Compile Data Set for Download or QSAR

Found 184 hits of ph data with Target = 'Mitogen-activated protein kinase 1 (aa 8-360)'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192321 (US9187462, I-1) Show SMILES CC(CO)Nc1ncc2ccc(cc2n1)C(=O)NC(c1cnn(C)c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C23H22ClFN6O2/c1-13(12-32)28-23-26-9-16-4-3-15(8-20(16)29-23)22(33)30-21(17-10-27-31(2)11-17)14-5-6-18(24)19(25)7-14/h3-11,13,21,32H,12H2,1-2H3,(H,30,33)(H,26,28,29)	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192322 (US9187462, I-2) Show SMILES Cn1cc(cn1)C(NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.800	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192323 (US9187462, I-3) Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@H]1CCCN1 Show InChI InChI=1S/C26H27F4N5O2/c27-20-12-15(5-6-19(20)26(28,29)30)23(21-2-1-9-31-21)35-24(36)16-3-4-17-14-32-25(34-22(17)13-16)33-18-7-10-37-11-8-18/h3-6,12-14,18,21,23,31H,1-2,7-11H2,(H,35,36)(H,32,33,34)/t21-,23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192324 (US9187462, I-4) Show SMILES Cn1ccc(n1)C(NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-33-9-6-21(32-33)23(15-4-5-19(26)20(27)12-15)31-24(34)16-2-3-17-14-28-25(30-22(17)13-16)29-18-7-10-35-11-8-18/h2-6,9,12-14,18,23H,7-8,10-11H2,1H3,(H,31,34)(H,28,29,30)	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192325 (US9187462, I-5) Show SMILES CC(C)Nc1ncc2ccc(cc2n1)C(=O)N[C@H]([C@H]1CCCN1)c1ccc(c(F)c1)C(F)(F)F Show InChI InChI=1S/C24H25F4N5O/c1-13(2)31-23-30-12-16-6-5-15(11-20(16)32-23)22(34)33-21(19-4-3-9-29-19)14-7-8-17(18(25)10-14)24(26,27)28/h5-8,10-13,19,21,29H,3-4,9H2,1-2H3,(H,33,34)(H,30,31,32)/t19-,21+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192326 (US9187462, I-6) Show SMILES CC(CO)Nc1ncc2ccc(cc2n1)C(=O)NC(c1ccn(C)n1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C23H22ClFN6O2/c1-13(12-32)27-23-26-11-16-4-3-15(10-20(16)28-23)22(33)29-21(19-7-8-31(2)30-19)14-5-6-17(24)18(25)9-14/h3-11,13,21,32H,12H2,1-2H3,(H,29,33)(H,26,27,28)	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192327 (US9187462, I-7) Show SMILES Fc1cc(ccc1C(F)(F)F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCCN1 Show InChI InChI=1S/C26H27F4N5O2/c27-20-12-15(5-6-19(20)26(28,29)30)23(21-2-1-9-31-21)35-24(36)16-3-4-17-14-32-25(34-22(17)13-16)33-18-7-10-37-11-8-18/h3-6,12-14,18,21,23,31H,1-2,7-11H2,(H,35,36)(H,32,33,34)/t21-,23+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192328 (US9187462, I-8) Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@H]1CCNC1 Show InChI InChI=1S/C25H27ClFN5O2/c26-20-11-15(3-4-21(20)27)23(18-5-8-28-13-18)32-24(33)16-1-2-17-14-29-25(31-22(17)12-16)30-19-6-9-34-10-7-19/h1-4,11-12,14,18-19,23,28H,5-10,13H2,(H,32,33)(H,29,30,31)/t18-,23+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192329 (US9187462, I-9) Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCNC1 Show InChI InChI=1S/C25H27ClFN5O2/c26-20-11-15(3-4-21(20)27)23(18-5-8-28-13-18)32-24(33)16-1-2-17-14-29-25(31-22(17)12-16)30-19-6-9-34-10-7-19/h1-4,11-12,14,18-19,23,28H,5-10,13H2,(H,32,33)(H,29,30,31)/t18-,23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.70	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192330 (US9187462, I-10) Show SMILES Fc1ccc(cc1Cl)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCNC1 Show InChI InChI=1S/C25H27ClFN5O2/c26-20-11-15(3-4-21(20)27)23(18-5-8-28-13-18)32-24(33)16-1-2-17-14-29-25(31-22(17)12-16)30-19-6-9-34-10-7-19/h1-4,11-12,14,18-19,23,28H,5-10,13H2,(H,32,33)(H,29,30,31)/t18-,23+/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192331 (US9187462, I-11) Show SMILES Fc1ccc(cc1Cl)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@H]1CCNC1 