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Found 257 hits of ph data with Target = 'Macrophage colony-stimulating factor 1 receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131906
PNG
(US8841455, 1)
Show SMILES COCCOc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3ccccc3)nc(I)c12
Show InChI InChI=1S/C25H22IN5O3/c1-33-12-13-34-18-10-11-30-21(15-27-22(30)14-18)25(32)28-19-8-5-9-20-23(19)24(26)29-31(20)16-17-6-3-2-4-7-17/h2-11,14-15H,12-13,16H2,1H3,(H,28,32)
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n/an/a 112n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131907
PNG
(US8841455, 2)
Show SMILES CCc1nn(Cc2ccccc2)c2cccc(NC(=O)c3cnc4cc(OCCOC)ccn34)c12
Show InChI InChI=1S/C27H27N5O3/c1-3-21-26-22(10-7-11-23(26)32(30-21)18-19-8-5-4-6-9-19)29-27(33)24-17-28-25-16-20(12-13-31(24)25)35-15-14-34-2/h4-13,16-17H,3,14-15,18H2,1-2H3,(H,29,33)
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n/an/a 118n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131908
PNG
(US8841455, 3)
Show SMILES COCCOc1ccn2c(cnc2c1)C(=O)Nc1cccc2n(Cc3ccccc3)nc(C3CC3)c12
Show InChI InChI=1S/C28H27N5O3/c1-35-14-15-36-21-12-13-32-24(17-29-25(32)16-21)28(34)30-22-8-5-9-23-26(22)27(20-10-11-20)31-33(23)18-19-6-3-2-4-7-19/h2-9,12-13,16-17,20H,10-11,14-15,18H2,1H3,(H,30,34)
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n/an/a 57.9n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131909
PNG
(US8841455, 4)
Show SMILES CCc1nn(Cc2ccccc2)c2ccc(Cl)c(NC(=O)c3cnc4cc(OCCOC)ccn34)c12
Show InChI InChI=1S/C27H26ClN5O3/c1-3-21-25-22(33(31-21)17-18-7-5-4-6-8-18)10-9-20(28)26(25)30-27(34)23-16-29-24-15-19(11-12-32(23)24)36-14-13-35-2/h4-12,15-16H,3,13-14,17H2,1-2H3,(H,30,34)
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n/an/a 42n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131910
PNG
(US8841455, 5)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H22N6O/c1-3-18-23-19(27-24(31)21-14-25-22-12-4-5-13-29(21)22)10-7-11-20(23)30(28-18)15-17-9-6-8-16(2)26-17/h4-14H,3,15H2,1-2H3,(H,27,31)
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n/an/a 137n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131911
PNG
(US8841455, 6)
Show SMILES CCc1nn(Cc2ccc(C)nc2OC)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C25H24N6O2/c1-4-18-23-19(28-24(32)21-14-26-22-10-5-6-13-30(21)22)8-7-9-20(23)31(29-18)15-17-12-11-16(2)27-25(17)33-3/h5-14H,4,15H2,1-3H3,(H,28,32)
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n/an/a 516n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131912
PNG
(US8841455, 7)
Show SMILES CCc1nn(Cc2ccn(CCN3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C27H31N9O/c1-2-21-26-22(30-27(37)24-18-29-25-8-3-4-12-35(24)25)6-5-7-23(26)36(32-21)19-20-9-13-34(31-20)17-16-33-14-10-28-11-15-33/h3-9,12-13,18,28H,2,10-11,14-17,19H2,1H3,(H,30,37)
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n/an/a 3.07E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131913
PNG
(US8841455, 8)
Show SMILES CCc1nn(Cc2ccnn2CC(O)CO)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H25N7O3/c1-2-18-23-19(27-24(34)21-12-25-22-8-3-4-11-29(21)22)6-5-7-20(23)31(28-18)13-16-9-10-26-30(16)14-17(33)15-32/h3-12,17,32-33H,2,13-15H2,1H3,(H,27,34)
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n/an/a 3.00E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131914
PNG
(US8841455, 9)
Show SMILES CCc1nn(Cc2cccc(OCCN)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C25H25N7O2/c1-2-18-24-19(29-25(33)21-15-27-22-10-3-4-13-31(21)22)8-6-9-20(24)32(30-18)16-17-7-5-11-23(28-17)34-14-12-26/h3-11,13,15H,2,12,14,16,26H2,1H3,(H,29,33)
