1-2-10(8-12)16(20)25/h1-9H,(H2,20,25)(H2,21,22,23,24)
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n/an/a 1.10E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26166
PNG
(2,4-dianilino pyrimidine, 23 | 3-({4-[(5-hydroxy-2...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1
Show InChI InChI=1S/C17H17N5O3S/c1-11-5-6-13(23)10-15(11)21-16-7-8-19-17(22-16)20-12-3-2-4-14(9-12)26(18,24)25/h2-10,23H,1H3,(H2,18,24,25)(H2,19,20,21,22)
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n/an/a 8.5n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26167
PNG
(2,4-dianilino pyrimidine, 24 | 3-({4-[(5-methoxy-2...)
Show SMILES COc1ccc(C)c(Nc2ccnc(Nc3cccc(c3)S(N)(=O)=O)n2)c1
Show InChI InChI=1S/C18H19N5O3S/c1-12-6-7-14(26-2)11-16(12)22-17-8-9-20-18(23-17)21-13-4-3-5-15(10-13)27(19,24)25/h3-11H,1-2H3,(H2,19,24,25)(H2,20,21,22,23)
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n/an/a 54n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26168
PNG
(2,4-dianilino pyrimidine, 25 | 3-({4-[(2,4-difluor...)
Show SMILES NS(=O)(=O)c1cccc(Nc2nccc(Nc3ccc(F)cc3F)n2)c1
Show InChI InChI=1S/C16H13F2N5O2S/c17-10-4-5-14(13(18)8-10)22-15-6-7-20-16(23-15)21-11-2-1-3-12(9-11)26(19,24)25/h1-9H,(H2,19,24,25)(H2,20,21,22,23)
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n/an/a 350n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26169
PNG
(2,4-dianilino pyrimidine, 26 | 3-{[4-(1,3-benzothi...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3ccc4ncsc4c3)n2)c1
Show InChI InChI=1S/C18H14N6OS/c19-17(25)11-2-1-3-12(8-11)23-18-20-7-6-16(24-18)22-13-4-5-14-15(9-13)26-10-21-14/h1-10H,(H2,19,25)(H2,20,22,23,24)
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n/an/a 3.00E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26170
PNG
(2,4-dianilino pyrimidine, 27 | 3-({4-[(1-methyl-1H...)
Show SMILES Cn1cnc2ccc(Nc3ccnc(Nc4cccc(c4)C(N)=O)n3)cc12
Show InChI InChI=1S/C19H17N7O/c1-26-11-22-15-6-5-14(10-16(15)26)23-17-7-8-21-19(25-17)24-13-4-2-3-12(9-13)18(20)27/h2-11H,1H3,(H2,20,27)(H2,21,23,24,25)
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n/an/a 1.60E+4n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26171
PNG
(2,4-dianilino pyrimidine, 28 | 3-{[4-(1H-indazol-5...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3ccc4[nH]ncc4c3)n2)c1
Show InChI InChI=1S/C18H15N7O/c19-17(26)11-2-1-3-13(8-11)23-18-20-7-6-16(24-18)22-14-4-5-15-12(9-14)10-21-25-15/h1-10H,(H2,19,26)(H,21,25)(H2,20,22,23,24)
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n/an/a 3.00E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26172
PNG
(2,4-dianilino pyrimidine, 29 | 3-({4-[(1-methyl-1H...)
Show SMILES Cn1cnc2cc(Nc3ccnc(Nc4cccc(c4)C(N)=O)n3)ccc12
Show InChI InChI=1S/C19H17N7O/c1-26-11-22-15-10-14(5-6-16(15)26)23-17-7-8-21-19(25-17)24-13-4-2-3-12(9-13)18(20)27/h2-11H,1H3,(H2,20,27)(H2,21,23,24,25)
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n/an/a 1.80E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26173
PNG
(2,4-dianilino pyrimidine, 30 | 3-{[4-(1H-1,2,3-ben...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3ccc4nn[nH]c4c3)n2)c1
Show InChI InChI=1S/C17H14N8O/c18-16(26)10-2-1-3-11(8-10)21-17-19-7-6-15(22-17)20-12-4-5-13-14(9-12)24-25-23-13/h1-9H,(H2,18,26)(H,23,24,25)(H2,19,20,21,22)
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n/an/a 4.40E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26145
PNG
(2,4-dianilino pyrimidine, 2 | 3-({4-[(5-hydroxy-2-...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H17N5O2/c1-11-5-6-14(24)10-15(11)22-16-7-8-20-18(23-16)21-13-4-2-3-12(9-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)
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n/an/a 13n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM25191
PNG
(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1csc(C=O)n1
Show InChI InChI=1S/C20H15N3O2S/c1-12-2-4-14(25)9-17(12)22-16-6-7-21-18-8-13(3-5-15(16)18)19-11-26-20(10-24)23-19/h2-11,25H,1H3,(H,21,22)
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n/an/a 59n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26147
PNG
(2,4-dianilino pyrimidine, 4 | 3-({4-[(3-hydroxy-5-...)
Show SMILES Cc1cc(O)cc(Nc2ccnc(Nc3cccc(c3)C(N)=O)n2)c1
Show InChI InChI=1S/C18H17N5O2/c1-11-7-14(10-15(24)8-11)21-16-5-6-20-18(23-16)22-13-4-2-3-12(9-13)17(19)25/h2-10,24H,1H3,(H2,19,25)(H2,20,21,22,23)
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n/an/a 73n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair
Lck


(Mus musculus)
BDBM26149
PNG
(2,4-dianilino pyrimidine, 6 | 3-({4-[(2-bromo-5-hy...)
Show SMILES NC(=O)c1cccc(Nc2nccc(Nc3cc(O)ccc3Br)n2)c1
Show InChI InChI=1S/C17H14BrN5O2/c18-13-5-4-12(24)9-14(13)22-15-6-7-20-17(23-15)21-11-3-1-2-10(8-11)16(19)25/h1-9,24H,(H2,19,25)(H2,20,21,22,23)
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n/an/a 41n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair