BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 26 hits of ph data with Target = 'Mdm2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mdm2


(Homo sapiens (Human))
BDBM207976
PNG
(N-Methyl-3,5-di(4-chlorobenzyl)-4-(6-chloro-1H-ind...)
Show SMILES CN1C(=O)C(Cc2ccc(Cl)cc2)=C(c2c[nH]c3cc(Cl)ccc23)C1(O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C27H21Cl3N2O2/c1-32-26(33)22(12-16-2-6-18(28)7-3-16)25(23-15-31-24-13-20(30)10-11-21(23)24)27(32,34)14-17-4-8-19(29)9-5-17/h2-11,13,15,31,34H,12,14H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/an/a<1.00E+3n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mdm2


(Homo sapiens (Human))
BDBM207989
PNG
(5-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-4-(4...)
Show SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1c1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C25H16Cl3NO3/c26-16-5-1-14(2-6-16)12-25(31)23(15-3-7-17(27)8-4-15)22(24(30)32-25)20-13-29-21-11-18(28)9-10-19(20)21/h1-11,13,29,31H,12H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 7.00E+3n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207978
PNG
(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3...)
Show SMILES CN1C(=O)C(=C(c2c[nH]c3cc(Cl)ccc23)C1(O)Cc1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H19Cl3N2O2/c1-31-25(32)23(16-4-8-18(28)9-5-16)24(21-14-30-22-12-19(29)10-11-20(21)22)26(31,33)13-15-2-6-17(27)7-3-15/h2-12,14,30,33H,13H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 5.10E+4n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207979
PNG
(N-methyl-5-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3...)
Show SMILES CN1C(=O)C(=C(c2ccc(Cl)cc2)C1(O)Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H19Cl3N2O2/c1-31-25(32)23(21-14-30-22-12-19(29)10-11-20(21)22)24(16-4-8-18(28)9-5-16)26(31,33)13-15-2-6-17(27)7-3-15/h2-12,14,30,33H,13H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.92E+5n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207980
PNG
(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1-methyl-1...)
Show SMILES CN1C(=O)C(=C(c2cn(C)c3cc(Cl)ccc23)C1(O)Cc1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H21Cl3N2O2/c1-31-15-22(21-12-11-20(30)13-23(21)31)25-24(17-5-9-19(29)10-6-17)26(33)32(2)27(25,34)14-16-3-7-18(28)8-4-16/h3-13,15,34H,14H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 3.65E+5n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207981
PNG
(N-methyl-5-(4-chlorobenzyl)-3-(6-chloro-1-methyl-1...)
Show SMILES CN1C(=O)C(=C(c2ccc(Cl)cc2)C1(O)Cc1ccc(Cl)cc1)c1cn(C)c2cc(Cl)ccc12
Show InChI InChI=1S/C27H21Cl3N2O2/c1-31-15-22(21-12-11-20(30)13-23(21)31)24-25(17-5-9-19(29)10-6-17)27(34,32(2)26(24)33)14-16-3-7-18(28)8-4-16/h3-13,15,34H,14H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.46E+5n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207982
PNG
(N-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)- 3-(...)
Show SMILES OC1N(Cc2ccc(Cl)cc2)C(=O)C(=C1c1c[nH]c2cc(Cl)ccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H17Cl3N2O2/c26-16-5-1-14(2-6-16)13-30-24(31)22(15-3-7-17(27)8-4-15)23(25(30)32)20-12-29-21-11-18(28)9-10-19(20)21/h1-12,25,29,32H,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.64E+5n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207983
PNG
(N-(4-Chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-4-(4...)
Show SMILES OC1N(Cc2ccc(Cl)cc2)C(=O)C(=C1c1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C25H17Cl3N2O2/c26-16-5-1-14(2-6-16)13-30-24(31)22(15-3-7-17(27)8-4-15)23(25(30)32)20-12-29-21-11-18(28)9-10-19(20)21/h1-12,24,29,31H,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 4.00E+4n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207984
PNG
(3,5-Di(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-...)
Show SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(Cc2ccc(Cl)cc2)=C1c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H18Cl3NO3/c27-17-5-1-15(2-6-17)11-21-24(22-14-30-23-12-19(29)9-10-20(22)23)26(32,33-25(21)31)13-16-3-7-18(28)8-4-16/h1-10,12,14,30,32H,11,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/an/a<1.00E+3n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mdm2


