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Compile Data Set for Download or QSAR

Found 1311 hits of ph data with Target = 'Lysine-specific histone demethylase 1A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50158875
PNG
(CHEMBL3787372 | US9676701, 69 N-(4′-((trans)...)
Show SMILES CC(C)S(=O)(=O)Nc1cccc(c1)-c1ccc(cc1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C18H22N2O2S/c1-12(2)23(21,22)20-16-5-3-4-15(10-16)13-6-8-14(9-7-13)17-11-18(17)19/h3-10,12,17-18,20H,11,19H2,1-2H3/t17-,18+/m1/s1
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Similars

US Patent
50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179835
PNG
(US9676701, 70 N-(4′-((trans)-2-aminocyclopro...)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc(cc1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C16H18N2O2S/c1-21(19,20)18-14-4-2-3-13(9-14)11-5-7-12(8-6-11)15-10-16(15)17/h2-9,15-16,18H,10,17H2,1H3/t15-,16+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179840
PNG
(US9676701, 75 N-(4′-((trans)-2-aminocyclopro...)
Show SMILES COc1ccc(NS(C)(=O)=O)cc1-c1ccc(cc1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C17H20N2O3S/c1-22-17-8-7-13(19-23(2,20)21)9-15(17)12-5-3-11(4-6-12)14-10-16(14)18/h3-9,14,16,19H,10,18H2,1-2H3/t14-,16+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179854
PNG
(US9676701, 88 N-(4′-((trans)-2-aminocyclopro...)
Show SMILES CS(=O)(=O)Nc1ccc(O)c(c1)-c1ccc(cc1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C16H18N2O3S/c1-22(20,21)18-12-6-7-16(19)14(8-12)11-4-2-10(3-5-11)13-9-15(13)17/h2-8,13,15,18-19H,9,17H2,1H3/t13-,15+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179855
PNG
(US9676701, 89 3-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cc(ccc1O)C#N
Show InChI InChI=1S/C15H13N3O/c16-7-9-1-4-15(19)12(5-9)14-3-2-10(8-18-14)11-6-13(11)17/h1-5,8,11,13,19H,6,17H2/t11-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179856
PNG
(US9676701, 90 N-(3-(5-((trans)-2-aminocyclopropyl)...)
Show SMILES CS(=O)(=O)Nc1ccc(O)c(c1)-c1ccc(cn1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C15H17N3O3S/c1-22(20,21)18-10-3-5-15(19)12(6-10)14-4-2-9(8-17-14)11-7-13(11)16/h2-6,8,11,13,18-19H,7,16H2,1H3/t11-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179860
PNG
(US9676701, 94 N-(4′-((trans)-2-aminocyclopro...)
Show SMILES CS(=O)(=O)Nc1cc(Cl)cc(c1)-c1ccc(cc1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C16H17ClN2O2S/c1-22(20,21)19-14-7-12(6-13(17)8-14)10-2-4-11(5-3-10)15-9-16(15)18/h2-8,15-16,19H,9,18H2,1H3/t15-,16+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179861
PNG
(US9676701, 95 N-(3-(5-((trans)-2-aminocyclopropyl)...)
Show SMILES CS(=O)(=O)Nc1cc(Cl)cc(c1)-c1ccc(cn1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C15H16ClN3O2S/c1-22(20,21)19-12-5-10(4-11(16)6-12)15-3-2-9(8-18-15)13-7-14(13)17/h2-6,8,13-14,19H,7,17H2,1H3/t13-,14+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179862
PNG
(US9676701, 96 N-(4′-((trans)-2-aminocyclopro...)
Show SMILES CS(=O)(=O)Nc1cc(ccc1F)-c1ccc(cc1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C16H17FN2O2S/c1-22(20,21)19-16-8-12(6-7-14(16)17)10-2-4-11(5-3-10)13-9-15(13)18/h2-8,13,15,19H,9,18H2,1H3/t13-,15+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179864
