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Compile Data Set for Download or QSAR

Found 37 hits of ph data with Target = 'Mitogen-Activated Protein Kinase 10 (JNK3)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32464
PNG
(piperazine amide, 4k)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CCc2ccccc2)CC1
Show InChI InChI=1S/C23H23BrClN3O2/c24-21-10-9-20(30-21)23(29)26-19-8-4-7-18(25)22(19)28-15-13-27(14-16-28)12-11-17-5-2-1-3-6-17/h1-10H,11-16H2,(H,26,29)
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Article
PubMed
n/an/a 1.40E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32481
PNG
(piperazine amide, 6h)
Show SMILES Cc1nc(cs1)C(=O)Nc1cccc(Cl)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H21ClN4OS/c1-3-7-22-8-10-23(11-9-22)17-14(19)5-4-6-15(17)21-18(24)16-12-25-13(2)20-16/h3-6,12H,1,7-11H2,2H3,(H,21,24)
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PubMed
n/an/a 5.80E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32480
PNG
(piperazine amide, 6g)
Show SMILES Clc1cccc(NC(=O)c2ccc[nH]2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H21ClN4O/c1-2-9-22-10-12-23(13-11-22)17-14(19)5-3-6-15(17)21-18(24)16-7-4-8-20-16/h2-8,20H,1,9-13H2,(H,21,24)
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PubMed
n/an/a 8.90E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32479
PNG
(piperazine amide, 6f)
Show SMILES Clc1cccc(NC(=O)c2ccno2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H19ClN4O2/c1-2-8-21-9-11-22(12-10-21)16-13(18)4-3-5-14(16)20-17(23)15-6-7-19-24-15/h2-7H,1,8-12H2,(H,20,23)
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PubMed
n/an/a 5.00E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32478
PNG
(piperazine amide, 6d)
Show SMILES Clc1cccc(NC(=O)c2cscn2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H19ClN4OS/c1-2-6-21-7-9-22(10-8-21)16-13(18)4-3-5-14(16)20-17(23)15-11-24-12-19-15/h2-5,11-12H,1,6-10H2,(H,20,23)
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PubMed
n/an/a 2.30E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32477
PNG
(piperazine amide, 6c)
Show SMILES Clc1cccc(NC(=O)c2nc(Br)cs2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H18BrClN4OS/c1-2-6-22-7-9-23(10-8-22)15-12(19)4-3-5-13(15)20-16(24)17-21-14(18)11-25-17/h2-5,11H,1,6-10H2,(H,20,24)
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n/an/a 1.80E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32476
PNG
(piperazine amide, 6b)
Show SMILES Clc1cccc(NC(=O)c2cnc(Br)s2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C17H18BrClN4OS/c1-2-6-22-7-9-23(10-8-22)15-12(19)4-3-5-13(15)21-16(24)14-11-20-17(18)25-14/h2-5,11H,1,6-10H2,(H,21,24)
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n/an/a 310n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32453
PNG
(piperazine amide, 4a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCNCC1
Show InChI InChI=1S/C15H15BrClN3O2/c16-13-5-4-12(22-13)15(21)19-11-3-1-2-10(17)14(11)20-8-6-18-7-9-20/h1-5,18H,6-9H2,(H,19,21)
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n/an/a 9.90E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32454
PNG
(piperazine amide, 4b)
Show SMILES CN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C16H17BrClN3O2/c1-20-7-9-21(10-8-20)15-11(18)3-2-4-12(15)19-16(22)13-5-6-14(17)23-13/h2-6H,7-10H2,1H3,(H,19,22)
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PubMed
n/an/a 1.20E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32455
PNG
(cid_979869 | piperazine amide, 1)
Show SMILES CCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H19BrClN3O2/c1-2-21-8-10-22(11-9-21)16-12(19)4-3-5-13(16)20-17(23)14-6-7-15(18)24-14/h3-7H,2,8-11H2,1H3,(H,20,23)
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n/an/a 1.10E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32456
PNG
(piperazine amide, 4c)
Show SMILES CCCN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C18H21BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h3-7H,2,8-12H2,1H3,(H,21,24)
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n/an/a 900n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32457
PNG
(piperazine amide, 4d)
Show SMILES CC(C)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C18H21BrClN3O2/c1-12(2)22-8-10-23(11-9-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h3-7,12H,8-11H2,1-2H3,(H,21,24)
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n/an/a 2.20E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32458
PNG
(piperazine amide, 4e | piperazine amide, 6a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h2-7H,1,8-12H2,(H,21,24)
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n/an/a 330n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32459
PNG
(piperazine amide, 4f)
Show SMILES CC(=C)CN1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C19H21BrClN3O2/c1-13(2)12-23-8-10-24(11-9-23)18-14(21)4-3-5-15(18)22-19(25)16-6-7-17(20)26-16/h3-7H,1,8-12H2,2H3,(H,22,25)
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n/an/a 540n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32460
PNG
(piperazine amide, 4g)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC#C)CC1
Show InChI InChI=1S/C18H17BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h1,3-7H,8-12H2,(H,21,24)
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n/an/a 160n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32461
PNG
(piperazine amide, 4h)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC1)C1CC1
Show InChI InChI=1S/C18H19BrClN3O2/c19-16-7-6-15(25-16)18(24)21-14-3-1-2-13(20)17(14)23-10-8-22(9-11-23)12-4-5-12/h1-3,6-7,12H,4-5,8-11H2,(H,21,24)
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n/an/a 960n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32462
PNG
(piperazine amide, 4i)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(Cc2ccco2)CC1
Show InChI InChI=1S/C20H19BrClN3O3/c21-18-7-6-17(28-18)20(26)23-16-5-1-4-15(22)19(16)25-10-8-24(9-11-25)13-14-3-2-12-27-14/h1-7,12H,8-11,13H2,(H,23,26)
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n/an/a 250n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32463
PNG
(piperazine amide, 4j)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H21BrClN3O2/c23-20-10-9-19(29-20)22(28)25-18-8-4-7-17(24)21(18)27-13-11-26(12-14-27)15-16-5-2-1-3-6-16/h1-10H,11-15H2,(H,25,28)
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n/an/a 1.10E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32482
PNG
(piperazine amide, 6i)
Show SMILES Clc1cccc(NC(=O)c2cccc(Br)n2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C19H20BrClN4O/c1-2-9-24-10-12-25(13-11-24)18-14(21)5-3-6-15(18)23-19(26)16-7-4-8-17(20)22-16/h2-8H,1,9-13H2,(H,23,26)
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n/an/a 2.00E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32465
PNG
(piperazine amide, 4l)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C20H18BrClN4O2/c21-17-8-7-16(28-17)20(27)24-15-5-3-4-14(22)19(15)26-12-10-25(11-13-26)18-6-1-2-9-23-18/h1-9H,10-13H2,(H,24,27)
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n/an/a 1.00E+3n/an/an/an/a7.022



