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Compile Data Set for Download or QSAR

Found 350 hits of ph data with Target = 'Mitogen-activated protein kinase 14'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14831
PNG
(3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chl...)
Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C
Show InChI InChI=1S/C15H19ClN4O/c1-15(2,3)12-9-13(20(4)19-12)18-14(21)17-11-7-5-10(16)6-8-11/h5-9H,1-4H3,(H2,17,18,21)
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n/an/an/a 1.16E+3n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


Nat Struct Biol 9: 268-72 (2002)


Article DOI: 10.1038/nsb770
BindingDB Entry DOI: 10.7270/Q2CV4FZ3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM36489
PNG
(BI-12H11)
Show SMILES CN1SC(=C)c2cc(ccc12)S(=O)(=O)Nc1ccccc1N1CCCCC1
Show InChI InChI=1S/C20H23N3O2S2/c1-15-17-14-16(10-11-19(17)22(2)26-15)27(24,25)21-18-8-4-5-9-20(18)23-12-6-3-7-13-23/h4-5,8-11,14,21H,1,3,6-7,12-13H2,2H3
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n/an/a 5.61E+3n/an/an/an/a7.0n/a



Burnham Institute for Medical Research



Assay Description
The competitive binding between test compounds and a fluorescence p38 alpha inhibitor, SK&F 86002.


ACS Chem Biol 2: 329-36 (2007)


Article DOI: 10.1021/cb700025j
BindingDB Entry DOI: 10.7270/Q2ZW1J99
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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n/an/an/a 0.100n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


Nat Struct Biol 9: 268-72 (2002)


Article DOI: 10.1038/nsb770
BindingDB Entry DOI: 10.7270/Q2CV4FZ3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14831
PNG
(3-(3-tert-butyl-1-methyl-1H-pyrazol-5-yl)-1-(4-chl...)
Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(Cl)cc1)C(C)(C)C
Show InChI InChI=1S/C15H19ClN4O/c1-15(2,3)12-9-13(20(4)19-12)18-14(21)17-11-7-5-10(16)6-8-11/h5-9H,1-4H3,(H2,17,18,21)
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n/an/an/a 1.16E+3n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


J Med Chem 46: 4669-75 (2003)


Article DOI: 10.1021/jm030120s
BindingDB Entry DOI: 10.7270/Q2833Q8J
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14834
PNG
(1-[5-(2-Hydroxy-1,1-dimethylethyl)-2-p-tolyl-2H-py...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)CO
Show InChI InChI=1S/C31H37N5O4/c1-22-8-10-23(11-9-22)36-29(20-28(34-36)31(2,3)21-37)33-30(38)32-26-12-13-27(25-7-5-4-6-24(25)26)40-19-16-35-14-17-39-18-15-35/h4-13,20,37H,14-19,21H2,1-3H3,(H2,32,33,38)
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n/an/an/a 36n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


J Med Chem 46: 4669-75 (2003)


Article DOI: 10.1021/jm030120s
BindingDB Entry DOI: 10.7270/Q2833Q8J
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14835
PNG
(1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-[4-(2-...)
Show SMILES Cn1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C25H33N5O3/c1-25(2,3)22-17-23(29(4)28-22)27-24(31)26-20-9-10-21(19-8-6-5-7-18(19)20)33-16-13-30-11-14-32-15-12-30/h5-10,17H,11-16H2,1-4H3,(H2,26,27,31)
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n/an/an/a 23n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


J Med Chem 46: 4669-75 (2003)


Article DOI: 10.1021/jm030120s
BindingDB Entry DOI: 10.7270/Q2833Q8J
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14836
PNG
(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccccc1)C(C)(C)C
Show InChI InChI=1S/C21H24N4O/c1-15-10-12-17(13-11-15)25-19(14-18(24-25)21(2,3)4)23-20(26)22-16-8-6-5-7-9-16/h5-14H,1-4H3,(H2,22,23,26)
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n/an/an/a 21n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


J Med Chem 46: 4669-75 (2003)


Article DOI: 10.1021/jm030120s
BindingDB Entry DOI: 10.7270/Q2833Q8J
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14837
PNG
(3-[3-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-yl...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1cccc2ccccc12)C(C)(C)C
Show InChI InChI=1S/C25H26N4O/c1-17-12-14-19(15-13-17)29-23(16-22(28-29)25(2,3)4)27-24(30)26-21-11-7-9-18-8-5-6-10-20(18)21/h5-16H,1-4H3,(H2,26,27,30)
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n/an/an/a 1n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


J Med Chem 46: 4669-75 (2003)


Article DOI: 10.1021/jm030120s
BindingDB Entry DOI: 10.7270/Q2833Q8J
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14839
PNG
(1-(5-tert-Butyl-2-phenyl-2H-pyrazol-3-yl)-3-[4-(2-...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(OCCN3CCOCC3)c3ccccc23)n(n1)-c1ccccc1
Show InChI InChI=1S/C30H35N5O3/c1-30(2,3)27-21-28(35(33-27)22-9-5-4-6-10-22)32-29(36)31-25-13-14-26(24-12-8-7-11-23(24)25)38-20-17-34-15-18-37-19-16-34/h4-14,21H,15-20H2,1-3H3,(H2,31,32,36)
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n/an/an/a 0.0900n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


J Med Chem 46: 4669-75 (2003)


