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Compile Data Set for Download or QSAR

Found 264 hits of ph data with Target = 'Metabotropic glutamate receptor 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160795
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES FC(F)(F)c1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H21ClF3N5/c22-19-17(12-26-30-18(11-13-5-6-13)27-28-20(19)30)29-9-7-14(8-10-29)15-3-1-2-4-16(15)21(23,24)25/h1-4,12-14H,5-11H2
PDB

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n/an/an/an/a 36n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160797
PNG
(US9682980, 8-Chloro-3-(2,2,2-trifluoroethyl)-7-(4-...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C19H16ClF6N5/c20-16-14(10-27-31-15(9-18(21,22)23)28-29-17(16)31)30-7-5-11(6-8-30)12-3-1-2-4-13(12)19(24,25)26/h1-4,10-11H,5-9H2
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n/an/an/an/a 23n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160800
PNG
(US9682980, 8-Chloro-7-(4-(2-fluorophenyl)piperidin...)
Show SMILES Fc1ccccc1C1CCN(CC1)c1ncn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C18H16ClF4N5/c19-15-16(24-10-28-14(9-18(21,22)23)25-26-17(15)28)27-7-5-11(6-8-27)12-3-1-2-4-13(12)20/h1-4,10-11H,5-9H2
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n/an/an/an/a 5n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160805
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES Fc1ccccc1C1CCN(CC1)c1ncn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H21ClFN5/c21-18-19(23-12-27-17(11-13-5-6-13)24-25-20(18)27)26-9-7-14(8-10-26)15-3-1-2-4-16(15)22/h1-4,12-14H,5-11H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160806
PNG
(US9682980, 8-Chloro-7-(4-(4-fluorophenyl)piperidin...)
Show SMILES Fc1ccc(cc1)C1CCN(CC1)c1ncn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C18H16ClF4N5/c19-15-16(24-10-28-14(9-18(21,22)23)25-26-17(15)28)27-7-5-12(6-8-27)11-1-3-13(20)4-2-11/h1-4,10,12H,5-9H2
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n/an/an/an/a 438n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160807
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluoro-6-...)
Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C22H23F4N5O/c1-32-17-4-2-3-15(23)19(17)14-7-9-30(10-8-14)16-12-27-31-18(11-13-5-6-13)28-29-21(31)20(16)22(24,25)26/h2-4,12-14H,5-11H2,1H3
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n/an/an/an/a 3n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160807
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluoro-6-...)
Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C22H23F4N5O/c1-32-17-4-2-3-15(23)19(17)14-7-9-30(10-8-14)16-12-27-31-18(11-13-5-6-13)28-29-21(31)20(16)22(24,25)26/h2-4,12-14H,5-11H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160810
PNG
(US9682980, 2-(1-(8-Chloro-3-(cyclopropylmethyl)-[1...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1C#N
Show InChI InChI=1S/C21H21ClN6/c22-20-18(13-24-28-19(11-14-5-6-14)25-26-21(20)28)27-9-7-15(8-10-27)17-4-2-1-3-16(17)12-23/h1-4,13-15H,5-11H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160811
PNG
(US9682980, 2-(1-(8-chloro-3-(2,2,2-trifluoroethyl)...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccc1C#N
Show InChI InChI=1S/C19H16ClF3N6/c20-17-15(11-25-29-16(9-19(21,22)23)26-27-18(17)29)28-7-5-12(6-8-28)14-4-2-1-3-13(14)10-24/h1-4,11-12H,5-9H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160812
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2,...)
Show SMILES Fc1ccc(C2CCN(CC2)c2cnn3c(CC4CC4)nnc3c2Cl)c(F)c1
Show InChI InChI=1S/C20H20ClF2N5/c21-19-17(11-24-28-18(9-12-1-2-12)25-26-20(19)28)27-7-5-13(6-8-27)15-4-3-14(22)10-16(15)23/h3-4,10-13H,1-2,5-9H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160814
PNG
(US9682980, 8-Chloro-7-(4-(2,4-difluorophenyl)piper...)
Show SMILES Fc1ccc(C2CCN(CC2)c2cnn3c(CC(F)(F)F)nnc3c2Cl)c(F)c1
Show InChI InChI=1S/C18H15ClF5N5/c19-16-14(9-25-29-15(8-18(22,23)24)26-27-17(16)29)28-5-3-10(4-6-28)12-2-1-11(20)7-13(12)21/h1-2,7,9-10H,3-6,8H2
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n/an/an/an/a 16n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160815
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(3-...)