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Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32466
PNG
(piperazine amide, 4m)
Show SMILES CC(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H17BrClN3O3/c1-11(23)21-7-9-22(10-8-21)16-12(19)3-2-4-13(16)20-17(24)14-5-6-15(18)25-14/h2-6H,7-10H2,1H3,(H,20,24)
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PubMed
n/an/a 810n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32467
PNG
(piperazine amide, 4n)
Show SMILES FC(F)(F)C(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C17H14BrClF3N3O3/c18-13-5-4-12(28-13)15(26)23-11-3-1-2-10(19)14(11)24-6-8-25(9-7-24)16(27)17(20,21)22/h1-5H,6-9H2,(H,23,26)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32468
PNG
(piperazine amide, 4o)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1c(Cl)cccc1NC(=O)c1ccc(Br)o1
Show InChI InChI=1S/C20H23BrClN3O4/c1-20(2,3)29-19(27)25-11-9-24(10-12-25)17-13(22)5-4-6-14(17)23-18(26)15-7-8-16(21)28-15/h4-8H,9-12H2,1-3H3,(H,23,26)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32469
PNG
(piperazine amide, 4p)
Show SMILES Cc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C19H22BrN3O2/c1-3-9-22-10-12-23(13-11-22)18-14(2)5-4-6-15(18)21-19(24)16-7-8-17(20)25-16/h3-8H,1,9-13H2,2H3,(H,21,24)
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n/an/a 200n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32470
PNG
(piperazine amide, 4q)
Show SMILES Fc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC#C)CC1
Show InChI InChI=1S/C18H17BrFN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h1,3-7H,8-12H2,(H,21,24)
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n/an/a 290n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32471
PNG
(piperazine amide, 4r)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(Br)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19Br2N3O2/c1-2-8-22-9-11-23(12-10-22)17-13(19)4-3-5-14(17)21-18(24)15-6-7-16(20)25-15/h2-7H,1,8-12H2,(H,21,24)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32472
PNG
(piperazine amide, 4s)
Show SMILES FC(F)(F)c1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C19H19BrF3N3O2/c1-2-8-25-9-11-26(12-10-25)17-13(19(21,22)23)4-3-5-14(17)24-18(27)15-6-7-16(20)28-15/h2-7H,1,8-12H2,(H,24,27)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32473
PNG
(piperazine amide, 4t)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(-c2ccccc2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C24H24BrN3O2/c1-2-13-27-14-16-28(17-15-27)23-19(18-7-4-3-5-8-18)9-6-10-20(23)26-24(29)21-11-12-22(25)30-21/h2-12H,1,13-17H2,(H,26,29)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32474
PNG
(piperazine amide, 4u)
Show SMILES Brc1ccc(o1)C(=O)Nc1cccc(Nc2ccccc2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C24H25BrN4O2/c1-2-13-28-14-16-29(17-15-28)23-19(26-18-7-4-3-5-8-18)9-6-10-20(23)27-24(30)21-11-12-22(25)31-21/h2-12,26H,1,13-17H2,(H,27,30)
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n/an/a>2.00E+4n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (Human))
BDBM32458
PNG
(piperazine amide, 4e | piperazine amide, 6a)
Show SMILES Clc1cccc(NC(=O)c2ccc(Br)o2)c1N1CCN(CC=C)CC1
Show InChI InChI=1S/C18H19BrClN3O2/c1-2-8-22-9-11-23(12-10-22)17-13(20)4-3-5-14(17)21-18(24)15-6-7-16(19)25-15/h2-7H,1,8-12H2,(H,21,24)
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PubMed
n/an/a 1.26E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Biochemical IC50s for JNK were determined using HTRF. In each assay the phosphor-Thr71-ATF-2 product was detected using a Europium-cryptate labeled a...