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n/an/a 455n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131915
PNG
(US8841455, 10)
Show SMILES CCc1nn(Cc2cccc(OCCCN)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C26H27N7O2/c1-2-19-25-20(30-26(34)22-16-28-23-11-3-4-14-32(22)23)9-6-10-21(25)33(31-19)17-18-8-5-12-24(29-18)35-15-7-13-27/h3-6,8-12,14,16H,2,7,13,15,17,27H2,1H3,(H,30,34)
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n/an/a 395n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131916
PNG
(US8841455, 11)
Show SMILES CCc1nn(Cc2cccc(OCCCN(C)C)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H31N7O2/c1-4-21-27-22(31-28(36)24-18-29-25-13-5-6-16-34(24)25)11-8-12-23(27)35(32-21)19-20-10-7-14-26(30-20)37-17-9-15-33(2)3/h5-8,10-14,16,18H,4,9,15,17,19H2,1-3H3,(H,31,36)
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n/an/a 4.88E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131917
PNG
(US8841455, 12)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)N3CCNCC3)c12
Show InChI InChI=1S/C29H30N8O2/c1-3-22-27-23(8-5-9-24(27)37(34-22)18-21-7-4-6-19(2)32-21)33-28(38)25-17-31-26-16-20(10-13-36(25)26)29(39)35-14-11-30-12-15-35/h4-10,13,16-17,30H,3,11-12,14-15,18H2,1-2H3,(H,33,38)
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n/an/a 903n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131918
PNG
(US8841455, 13)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)N3CCN(C)CC3)c12
Show InChI InChI=1S/C30H32N8O2/c1-4-23-28-24(9-6-10-25(28)38(34-23)19-22-8-5-7-20(2)32-22)33-29(39)26-18-31-27-17-21(11-12-37(26)27)30(40)36-15-13-35(3)14-16-36/h5-12,17-18H,4,13-16,19H2,1-3H3,(H,33,39)
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n/an/a 2.56E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131919
PNG
(US8841455, 14)
Show SMILES CCc1nn(Cc2cccc(CN3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H30N8O/c1-2-22-27-23(32-28(37)25-17-30-26-11-3-4-14-35(25)26)9-6-10-24(27)36(33-22)19-21-8-5-7-20(31-21)18-34-15-12-29-13-16-34/h3-11,14,17,29H,2,12-13,15-16,18-19H2,1H3,(H,32,37)
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n/an/a 3.84E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131920
PNG
(US8841455, 15)
Show SMILES CCc1nn(Cc2cccc(OC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H22N6O2/c1-3-17-23-18(27-24(31)20-14-25-21-11-4-5-13-29(20)21)9-7-10-19(23)30(28-17)15-16-8-6-12-22(26-16)32-2/h4-14H,3,15H2,1-2H3,(H,27,31)
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n/an/a 138n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131921
PNG
(US8841455, 16)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCOCC5)ccn34)c12
Show InChI InChI=1S/C30H33N7O3/c1-3-24-29-25(8-5-9-26(29)37(34-24)20-22-7-4-6-21(2)32-22)33-30(38)27-19-31-28-18-23(10-11-36(27)28)40-17-14-35-12-15-39-16-13-35/h4-11,18-19H,3,12-17,20H2,1-2H3,(H,33,38)
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n/an/a 145n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131922
PNG
(US8841455, 17)
Show SMILES CCc1nn(Cc2cccc(OC3CCNC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C27H27N7O2/c1-2-20-26-21(31-27(35)23-16-29-24-10-3-4-14-33(23)24)8-6-9-22(26)34(32-20)17-18-7-5-11-25(30-18)36-19-12-13-28-15-19/h3-11,14,16,19,28H,2,12-13,15,17H2,1H3,(H,31,35)
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n/an/a 1.40E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131923