Show SMILES FC(F)(F)c1cccc(n1)C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H20ClF3N6/c21-18-15(11-25-30-17(10-12-4-5-12)27-28-19(18)30)29-8-6-13(7-9-29)14-2-1-3-16(26-14)20(22,23)24/h1-3,11-13H,4-10H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160817
PNG
(US9682980, 2-(1-(3-(Cyclopropylmethyl)-8-(trifluor...)
Show SMILES FC(F)(F)c1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1C#N
Show InChI InChI=1S/C22H21F3N6/c23-22(24,25)20-18(13-27-31-19(11-14-5-6-14)28-29-21(20)31)30-9-7-15(8-10-30)17-4-2-1-3-16(17)12-26/h1-4,13-15H,5-11H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160818
PNG
(US9682980, 2-(1-(3-(2,2,2-Trifluoroethyl)-8-(trifl...)
Show SMILES FC(F)(F)Cc1nnc2c(c(cnn12)N1CCC(CC1)c1ccccc1C#N)C(F)(F)F
Show InChI InChI=1S/C20H16F6N6/c21-19(22,23)9-16-29-30-18-17(20(24,25)26)15(11-28-32(16)18)31-7-5-12(6-8-31)14-4-2-1-3-13(14)10-27/h1-4,11-12H,5-9H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160820
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(py...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccn1
Show InChI InChI=1S/C19H21ClN6/c20-18-16(12-22-26-17(11-13-4-5-13)23-24-19(18)26)25-9-6-14(7-10-25)15-3-1-2-8-21-15/h1-3,8,12-14H,4-7,9-11H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160821
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(3,6-difluor...)
Show SMILES COc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C22H22F5N5O/c1-33-20-15(24)5-4-14(23)18(20)13-6-8-31(9-7-13)16-11-28-32-17(10-12-2-3-12)29-30-21(32)19(16)22(25,26)27/h4-5,11-13H,2-3,6-10H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160822
PNG
(US9682980, 7-(4-(3,6-Difluoro-2-methoxyphenyl)pipe...)
Show SMILES COc1c(F)ccc(F)c1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1C(F)(F)F
Show InChI InChI=1S/C20H17F8N5O/c1-34-17-12(22)3-2-11(21)15(17)10-4-6-32(7-5-10)13-9-29-33-14(8-19(23,24)25)30-31-18(33)16(13)20(26,27)28/h2-3,9-10H,4-8H2,1H3
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160823
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(py...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1cccnc1
Show InChI InChI=1S/C19H21ClN6/c20-18-16(12-22-26-17(10-13-3-4-13)23-24-19(18)26)25-8-5-14(6-9-25)15-2-1-7-21-11-15/h1-2,7,11-14H,3-6,8-10H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160825
PNG
(US9682980, 8-Chloro-7-(4-(3-methoxypyridin-2-yl)pi...)
Show SMILES FC(F)(F)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccccn1
Show InChI InChI=1S/C17H16ClF3N6/c18-15-13(10-23-27-14(9-17(19,20)21)24-25-16(15)27)26-7-4-11(5-8-26)12-3-1-2-6-22-12/h1-3,6,10-11H,4-5,7-9H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160826
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(2-fluorophe...)
Show SMILES Fc1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1C(F)(F)F
Show InChI InChI=1S/C21H21F4N5/c22-16-4-2-1-3-15(16)14-7-9-29(10-8-14)17-12-26-30-18(11-13-5-6-13)27-28-20(30)19(17)21(23,24)25/h1-4,12-14H,5-11H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160828
PNG
(US9682980, Trans-N-((2-(2-methoxyphenyl)cyclopropy...)
Show SMILES COc1ccccc1C1CC1CNc1cnn2c(CC(F)(F)F)nnc2c1C(F)(F)F
Show InChI InChI=1S/C19H17F6N5O/c1-31-14-5-3-2-4-11(14)12-6-10(12)8-26-13-9-27-30-15(7-18(20,21)22)28-29-17(30)16(13)19(23,24)25/h2-5,9-10,12,26H,6-8H2,1H3
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n/an/an/an/a 10n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160547
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-phe...)
Show SMILES Clc1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H22ClN5/c21-18-19(22-13-26-17(12-14-6-7-14)23-24-20(18)26)25-10-8-16(9-11-25)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160555
PNG
(US9682980, 3-(Cyclopropylmethyl)-8-methyl-7-(4-phe...)
Show SMILES Cc1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H25N5/c1-15-20(22-14-26-19(13-16-7-8-16)23-24-21(15)26)25-11-9-18(10-12-25)17-5-3-2-4-6-17/h2-6,14,16,18H,7-13H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160556
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(4-fluorophe...)
Show SMILES COc1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H25N5O/c1-27-19-20(22-14-26-18(13-15-7-8-15)23-24-21(19)26)25-11-9-17(10-12-25)16-5-3-2-4-6-16/h2-6,14-15,17H,7-13H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160557