Bioorg Med Chem Lett 19: 3344-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.086
BindingDB Entry DOI: 10.7270/Q2ST7N67
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (human))
BDBM25981
PNG
(BMCL18324 Compound 17 | CHEMBL273158 | N-(cyclopro...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)NCC1CC1
Show InChI InChI=1S/C21H21N3O2/c1-13-3-6-18(21-24-23-14(2)26-21)11-19(13)16-7-9-17(10-8-16)20(25)22-12-15-4-5-15/h3,6-11,15H,4-5,12H2,1-2H3,(H,22,25)
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>4.00E+3>-30.5>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 318-23 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.076
BindingDB Entry DOI: 10.7270/Q2KP80G3
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (human))
BDBM25980
PNG
(BMCL18324 Compound 3 | CHEMBL270164 | N-(3-cyanoph...)
Show SMILES Cc1nnc(o1)-c1ccc(C)c(c1)-c1ccc(cc1)C(=O)Nc1cccc(c1)C#N
Show InChI InChI=1S/C24H18N4O2/c1-15-6-7-20(24-28-27-16(2)30-24)13-22(15)18-8-10-19(11-9-18)23(29)26-21-5-3-4-17(12-21)14-25/h3-13H,1-2H3,(H,26,29)
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>4.00E+3>-30.5>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 318-23 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.076
BindingDB Entry DOI: 10.7270/Q2KP80G3
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (human))
BDBM25979
PNG
(BMCL18324 Compound 1 | N-[4-methoxy-3-(4-methylpip...)
Show SMILES COc1ccc(NC(=O)c2ccc(cc2)-c2cc(ccc2C)-c2nnc(C)o2)cc1N1CCN(C)CC1
Show InChI InChI=1S/C29H31N5O3/c1-19-5-6-23(29-32-31-20(2)37-29)17-25(19)21-7-9-22(10-8-21)28(35)30-24-11-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,30,35)
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>4.00E+3>-30.5>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 318-23 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.076
BindingDB Entry DOI: 10.7270/Q2KP80G3
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (human))
BDBM25191
PNG
(4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-y...)
Show SMILES Cc1ccc(O)cc1Nc1ccnc2cc(ccc12)-c1csc(C=O)n1
Show InChI InChI=1S/C20H15N3O2S/c1-12-2-4-14(25)9-17(12)22-16-6-7-21-18-8-13(3-5-15(16)18)19-11-26-20(10-24)23-19/h2-11,25H,1H3,(H,21,22)
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>4.00E+3>-30.5>1.60E+4n/an/an/an/a7.522



