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Found 27 hits of ph data with Target = 'Melanin-concentrating hormone receptor'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM103905
PNG
(JNK3 inhibitor 2 | US8563583, C-1)
Show SMILES COc1cc(ccc1OCCO)-n1ccc(cc1=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C21H18F3NO5/c1-28-19-13-16(4-7-18(19)29-11-10-26)25-9-8-15(12-20(25)27)14-2-5-17(6-3-14)30-21(22,23)24/h2-9,12-13,26H,10-11H2,1H3
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3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Compounds were characterized in an in vitro binding assay to determine their Ki or ability to antagonized binding of a peptide agonist to the human m...


US Patent US8563583 (2013)


BindingDB Entry DOI: 10.7270/Q22F7M2Q
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM103907
PNG
(JNK3 inhibitor 4 | US8563583, D-4)
Show SMILES COc1cc(ccc1OCC(C)(C)O)-n1ccc(SCc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C23H24ClNO4S/c1-23(2,27)15-29-20-9-8-18(12-21(20)28-3)25-11-10-19(13-22(25)26)30-14-16-4-6-17(24)7-5-16/h4-13,27H,14-15H2,1-3H3
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4n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Compounds were characterized in an in vitro binding assay to determine their Ki or ability to antagonized binding of a peptide agonist to the human m...


US Patent US8563583 (2013)


BindingDB Entry DOI: 10.7270/Q22F7M2Q
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM103906
PNG
(JNK3 inhibitor 3 | US8563583, B-2)
Show SMILES COc1cc(ccc1OCC(C)(C)O)-n1ccc(cc1=O)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C23H22F3NO4/c1-22(2,29)14-31-19-9-8-18(13-20(19)30-3)27-11-10-16(12-21(27)28)15-4-6-17(7-5-15)23(24,25)26/h4-13,29H,14H2,1-3H3
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7n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Compounds were characterized in an in vitro binding assay to determine their Ki or ability to antagonized binding of a peptide agonist to the human m...


US Patent US8563583 (2013)


BindingDB Entry DOI: 10.7270/Q22F7M2Q
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM103903
PNG
(Disubstituted aryl-Me ATX inhibitor 10 | US8563583...)
Show SMILES COc1ccc(\C=C2/SC(=NC2=O)N2CCN(C)CC2)cc1OC
Show InChI InChI=1S/C17H21N3O3S/c1-19-6-8-20(9-7-19)17-18-16(21)15(24-17)11-12-4-5-13(22-2)14(10-12)23-3/h4-5,10-11H,6-9H2,1-3H3/b15-11-
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29n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Compounds were characterized in an in vitro binding assay to determine their Ki or ability to antagonized binding of a peptide agonist to the human m...


US Patent US8563583 (2013)


BindingDB Entry DOI: 10.7270/Q22F7M2Q
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM103904
PNG
(JNK3 inhibitor 1 | US8563583, A-33)
Show SMILES COc1cc(ccc1OCC(C)(C)O)-n1ccc(CNc2ccc(Cl)cc2)cc1=O
Show InChI InChI=1S/C23H25ClN2O4/c1-23(2,28)15-30-20-9-8-19(13-21(20)29-3)26-11-10-16(12-22(26)27)14-25-18-6-4-17(24)5-7-18/h4-13,25,28H,14-15H2,1-3H3
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500n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Compounds were characterized in an in vitro binding assay to determine their Ki or ability to antagonized binding of a peptide agonist to the human m...


US Patent US8563583 (2013)


BindingDB Entry DOI: 10.7270/Q22F7M2Q
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM103902
PNG
(Disubstituted aryl-Me ATX inhibitor 9 | US8563583,...)
Show SMILES COc1cc(ccc1OCC(C)(C)O)-n1ccc(COc2ccccn2)cc1=O
Show InChI InChI=1S/C22H24N2O5/c1-22(2,26)15-29-18-8-7-17(13-19(18)27-3)24-11-9-16(12-21(24)25)14-28-20-6-4-5-10-23-20/h4-13,26H,14-15H2,1-3H3
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2.34E+3n/an/an/an/an/an/a7.4n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Compounds were characterized in an in vitro binding assay to determine their Ki or ability to antagonized binding of a peptide agonist to the human m...