PNG
(US9676701, 98 N-(3-(5-((trans)-2-aminocyclopropyl)...)
Show SMILES CCS(=O)(=O)Nc1cccc(c1)-c1ccc(cn1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C16H19N3O2S/c1-2-22(20,21)19-13-5-3-4-11(8-13)16-7-6-12(10-18-16)14-9-15(14)17/h3-8,10,14-15,19H,2,9,17H2,1H3/t14-,15+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179865
PNG
(US9676701, 99 N-(3-(5-((trans)-2-aminocyclopropyl)...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(NS(=O)(=O)c2ccc(cc2)C#N)c1
Show InChI InChI=1S/C21H18N4O2S/c22-12-14-4-7-18(8-5-14)28(26,27)25-17-3-1-2-15(10-17)21-9-6-16(13-24-21)19-11-20(19)23/h1-10,13,19-20,25H,11,23H2/t19-,20+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179905
PNG
(US9676701, 100 N-(3-(5-((trans)-2-aminocyclopropyl...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(NS(=O)(=O)c2cccc(c2)C#N)c1
Show InChI InChI=1S/C21H18N4O2S/c22-12-14-3-1-6-18(9-14)28(26,27)25-17-5-2-4-15(10-17)21-8-7-16(13-24-21)19-11-20(19)23/h1-10,13,19-20,25H,11,23H2/t19-,20+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179906
PNG
(US9676701, 101 N-(3-(5-((trans)-2-aminocyclopropyl...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(NS(=O)(=O)c2ccccc2C#N)c1
Show InChI InChI=1S/C21H18N4O2S/c22-12-15-4-1-2-7-21(15)28(26,27)25-17-6-3-5-14(10-17)20-9-8-16(13-24-20)18-11-19(18)23/h1-10,13,18-19,25H,11,23H2/t18-,19+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179933
PNG
(US9676701, 102 N-(3-(5-((trans)-2-aminocyclopropyl...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cc(NS(=O)(=O)c2ccc(cc2)C#N)cc(c1)C(F)(F)F
Show InChI InChI=1S/C22H17F3N4O2S/c23-22(24,25)16-7-15(21-6-3-14(12-28-21)19-10-20(19)27)8-17(9-16)29-32(30,31)18-4-1-13(11-26)2-5-18/h1-9,12,19-20,29H,10,27H2/t19-,20+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179973
PNG
(US9676701, 113 3-(5-((trans)-2-aminocyclopropyl)th...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(s1)-c1cccc(O)c1
Show InChI InChI=1S/C13H13NOS/c14-11-7-10(11)13-5-4-12(16-13)8-2-1-3-9(15)6-8/h1-6,10-11,15H,7,14H2/t10-,11-/m0/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179976
PNG
(US9676701, 116 3-(5-((trans)-2-aminocyclopropyl)th...)
Show SMILES N[C@H]1C[C@@H]1c1cnc(s1)-c1cccc(O)c1
Show InChI InChI=1S/C12H12N2OS/c13-10-5-9(10)11-6-14-12(16-11)7-2-1-3-8(15)4-7/h1-4,6,9-10,15H,5,13H2/t9-,10-/m0/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179984
PNG
(US9676701, 124 N-(3-(5-((trans)-2-aminocyclopropyl...)
Show SMILES N[C@H]1C[C@@H]1c1cnc(s1)-c1cccc(NS(=O)(=O)c2ccccc2C#N)c1
Show InChI InChI=1S/C19H16N4O2S2/c20-10-13-4-1-2-7-18(13)27(24,25)23-14-6-3-5-12(8-14)19-22-11-17(26-19)15-9-16(15)21/h1-8,11,15-16,23H,9,21H2/t15-,16-/m0/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM182862
PNG
(US9670136, 1 N1-((trans)-2-phenylcyclopropyl)cyclo...)
Show SMILES NC1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...


US Patent US9670136 (2017)


BindingDB Entry DOI: 10.7270/Q2PN93SB
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM254546
PNG
(US9469597, 1 | US9670136, 5 (trans)-N1-((1R,2S)-2-...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...