Show InChI InChI=1S/C25H27ClFN5O2/c26-20-11-15(3-4-21(20)27)23(18-5-8-28-13-18)32-24(33)16-1-2-17-14-29-25(31-22(17)12-16)30-19-6-9-34-10-7-19/h1-4,11-12,14,18-19,23,28H,5-10,13H2,(H,32,33)(H,29,30,31)/t18-,23-/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192332 (US9187462, I-12) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)/t23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192333 (US9187462, I-13) Show SMILES Cn1cc(cn1)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-33-14-18(13-29-33)23(15-4-5-20(26)21(27)10-15)32-24(34)16-2-3-17-12-28-25(31-22(17)11-16)30-19-6-8-35-9-7-19/h2-5,10-14,19,23H,6-9H2,1H3,(H,32,34)(H,28,30,31)/t23-/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38.8	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192334 (US9187462, I-14) Show SMILES C[C@@H](CO)Nc1ncc2ccc(cc2n1)C(=O)N[C@@H](c1cnn(C)c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C23H22ClFN6O2/c1-13(12-32)28-23-26-9-16-4-3-15(8-20(16)29-23)22(33)30-21(17-10-27-31(2)11-17)14-5-6-18(24)19(25)7-14/h3-11,13,21,32H,12H2,1-2H3,(H,30,33)(H,26,28,29)/t13-,21+/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	56.8	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192335 (US9187462, I-15) Show SMILES CC(CO)Nc1ncc2ccc(cc2n1)C(=O)N[C@H](c1cnn(C)c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C23H22ClFN6O2/c1-13(12-32)28-23-26-9-16-4-3-15(8-20(16)29-23)22(33)30-21(17-10-27-31(2)11-17)14-5-6-18(24)19(25)7-14/h3-11,13,21,32H,12H2,1-2H3,(H,30,33)(H,26,28,29)/t13?,21-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192337 (US9187462, I-17) Show SMILES CN1CCC[C@@H]1[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(c(F)c1)C(F)(F)F Show InChI InChI=1S/C27H29F4N5O2/c1-36-10-2-3-23(36)24(16-6-7-20(21(28)13-16)27(29,30)31)35-25(37)17-4-5-18-15-32-26(34-22(18)14-17)33-19-8-11-38-12-9-19/h4-7,13-15,19,23-24H,2-3,8-12H2,1H3,(H,35,37)(H,32,33,34)/t23-,24+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192338 (US9187462, I-18) Show SMILES CCn1ccc(n1)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C26H26ClFN6O2/c1-2-34-10-7-22(33-34)24(16-5-6-20(27)21(28)13-16)32-25(35)17-3-4-18-15-29-26(31-23(18)14-17)30-19-8-11-36-12-9-19/h3-7,10,13-15,19,24H,2,8-9,11-12H2,1H3,(H,32,35)(H,29,30,31)/t24-/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.8	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192339 (US9187462, I-19) Show SMILES Fc1cc(ccc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cc[nH]n1 Show InChI	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192340 (US9187462, I-20) Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-33-9-6-21(32-33)23(15-4-5-19(26)20(27)12-15)31-24(34)16-2-3-17-14-28-25(30-22(17)13-16)29-18-7-10-35-11-8-18/h2-6,9,12-14,18,23H,7-8,10-11H2,1H3,(H,31,34)(H,28,29,30)/t23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192341 (US9187462, I-21) Show SMILES Cn1ccc(n1)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H24ClFN6O2/c1-33-9-6-21(32-33)23(15-4-5-19(26)20(27)12-15)31-24(34)16-2-3-17-14-28-25(30-22(17)13-16)29-18-7-10-35-11-8-18/h2-6,9,12-14,18,23H,7-8,10-11H2,1H3,(H,31,34)(H,28,29,30)/t23-/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	69	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192342 (US9187462, I-22) Show SMILES Cn1ccc(n1)[C@@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-7-4-21(33-34)23(14-2-3-18(26)20(28)10-14)32-24(35)15-11-19(27)17-13-29-25(31-22(17)12-15)30-16-5-8-36-9-6-16/h2-4,7,10-13,16,23H,5-6,8-9H2,1H3,(H,32,35)(H,29,30,31)/t23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192343 (US9187462, I-23) Show SMILES Fc1cc(ccc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCCN1 