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-phenylpiperi...)
Show SMILES FC(F)(F)c1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H22F3N5/c22-21(23,24)18-19(25-13-29-17(12-14-6-7-14)26-27-20(18)29)28-10-8-16(9-11-28)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160562
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-phe...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C20H22ClN5/c21-19-17(13-22-26-18(12-14-6-7-14)23-24-20(19)26)25-10-8-16(9-11-25)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160566
PNG
(US9682980, 3-(Cyclopropylmethyl)-8-methyl-7-(4-phe...)
Show SMILES Cc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H25N5/c1-15-19(14-22-26-20(13-16-7-8-16)23-24-21(15)26)25-11-9-18(10-12-25)17-5-3-2-4-6-17/h2-6,14,16,18H,7-13H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160573
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-phenylpiperi...)
Show SMILES FC(F)(F)c1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H22F3N5/c22-21(23,24)19-17(13-25-29-18(12-14-6-7-14)26-27-20(19)29)28-10-8-16(9-11-28)15-4-2-1-3-5-15/h1-5,13-14,16H,6-12H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160574
PNG
(US9682980, 7-(4-Benzylpiperidin-1-yl)-8-chloro-3-(...)
Show SMILES Clc1c(ncn2c(CC3CC3)nnc12)N1CCC(Cc2ccccc2)CC1
Show InChI InChI=1S/C21H24ClN5/c22-19-20(23-14-27-18(13-16-6-7-16)24-25-21(19)27)26-10-8-17(9-11-26)12-15-4-2-1-3-5-15/h1-5,14,16-17H,6-13H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160605
PNG
(US9682980, Trans-8-chloro-3-(cyclopropylmethyl)-N-...)
Show SMILES Cc1c(NCC2CC2c2ccc(F)cc2)cnn2c(CC3CC3)nnc12
Show InChI InChI=1S/C20H22FN5/c1-12-18(11-23-26-19(8-13-2-3-13)24-25-20(12)26)22-10-15-9-17(15)14-4-6-16(21)7-5-14/h4-7,11,13,15,17,22H,2-3,8-10H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160615
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-(((1R,...)
Show SMILES Cc1c(NC[C@@H]2C[C@@H]2c2ccc(F)cc2)cnn2c(CC3CC3)nnc12
Show InChI InChI=1S/C20H22FN5/c1-12-18(11-23-26-19(8-13-2-3-13)24-25-20(12)26)22-10-15-9-17(15)14-4-6-16(21)7-5-14/h4-7,11,13,15,17,22H,2-3,8-10H2,1H3/t15-,17+/m0/s1
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160641
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-(((1S,...)
Show SMILES Cc1c(NC[C@H]2C[C@H]2c2ccc(F)cc2)cnn2c(CC3CC3)nnc12
Show InChI InChI=1S/C20H22FN5/c1-12-18(11-23-26-19(8-13-2-3-13)24-25-20(12)26)22-10-15-9-17(15)14-4-6-16(21)7-5-14/h4-7,11,13,15,17,22H,2-3,8-10H2,1H3/t15-,17+/m1/s1
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160556
PNG
(US9682980, 3-(Cyclopropylmethyl)-7-(4-(4-fluorophe...)
Show SMILES COc1c(ncn2c(CC3CC3)nnc12)N1CCC(CC1)c1ccccc1
Show InChI InChI=1S/C21H25N5O/c1-27-19-20(22-14-26-18(13-15-7-8-15)23-24-21(19)26)25-11-9-17(10-12-25)16-5-3-2-4-6-16/h2-6,14-15,17H,7-13H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160719
PNG
(US9682980, 7-(4-(4-Fluorophenyl)piperidin-1-yl)-8-...)
Show SMILES COc1c(ncn2c(CC(C)(C)C)nnc12)N1CCC(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C22H28FN5O/c1-22(2,3)13-18-25-26-21-19(29-4)20(24-14-28(18)21)27-11-9-16(10-12-27)15-5-7-17(23)8-6-15/h5-8,14,16H,9-13H2,1-4H3
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160720
PNG
(US9682980, 1-(3-(Cyclopropylmethyl)-8-methoxy-[1,2...)
Show SMILES OC1(CCN(CC1)c1ncn2c(CC3CC3)nnc2c1Cl)c1ccc(F)cc1
Show InChI InChI=1S/C20H21ClFN5O/c21-17-18(23-12-27-16(11-13-1-2-13)24-25-19(17)27)26-9-7-20(28,8-10-26)14-3-5-15(22)6-4-14/h3-6,12-13,28H,1-2,7-11H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160721
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(py...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC(CC1)c1ncccn1
Show InChI InChI=1S/C18H20ClN7/c19-16-14(11-22-26-15(10-12-2-3-12)23-24-18(16)26)25-8-4-13(5-9-25)17-20-6-1-7-21-17/h1,6-7,11-13H,2-5,8-10H2
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160723
PNG
(US9682980, 8-Chloro-3-neopentyl-7-(4-(pyrimidin-2-...)
Show SMILES CC(C)(C)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ncccn1
Show InChI InChI=1S/C19H24ClN7/c1-19(2,3)11-15-24-25-18-16(20)14(12-23-27(15)18)26-9-5-13(6-10-26)17-21-7-4-8-22-17/h4,7-8,12-13H,5-6,9-11H2,1-3H3
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Bristol-Myers Squibb Company

