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Compile Data Set for Download or QSAR

Found 52 hits of ph data with Target = 'MAPK-Activated Protein Kinase 2 (MK2)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30207
PNG
(carboline analog, 20)
Show SMILES CC1CNC(=O)c2[nH]c3ccccc3c12
Show InChI InChI=1S/C12H12N2O/c1-7-6-13-12(15)11-10(7)8-4-2-3-5-9(8)14-11/h2-5,7,14H,6H2,1H3,(H,13,15)
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n/an/a>4.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30297
PNG
(indole-based 6-membered lactam, 4k)
Show SMILES CC(=O)NCC1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C18H17N5O3S/c1-10(24)20-8-13-9-23-14-7-12(16(25)22-18-19-4-5-27-18)3-2-11(14)6-15(23)17(26)21-13/h2-7,13H,8-9H2,1H3,(H,20,24)(H,21,26)(H,19,22,25)
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n/an/a 6.90E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30209
PNG
(carboline analog, 22)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)-c1ccccc1
Show InChI InChI=1S/C18H16N2O/c1-11-10-19-18(21)17-16(11)14-9-13(7-8-15(14)20-17)12-5-3-2-4-6-12/h2-9,11,20H,10H2,1H3,(H,19,21)
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n/an/a>4.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30210
PNG
(carboline analog, 23)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(Br)cc3c12
Show InChI InChI=1S/C12H11BrN2O/c1-6-5-14-12(16)11-10(6)8-4-7(13)2-3-9(8)15-11/h2-4,6,15H,5H2,1H3,(H,14,16)
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n/an/a 1.50E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30211
PNG
(carboline analog, 24)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(O)cc3c12
Show InChI InChI=1S/C12H12N2O2/c1-6-5-13-12(16)11-10(6)8-4-7(15)2-3-9(8)14-11/h2-4,6,14-15H,5H2,1H3,(H,13,16)
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n/an/a>4.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30212
PNG
(carboline analog, 17)
Show SMILES COc1ccc2[nH]c3c(C(C)CNC3=O)c2c1
Show InChI InChI=1S/C13H14N2O2/c1-7-6-14-13(16)12-11(7)9-5-8(17-2)3-4-10(9)15-12/h3-5,7,15H,6H2,1-2H3,(H,14,16)
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n/an/a 4.50E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30213
PNG
(carboline analog, 25)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(OCc4ccccc4)cc3c12
Show InChI InChI=1S/C19H18N2O2/c1-12-10-20-19(22)18-17(12)15-9-14(7-8-16(15)21-18)23-11-13-5-3-2-4-6-13/h2-9,12,21H,10-11H2,1H3,(H,20,22)
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n/an/a>4.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30214
PNG
(carboline analog, 26)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(NC(C)=O)cc3c12
Show InChI InChI=1S/C14H15N3O2/c1-7-6-15-14(19)13-12(7)10-5-9(16-8(2)18)3-4-11(10)17-13/h3-5,7,17H,6H2,1-2H3,(H,15,19)(H,16,18)
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n/an/a>4.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30215
PNG
(carboline analog, 27)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(N)=O
Show InChI InChI=1S/C13H13N3O2/c1-6-5-15-13(18)11-10(6)8-4-7(12(14)17)2-3-9(8)16-11/h2-4,6,16H,5H2,1H3,(H2,14,17)(H,15,18)
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n/an/a 5.40E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30216
PNG
(carboline analog, 28)
Show SMILES CNC(=O)c1ccc2[nH]c3c(C(C)CNC3=O)c2c1
Show InChI InChI=1S/C14H15N3O2/c1-7-6-16-14(19)12-11(7)9-5-8(13(18)15-2)3-4-10(9)17-12/h3-5,7,17H,6H2,1-2H3,(H,15,18)(H,16,19)
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n/an/a 1.20E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30217
PNG
(carboline analog, 29)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)N(C)C
Show InChI InChI=1S/C15H17N3O2/c1-8-7-16-14(19)13-12(8)10-6-9(15(20)18(2)3)4-5-11(10)17-13/h4-6,8,17H,7H2,1-3H3,(H,16,19)