Show InChI InChI=1S/C25H27ClFN5O2/c26-19-6-5-15(12-20(19)27)23(21-2-1-9-28-21)32-24(33)16-3-4-17-14-29-25(31-22(17)13-16)30-18-7-10-34-11-8-18/h3-6,12-14,18,21,23,28H,1-2,7-11H2,(H,32,33)(H,29,30,31)/t21-,23+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192344 (US9187462, I-24) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1CCCN1 Show InChI InChI=1S/C26H30FN5O3/c1-34-23-7-6-16(13-20(23)27)24(21-3-2-10-28-21)32-25(33)17-4-5-18-15-29-26(31-22(18)14-17)30-19-8-11-35-12-9-19/h4-7,13-15,19,21,24,28H,2-3,8-12H2,1H3,(H,32,33)(H,29,30,31)/t21-,24+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192345 (US9187462, I-25) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)[C@H]1CCCN1 Show InChI InChI=1S/C26H29F2N5O3/c1-35-23-5-4-15(11-20(23)28)24(21-3-2-8-29-21)33-25(34)16-12-19(27)18-14-30-26(32-22(18)13-16)31-17-6-9-36-10-7-17/h4-5,11-14,17,21,24,29H,2-3,6-10H2,1H3,(H,33,34)(H,30,31,32)/t21-,24+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192346 (US9187462, I-26) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(N[C@H](C)C3CC3)nc2c1)[C@H]1CCCN1 Show InChI InChI=1S/C26H30FN5O2/c1-15(16-5-6-16)30-26-29-14-19-8-7-18(13-22(19)31-26)25(33)32-24(21-4-3-11-28-21)17-9-10-23(34-2)20(27)12-17/h7-10,12-16,21,24,28H,3-6,11H2,1-2H3,(H,32,33)(H,29,30,31)/t15-,21-,24+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192347 (US9187462, I-27) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCOC[C@@H]3F)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-12-17(11-30-34)23(14-4-5-18(26)19(27)8-14)33-24(35)15-2-3-16-10-29-25(32-22(16)9-15)31-21-6-7-36-13-20(21)28/h2-5,8-12,20-21,23H,6-7,13H2,1H3,(H,33,35)(H,29,31,32)/t20-,21+,23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	15.8	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192348 (US9187462, I-28) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@H]3CCOC[C@H]3F)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-12-17(11-30-34)23(14-4-5-18(26)19(27)8-14)33-24(35)15-2-3-16-10-29-25(32-22(16)9-15)31-21-6-7-36-13-20(21)28/h2-5,8-12,20-21,23H,6-7,13H2,1H3,(H,33,35)(H,29,31,32)/t20-,21+,23+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192349 (US9187462, I-29) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@H]3CCOC[C@@H]3F)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-12-17(11-30-34)23(14-4-5-18(26)19(27)8-14)33-24(35)15-2-3-16-10-29-25(32-22(16)9-15)31-21-6-7-36-13-20(21)28/h2-5,8-12,20-21,23H,6-7,13H2,1H3,(H,33,35)(H,29,31,32)/t20-,21-,23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.80	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192350 (US9187462, I-30) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCOC[C@H]3F)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C25H23ClF2N6O2/c1-34-12-17(11-30-34)23(14-4-5-18(26)19(27)8-14)33-24(35)15-2-3-16-10-29-25(32-22(16)9-15)31-21-6-7-36-13-20(21)28/h2-5,8-12,20-21,23H,6-7,13H2,1H3,(H,33,35)(H,29,31,32)/t20-,21-,23+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192351 (US9187462, I-31) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@H]1C[C@H](F)CN1 Show InChI InChI=1S/C26H29F2N5O3/c1-35-23-5-4-15(10-20(23)28)24(22-12-18(27)14-29-22)33-25(34)16-2-3-17-13-30-26(32-21(17)11-16)31-19-6-8-36-9-7-19/h2-5,10-11,13,18-19,22,24,29H,6-9,12,14H2,1H3,(H,33,34)(H,30,31,32)/t18-,22+,24-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.70	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192352 (US9187462, I-32) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 Show InChI InChI=1S/C26H27FN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192353 (US9187462, I-33) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 Show InChI