(Homo sapiens (Human))
BDBM207985
PNG
(4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-...)
Show SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H18Cl3NO3/c27-17-5-1-15(2-6-17)11-22-24(21-14-30-23-12-19(29)9-10-20(21)23)25(31)33-26(22,32)13-16-3-7-18(28)8-4-16/h1-10,12,14,30,32H,11,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 8.60E+4n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207986
PNG
(3-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-(4...)
Show SMILES OC1(Cc2ccc(F)cc2)OC(=O)C(Cc2ccc(Cl)cc2)=C1c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H18Cl2FNO3/c27-17-5-1-15(2-6-17)11-21-24(22-14-30-23-12-18(28)7-10-20(22)23)26(32,33-25(21)31)13-16-3-8-19(29)9-4-16/h1-10,12,14,30,32H,11,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.80E+4n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207988
PNG
(5-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-3-(4...)
Show SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1c1c[nH]c2cc(Cl)ccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H16Cl3NO3/c26-16-5-1-14(2-6-16)12-25(31)23(20-13-29-21-11-18(28)9-10-19(20)21)22(24(30)32-25)15-3-7-17(27)8-4-15/h1-11,13,29,31H,12H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 6.00E+4n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207989
PNG
(5-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-4-(4...)
Show SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1c1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C25H16Cl3NO3/c26-16-5-1-14(2-6-16)12-25(31)23(15-3-7-17(27)8-4-15)22(24(30)32-25)20-13-29-21-11-18(28)9-10-19(20)21/h1-11,13,29,31H,12H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 6.80E+4n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207976
PNG
(N-Methyl-3,5-di(4-chlorobenzyl)-4-(6-chloro-1H-ind...)
Show SMILES CN1C(=O)C(Cc2ccc(Cl)cc2)=C(c2c[nH]c3cc(Cl)ccc23)C1(O)Cc1ccc(Cl)cc1
Show InChI InChI=1S/C27H21Cl3N2O2/c1-32-26(33)22(12-16-2-6-18(28)7-3-16)25(23-15-31-24-13-20(30)10-11-21(23)24)27(32,34)14-17-4-8-19(29)9-5-17/h2-11,13,15,31,34H,12,14H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/an/a 500n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mdm2


(Homo sapiens (Human))
BDBM207978
PNG
(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3...)
Show SMILES CN1C(=O)C(=C(c2c[nH]c3cc(Cl)ccc23)C1(O)Cc1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C26H19Cl3N2O2/c1-31-25(32)23(16-4-8-18(28)9-5-16)24(21-14-30-22-12-19(29)10-11-20(21)22)26(31,33)13-15-2-6-17(27)7-3-15/h2-12,14,30,33H,13H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.87E+4n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207979
PNG
(N-methyl-5-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3...)
Show SMILES CN1C(=O)C(=C(c2ccc(Cl)cc2)C1(O)Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H19Cl3N2O2/c1-31-25(32)23(21-14-30-22-12-19(29)10-11-20(21)22)24(16-4-8-18(28)9-5-16)26(31,33)13-15-2-6-17(27)7-3-15/h2-12,14,30,33H,13H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.77E+4n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207980
PNG
(N-Methyl-5-(4-chlorobenzyl)-4-(6-chloro-1-methyl-1...)
Show SMILES CN1C(=O)C(=C(c2cn(C)c3cc(Cl)ccc23)C1(O)Cc1ccc(Cl)cc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H21Cl3N2O2/c1-31-15-22(21-12-11-20(30)13-23(21)31)25-24(17-5-9-19(29)10-6-17)26(33)32(2)27(25,34)14-16-3-7-18(28)8-4-16/h3-13,15,34H,14H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 4.05E+4n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207981
PNG
(N-methyl-5-(4-chlorobenzyl)-3-(6-chloro-1-methyl-1...)
Show SMILES CN1C(=O)C(=C(c2ccc(Cl)cc2)C1(O)Cc1ccc(Cl)cc1)c1cn(C)c2cc(Cl)ccc12
Show InChI InChI=1S/C27H21Cl3N2O2/c1-31-15-22(21-12-11-20(30)13-23(21)31)24-25(17-5-9-19(29)10-6-17)27(34,32(2)26(24)33)14-16-3-7-18(28)8-4-16/h3-13,15,34H,14H2,1-2H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 3.04E+4n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207982
PNG
(N-(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)- 3-(...)
Show SMILES OC1N(Cc2ccc(Cl)cc2)C(=O)C(=C1c1c[nH]c2cc(Cl)ccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H17Cl3N2O2/c26-16-5-1-14(2-6-16)13-30-24(31)22(15-3-7-17(27)8-4-15)23(25(30)32)20-12-29-21-11-18(28)9-10-19(20)21/h1-12,25,29,32H,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.44E+4n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207983
PNG
(N-(4-Chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-4-(4...)
Show SMILES OC1N(Cc2ccc(Cl)cc2)C(=O)C(=C1c1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C25H17Cl3N2O2/c26-16-5-1-14(2-6-16)13-30-24(31)22(15-3-7-17(27)8-4-15)23(25(30)32)20-12-29-21-11-18(28)9-10-19(20)21/h1-12,24,29,31H,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.10E+3n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207984
PNG
(3,5-Di(4-chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-...)
Show SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(Cc2ccc(Cl)cc2)=C1c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H18Cl3NO3/c27-17-5-1-15(2-6-17)11-21-24(22-14-30-23-12-19(29)9-10-20(22)23)26(32,33-25(21)31)13-16-3-7-18(28)8-4-16/h1-10,12,14,30,32H,11,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/an/a 3.10E+3n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mdm2