US Patent US9670136 (2017)


BindingDB Entry DOI: 10.7270/Q2PN93SB
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM254546
PNG
(US9469597, 1 | US9670136, 5 (trans)-N1-((1R,2S)-2-...)
Show SMILES NC1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C15H22N2/c16-12-6-8-13(9-7-12)17-15-10-14(15)11-4-2-1-3-5-11/h1-5,12-15,17H,6-10,16H2/t12?,13?,14-,15+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...


US Patent US9670136 (2017)


BindingDB Entry DOI: 10.7270/Q2PN93SB
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM254553
PNG
(US9469597, 12 | US9670136, 12 4-(((trans)-2-(6-(3-...)
Show SMILES NC(=O)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H24F3N3O/c23-22(24,25)16-3-1-2-14(10-16)19-9-6-15(12-27-19)18-11-20(18)28-17-7-4-13(5-8-17)21(26)29/h1-3,6,9-10,12-13,17-18,20,28H,4-5,7-8,11H2,(H2,26,29)/t13?,17?,18-,20+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...


US Patent US9670136 (2017)


BindingDB Entry DOI: 10.7270/Q2PN93SB
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM254556
PNG
(US9469597, 15 | US9670136, 15 (R)-1-(4-(((trans)-2...)
Show SMILES N[C@@H]1CCN(C1)C1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C19H29N3/c20-15-10-11-22(13-15)17-8-6-16(7-9-17)21-19-12-18(19)14-4-2-1-3-5-14/h1-5,15-19,21H,6-13,20H2/t15-,16?,17?,18-,19+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of at least eight 3-fold serial dilutions ...


US Patent US9670136 (2017)


