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Compile Data Set for Download or QSAR

Found 14 hits of ph data with Target = 'Methionine Aminopeptidase Type 1 (MetAP1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17587
PNG
(bestatin-type inhibitor, 2 | ethyl (2S)-2-[(2S,3R)...)
Show SMILES CCOC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)CCSCC
Show InChI InChI=1S/C12H24N2O4S/c1-4-18-12(17)8(3)14-11(16)10(15)9(13)6-7-19-5-2/h8-10,15H,4-7,13H2,1-3H3,(H,14,16)/t8-,9+,10-/m0/s1
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n/an/a 6.90E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17593
PNG
(CHEMBL170733 | N'-[(2S,3S)-3-amino-2-hydroxy-4-[(2...)
Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)7-23-8-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)6-10/h3-6,9,12-13,20H,7-8,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
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n/an/a 8.10E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17592
PNG
(CHEMBL169958 | N'-[(2S,3R)-3-amino-5-(ethylsulfany...)
Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C14H20ClN3O3S/c1-2-22-7-6-11(16)12(19)14(21)18-17-13(20)9-4-3-5-10(15)8-9/h3-5,8,11-12,19H,2,6-7,16H2,1H3,(H,17,20)(H,18,21)/t11-,12+/m1/s1
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n/an/a 2.00E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17591
PNG
((2S,3R)-3-amino-2-hydroxy-N-[(1S)-1-(naphthalen-1-...)
Show SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Show InChI InChI=1S/C20H28N2O2S/c1-13(2)25-12-11-18(21)19(23)20(24)22-14(3)16-10-6-8-15-7-4-5-9-17(15)16/h4-10,13-14,18-19,23H,11-12,21H2,1-3H3,(H,22,24)/t14-,18+,19-/m0/s1
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n/an/a 1.20E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17590
PNG
((2S,3S)-3-amino-2-hydroxy-4-[(2-methylpropyl)sulfa...)
Show SMILES CC(C)CSC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Show InChI InChI=1S/C20H28N2O2S/c1-13(2)11-25-12-18(21)19(23)20(24)22-14(3)16-10-6-8-15-7-4-5-9-17(15)16/h4-10,13-14,18-19,23H,11-12,21H2,1-3H3,(H,22,24)/t14-,18+,19-/m0/s1
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n/an/a 2.20E+3n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17586
PNG
(bestatin-type inhibitor, 1 | ethyl (2S)-2-[(2S,3R)...)
Show SMILES CCOC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)CCSC
Show InChI InChI=1S/C11H22N2O4S/c1-4-17-11(16)7(2)13-10(15)9(14)8(12)5-6-18-3/h7-9,14H,4-6,12H2,1-3H3,(H,13,15)/t7-,8+,9-/m0/s1
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n/an/a 6.30E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17594
PNG
(A-357300 | CHEMBL352764 | N'-[(2S,3R)-3-amino-2-hy...)
Show SMILES CC(C)SCC[C@@H](N)[C@H](O)C(=O)NNC(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C15H22ClN3O3S/c1-9(2)23-7-6-12(17)13(20)15(22)19-18-14(21)10-4-3-5-11(16)8-10/h3-5,8-9,12-13,20H,6-7,17H2,1-2H3,(H,18,21)(H,19,22)/t12-,13+/m1/s1
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n/an/a 5.70E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17588
PNG
(bestatin-type inhibitor, 3 | ethyl (2S)-2-[(2S,3S)...)
Show SMILES CCOC(=O)[C@H](C)NC(=O)[C@@H](O)[C@H](N)CSCC(C)C
Show InChI InChI=1S/C13H26N2O4S/c1-5-19-13(18)9(4)15-12(17)11(16)10(14)7-20-6-8(2)3/h8-11,16H,5-7,14H2,1-4H3,(H,15,17)/t9-,10+,11-/m0/s1
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n/an/a 6.60E+4n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17589
PNG
((2S,3R)-3-amino-5-(ethylsulfanyl)-2-hydroxy-N-[(1S...)
Show SMILES CCSCC[C@@H](N)[C@H](O)C(=O)N[C@@H](C)c1cccc2ccccc12
Show InChI InChI=1S/C19H26N2O2S/c1-3-24-12-11-17(20)18(22)19(23)21-13(2)15-10-6-8-14-7-4-5-9-16(14)15/h4-10,13,17-18,22H,3,11-12,20H2,1-2H3,(H,21,23)/t13-,17+,18-/m0/s1
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n/an/a 370n/an/an/an/a7.422