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n/an/a>2.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30218
PNG
(carboline analog, 30)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)NC1CCCCC1
Show InChI InChI=1S/C19H23N3O2/c1-11-10-20-19(24)17-16(11)14-9-12(7-8-15(14)22-17)18(23)21-13-5-3-2-4-6-13/h7-9,11,13,22H,2-6,10H2,1H3,(H,20,24)(H,21,23)
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n/an/a>2.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30219
PNG
(carboline analog, 31)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)N1CCCCC1
Show InChI InChI=1S/C18H21N3O2/c1-11-10-19-17(22)16-15(11)13-9-12(5-6-14(13)20-16)18(23)21-7-3-2-4-8-21/h5-6,9,11,20H,2-4,7-8,10H2,1H3,(H,19,22)
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n/an/a>2.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30220
PNG
(carboline analog, 32)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C19H17N3O2/c1-11-10-20-19(24)17-16(11)14-9-12(7-8-15(14)22-17)18(23)21-13-5-3-2-4-6-13/h2-9,11,22H,10H2,1H3,(H,20,24)(H,21,23)
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n/an/a 2.90E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30221
PNG
(carboline analog, 33)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)NCc1ccccc1
Show InChI InChI=1S/C20H19N3O2/c1-12-10-21-20(25)18-17(12)15-9-14(7-8-16(15)23-18)19(24)22-11-13-5-3-2-4-6-13/h2-9,12,23H,10-11H2,1H3,(H,21,25)(H,22,24)
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n/an/a>2.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30222
PNG
(carboline analog, 34)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C21H21N3O2/c1-13-12-23-21(26)19-18(13)16-11-15(7-8-17(16)24-19)20(25)22-10-9-14-5-3-2-4-6-14/h2-8,11,13,24H,9-10,12H2,1H3,(H,22,25)(H,23,26)
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n/an/a>2.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30223
PNG
(carboline analog, 35)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1cccnc1
Show InChI InChI=1S/C18H16N4O2/c1-10-8-20-18(24)16-15(10)13-7-11(4-5-14(13)22-16)17(23)21-12-3-2-6-19-9-12/h2-7,9-10,22H,8H2,1H3,(H,20,24)(H,21,23)
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n/an/a 520n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30224
PNG
(carboline analog, 36)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccncc1
Show InChI InChI=1S/C18H16N4O2/c1-10-9-20-18(24)16-15(10)13-8-11(2-3-14(13)22-16)17(23)21-12-4-6-19-7-5-12/h2-8,10,22H,9H2,1H3,(H,20,24)(H,19,21,23)
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n/an/a 760n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30225
PNG
(carboline analog, 37)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1nccs1
Show InChI InChI=1S/C16H14N4O2S/c1-8-7-18-15(22)13-12(8)10-6-9(2-3-11(10)19-13)14(21)20-16-17-4-5-23-16/h2-6,8,19H,7H2,1H3,(H,18,22)(H,17,20,21)
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n/an/a 820n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30226
PNG
(carboline analog, 38)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccon1
Show InChI InChI=1S/C16H14N4O3/c1-8-7-17-16(22)14-13(8)10-6-9(2-3-11(10)18-14)15(21)19-12-4-5-23-20-12/h2-6,8,18H,7H2,1H3,(H,17,22)(H,19,20,21)
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n/an/a 1.50E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30227
PNG
(carboline analog, 39)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccncn1
Show InChI InChI=1S/C17H15N5O2/c1-9-7-19-17(24)15-14(9)11-6-10(2-3-12(11)21-15)16(23)22-13-4-5-18-8-20-13/h2-6,8-9,21H,7H2,1H3,(H,19,24)(H,18,20,22,23)
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n/an/a 1.50E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30228
PNG
(carboline analog, 40)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1cnccn1