BindingDB Entry DOI: 10.7270/Q2PN93SB
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179446
PNG
(US9676701, 4 4′-((trans)-2-aminocyclopropyl)...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(O)c1
Show InChI InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179641
PNG
(US9676701, 13 3-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1CC1c1ccc(nc1)-c1cccc(c1)C#N
Show InChI InChI=1S/C15H13N3/c16-8-10-2-1-3-11(6-10)15-5-4-12(9-18-15)13-7-14(13)17/h1-6,9,13-14H,7,17H2/t13?,14-/m0/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179646
PNG
(US9676701, 17 3-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(O)c1
Show InChI InChI=1S/C14H14N2O/c15-13-7-12(13)10-4-5-14(16-8-10)9-2-1-3-11(17)6-9/h1-6,8,12-13,17H,7,15H2/t12-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179649
PNG
(US9676701, 20 2-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1ccccc1O
Show InChI InChI=1S/C14H14N2O/c15-12-7-11(12)9-5-6-13(16-8-9)10-3-1-2-4-14(10)17/h1-6,8,11-12,17H,7,15H2/t11-,12+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179646
PNG
(US9676701, 17 3-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(O)c1
Show InChI InChI=1S/C14H14N2O/c15-13-7-12(13)10-4-5-14(16-8-10)9-2-1-3-11(17)6-9/h1-6,8,12-13,17H,7,15H2/t12-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179652
PNG
(US9676701, 23 5-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1ccc(F)c(O)c1
Show InChI InChI=1S/C14H13FN2O/c15-11-3-1-8(5-14(11)18)13-4-2-9(7-17-13)10-6-12(10)16/h1-5,7,10,12,18H,6,16H2/t10-,12+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179653
PNG
(US9676701, 24 3-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cc(O)cc(F)c1
Show InChI InChI=1S/C14H13FN2O/c15-10-3-9(4-11(18)5-10)14-2-1-8(7-17-14)12-6-13(12)16/h1-5,7,12-13,18H,6,16H2/t12-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179654
PNG
(US9676701, 25 3-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cc(O)ccc1F
Show InChI InChI=1S/C14H13FN2O/c15-12-3-2-9(18)5-11(12)14-4-1-8(7-17-14)10-6-13(10)16/h1-5,7,10,13,18H,6,16H2/t10-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179670
PNG
(US9676701, 29 3-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cc(O)cc(Cl)c1
Show InChI InChI=1S/C14H13ClN2O/c15-10-3-9(4-11(18)5-10)14-2-1-8(7-17-14)12-6-13(12)16/h1-5,7,12-13,18H,6,16H2/t12-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179672
PNG
(US9676701, 31 (trans)-2-(6-(5-chlorothiophen-2-yl)...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1ccc(Cl)s1
Show InChI InChI=1S/C12H11ClN2S/c13-12-4-3-11(16-12)10-2-1-7(6-15-10)8-5-9(8)14/h1-4,6,8-9H,5,14H2/t8-,9+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179724
PNG
(US9676701, 46 5-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES Cc1ccc(cc1O)-c1ccc(cn1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C15H16N2O/c1-9-2-3-10(6-15(9)18)14-5-4-11(8-17-14)12-7-13(12)16/h2-6,8,12-13,18H,7,16H2,1H3/t12-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179729
PNG
(US9676701, 48 3-(5-((trans)-2-amninocyclopropyl)py...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cc(O)cc(c1)C(F)(F)F
Show InChI InChI=1S/C15H13F3N2O/c16-15(17,18)10-3-9(4-11(21)5-10)14-2-1-8(7-20-14)12-6-13(12)19/h1-5,7,12-13,21H,6,19H2/t12-,13+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179740
PNG
(US9676701, 53 N-(3-(5-((trans)-2-aminocyclopropyl)...)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccc(cn1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C15H17N3O2S/c1-21(19,20)18-12-4-2-3-10(7-12)15-6-5-11(9-17-15)13-8-14(13)16/h2-7,9,13-14,18H,8,16H2,1H3/t13-,14+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179745
PNG
(US9676701, 56 5-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1ccc(s1)C#N
Show InChI InChI=1S/C13H11N3S/c14-6-9-2-4-13(17-9)12-3-1-8(7-16-12)10-5-11(10)15/h1-4,7,10-11H,5,15H2/t10-,11+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179823
PNG
(US9676701, 59 5-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cc(O)c(F)c(F)c1
Show InChI InChI=1S/C14H12F2N2O/c15-10-3-8(4-13(19)14(10)16)12-2-1-7(6-18-12)9-5-11(9)17/h1-4,6,9,11,19H,5,17H2/t9-,11+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50445349
PNG
(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Show SMILES N[C@@H]1C[C@H]1c1ccc(cc1)-c1cccc(O)c1
Show InChI InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m0/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM50445349
PNG
(CHEMBL3104261 | US9676701, 63 Enantiomers of 4R...)
Show SMILES N[C@@H]1C[C@H]1c1ccc(cc1)-c1cccc(O)c1
