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Compile Data Set for Download or QSAR

Found 105 hits of ph data with Target = 'Microtubule-associated protein tau'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281656
PNG
(US10022461, Compound 126)
Show SMILES Nc1cc2cc(ncc2cc1I)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-13-5-12-8-20-16(7-11(12)6-14(13)18)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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PC sid
UniChem
US Patent
0.180 -55.6n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281558
PNG
(US10022461, Compound 9)
Show SMILES Fc1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H10FN3/c17-14-2-1-12-9-19-16(8-13(12)7-14)20-6-4-11-3-5-18-10-15(11)20/h1-10H
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.220 -55.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281645
PNG
(US10022461, Compound 115)
Show SMILES Nc1cc(F)cc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-12-5-11-8-20-16(7-13(11)14(18)6-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
0.224 -55.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281560
PNG
(US10022461, Compound 12)
Show SMILES Nc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12N4/c17-14-2-1-12-8-16(19-9-13(12)7-14)20-6-4-11-3-5-18-10-15(11)20/h1-10H,17H2
PDB

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PC sid
UniChem
US Patent
0.290 -54.4n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281561
PNG
(US10022461, Compound 13)
Show SMILES COc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N3O/c1-21-15-3-2-13-9-17(19-10-14(13)8-15)20-7-5-12-4-6-18-11-16(12)20/h2-11H,1H3
PDB

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UniChem
US Patent
0.290 -54.4n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281633
PNG
(US10022461, Compound 103)
Show SMILES COc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N3O/c1-21-16-4-2-3-13-9-17(19-10-14(13)16)20-8-6-12-5-7-18-11-15(12)20/h2-11H,1H3
PDB

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UniChem
US Patent
0.320 -54.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281563
PNG
(US10022461, Compound 14-1)
Show SMILES CNc1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H14N4/c1-18-15-3-2-13-10-20-17(9-14(13)8-15)21-7-5-12-4-6-19-11-16(12)21/h2-11,18H,1H3
PDB

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UniChem
US Patent
0.330 -54.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281609
PNG
(US10022461, Compound 59)
Show SMILES Nc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12N4/c17-14-3-1-2-12-8-16(19-9-13(12)14)20-7-5-11-4-6-18-10-15(11)20/h1-10H,17H2
PDB

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UniChem
US Patent
0.330 -54.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281635
PNG
(US10022461, Compound 105)
Show SMILES Nc1cc2cnc(cc2cc1F)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-5-11-7-16(20-8-12(11)6-14(13)18)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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UniChem
US Patent
0.383 -53.7n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281559
PNG
(US10022461, Compound 11-5)
Show SMILES Nc1cccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12N4/c17-14-3-1-2-12-9-19-16(8-13(12)14)20-7-5-11-4-6-18-10-15(11)20/h1-10H,17H2
PDB

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UniChem
US Patent
0.400 -53.6n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281565
PNG
(US10022461, Compound 16)
Show SMILES FCCOc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C18H14FN3O/c19-5-8-23-16-2-1-14-10-18(21-11-15(14)9-16)22-7-4-13-3-6-20-12-17(13)22/h1-4,6-7,9-12H,5,8H2
PDB

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US Patent
0.410 -53.6n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281639
PNG
(US10022461, Compound 109)
Show SMILES Nc1cc2cc(ncc2cc1F)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-5-12-8-20-16(7-11(12)6-14(13)18)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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UniChem
US Patent
0.423 -53.5n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281566
PNG
(US10022461, Compound 17)
Show SMILES FCOc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H12FN3O/c18-11-22-15-2-1-13-8-17(20-9-14(13)7-15)21-6-4-12-3-5-19-10-16(12)21/h1-10H,11H2
PDB

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UniChem
US Patent
0.430 -53.5n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281567
PNG
(US10022461, Compound 18)
Show SMILES Nc1c(F)ccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-2-1-11-8-20-15(7-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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PC sid
UniChem
US Patent
0.430 -53.5n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281649
PNG
(US10022461, Compound 119)
Show SMILES Nc1c(I)ccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-13-2-1-11-8-20-15(7-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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US Patent
0.438 -53.4n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281623
PNG
(US10022461, Compound 75)
Show SMILES Oc1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-14-2-1-12-9-18-16(8-13(12)7-14)19-6-4-11-3-5-17-10-15(11)19/h1-10,20H
PDB

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US Patent
0.480 -53.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281557
PNG
(US10022461, Compound 8)
Show SMILES c1cc2cc(ncc2[nH]1)-n1ccc2ccncc12
Show InChI InChI=1S/C14H10N4/c1-4-15-9-13-10(1)3-6-18(13)14-7-11-2-5-16-12(11)8-17-14/h1-9,16H
PDB