PNG
(US8841455, 18)
Show SMILES CCc1nn(Cc2cccc(OC3CCNC[C@H]3F)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H28FN7O2/c1-2-20-27-21(33-28(37)23-16-31-25-10-3-4-14-35(23)25)8-6-9-22(27)36(34-20)17-18-7-5-11-26(32-18)38-24-12-13-30-15-19(24)29/h3-11,14,16,19,24,30H,2,12-13,15,17H2,1H3,(H,33,37)/t19-,24?/m1/s1
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n/an/a 1.14E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131924
PNG
(US8841455, 19)
Show SMILES CCc1nn(Cc2cccc(OC3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H29N7O2/c1-2-21-27-22(32-28(36)24-17-30-25-10-3-4-16-34(24)25)8-6-9-23(27)35(33-21)18-19-7-5-11-26(31-19)37-20-12-14-29-15-13-20/h3-11,16-17,20,29H,2,12-15,18H2,1H3,(H,32,36)
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n/an/a 860n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131925
PNG
(US8841455, 20)
Show SMILES CCc1nn(Cc2cnn(Cc3ccc(OC)cc3)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C29H27N7O2/c1-3-23-28-24(32-29(37)26-16-30-27-9-4-5-14-35(26)27)7-6-8-25(28)36(33-23)19-21-15-31-34(18-21)17-20-10-12-22(38-2)13-11-20/h4-16,18H,3,17,19H2,1-2H3,(H,32,37)
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n/an/a 1.04E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131926
PNG
(US8841455, 21)
Show SMILES CCc1nn(Cc2cnn(CCO)c2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C23H23N7O2/c1-2-17-22-18(26-23(32)20-13-24-21-8-3-4-9-29(20)21)6-5-7-19(22)30(27-17)15-16-12-25-28(14-16)10-11-31/h3-9,12-14,31H,2,10-11,15H2,1H3,(H,26,32)
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n/an/a 2.91E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131927
PNG
(US8841455, 22)
Show SMILES CCc1nn(Cc2cnn(c2)C2CCNC[C@H]2F)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C26H27FN8O/c1-2-19-25-20(31-26(36)23-14-29-24-8-3-4-11-33(23)24)6-5-7-22(25)35(32-19)16-17-12-30-34(15-17)21-9-10-28-13-18(21)27/h3-8,11-12,14-15,18,21,28H,2,9-10,13,16H2,1H3,(H,31,36)/t18-,21?/m1/s1
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n/an/a 2.26E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131928
PNG
(US8841455, 23)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CC)ccn34)c12
Show InChI InChI=1S/C26H26N6O/c1-4-18-12-13-31-23(15-27-24(31)14-18)26(33)29-21-10-7-11-22-25(21)20(5-2)30-32(22)16-19-9-6-8-17(3)28-19/h6-15H,4-5,16H2,1-3H3,(H,29,33)
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n/an/a 141n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131929
PNG
(US8841455, 24)
Show SMILES CCc1nn(Cc2cccc(CC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C25H24N6O/c1-3-17-9-7-10-18(27-17)16-31-21-12-8-11-20(24(21)19(4-2)29-31)28-25(32)22-15-26-23-13-5-6-14-30(22)23/h5-15H,3-4,16H2,1-2H3,(H,28,32)
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Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131930
PNG
(US8841455, 25)
Show SMILES CCc1nn(Cc2cccc(=O)n2C)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C24H22N6O2/c1-3-17-23-18(26-24(32)20-14-25-21-11-4-5-13-29(20)21)9-7-10-19(23)30(27-17)15-16-8-6-12-22(31)28(16)2/h4-14H,3,15H2,1-2H3,(H,26,32)
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n/an/a 1.97E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131931
PNG
(US8841455, 26)
Show SMILES CCc1nn(Cc2cccc(=O)n2CC)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C25H24N6O2/c1-3-18-24-19(27-25(33)21-15-26-22-12-5-6-14-30(21)22)10-8-11-20(24)31(28-18)16-17-9-7-13-23(32)29(17)4-2/h5-15H,3-4,16H2,1-2H3,(H,27,33)