GSK



Assay Description
Fluorescence polarization assays used GST-tagged enzyme and an ATP-competitive Rhodamine-green labelled fluoroligand. These components were dissolved...


Bioorg Med Chem Lett 18: 318-23 (2008)


Article DOI: 10.1016/j.bmcl.2007.10.076
BindingDB Entry DOI: 10.7270/Q2KP80G3
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (human))
BDBM27785
PNG
(2-fluoro-6-{[2-({2-methoxy-4-methyl-5-[4-(propan-2...)
Show SMILES COc1cc(C)c(cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C28H33FN8O2/c1-16(2)36-10-12-37(13-11-36)22-15-21(23(39-4)14-17(22)3)33-28-34-26-18(8-9-31-26)27(35-28)32-20-7-5-6-19(29)24(20)25(30)38/h5-9,14-16H,10-13H2,1-4H3,(H2,30,38)(H3,31,32,33,34,35)
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n/an/a 6.31E+3n/an/an/an/a7.522



GSK



Assay Description
Inhibitor binding to JNK3 was assessed by a fluorescence anisotropy competitive binding assay. The reaction mixture (JNK3 and fluorescently labelled ...


Bioorg Med Chem Lett 19: 360-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.077
BindingDB Entry DOI: 10.7270/Q2NZ85ZT
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (human))
BDBM27784
PNG
(2-fluoro-6-{[2-({2-methoxy-5-[4-(propan-2-yl)piper...)
Show SMILES COc1ccc(cc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C27H31FN8O2/c1-16(2)35-11-13-36(14-12-35)17-7-8-22(38-3)21(15-17)32-27-33-25-18(9-10-30-25)26(34-27)31-20-6-4-5-19(28)23(20)24(29)37/h4-10,15-16H,11-14H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34)
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n/an/a 5.01E+3n/an/an/an/a7.522



GSK



Assay Description
Inhibitor binding to JNK3 was assessed by a fluorescence anisotropy competitive binding assay. The reaction mixture (JNK3 and fluorescently labelled ...


Bioorg Med Chem Lett 19: 360-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.077
BindingDB Entry DOI: 10.7270/Q2NZ85ZT
More data for this
Ligand-Target Pair
Mitogen-Activated Protein Kinase 10 (JNK3)


(Homo sapiens (human))
BDBM27783
PNG
(2-fluoro-6-{[2-({2-methoxy-4-[4-(propan-2-yl)piper...)
Show SMILES COc1cc(ccc1Nc1nc(Nc2cccc(F)c2C(N)=O)c2cc[nH]c2n1)N1CCN(CC1)C(C)C
Show InChI InChI=1S/C27H31FN8O2/c1-16(2)35-11-13-36(14-12-35)17-7-8-20(22(15-17)38-3)32-27-33-25-18(9-10-30-25)26(34-27)31-21-6-4-5-19(28)23(21)24(29)37/h4-10,15-16H,11-14H2,1-3H3,(H2,29,37)(H3,30,31,32,33,34)
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n/an/a 100n/an/an/an/a7.522



GSK



Assay Description
Inhibitor binding to JNK3 was assessed by a fluorescence anisotropy competitive binding assay. The reaction mixture (JNK3 and fluorescently labelled ...


Bioorg Med Chem Lett 19: 360-4 (2009)


Article DOI: 10.1016/j.bmcl.2008.11.077
BindingDB Entry DOI: 10.7270/Q2NZ85ZT
More data for this
Ligand-Target Pair