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US Patent
0.480 -53.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281644
PNG
(US10022461, Compound 114)
Show SMILES Nc1cc(F)c2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-14-6-12(18)5-11-8-20-16(7-13(11)14)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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UniChem
US Patent
0.494 -53.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281651
PNG
(US10022461, Compound 121)
Show SMILES Nc1c(I)ccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-13-2-1-11-7-15(20-8-12(11)16(13)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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UniChem
US Patent
0.512 -53.0n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281626
PNG
(US10022461, Compound 93)
Show SMILES CNc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C18H15N5/c1-19-17-10-14(5-8-21-17)15-2-3-18(22-11-15)23-9-6-13-4-7-20-12-16(13)23/h2-12H,1H3,(H,19,21)
PDB

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US Patent
0.530 -52.9n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281564
PNG
(US10022461, Compound 15)
Show SMILES Oc1ccc2cc(ncc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-14-2-1-12-8-16(18-9-13(12)7-14)19-6-4-11-3-5-17-10-15(11)19/h1-10,20H
PDB

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US Patent
0.530 -52.9n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281555
PNG
(US10022461, Compound 6)
Show SMILES c1cc2ccncc2n1-c1cc2ccccc2cn1
Show InChI InChI=1S/C16H11N3/c1-2-4-14-10-18-16(9-13(14)3-1)19-8-6-12-5-7-17-11-15(12)19/h1-11H
PDB

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US Patent
0.540 -52.9n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281630
PNG
(US10022461, Compound 99)
Show SMILES Nc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N5/c18-16-9-13(4-7-20-16)14-1-2-17(21-10-14)22-8-5-12-3-6-19-11-15(12)22/h1-11H,(H2,18,20)
PDB

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US Patent
0.550 -52.9n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281568
PNG
(US10022461, Compound 19)
Show SMILES Cn1ccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C15H12N4/c1-18-6-3-12-8-15(17-10-13(12)18)19-7-4-11-2-5-16-9-14(11)19/h2-10H,1H3
PDB

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US Patent
0.620 -52.6n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281599
PNG
(US10022461, Compound 49)
Show SMILES Oc1cccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-15-3-1-2-12-9-18-16(8-13(12)15)19-7-5-11-4-6-17-10-14(11)19/h1-10,20H
PDB

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PC sid
UniChem
US Patent
0.670 -52.4n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281642
PNG
(US10022461, Compound 112)
Show SMILES Nc1cc(F)cc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-12-5-11-6-16(20-8-13(11)14(18)7-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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US Patent
0.672 -52.4n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281638
PNG
(US10022461, Compound 108)
Show SMILES Nc1ccc2cc(ncc2c1F)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-16-12-8-20-15(7-11(12)1-2-13(16)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
PDB

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UniChem
US Patent
0.677 -52.3n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281624
PNG
(US10022461, Compound 88)
Show SMILES CNc1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C18H15N5/c1-19-17-4-2-14(10-21-17)15-3-5-18(22-11-15)23-9-7-13-6-8-20-12-16(13)23/h2-12H,1H3,(H,19,21)
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UniChem
US Patent
0.690 -52.3n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281569
PNG
(US10022461, Compound 20)
Show SMILES Ic1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H10IN3/c17-14-2-1-12-9-19-16(8-13(12)7-14)20-6-4-11-3-5-18-10-15(11)20/h1-10H
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US Patent
0.75 -52.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281600
PNG
(US10022461, Compound 50)
Show SMILES Cc1cc(ncc1C#C)-n1ccc2ccncc12
Show InChI InChI=1S/C15H11N3/c1-3-12-9-17-15(8-11(12)2)18-7-5-13-4-6-16-10-14(13)18/h1,4-10H,2H3
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US Patent
0.75 -52.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281622
PNG
(US10022461, Compound 72)
Show SMILES CNc1cccc(c1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H16N4/c1-20-17-4-2-3-15(11-17)16-5-6-19(22-12-16)23-10-8-14-7-9-21-13-18(14)23/h2-13,20H,1H3
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US Patent
0.760 -52.0n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281643
PNG
(US10022461, Compound 113)
Show SMILES Nc1cc(F)c2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-14-7-12(18)5-11-6-16(20-8-13(11)14)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
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US Patent
0.784 -52.0n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281601
PNG
(US10022461, Compound 51)
Show SMILES Cc1cc(ncc1C#CCF)-n1ccc2ccncc12
Show InChI InChI=1S/C16H12FN3/c1-12-9-16(19-10-14(12)3-2-6-17)20-8-5-13-4-7-18-11-15(13)20/h4-5,7-11H,6H2,1H3
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US Patent
0.870 -51.7n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281628
PNG
(US10022461, Compound 95)
Show SMILES CN(C)c1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H17N5/c1-23(2)18-5-3-15(11-21-18)16-4-6-19(22-12-16)24-10-8-14-7-9-20-13-17(14)24/h3-13H,1-2H3
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US Patent
0.960 -51.5n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281602
PNG
(US10022461, Compound 52)
Show SMILES CC#Cc1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H11N3/c1-2-3-12-4-5-15(17-10-12)18-9-7-13-6-8-16-11-14(13)18/h4-11H,1H3
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US Patent
0.980 -51.4n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281603
PNG
(US10022461, Compound 53)
Show SMILES c1ncc(s1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H10N4S/c1-2-15(18-7-12(1)14-9-17-10-20-14)19-6-4-11-3-5-16-8-13(11)19/h1-10H
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US Patent
1.02 -51.3n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281604
PNG
(US10022461, Compound 54)
Show SMILES Fc1cccc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H10FN3/c17-14-3-1-2-12-9-19-16(8-13(12)14)20-7-5-11-4-6-18-10-15(11)20/h1-10H
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US Patent
1.05 -51.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281631
PNG
(US10022461, Compound 100)
Show SMILES Nc1ccc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H13N5/c18-16-3-1-13(9-20-16)14-2-4-17(21-10-14)22-8-6-12-5-7-19-11-15(12)22/h1-11H,(H2,18,20)
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US Patent
1.06 -51.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281654
PNG
(US10022461, Compound 124)
Show SMILES Nc1cc(I)cc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-12-5-11-6-16(20-8-13(11)14(18)7-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
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US Patent
1.07 -51.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281641
PNG
(US10022461, Compound 111)
Show SMILES Nc1ccc2cnc(cc2c1F)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-16-12-7-15(20-8-11(12)1-2-13(16)18)21-6-4-10-3-5-19-9-14(10)21/h1-9H,18H2
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US Patent
1.09 -51.2n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281629
PNG
(US10022461, Compound 98)
Show SMILES c1cc([nH]n1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C15H11N5/c1-2-15(17-9-12(1)13-4-7-18-19-13)20-8-5-11-3-6-16-10-14(11)20/h1-10H,(H,18,19)
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US Patent
1.13 -51.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281597
PNG
(US10022461, Compound 44)
Show SMILES Fc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H11FN4/c18-16-9-13(4-7-20-16)14-1-2-17(21-10-14)22-8-5-12-3-6-19-11-15(12)22/h1-11H
PDB