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n/an/a 4.91E+3n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131932
PNG
(US8841455, 27)
Show SMILES CCOc1cccc(Cn2nc(CC)c3c(NC(=O)c4cnc5ccccn45)cccc23)n1
Show InChI InChI=1S/C25H24N6O2/c1-3-18-24-19(28-25(32)21-15-26-22-12-5-6-14-30(21)22)10-8-11-20(24)31(29-18)16-17-9-7-13-23(27-17)33-4-2/h5-15H,3-4,16H2,1-2H3,(H,28,32)
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n/an/a 101n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131933
PNG
(US8841455, 28)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)-c3nnco3)c12
Show InChI InChI=1S/C26H22N8O2/c1-3-19-24-20(8-5-9-21(24)34(32-19)14-18-7-4-6-16(2)29-18)30-25(35)22-13-27-23-12-17(10-11-33(22)23)26-31-28-15-36-26/h4-13,15H,3,14H2,1-2H3,(H,30,35)
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n/an/a 176n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131934
PNG
(US8841455, 29)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)-c3nnc(C)o3)c12
Show InChI InChI=1S/C27H24N8O2/c1-4-20-25-21(9-6-10-22(25)35(33-20)15-19-8-5-7-16(2)29-19)30-26(36)23-14-28-24-13-18(11-12-34(23)24)27-32-31-17(3)37-27/h5-14H,4,15H2,1-3H3,(H,30,36)
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n/an/a 556n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131935
PNG
(US8841455, 30)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CN5CCNCC5)ccn34)c12
Show InChI InChI=1S/C29H32N8O/c1-3-23-28-24(8-5-9-25(28)37(34-23)19-22-7-4-6-20(2)32-22)33-29(38)26-17-31-27-16-21(10-13-36(26)27)18-35-14-11-30-12-15-35/h4-10,13,16-17,30H,3,11-12,14-15,18-19H2,1-2H3,(H,33,38)
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n/an/a 191n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131936
PNG
(US8841455, 31)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(CN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C30H34N8O/c1-4-24-29-25(9-6-10-26(29)38(34-24)20-23-8-5-7-21(2)32-23)33-30(39)27-18-31-28-17-22(11-12-37(27)28)19-36-15-13-35(3)14-16-36/h5-12,17-18H,4,13-16,19-20H2,1-3H3,(H,33,39)
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n/an/a 333n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131937
PNG
(US8841455, 32)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@H]5CNC[C@@H]5O)ccn34)c12
Show InChI InChI=1S/C28H29N7O3/c1-3-20-27-21(8-5-9-22(27)35(33-20)16-18-7-4-6-17(2)31-18)32-28(37)23-13-30-26-12-19(10-11-34(23)26)38-25-15-29-14-24(25)36/h4-13,24-25,29,36H,3,14-16H2,1-2H3,(H,32,37)/t24-,25-/m0/s1
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n/an/a 342n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131938
PNG
(US8841455, 33)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@@H]5CNC[C@H]5O)ccn34)c12
Show InChI InChI=1S/C28H29N7O3/c1-3-20-27-21(8-5-9-22(27)35(33-20)16-18-7-4-6-17(2)31-18)32-28(37)23-13-30-26-12-19(10-11-34(23)26)38-25-15-29-14-24(25)36/h4-13,24-25,29,36H,3,14-16H2,1-2H3,(H,32,37)/t24-,25-/m1/s1
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n/an/a 287n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131939
PNG
(US8841455, 34)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@H]5CN(C)C[C@@H]5O)ccn34)c12
Show InChI InChI=1S/C29H31N7O3/c1-4-21-28-22(9-6-10-23(28)36(33-21)15-19-8-5-7-18(2)31-19)32-29(38)24-14-30-27-13-20(11-12-35(24)27)39-26-17-34(3)16-25(26)37/h5-14,25-26,37H,4,15-17H2,1-3H3,(H,32,38)/t25-,26-/m0/s1
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Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131940
PNG