US Patent US8563583 (2013)


BindingDB Entry DOI: 10.7270/Q22F7M2Q
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30164
PNG
(2-aminobenzimidazole-based compound, 12)
Show SMILES CN(C1CCCC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C23H25F3N4O/c1-30(18-4-2-3-5-18)22-28-19-12-11-17(14-20(19)29-22)27-21(31)13-8-15-6-9-16(10-7-15)23(24,25)26/h6-7,9-12,14,18H,2-5,8,13H2,1H3,(H,27,31)(H,28,29)
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n/an/a 4n/a 22n/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30165
PNG
(2-aminobenzimidazole-based compound, 13)
Show SMILES CN(C1CCCCC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C24H27F3N4O/c1-31(19-5-3-2-4-6-19)23-29-20-13-12-18(15-21(20)30-23)28-22(32)14-9-16-7-10-17(11-8-16)24(25,26)27/h7-8,10-13,15,19H,2-6,9,14H2,1H3,(H,28,32)(H,29,30)
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n/an/a 6.70n/a 27n/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30166
PNG
(2-aminobenzimidazole-based compound, 14)
Show SMILES CN(C1CCOC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C22H23F3N4O2/c1-29(17-10-11-31-13-17)21-27-18-8-7-16(12-19(18)28-21)26-20(30)9-4-14-2-5-15(6-3-14)22(23,24)25/h2-3,5-8,12,17H,4,9-11,13H2,1H3,(H,26,30)(H,27,28)
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n/an/a 27n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30167
PNG
(2-aminobenzimidazole-based compound, 15)
Show SMILES CN(C1CCN(C1)C(C)=O)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C24H26F3N5O2/c1-15(33)32-12-11-19(14-32)31(2)23-29-20-9-8-18(13-21(20)30-23)28-22(34)10-5-16-3-6-17(7-4-16)24(25,26)27/h3-4,6-9,13,19H,5,10-12,14H2,1-2H3,(H,28,34)(H,29,30)
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n/an/a 30n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30168
PNG
(2-aminobenzimidazole-based compound, 16)
Show SMILES CN(C1CCN(C)CC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C24H28F3N5O/c1-31-13-11-19(12-14-31)32(2)23-29-20-9-8-18(15-21(20)30-23)28-22(33)10-5-16-3-6-17(7-4-16)24(25,26)27/h3-4,6-9,15,19H,5,10-14H2,1-2H3,(H,28,33)(H,29,30)
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n/an/a 23n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30169
PNG
(2-aminobenzimidazole-based compound, 17)
Show SMILES CCN(C1CCCCC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C25H29F3N4O/c1-2-32(20-6-4-3-5-7-20)24-30-21-14-13-19(16-22(21)31-24)29-23(33)15-10-17-8-11-18(12-9-17)25(26,27)28/h8-9,11-14,16,20H,2-7,10,15H2,1H3,(H,29,33)(H,30,31)
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n/an/a 135n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30170
PNG
(2-aminobenzimidazole-based compound, 18)
Show SMILES FC(F)(F)c1ccc(CCC(=O)Nc2ccc3nc([nH]c3c2)N2CCOCC2)cc1
Show InChI InChI=1S/C21H21F3N4O2/c22-21(23,24)15-4-1-14(2-5-15)3-8-19(29)25-16-6-7-17-18(13-16)27-20(26-17)28-9-11-30-12-10-28/h1-2,4-7,13H,3,8-12H2,(H,25,29)(H,26,27)
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n/an/a 428n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30174
PNG
(2-aminobenzimidazole-based compound, 22)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(nc3)-c3ccc(F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H22FN5O/c1-14(2)29(3)23-27-20-11-9-18(12-21(20)28-23)26-22(30)16-6-10-19(25-13-16)15-4-7-17(24)8-5-15/h4-14H,1-3H3,(H,26,30)(H,27,28)
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n/an/a 5.5n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30175
PNG
(2-aminobenzimidazole-based compound, 23)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3cncc(c3)-c3ccc(F)cc3)cc2[nH]1
Show InChI InChI=1S/C23H22FN5O/c1-14(2)29(3)23-27-20-9-8-19(11-21(20)28-23)26-22(30)17-10-16(12-25-13-17)15-4-6-18(24)7-5-15/h4-14H,1-3H3,(H,26,30)(H,27,28)
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n/an/a 900n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30171
PNG
(2-aminobenzimidazole-based compound, 19)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)CCc3ccc(cn3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C20H22F3N5O/c1-12(2)28(3)19-26-16-8-6-15(10-17(16)27-19)25-18(29)9-7-14-5-4-13(11-24-14)20(21,22)23/h4-6,8,10-12H,7,9H2,1-3H3,(H,25,29)(H,26,27)
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n/an/a 41n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30172
PNG
(2-aminobenzimidazole-based compound, 20)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(cc3)-c3ccc(cn3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C24H22F3N5O/c1-14(2)32(3)23-30-20-11-9-18(12-21(20)31-23)29-22(33)16-6-4-15(5-7-16)19-10-8-17(13-28-19)24(25,26)27/h4-14H,1-3H3,(H,29,33)(H,30,31)