Show InChI InChI=1S/C17H15N5O2/c1-9-7-20-17(24)15-14(9)11-6-10(2-3-12(11)21-15)16(23)22-13-8-18-4-5-19-13/h2-6,8-9,21H,7H2,1H3,(H,20,24)(H,19,22,23)
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n/an/a 440n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30229
PNG
(carboline analog, 41)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ncccn1
Show InChI InChI=1S/C17H15N5O2/c1-9-8-20-16(24)14-13(9)11-7-10(3-4-12(11)21-14)15(23)22-17-18-5-2-6-19-17/h2-7,9,21H,8H2,1H3,(H,20,24)(H,18,19,22,23)
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n/an/a>2.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30230
PNG
(carboline analog, 42)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1nc2ccccc2s1
Show InChI InChI=1S/C20H16N4O2S/c1-10-9-21-19(26)17-16(10)12-8-11(6-7-13(12)22-17)18(25)24-20-23-14-4-2-3-5-15(14)27-20/h2-8,10,22H,9H2,1H3,(H,21,26)(H,23,24,25)
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n/an/a 1.50E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30231
PNG
(carboline analog, 43)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccccc1C
Show InChI InChI=1S/C20H19N3O2/c1-11-5-3-4-6-15(11)23-19(24)13-7-8-16-14(9-13)17-12(2)10-21-20(25)18(17)22-16/h3-9,12,22H,10H2,1-2H3,(H,21,25)(H,23,24)
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n/an/a>2.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30232
PNG
(carboline analog, 44)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccccc1F
Show InChI InChI=1S/C19H16FN3O2/c1-10-9-21-19(25)17-16(10)12-8-11(6-7-14(12)22-17)18(24)23-15-5-3-2-4-13(15)20/h2-8,10,22H,9H2,1H3,(H,21,25)(H,23,24)
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n/an/a 9.70E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30233
PNG
(carboline analog, 45)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccccc1Br
Show InChI InChI=1S/C19H16BrN3O2/c1-10-9-21-19(25)17-16(10)12-8-11(6-7-14(12)22-17)18(24)23-15-5-3-2-4-13(15)20/h2-8,10,22H,9H2,1H3,(H,21,25)(H,23,24)
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n/an/a>1.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30234
PNG
(carboline analog, 46)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccccc1C#N
Show InChI InChI=1S/C20H16N4O2/c1-11-10-22-20(26)18-17(11)14-8-12(6-7-16(14)23-18)19(25)24-15-5-3-2-4-13(15)9-21/h2-8,11,23H,10H2,1H3,(H,22,26)(H,24,25)
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n/an/a>1.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30235
PNG
(carboline analog, 47)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1ccccc1C(N)=O
Show InChI InChI=1S/C20H18N4O3/c1-10-9-22-20(27)17-16(10)13-8-11(6-7-15(13)23-17)19(26)24-14-5-3-2-4-12(14)18(21)25/h2-8,10,23H,9H2,1H3,(H2,21,25)(H,22,27)(H,24,26)
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n/an/a 3.00E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30236
PNG
(carboline analog, 48)
Show SMILES CC1CNC(=O)c2[nH]c3ccc(cc3c12)C(=O)Nc1cccc(C)c1
Show InChI InChI=1S/C20H19N3O2/c1-11-4-3-5-14(8-11)22-19(24)13-6-7-16-15(9-13)17-12(2)10-21-20(25)18(17)23-16/h3-9,12,23H,10H2,1-2H3,(H,21,25)(H,22,24)
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PubMed
n/an/a 3.40E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 17: 4664-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.101
BindingDB Entry DOI: 10.7270/Q23N21QP
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30276
PNG
(indole-based 6-membered lactam, 1)
Show SMILES O=C(Nc1cccnc1)c1ccc2[nH]c3c(CCNC3=O)c2c1
Show InChI InChI=1S/C17H14N4O2/c22-16(20-11-2-1-6-18-9-11)10-3-4-14-13(8-10)12-5-7-19-17(23)15(12)21-14/h1-4,6,8-9,21H,5,7H2,(H,19,23)(H,20,22)
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n/an/a 2.60E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30277