(US8841455, 35)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(O[C@@H]5CN(C)C[C@H]5O)ccn34)c12
Show InChI InChI=1S/C29H31N7O3/c1-4-21-28-22(9-6-10-23(28)36(33-21)15-19-8-5-7-18(2)31-19)32-29(38)24-14-30-27-13-20(11-12-35(24)27)39-26-17-34(3)16-25(26)37/h5-14,25-26,37H,4,15-17H2,1-3H3,(H,32,38)/t25-,26-/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131941
PNG
(US8841455, 36)
Show SMILES CCc1nn(Cc2cccc(OC[C@H]3NCC[C@@H]3O)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C28H29N7O3/c1-2-19-27-20(32-28(37)23-15-30-25-10-3-4-14-34(23)25)8-6-9-22(27)35(33-19)16-18-7-5-11-26(31-18)38-17-21-24(36)12-13-29-21/h3-11,14-15,21,24,29,36H,2,12-13,16-17H2,1H3,(H,32,37)/t21-,24+/m1/s1
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n/an/a 555n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131942
PNG
(US8841455, 37)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CC[N+](C)([O-])CC5)ccn34)c12
Show InChI InChI=1S/C31H36N8O3/c1-4-25-30-26(9-6-10-27(30)38(35-25)21-23-8-5-7-22(2)33-23)34-31(40)28-20-32-29-19-24(11-12-37(28)29)42-18-15-36-13-16-39(3,41)17-14-36/h5-12,19-20H,4,13-18,21H2,1-3H3,(H,34,40)
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Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131943
PNG
(US8841455, 38)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OC[C@H]5NCC[C@@H]5O)ccn34)c12
Show InChI InChI=1S/C29H31N7O3/c1-3-21-28-22(8-5-9-24(28)36(34-21)16-19-7-4-6-18(2)32-19)33-29(38)25-15-31-27-14-20(11-13-35(25)27)39-17-23-26(37)10-12-30-23/h4-9,11,13-15,23,26,30,37H,3,10,12,16-17H2,1-2H3,(H,33,38)/t23-,26+/m1/s1
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Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131944
PNG
(US8841455, 39)
Show SMILES CCc1nn(Cc2ccnn2CC)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C23H23N7O/c1-3-17-22-18(26-23(31)20-14-24-21-10-5-6-13-28(20)21)8-7-9-19(22)30(27-17)15-16-11-12-25-29(16)4-2/h5-14H,3-4,15H2,1-2H3,(H,26,31)
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n/an/a 332n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131945
PNG
(US8841455, 40)
Show SMILES CCc1nn(Cc2ccn(CC)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C23H23N7O/c1-3-17-22-18(25-23(31)20-14-24-21-10-5-6-12-29(20)21)8-7-9-19(22)30(27-17)15-16-11-13-28(4-2)26-16/h5-14H,3-4,15H2,1-2H3,(H,25,31)
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n/an/a 359n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131946
PNG
(US8841455, 41)
Show SMILES CCc1nn(Cc2cccc(OC[C@@H]3[C@@H](O)CCN3C)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C29H31N7O3/c1-3-20-28-21(32-29(38)23-16-30-26-11-4-5-14-35(23)26)9-7-10-22(28)36(33-20)17-19-8-6-12-27(31-19)39-18-24-25(37)13-15-34(24)2/h4-12,14,16,24-25,37H,3,13,15,17-18H2,1-2H3,(H,32,38)/t24-,25+/m1/s1
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n/an/a 932n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131947
PNG
(US8841455, 42)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OC[C@@H]5[C@@H](O)CCN5C)ccn34)c12
Show InChI InChI=1S/C30H33N7O3/c1-4-22-29-23(9-6-10-24(29)37(34-22)17-20-8-5-7-19(2)32-20)33-30(39)25-16-31-28-15-21(11-14-36(25)28)40-18-26-27(38)12-13-35(26)3/h5-11,14-16,26-27,38H,4,12-13,17-18H2,1-3H3,(H,33,39)/t26-,27+/m1/s1
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n/an/a 275n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131948
PNG
(US8841455, 43)
Show SMILES CCc1nn(Cc2cccc(OCCN3CCNCC3)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12