(Homo sapiens (Human))
BDBM207985
PNG
(4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-...)
Show SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H18Cl3NO3/c27-17-5-1-15(2-6-17)11-22-24(21-14-30-23-12-19(29)9-10-20(21)23)25(31)33-26(22,32)13-16-3-7-18(28)8-4-16/h1-10,12,14,30,32H,11,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.50E+3n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207986
PNG
(3-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-5-(4...)
Show SMILES OC1(Cc2ccc(F)cc2)OC(=O)C(Cc2ccc(Cl)cc2)=C1c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H18Cl2FNO3/c27-17-5-1-15(2-6-17)11-21-24(22-14-30-23-12-18(28)7-10-20(22)23)26(32,33-25(21)31)13-16-3-8-19(29)9-4-16/h1-10,12,14,30,32H,11,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.87E+4n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207987
PNG
(4-(4-chlorobenzyl)-3-(6-chloro-1H-indol-3-yl)-5-(4...)
Show SMILES OC1(Cc2ccc(F)cc2)OC(=O)C(=C1Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C26H18Cl2FNO3/c27-17-5-1-15(2-6-17)11-22-24(21-14-30-23-12-18(28)7-10-20(21)23)25(31)33-26(22,32)13-16-3-8-19(29)9-4-16/h1-10,12,14,30,32H,11,13H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 2.60E+4n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207988
PNG
(5-(4-Chlorobenzyl)-4-(6-chloro-1H-indol-3-yl)-3-(4...)
Show SMILES OC1(Cc2ccc(Cl)cc2)OC(=O)C(=C1c1c[nH]c2cc(Cl)ccc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H16Cl3NO3/c26-16-5-1-14(2-6-16)12-25(31)23(20-13-29-21-11-18(28)9-10-19(20)21)22(24(30)32-25)15-3-7-17(27)8-4-15/h1-11,13,29,31H,12H2
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 1.30E+3n/an/an/a7.425



Jagiellonian University



Assay Description
MST (NanoTemper Technologies GmbH) was used to determine the binding affinities between Mdm2 (residues 1−118 T47W; 500 nM) and inhibitors. T47W...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair
Mdm2


(Homo sapiens (Human))
BDBM207977
PNG
(N-methyl-4,5-di(4-chlorobenzyl)-3-(6-chloro-1H-ind...)
Show SMILES CN1C(=O)C(=C(Cc2ccc(Cl)cc2)C1(O)Cc1ccc(Cl)cc1)c1c[nH]c2cc(Cl)ccc12
Show InChI InChI=1S/C27H21Cl3N2O2/c1-32-26(33)25(22-15-31-24-13-20(30)10-11-21(22)24)23(12-16-2-6-18(28)7-3-16)27(32,34)14-17-4-8-19(29)9-5-17/h2-11,13,15,31,34H,12,14H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 5.60E+4n/an/an/a7.415



Jagiellonian University



Assay Description
Uniform 15N isotope labeling was achieved by expression of the protein in the M9 minimal media containing 15NH4Cl as the sole nitrogen source. The fi...


ACS Chem Biol 11: 3310-3318 (2016)


Article DOI: 10.1021/acschembio.6b00596
BindingDB Entry DOI: 10.7270/Q2K35SH2
More data for this
Ligand-Target Pair