Show InChI InChI=1S/C15H15NO/c16-15-9-14(15)11-6-4-10(5-7-11)12-2-1-3-13(17)8-12/h1-8,14-15,17H,9,16H2/t14-,15+/m0/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179828
PNG
(US9676701, 64 N-(3-(5-((trans)-2-aminocyclopropyl)...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1cccc(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H19N3O2S/c21-19-12-18(19)15-9-10-20(22-13-15)14-5-4-6-16(11-14)23-26(24,25)17-7-2-1-3-8-17/h1-11,13,18-19,23H,12,21H2/t18-,19+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179829
PNG
(US9676701, 65 N-(3-(5-((trans)-2-aminocyclopropyl)...)
Show SMILES CC(C)S(=O)(=O)Nc1cccc(c1)-c1ccc(cn1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C17H21N3O2S/c1-11(2)23(21,22)20-14-5-3-4-12(8-14)17-7-6-13(10-19-17)15-9-16(15)18/h3-8,10-11,15-16,20H,9,18H2,1-2H3/t15-,16+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179830
PNG
(US9676701, 66 4′-((trans)-2-aminocyclopropyl...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(cc1)-c1ccc(F)c(O)c1
Show InChI InChI=1S/C15H14FNO/c16-13-6-5-11(7-15(13)18)9-1-3-10(4-2-9)12-8-14(12)17/h1-7,12,14,18H,8,17H2/t12-,14+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179832
PNG
(US9676701, 67 4′-((trans)-2-aminocyclopropyl...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(cc1)-c1cc(O)cc(Cl)c1
Show InChI InChI=1S/C15H14ClNO/c16-12-5-11(6-13(18)7-12)9-1-3-10(4-2-9)14-8-15(14)17/h1-7,14-15,18H,8,17H2/t14-,15+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179833
PNG
(US9676701, 68 N-(4′-((trans)-2-aminocyclopro...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H20N2O2S/c22-21-14-20(21)16-11-9-15(10-12-16)17-5-4-6-18(13-17)23-26(24,25)19-7-2-1-3-8-19/h1-13,20-21,23H,14,22H2/t20-,21+/m1/s1
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50 -41.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179824
PNG
(US9676701, 60 (Trans)-2-(6-(1H-indazol-6-yl)pyridi...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1ccc2cn[nH]c2c1
Show InChI InChI=1S/C15H14N4/c16-13-6-12(13)10-3-4-14(17-7-10)9-1-2-11-8-18-19-15(11)5-9/h1-5,7-8,12-13H,6,16H2,(H,18,19)/t12-,13+/m1/s1
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500 -36.0n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179838
PNG
(US9676701, 73 N-(4′-((trans)-2-aminocyclopro...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cc1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C16H18N2O2S/c1-21(19,20)18-16-5-3-2-4-13(16)11-6-8-12(9-7-11)14-10-15(14)17/h2-9,14-15,18H,10,17H2,1H3/t14-,15+/m1/s1
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500 -36.0n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179839
PNG
(US9676701, 74 4′-((trans)-2-aminocyclopropyl...)
Show SMILES COc1ccc(cc1-c1ccc(cc1)[C@H]1C[C@@H]1N)C#N
Show InChI InChI=1S/C17H16N2O/c1-20-17-7-2-11(10-18)8-15(17)13-5-3-12(4-6-13)14-9-16(14)19/h2-8,14,16H,9,19H2,1H3/t14-,16+/m1/s1
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500 -36.0n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179841
PNG
(US9676701, 76 (trans)-2-(2-chloro-6-(3-(trifluorom...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1Cl)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C15H12ClF3N2/c16-14-10(11-7-12(11)20)4-5-13(21-14)8-2-1-3-9(6-8)15(17,18)19/h1-6,11-12H,7,20H2/t11-,12+/m1/s1
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550 -35.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179826
PNG
(US9676701, 62 6-(5-((trans)-2-aminocyclopropyl)pyr...)
Show SMILES N[C@H]1C[C@@H]1c1ccc(nc1)-c1ccc2CC(=O)Nc2c1
Show InChI InChI=1S/C16H15N3O/c17-13-7-12(13)11-3-4-14(18-8-11)9-1-2-10-6-16(20)19-15(10)5-9/h1-5,8,12-13H,6-7,17H2,(H,19,20)/t12-,13+/m1/s1
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550 -35.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM179836
PNG
(US9676701, 71 N-(2-(5-((trans)-2-aminocyclopropyl)...)
Show SMILES CS(=O)(=O)Nc1ccccc1-c1ccc(cn1)[C@H]1C[C@@H]1N
Show InChI InChI=1S/C15H17N3O2S/c1-21(19,20)18-15-5-3-2-4-11(15)14-7-6-10(9-17-14)12-8-13(12)16/h2-7,9,12-13,18H,8,16H2,1H3/t12-,13+/m1/s1
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550 -35.7n/an/an/an/an/a7.425



ORYZON GENOMICS, S.A.

US Patent


Assay Description
Briefly, a fixed amount of LSD1 was incubated on ice for 15 minutes, in the absence and/or in the presence of various concentrations of inhibitor (e....


US Patent US9676701 (2017)


BindingDB Entry DOI: 10.7270/Q27P8WJN
More data for this
Ligand-Target Pair
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