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Compile Data Set for Download or QSAR

Found 13 hits of ph data with Target = 'Mitogen-activated protein kinase 10'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM16015
PNG
(CHEMBL252967 | N-cyclopropyl-4-[4-(3,4-dichlorophe...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCN(C)CC1
Show InChI InChI=1S/C25H30Cl2N6/c1-3-12-33-23(21-8-11-28-25(30-21)29-18-5-6-18)22(17-4-7-19(26)20(27)15-17)31-24(33)16-9-13-32(2)14-10-16/h4,7-8,11,15-16,18H,3,5-6,9-10,12-14H2,1-2H3,(H,28,29,30)
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n/an/a 7.10n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM16016
PNG
(CHEMBL437747 | N-cyclohexyl-4-[4-(3,4-dichlorophen...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1
Show InChI InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33)
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n/an/a 1.60n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM16017
PNG
(4-(2,7-phenanthrolin-9-yl)phenol | 4-(2=7-phenantr...)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc3ccncc3c2c1
Show InChI InChI=1S/C18H12N2O/c21-15-4-1-12(2-5-15)14-9-16-17-11-19-8-7-13(17)3-6-18(16)20-10-14/h1-11,21H
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n/an/a 590n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM16018
PNG
(14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexa...)
Show SMILES O=C1c2ccccc2-c2n[nH]c3cccc1c23
Show InChI InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
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n/an/a 150n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92522
PNG
(Aminopyrazole inhibitor, 3451)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3)cn2)cc(OC)c1OC
Show InChI InChI=1S/C26H25N5O5/c1-34-22-13-19(14-23(35-2)24(22)36-3)28-25(32)17-8-7-11-21(12-17)31-16-20(15-27-31)30-26(33)29-18-9-5-4-6-10-18/h4-16H,1-3H3,(H,28,32)(H2,29,30,33)
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n/an/a 25n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92523
PNG
(Aminopyrazole inhibitor, 3528)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)cc(OC)c1OC
Show InChI InChI=1S/C26H24ClN5O5/c1-35-22-12-17(13-23(36-2)24(22)37-3)29-25(33)16-7-6-8-19(11-16)32-15-18(14-28-32)30-26(34)31-21-10-5-4-9-20(21)27/h4-15H,1-3H3,(H,29,33)(H2,30,31,34)
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n/an/a 23n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92530
PNG
(Aminopyrazole inhibitor, 4276)
Show SMILES Clc1ccccc1NC(=O)Nc1cnn(c1)-c1cccc(c1)C(=O)NCCCN1CCOCC1
Show InChI InChI=1S/C24H27ClN6O3/c25-21-7-1-2-8-22(21)29-24(33)28-19-16-27-31(17-19)20-6-3-5-18(15-20)23(32)26-9-4-10-30-11-13-34-14-12-30/h1-3,5-8,15-17H,4,9-14H2,(H,26,32)(H2,28,29,33)
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n/an/a 350n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92525
PNG
(Aminopyrazole inhibitor, 3583)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccc(Cl)cc3)cn2)cc(OC)c1OC
Show InChI InChI=1S/C26H24ClN5O5/c1-35-22-12-19(13-23(36-2)24(22)37-3)29-25(33)16-5-4-6-21(11-16)32-15-20(14-28-32)31-26(34)30-18-9-7-17(27)8-10-18/h4-15H,1-3H3,(H,29,33)(H2,30,31,34)
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n/an/a 480n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92526
PNG
(Aminopyrazole inhibitor, 4326)
Show SMILES Cc1cncc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)c1
Show InChI InChI=1S/C23H19ClN6O2/c1-15-9-17(12-25-11-15)27-22(31)16-5-4-6-19(10-16)30-14-18(13-26-30)28-23(32)29-21-8-3-2-7-20(21)24/h2-14H,1H3,(H,27,31)(H2,28,29,32)
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n/an/a 55n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92527
PNG
(Aminopyrazole inhibitor, 4642)
Show SMILES CN(C)c1cc(cc(c1)-n1cc(NC(=O)Nc2ccccc2Cl)cn1)C(=O)Nc1cncc(C)c1
Show InChI InChI=1S/C25H24ClN7O2/c1-16-8-18(13-27-12-16)29-24(34)17-9-20(32(2)3)11-21(10-17)33-15-19(14-28-33)30-25(35)31-23-7-5-4-6-22(23)26/h4-15H,1-3H3,(H,29,34)(H2,30,31,35)
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n/an/a 2.20E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92528
PNG
(Aminopyrazole inhibitor, 4643)
Show SMILES Cc1cncc(NC(=O)c2cc(cc(c2)-n2cc(NC(=O)Nc3ccccc3Cl)cn2)N2CCOCC2)c1
Show InChI InChI=1S/C27H26ClN7O3/c1-18-10-20(15-29-14-18)31-26(36)19-11-22(34-6-8-38-9-7-34)13-23(12-19)35-17-21(16-30-35)32-27(37)33-25-5-3-2-4-24(25)28/h2-5,10-17H,6-9H2,1H3,(H,31,36)(H2,32,33,37)
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n/an/a 1.50E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92529
PNG
(Aminopyrazole inhibitor, 4018)
Show SMILES Cc1cccc(NC(=O)Nc2cnn(c2)-c2cccc(c2)C(=O)NCCN2CCOCC2)c1
Show InChI InChI=1S/C24H28N6O3/c1-18-4-2-6-20(14-18)27-24(32)28-21-16-26-30(17-21)22-7-3-5-19(15-22)23(31)25-8-9-29-10-12-33-13-11-29/h2-7,14-17H,8-13H2,1H3,(H,25,31)(H2,27,28,32)
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n/an/a 2.10E+3n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10


(Homo sapiens (human))
BDBM92524
PNG
(Aminopyrazole inhibitor, 3576)
Show SMILES COc1cc(NC(=O)c2cccc(c2)-n2cc(NC(=O)Nc3cccc(C)c3)cn2)cc(OC)c1OC
Show InChI InChI=1S/C27H27N5O5/c1-17-7-5-9-19(11-17)30-27(34)31-21-15-28-32(16-21)22-10-6-8-18(12-22)26(33)29-20-13-23(35-2)25(37-4)24(14-20)36-3/h5-16H,1-4H3,(H,29,33)(H2,30,31,34)
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n/an/a 7n/an/an/an/a7.022



The Scripps Research Institute



Assay Description
Homogeneous time-resolved fluorescence assay is an enzyme inhibition studies that were performed in 384-well polystyrene homogeneous time-resolved fl...


J Biol Chem 284: 12853-61 (2009)


Article DOI: 10.1074/jbc.M809430200
BindingDB Entry DOI: 10.7270/Q2NZ867T
More data for this
Ligand-Target Pair