PNG
(indole-based 6-membered lactam, 3a)
Show SMILES NCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1
Show InChI InChI=1S/C18H17N5O2/c19-8-12-7-14-13-6-10(17(24)21-11-2-1-5-20-9-11)3-4-15(13)23-16(14)18(25)22-12/h1-6,9,12,23H,7-8,19H2,(H,21,24)(H,22,25)
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n/an/a 260n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30278
PNG
(indole-based 6-membered lactam, 3c)
Show SMILES OCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1
Show InChI InChI=1S/C18H16N4O3/c23-9-12-7-14-13-6-10(17(24)20-11-2-1-5-19-8-11)3-4-15(13)22-16(14)18(25)21-12/h1-6,8,12,22-23H,7,9H2,(H,20,24)(H,21,25)
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PubMed
n/an/a 1.20E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30279
PNG
(indole-based 6-membered lactam, 3b)
Show SMILES NCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C16H15N5O2S/c17-7-9-6-11-10-5-8(14(22)21-16-18-3-4-24-16)1-2-12(10)20-13(11)15(23)19-9/h1-5,9,20H,6-7,17H2,(H,19,23)(H,18,21,22)
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n/an/a 140n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30280
PNG
(indole-based 6-membered lactam, 3d)
Show SMILES OCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C16H14N4O3S/c21-7-9-6-11-10-5-8(14(22)20-16-17-3-4-24-16)1-2-12(10)19-13(11)15(23)18-9/h1-5,9,19,21H,6-7H2,(H,18,23)(H,17,20,22)
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n/an/a 1.00E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30281
PNG
(indole-based 6-membered lactam, 3e)
Show SMILES CNCC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C17H17N5O2S/c1-18-8-10-7-12-11-6-9(15(23)22-17-19-4-5-25-17)2-3-13(11)21-14(12)16(24)20-10/h2-6,10,18,21H,7-8H2,1H3,(H,20,24)(H,19,22,23)
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n/an/a 210n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30282
PNG
(indole-based 6-membered lactam, 3f)
Show SMILES CN(C)CC1Cc2c([nH]c3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C18H19N5O2S/c1-23(2)9-11-8-13-12-7-10(16(24)22-18-19-5-6-26-18)3-4-14(12)21-15(13)17(25)20-11/h3-7,11,21H,8-9H2,1-2H3,(H,20,25)(H,19,22,24)
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n/an/a>1.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30283
PNG
(indole-based 6-membered lactam, 2)
Show SMILES O=C(Nc1cccnc1)c1ccc2cc3C(=O)NCCn3c2c1
Show InChI InChI=1S/C17H14N4O2/c22-16(20-13-2-1-5-18-10-13)12-4-3-11-8-15-17(23)19-6-7-21(15)14(11)9-12/h1-5,8-10H,6-7H2,(H,19,23)(H,20,22)
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n/an/a 1.70E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30284
PNG
(indole-based 6-membered lactam, (R)-4a)
Show SMILES NC[C@@H]1Cn2c(cc3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1
Show InChI InChI=1S/C18H17N5O2/c19-8-14-10-23-15-7-12(17(24)21-13-2-1-5-20-9-13)4-3-11(15)6-16(23)18(25)22-14/h1-7,9,14H,8,10,19H2,(H,21,24)(H,22,25)/t14-/m1/s1
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n/an/a 320n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30285
PNG
(indole-based 6-membered lactam, (S)-4a)
Show SMILES NC[C@H]1Cn2c(cc3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1
Show InChI InChI=1S/C18H17N5O2/c19-8-14-10-23-15-7-12(17(24)21-13-2-1-5-20-9-13)4-3-11(15)6-16(23)18(25)22-14/h1-7,9,14H,8,10,19H2,(H,21,24)(H,22,25)/t14-/m0/s1
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n/an/a 2.30E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30286
PNG
(indole-based 6-membered lactam, 4d)
Show SMILES CC1Cn2c(cc3ccc(cc23)C(=O)Nc2cccnc2)C(=O)N1
Show InChI InChI=1S/C18H16N4O2/c1-11-10-22-15-8-13(17(23)21-14-3-2-6-19-9-14)5-4-12(15)7-16(22)18(24)20-11/h2-9,11H,10H2,1H3,(H,20,24)(H,21,23)