InChI=1S/C26H26F2N6O3/c1-34-14-17(12-30-34)24(15-3-4-23(36-2)21(28)9-15)33-25(35)16-10-20(27)19-13-29-26(32-22(19)11-16)31-18-5-7-37-8-6-18/h3-4,9-14,18,24H,5-8H2,1-2H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192354 (US9187462, I-34) Show SMILES Fc1cc(ccc1Cl)C(NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ncno1 Show InChI InChI=1S/C23H20ClFN6O3/c24-17-4-3-13(9-18(17)25)20(22-27-12-28-34-22)31-21(32)14-1-2-15-11-26-23(30-19(15)10-14)29-16-5-7-33-8-6-16/h1-4,9-12,16,20H,5-8H2,(H,31,32)(H,26,29,30)	PDB GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192355 (US9187462, I-35) Show SMILES C[C@@H]1CC[C@@H](N1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C26H29ClFN5O2/c1-15-2-7-22(30-15)24(16-5-6-20(27)21(28)12-16)33-25(34)17-3-4-18-14-29-26(32-23(18)13-17)31-19-8-10-35-11-9-19/h3-6,12-15,19,22,24,30H,2,7-11H2,1H3,(H,33,34)(H,29,31,32)/t15-,22-,24+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192356 (US9187462, I-36) Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@]1(F)CCNC1 Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192357 (US9187462, I-37) Show SMILES Fc1ccc(cc1Cl)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@]1(F)CCNC1 Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25-/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	73.6	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192358 (US9187462, I-38) Show SMILES Fc1ccc(cc1Cl)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@]1(F)CCNC1 Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.4	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192359 (US9187462, I-39) Show SMILES Fc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)[C@@]1(F)CCNC1 Show InChI InChI=1S/C25H26ClF2N5O2/c26-19-11-15(3-4-20(19)27)22(25(28)7-8-29-14-25)33-23(34)16-1-2-17-13-30-24(32-21(17)12-16)31-18-5-9-35-10-6-18/h1-4,11-13,18,22,29H,5-10,14H2,(H,33,34)(H,30,31,32)/t22-,25+/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192360 (US9187462, I-40) Show SMILES C[C@H](Nc1ncc2ccc(cc2n1)C(=O)N[C@H]([C@@H]1CCCN1)c1ccc(Cl)c(F)c1)C(F)(F)F Show InChI InChI=1S/C23H22ClF4N5O/c1-12(23(26,27)28)31-22-30-11-15-5-4-14(10-19(15)32-22)21(34)33-20(18-3-2-8-29-18)13-6-7-16(24)17(25)9-13/h4-7,9-12,18,20,29H,2-3,8H2,1H3,(H,33,34)(H,30,31,32)/t12-,18-,20-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.30	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192361 (US9187462, I-41) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(OC(F)F)cc1 Show InChI InChI=1S/C26H26F2N6O3/c1-34-15-19(14-30-34)23(16-4-6-21(7-5-16)37-25(27)28)33-24(35)17-2-3-18-13-29-26(32-22(18)12-17)31-20-8-10-36-11-9-20/h2-7,12-15,20,23,25H,8-11H2,1H3,(H,33,35)(H,29,31,32)/t23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192362 (US9187462, I-42) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@H]3CCO[C@H](CO)C3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C26H26ClFN6O3/c1-34-13-18(12-30-34)24(15-4-5-21(27)22(28)8-15)33-25(36)16-2-3-17-11-29-26(32-23(17)9-16)31-19-6-7-37-20(10-19)14-35/h2-5,8-9,11-13,19-20,24,35H,6-7,10,14H2,1H3,(H,33,36)(H,29,31,32)/t19-,20-,24-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192364 (US9187462, I-44) Show SMILES COc1ccc(cc1Cl)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 Show InChI InChI=1S/C26H27ClN6O3/c1-33-15-19(14-29-33)24(16-5-6-23(35-2)21(27)11-16)32-25(34)17-3-4-18-13-28-26(31-22(18)12-17)30-20-7-9-36-10-8-20/h3-6,11-15,20,24H,7-10H2,1-2H3,(H,32,34)(H,28,30,31)/t24-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192365 (BDBM192434 | US9187462, I-45) Show SMILES Cn1cc(cn1)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(F)c1 Show InChI