Abbott Laboratories



Assay Description
A coupled enzyme chromogenic assay was developed to measure methionine aminopeptidase activity by monitoring the production of free methionine with L...


Cancer Res 63: 7861-9 (2003)


BindingDB Entry DOI: 10.7270/Q2Z31WXK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17852
PNG
(3-octanamido-N-(1,3-thiazol-2-yl)pyridine-2-carbox...)
Show SMILES CCCCCCCC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C17H22N4O2S/c1-2-3-4-5-6-9-14(22)20-13-8-7-10-18-15(13)16(23)21-17-19-11-12-24-17/h7-8,10-12H,2-6,9H2,1H3,(H,20,22)(H,19,21,23)
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n/an/a>5.00E+5n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)


Article DOI: 10.1073/pnas.0608389103
BindingDB Entry DOI: 10.7270/Q2RB72VK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17851
PNG
(3-[(E)-(2-methylpropylidene)amino]-N-(1,3-thiazol-...)
Show SMILES CC(C)C=Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C13H14N4OS/c1-9(2)8-16-10-4-3-5-14-11(10)12(18)17-13-15-6-7-19-13/h3-9H,1-2H3,(H,15,17,18)
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n/an/a 6.40E+3n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)


Article DOI: 10.1073/pnas.0608389103
BindingDB Entry DOI: 10.7270/Q2RB72VK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17850
PNG
(3-(3-phenylpropanamido)-N-(1,3-thiazol-2-yl)pyridi...)
Show SMILES O=C(CCc1ccccc1)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C18H16N4O2S/c23-15(9-8-13-5-2-1-3-6-13)21-14-7-4-10-19-16(14)17(24)22-18-20-11-12-25-18/h1-7,10-12H,8-9H2,(H,21,23)(H,20,22,24)
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n/an/a 3.50E+3n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)


Article DOI: 10.1073/pnas.0608389103
BindingDB Entry DOI: 10.7270/Q2RB72VK
More data for this
Ligand-Target Pair
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17849
PNG
(3-(2,2-dimethylpropanamido)-N-(1,3-thiazol-2-yl)py...)
Show SMILES CC(C)(C)C(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H16N4O2S/c1-14(2,3)12(20)17-9-5-4-6-15-10(9)11(19)18-13-16-7-8-21-13/h4-8H,1-3H3,(H,17,20)(H,16,18,19)
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n/an/a 2.90E+3n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)


Article DOI: 10.1073/pnas.0608389103
BindingDB Entry DOI: 10.7270/Q2RB72VK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Methionine Aminopeptidase Type 1 (MetAP1)


(Homo sapiens (human))
BDBM17847
PNG
(CHEMBL327579 | pyridine-2-carboxylic acid inhibito...)
Show SMILES CC(C)(C)OC(=O)Nc1cccnc1C(=O)Nc1nccs1
Show InChI InChI=1S/C14H16N4O3S/c1-14(2,3)21-13(20)17-9-5-4-6-15-10(9)11(19)18-12-16-7-8-22-12/h4-8H,1-3H3,(H,17,20)(H,16,18,19)
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n/an/a 1.50E+3n/an/an/an/a7.522



Johns Hopkins University



Assay Description
The MetAP reaction with Co2+ as a cofactor is coupled to a prolyl aminopeptidase (ProAP) using Met-Pro-p-nitroanilide as substrate. MetAP-catalyzed c...


Proc Natl Acad Sci U S A 103: 18148-53 (2006)


Article DOI: 10.1073/pnas.0608389103
BindingDB Entry DOI: 10.7270/Q2RB72VK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)