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n/an/a 3.10n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30173
PNG
(2-aminobenzimidazole-based compound, 21)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ccc(nc3)-c3ccccc3)cc2[nH]1
Show InChI InChI=1S/C23H23N5O/c1-15(2)28(3)23-26-20-12-10-18(13-21(20)27-23)25-22(29)17-9-11-19(24-14-17)16-7-5-4-6-8-16/h4-15H,1-3H3,(H,25,29)(H,26,27)
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n/an/a 8.80n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30176
PNG
(2-aminobenzimidazole-based compound, 24)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3ncc(cn3)-c3ccc(F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H21FN6O/c1-13(2)29(3)22-27-18-9-8-17(10-19(18)28-22)26-21(30)20-24-11-15(12-25-20)14-4-6-16(23)7-5-14/h4-13H,1-3H3,(H,26,30)(H,27,28)
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n/an/a 15n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30177
PNG
(2-aminobenzimidazole-based compound, 25)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)c3cnc(cn3)-c3ccc(F)cc3)cc2[nH]1
Show InChI InChI=1S/C22H21FN6O/c1-13(2)29(3)22-27-17-9-8-16(10-18(17)28-22)26-21(30)20-12-24-19(11-25-20)14-4-6-15(23)7-5-14/h4-13H,1-3H3,(H,26,30)(H,27,28)
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n/an/a 2.70n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30163
PNG
(2-aminobenzimidazole-based compound, 11)
Show SMILES CN(C1CC1)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C21H21F3N4O/c1-28(16-8-9-16)20-26-17-10-7-15(12-18(17)27-20)25-19(29)11-4-13-2-5-14(6-3-13)21(22,23)24/h2-3,5-7,10,12,16H,4,8-9,11H2,1H3,(H,25,29)(H,26,27)
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n/an/a 24n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30162
PNG
(2-aminobenzimidazole-based compound, 10)
Show SMILES CCN(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C20H21F3N4O/c1-3-27(2)19-25-16-10-9-15(12-17(16)26-19)24-18(28)11-6-13-4-7-14(8-5-13)20(21,22)23/h4-5,7-10,12H,3,6,11H2,1-2H3,(H,24,28)(H,25,26)
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n/an/a 19n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30161
PNG
(2-aminobenzimidazole-based compound, 9)
Show SMILES CN(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C19H19F3N4O/c1-26(2)18-24-15-9-8-14(11-16(15)25-18)23-17(27)10-5-12-3-6-13(7-4-12)19(20,21)22/h3-4,6-9,11H,5,10H2,1-2H3,(H,23,27)(H,24,25)
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n/an/a 12n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30160
PNG
(aminobenzothiazole-based compound, 39)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2s1
Show InChI InChI=1S/C21H22F3N3OS/c1-13(2)27(3)20-26-17-10-9-16(12-18(17)29-20)25-19(28)11-6-14-4-7-15(8-5-14)21(22,23)24/h4-5,7-10,12-13H,6,11H2,1-3H3,(H,25,28)
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n/an/a>750n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30159
PNG
(aminonaphthyridine-based compound, 36)
Show SMILES CC(C)N(C)c1ccc2cc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cnc2n1
Show InChI InChI=1S/C22H23F3N4O/c1-14(2)29(3)19-10-7-16-12-18(13-26-21(16)28-19)27-20(30)11-6-15-4-8-17(9-5-15)22(23,24)25/h4-5,7-10,12-14H,6,11H2,1-3H3,(H,27,30)
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n/an/a 365n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30156
PNG
(2-aminobenzimidazole-based compound, 8)
Show SMILES CC(C)N(C)c1nc2ccc(NC(=O)CCc3ccc(cc3)C(F)(F)F)cc2[nH]1
Show InChI InChI=1S/C21H23F3N4O/c1-13(2)28(3)20-26-17-10-9-16(12-18(17)27-20)25-19(29)11-6-14-4-7-15(8-5-14)21(22,23)24/h4-5,7-10,12-13H,6,11H2,1-3H3,(H,25,29)(H,26,27)
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n/an/a 5.90n/a 21n/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (human))
BDBM30158
PNG
(aminonaphthyridine-based compound, 31)
Show SMILES CC(C)N(C)c1ccc2nc(NC(=O)CCc3ccc(cc3)C(F)(F)F)ccc2n1
Show InChI InChI=1S/C22H23F3N4O/c1-14(2)29(3)20-12-10-17-18(27-20)9-11-19(26-17)28-21(30)13-6-15-4-7-16(8-5-15)22(23,24)25/h4-5,7-12,14H,6,13H2,1-3H3,(H,26,28,30)
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n/an/a 375n/an/an/an/a7.422



Banyu Pharmaceutical Co.



Assay Description
Compounds were evaluated for their binding affinity to the membranes of CHO-K1 cells expressing human MCH1R (hMCH1R) in a competition binding assay w...


Bioorg Med Chem Lett 19: 3568-72 (2009)


Article DOI: 10.1016/j.bmcl.2009.04.147
BindingDB Entry DOI: 10.7270/Q2C24TR1
More data for this
Ligand-Target Pair