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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160724
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(4-...)
Show SMILES Fc1ccc(cc1)C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H21ClFN5/c21-19-17(12-23-27-18(11-13-1-2-13)24-25-20(19)27)26-9-7-15(8-10-26)14-3-5-16(22)6-4-14/h3-6,12-13,15H,1-2,7-11H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160725
PNG
(US9682980, 8-Chloro-7-(4-(4-fluorophenyl)piperidin...)
Show SMILES CC(C)(C)Cc1nnc2c(Cl)c(cnn12)N1CCC(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H25ClFN5/c1-21(2,3)12-18-25-26-20-19(22)17(13-24-28(18)20)27-10-8-15(9-11-27)14-4-6-16(23)7-5-14/h4-7,13,15H,8-12H2,1-3H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160727
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(4-...)
Show SMILES Fc1ccc(cc1)N1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C19H20ClFN6/c20-18-16(12-22-27-17(11-13-1-2-13)23-24-19(18)27)26-9-7-25(8-10-26)15-5-3-14(21)4-6-15/h3-6,12-13H,1-2,7-11H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160729
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(spiro...)
Show SMILES Clc1c(cnn2c(CC3CC3)nnc12)N1CCC2(CC1)C=Cc1ccccc21
Show InChI InChI=1S/C22H22ClN5/c23-20-18(14-24-28-19(13-15-5-6-15)25-26-21(20)28)27-11-9-22(10-12-27)8-7-16-3-1-2-4-17(16)22/h1-4,7-8,14-15H,5-6,9-13H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160738
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-N-((1-(p...)
Show SMILES Clc1c(NCC2(COc3ccccc3)CC2)cnn2c(CC3CC3)nnc12
Show InChI InChI=1S/C20H22ClN5O/c21-18-16(11-23-26-17(10-14-6-7-14)24-25-19(18)26)22-12-20(8-9-20)13-27-15-4-2-1-3-5-15/h1-5,11,14,22H,6-10,12-13H2
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160739
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H23ClFN5O/c1-29-17-4-2-3-15(23)19(17)14-7-9-27(10-8-14)16-12-24-28-18(11-13-5-6-13)25-26-21(28)20(16)22/h2-4,12-14H,5-11H2,1H3
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Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160740
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES Fc1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H21ClFN5/c21-19-17(12-23-27-18(11-13-5-6-13)24-25-20(19)27)26-9-7-14(8-10-26)15-3-1-2-4-16(15)22/h1-4,12-14H,5-11H2
PDB