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US Patent
1.13 -51.1n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281632
PNG
(US10022461, Compound 101)
Show SMILES c1cc2ccncc2n1-c1ccc(cn1)-c1ccccn1
Show InChI InChI=1S/C17H12N4/c1-2-8-19-15(3-1)14-4-5-17(20-11-14)21-10-7-13-6-9-18-12-16(13)21/h1-12H
PDB

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US Patent
1.14 -51.0n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281605
PNG
(US10022461, Compound 55)
Show SMILES FCOc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C17H12FN3O/c18-11-22-16-3-1-2-13-8-17(20-9-14(13)16)21-7-5-12-4-6-19-10-15(12)21/h1-10H,11H2
PDB

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US Patent
1.14 -51.0n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281606
PNG
(US10022461, Compound 56)
Show SMILES Oc1cccc2cc(ncc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11N3O/c20-15-3-1-2-12-8-16(18-9-13(12)15)19-7-5-11-4-6-17-10-14(11)19/h1-10,20H
PDB

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US Patent
1.16 -51.0n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281657
PNG
(US10022461, Compound 127)
Show SMILES Nc1cc(I)cc2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11IN4/c17-12-5-11-8-20-16(7-13(11)14(18)6-12)21-4-2-10-1-3-19-9-15(10)21/h1-9H,18H2
PDB

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US Patent
1.17 -51.0n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281607
PNG
(US10022461, Compound 57)
Show SMILES FCOc1ccc2cnc(cc2c1)-n1ccc2ccncc12
Show InChI InChI=1S/C17H12FN3O/c18-11-22-15-2-1-13-9-20-17(8-14(13)7-15)21-6-4-12-3-5-19-10-16(12)21/h1-10H,11H2
PDB

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US Patent
1.23 -50.9n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281646
PNG
(US10022461, Compound 116)
Show SMILES Nc1ccc(F)c2cnc(cc12)-n1ccc2ccncc12
Show InChI InChI=1S/C16H11FN4/c17-13-1-2-14(18)11-7-16(20-8-12(11)13)21-6-4-10-3-5-19-9-15(10)21/h1-9H,18H2
PDB

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US Patent
1.28 -50.8n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281608
PNG
(US10022461, Compound 58)
Show SMILES Cn1cc(cn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C16H13N5/c1-20-11-14(9-19-20)13-2-3-16(18-8-13)21-7-5-12-4-6-17-10-15(12)21/h2-11H,1H3
PDB

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US Patent
1.32 -50.7n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
Microtubule-associated protein tau


(Homo sapiens (Human))
BDBM281627
PNG
(US10022461, Compound 94)
Show SMILES CCNc1cc(ccn1)-c1ccc(nc1)-n1ccc2ccncc12
Show InChI InChI=1S/C19H17N5/c1-2-21-18-11-15(6-9-22-18)16-3-4-19(23-12-16)24-10-7-14-5-8-20-13-17(14)24/h3-13H,2H2,1H3,(H,21,22)
PDB

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1.40 -50.5n/an/an/an/an/a7.425



Merck Sharp & Dohme Corp.

US Patent


Assay Description
For displacement tau binding assay, unlabeled test compounds were dissolved in DMSO at 1 mM. Dilutions of tests compounds to various concentrations w...


US Patent US10022461 (2018)

More data for this
Ligand-Target Pair
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