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n/an/a 1.20E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30287
PNG
(indole-based 6-membered lactam, 22)
Show SMILES O=C(Nc1nccs1)c1ccc2cc3C(=O)NCCn3c2c1
Show InChI InChI=1S/C15H12N4O2S/c20-13(18-15-17-4-6-22-15)10-2-1-9-7-12-14(21)16-3-5-19(12)11(9)8-10/h1-2,4,6-8H,3,5H2,(H,16,21)(H,17,18,20)
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n/an/a 1.10E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30288
PNG
(indole-based 6-membered lactam, (R)-4b)
Show SMILES NC[C@@H]1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C16H15N5O2S/c17-7-11-8-21-12-6-10(14(22)20-16-18-3-4-24-16)2-1-9(12)5-13(21)15(23)19-11/h1-6,11H,7-8,17H2,(H,19,23)(H,18,20,22)/t11-/m1/s1
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n/an/a 160n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30289
PNG
(indole-based 6-membered lactam, (S)-4b)
Show SMILES NC[C@H]1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C16H15N5O2S/c17-7-11-8-21-12-6-10(14(22)20-16-18-3-4-24-16)2-1-9(12)5-13(21)15(23)19-11/h1-6,11H,7-8,17H2,(H,19,23)(H,18,20,22)/t11-/m0/s1
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n/an/a 1.40E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30290
PNG
(indole-based 6-membered lactam, 4c)
Show SMILES OCC1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C16H14N4O3S/c21-8-11-7-20-12-6-10(14(22)19-16-17-3-4-24-16)2-1-9(12)5-13(20)15(23)18-11/h1-6,11,21H,7-8H2,(H,18,23)(H,17,19,22)
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n/an/a 550n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30291
PNG
(indole-based 6-membered lactam, 4e)
Show SMILES CC1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C16H14N4O2S/c1-9-8-20-12-7-11(14(21)19-16-17-4-5-23-16)3-2-10(12)6-13(20)15(22)18-9/h2-7,9H,8H2,1H3,(H,18,22)(H,17,19,21)
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n/an/a 4.00E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30292
PNG
(indole-based 6-membered lactam, 4f)
Show SMILES CNCC1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C17H17N5O2S/c1-18-8-12-9-22-13-7-11(15(23)21-17-19-4-5-25-17)3-2-10(13)6-14(22)16(24)20-12/h2-7,12,18H,8-9H2,1H3,(H,20,24)(H,19,21,23)
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n/an/a 580n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30293
PNG
(indole-based 6-membered lactam, 4g)
Show SMILES CCNCC1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C18H19N5O2S/c1-2-19-9-13-10-23-14-8-12(16(24)22-18-20-5-6-26-18)4-3-11(14)7-15(23)17(25)21-13/h3-8,13,19H,2,9-10H2,1H3,(H,21,25)(H,20,22,24)
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n/an/a 3.00E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30294
PNG
(indole-based 6-membered lactam, 4h)
Show SMILES CCCNCC1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C19H21N5O2S/c1-2-5-20-10-14-11-24-15-9-13(17(25)23-19-21-6-7-27-19)4-3-12(15)8-16(24)18(26)22-14/h3-4,6-9,14,20H,2,5,10-11H2,1H3,(H,22,26)(H,21,23,25)
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n/an/a 4.00E+3n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
MAPK-Activated Protein Kinase 2 (MK2)


(Homo sapiens (human))
BDBM30295
PNG
(indole-based 6-membered lactam, 4i)
Show SMILES CC(C)NCC1Cn2c(cc3ccc(cc23)C(=O)Nc2nccs2)C(=O)N1
Show InChI InChI=1S/C19H21N5O2S/c1-11(2)21-9-14-10-24-15-8-13(17(25)23-19-20-5-6-27-19)4-3-12(15)7-16(24)18(26)22-14/h3-8,11,14,21H,9-10H2,1-2H3,(H,22,26)(H,20,23,25)
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n/an/a>1.00E+4n/an/an/an/a7.625



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...


Bioorg Med Chem Lett 18: 1994-9 (2008)


Article DOI: 10.1016/j.bmcl.2008.01.119
BindingDB Entry DOI: 10.7270/Q2ZW1J8V
More data for this
Ligand-Target Pair
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