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n/an/an/an/a 13n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160741
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(3-...)
Show SMILES Fc1cccc(c1)C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H21ClFN5/c21-19-17(12-23-27-18(10-13-4-5-13)24-25-20(19)27)26-8-6-14(7-9-26)15-2-1-3-16(22)11-15/h1-3,11-14H,4-10H2
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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160742
PNG
(US9682980, 8-Chloro-7-(4-(2-fluorophenyl)piperidin...)
Show SMILES Fc1ccccc1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C18H16ClF4N5/c19-16-14(10-24-28-15(9-18(21,22)23)25-26-17(16)28)27-7-5-11(6-8-27)12-3-1-2-4-13(12)20/h1-4,10-11H,5-9H2
PDB

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Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160743
PNG
(US9682980, 8-Chloro-7-(4-(2-fluoro-6-methoxyphenyl...)
Show SMILES COc1cccc(F)c1C1CCN(CC1)c1cnn2c(CC(F)(F)F)nnc2c1Cl
Show InChI InChI=1S/C19H18ClF4N5O/c1-30-14-4-2-3-12(21)16(14)11-5-7-28(8-6-11)13-10-25-29-15(9-19(22,23)24)26-27-18(29)17(13)20/h2-4,10-11H,5-9H2,1H3
PDB

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n/an/an/an/a 2n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160744
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(2-...)
Show SMILES COc1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H24ClN5O/c1-28-18-5-3-2-4-16(18)15-8-10-26(11-9-15)17-13-23-27-19(12-14-6-7-14)24-25-21(27)20(17)22/h2-5,13-15H,6-12H2,1H3
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n/an/an/an/a 9n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160745
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(3-...)
Show SMILES OOc1cccc(c1)C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C20H22ClN5O2/c21-19-17(12-22-26-18(10-13-4-5-13)23-24-20(19)26)25-8-6-14(7-9-25)15-2-1-3-16(11-15)28-27/h1-3,11-14,27H,4-10H2
PDB

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n/an/an/an/a 38n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))
BDBM160746
PNG
(US9682980, 8-Chloro-3-(cyclopropylmethyl)-7-(4-(o-...)
Show SMILES Cc1ccccc1C1CCN(CC1)c1cnn2c(CC3CC3)nnc2c1Cl
Show InChI InChI=1S/C21H24ClN5/c1-14-4-2-3-5-17(14)16-8-10-26(11-9-16)18-13-23-27-19(12-15-6-7-15)24-25-21(27)20(18)22/h2-5,13,15-16H,6-12H2,1H3
PDB

UniProtKB/SwissProt

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n/an/an/an/a 21n/an/a7.0n/a



Bristol-Myers Squibb Company

US Patent


Assay Description
Clonally expressed human mGluR2 in HEK293 background was glutamate starved overnight in media without glutamine (GIBCO MEM 12360), containing 10% FBS...


US Patent US9682980 (2017)


BindingDB Entry DOI: 10.7270/Q2J964JS
More data for this
Ligand-Target Pair
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