InChI=1S/C26H24FN7O2/c1-34-15-20(14-30-34)24(16-2-4-18(12-28)22(27)10-16)33-25(35)17-3-5-19-13-29-26(32-23(19)11-17)31-21-6-8-36-9-7-21/h2-5,10-11,13-15,21,24H,6-9H2,1H3,(H,33,35)(H,29,31,32)/t24-/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	22	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192366 (US9187462, I-46) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1ccc2cnc(N[C@H]3CCO[C@H](CO)C3)nc2c1)c1cnn(C)c1 Show InChI InChI=1S/C27H29FN6O4/c1-34-14-19(13-30-34)25(16-5-6-24(37-2)22(28)9-16)33-26(36)17-3-4-18-12-29-27(32-23(18)10-17)31-20-7-8-38-21(11-20)15-35/h3-6,9-10,12-14,20-21,25,35H,7-8,11,15H2,1-2H3,(H,33,36)(H,29,31,32)/t20-,21-,25-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.20	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192367 (US9187462, I-47) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(N[C@@H]3CCO[C@H](CO)C3)nc2c1)c1ccc(Cl)c(F)c1 Show InChI InChI=1S/C26H26ClFN6O3/c1-34-13-18(12-30-34)24(15-4-5-21(27)22(28)8-15)33-25(36)16-2-3-17-11-29-26(32-23(17)9-16)31-19-6-7-37-20(10-19)14-35/h2-5,8-9,11-13,19-20,24,35H,6-7,10,14H2,1H3,(H,33,36)(H,29,31,32)/t19-,20+,24+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.40	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192368 (US9187462, I-48) Show SMILES Cn1cc(cn1)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1 Show InChI InChI=1S/C26H24ClN7O2/c1-34-15-20(14-30-34)24(16-2-4-18(12-28)22(27)10-16)33-25(35)17-3-5-19-13-29-26(32-23(19)11-17)31-21-6-8-36-9-7-21/h2-5,10-11,13-15,21,24H,6-9H2,1H3,(H,33,35)(H,29,31,32)/t24-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.10	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192369 (US9187462, I-49) Show SMILES COc1ccc(cc1C#N)[C@@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1cnn(C)c1 Show InChI InChI=1S/C27H27N7O3/c1-34-16-21(15-30-34)25(17-5-6-24(36-2)20(11-17)13-28)33-26(35)18-3-4-19-14-29-27(32-23(19)12-18)31-22-7-9-37-10-8-22/h3-6,11-12,14-16,22,25H,7-10H2,1-2H3,(H,33,35)(H,29,31,32)/t25-/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	141	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192370 (US9187462, I-50) Show SMILES Cn1cc(cn1)[C@H](NC(=O)c1ccc2cnc(NC3CCOCC3)nc2c1)c1ccc(C#N)c(Cl)c1 Show InChI InChI=1S/C26H24ClN7O2/c1-34-15-20(14-30-34)24(16-2-4-18(12-28)22(27)10-16)33-25(35)17-3-5-19-13-29-26(32-23(19)11-17)31-21-6-8-36-9-7-21/h2-5,10-11,13-15,21,24H,6-9H2,1H3,(H,33,35)(H,29,31,32)/t24-/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	25	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192371 (US9187462, I-51) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(NC3CCOCC3)nc2c1)c1cnn(C)n1 Show InChI InChI=1S/C25H25F2N7O3/c1-34-29-13-21(33-34)23(14-3-4-22(36-2)19(27)9-14)32-24(35)15-10-18(26)17-12-28-25(31-20(17)11-15)30-16-5-7-37-8-6-16/h3-4,9-13,16,23H,5-8H2,1-2H3,(H,32,35)(H,28,30,31)/t23-/m0/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.80	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (aa 8-360) (Homo sapiens (Human))	BDBM192372 (US9187462, I-52) Show SMILES COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CCOC[C@H]3F)nc2c1)c1cnn(C)c1 Show InChI InChI=1S/C26H25F3N6O3/c1-35-12-16(10-31-35)24(14-3-4-23(37-2)19(28)7-14)34-25(36)15-8-18(27)17-11-30-26(33-22(17)9-15)32-21-5-6-38-13-20(21)29/h3-4,7-12,20-21,24H,5-6,13H2,1-2H3,(H,34,36)(H,30,32,33)/t20-,21+,24+/m1/s1	PDB GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.60	n/a	n/a	n/a	n/a	7.3	n/a
Array BioPharma Inc US Patent					Assay Description Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...				US Patent US9187462 (2015) BindingDB Entry DOI: 10.7270/Q21G0K2P
					More data for this Ligand-Target Pair

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