Show InChI InChI=1S/C29H32N8O2/c1-2-22-28-23(33-29(38)25-19-31-26-10-3-4-14-36(25)26)8-6-9-24(28)37(34-22)20-21-7-5-11-27(32-21)39-18-17-35-15-12-30-13-16-35/h3-11,14,19,30H,2,12-13,15-18,20H2,1H3,(H,33,38)
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n/an/a 396n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131949
PNG
(US8841455, 44)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)-c3nncs3)c12
Show InChI InChI=1S/C26H22N8OS/c1-3-19-24-20(8-5-9-21(24)34(32-19)14-18-7-4-6-16(2)29-18)30-25(35)22-13-27-23-12-17(10-11-33(22)23)26-31-28-15-36-26/h4-13,15H,3,14H2,1-2H3,(H,30,35)
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n/an/a 233n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131950
PNG
(US8841455, 45)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(OCCN5CCN(C)CC5)ccn34)c12
Show InChI InChI=1S/C31H36N8O2/c1-4-25-30-26(9-6-10-27(30)39(35-25)21-23-8-5-7-22(2)33-23)34-31(40)28-20-32-29-19-24(11-12-38(28)29)41-18-17-37-15-13-36(3)14-16-37/h5-12,19-20H,4,13-18,21H2,1-3H3,(H,34,40)
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n/an/a 172n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131951
PNG
(US8841455, 46)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)NC3CCNC3)c12
Show InChI InChI=1S/C29H30N8O2/c1-3-22-27-23(8-5-9-24(27)37(35-22)17-21-7-4-6-18(2)32-21)34-29(39)25-16-31-26-14-19(11-13-36(25)26)28(38)33-20-10-12-30-15-20/h4-9,11,13-14,16,20,30H,3,10,12,15,17H2,1-2H3,(H,33,38)(H,34,39)
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n/an/a 265n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131952
PNG
(US8841455, 47)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)NCCN)c12
Show InChI InChI=1S/C27H28N8O2/c1-3-20-25-21(8-5-9-22(25)35(33-20)16-19-7-4-6-17(2)31-19)32-27(37)23-15-30-24-14-18(10-13-34(23)24)26(36)29-12-11-28/h4-10,13-15H,3,11-12,16,28H2,1-2H3,(H,29,36)(H,32,37)
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n/an/a 311n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131953
PNG
(US8841455, 48)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)NC)c12
Show InChI InChI=1S/C26H25N7O2/c1-4-19-24-20(9-6-10-21(24)33(31-19)15-18-8-5-7-16(2)29-18)30-26(35)22-14-28-23-13-17(25(34)27-3)11-12-32(22)23/h5-14H,4,15H2,1-3H3,(H,27,34)(H,30,35)
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n/an/a 426n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131954
PNG
(US8841455, 49)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)N(C)C)c12
Show InChI InChI=1S/C27H27N7O2/c1-5-20-25-21(10-7-11-22(25)34(31-20)16-19-9-6-8-17(2)29-19)30-26(35)23-15-28-24-14-18(12-13-33(23)24)27(36)32(3)4/h6-15H,5,16H2,1-4H3,(H,30,35)
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n/an/a 738n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (human))
BDBM131955
PNG
(US8841455, 50)
Show SMILES CCc1nn(Cc2cccc(C)n2)c2cccc(NC(=O)c3cnc4cc(ccn34)C(=O)NC3CCN(C)C3)c12
Show InChI InChI=1S/C30H32N8O2/c1-4-23-28-24(9-6-10-25(28)38(35-23)18-21-8-5-7-19(2)32-21)34-30(40)26-16-31-27-15-20(11-14-37(26)27)29(39)33-22-12-13-36(3)17-22/h5-11,14-16,22H,4,12-13,17-18H2,1-3H3,(H,33,39)(H,34,40)
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n/an/a 348n/an/an/an/a7.322



Array BioPharma Inc.

US Patent


Assay Description
The ability of compounds of Formula I to inhibit cFMS was determined by the following assay. cFMS enzymatic activity was measured using the LANCE Ult...


US Patent US8841455 (2014)


BindingDB Entry DOI: 10.7270/Q2125RB3
More data for this
Ligand-Target Pair
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