Article DOI: 10.1021/jm030120s
BindingDB Entry DOI: 10.7270/Q2833Q8J
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14840
PNG
(1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCc2ccncc2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C32H33N5O2/c1-22-9-11-24(12-10-22)37-30(21-29(36-37)32(2,3)4)35-31(38)34-27-13-14-28(26-8-6-5-7-25(26)27)39-20-17-23-15-18-33-19-16-23/h5-16,18-19,21H,17,20H2,1-4H3,(H2,34,35,38)
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n/an/an/a 0.5n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


J Med Chem 46: 4669-75 (2003)


Article DOI: 10.1021/jm030120s
BindingDB Entry DOI: 10.7270/Q2833Q8J
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM13533
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C31H37N5O3/c1-22-9-11-23(12-10-22)36-29(21-28(34-36)31(2,3)4)33-30(37)32-26-13-14-27(25-8-6-5-7-24(25)26)39-20-17-35-15-18-38-19-16-35/h5-14,21H,15-20H2,1-4H3,(H2,32,33,37)
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n/an/an/a 0.100n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


J Med Chem 46: 4669-75 (2003)


Article DOI: 10.1021/jm030120s
BindingDB Entry DOI: 10.7270/Q2833Q8J
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16015
PNG
(CHEMBL252967 | N-cyclopropyl-4-[4-(3,4-dichlorophe...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCN(C)CC1
Show InChI InChI=1S/C25H30Cl2N6/c1-3-12-33-23(21-8-11-28-25(30-21)29-18-5-6-18)22(17-4-7-19(26)20(27)15-17)31-24(33)16-9-13-32(2)14-10-16/h4,7-8,11,15-16,18H,3,5-6,9-10,12-14H2,1-2H3,(H,28,29,30)
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PubMed
n/an/a 0.0780n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16016
PNG
(CHEMBL437747 | N-cyclohexyl-4-[4-(3,4-dichlorophen...)
Show SMILES CCCn1c(nc(c1-c1ccnc(NC2CCCCC2)n1)-c1ccc(Cl)c(Cl)c1)C1CCNCC1
Show InChI InChI=1S/C27H34Cl2N6/c1-2-16-35-25(23-12-15-31-27(33-23)32-20-6-4-3-5-7-20)24(19-8-9-21(28)22(29)17-19)34-26(35)18-10-13-30-14-11-18/h8-9,12,15,17-18,20,30H,2-7,10-11,13-14,16H2,1H3,(H,31,32,33)
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n/an/a 4n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16017
PNG
(4-(2,7-phenanthrolin-9-yl)phenol | 4-(2=7-phenantr...)
Show SMILES Oc1ccc(cc1)-c1cnc2ccc3ccncc3c2c1
Show InChI InChI=1S/C18H12N2O/c21-15-4-1-12(2-5-15)14-9-16-17-11-19-8-7-13(17)3-6-18(16)20-10-14/h1-11,21H
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n/an/a>4.00E+4n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16018
PNG
(14,15-diazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexa...)
Show SMILES O=C1c2ccccc2-c2n[nH]c3cccc1c23
Show InChI InChI=1S/C14H8N2O/c17-14-9-5-2-1-4-8(9)13-12-10(14)6-3-7-11(12)15-16-13/h1-7H,(H,15,16)
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n/an/a>3.00E+4n/an/an/an/a7.022



Merck Research Laboratories



Assay Description
HTRF relies on fluorescence resonance energy transfer (FRET) between the donor, a europium cryptate (EuK), and the acceptor, the light harvesting pro...


Chem Biol 10: 705-12 (2003)


Article DOI: 10.1016/S1074-5521(03)00159-5
BindingDB Entry DOI: 10.7270/Q2DJ5CWZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM36489
PNG
(BI-12H11)
Show SMILES CN1SC(=C)c2cc(ccc12)S(=O)(=O)Nc1ccccc1N1CCCCC1
Show InChI InChI=1S/C20H23N3O2S2/c1-15-17-14-16(10-11-19(17)22(2)26-15)27(24,25)21-18-8-4-5-9-20(18)23-12-6-3-7-13-23/h4-5,8-11,14,21H,1,3,6-7,12-13H2,2H3
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n/an/a 710 760n/an/an/a7.0n/a



Burnham Institute for Medical Research



Assay Description
In vitro kinase activity and selectivity was determined by using SelectScreen kinase profiling Z'-LYTE assay from Invitrogen.


ACS Chem Biol 2: 329-36 (2007)


Article DOI: 10.1021/cb700025j
BindingDB Entry DOI: 10.7270/Q2ZW1J99
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM14832
PNG
(3-(4-fluorophenyl)-2-pyridin-4-yl-6-thia-1,4-diaza...)
Show SMILES Fc1ccc(cc1)-c1nc2SCCn2c1-c1ccncc1
Show InChI InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
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n/an/an/a 180n/an/an/a7.023



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The exchange curve assays were run as two half-reactions using an SLM Aminco Bowman Series 2 model SQ-340 fluorescence detector. In the first half re...


Nat Struct Biol 9: 268-72 (2002)


Article DOI: 10.1038/nsb770
BindingDB Entry DOI: 10.7270/Q2CV4FZ3
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16333
PNG
(4-phenyl-5-[3-(propan-2-yl)-[1,2,4]triazolo[3,4-a]...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-12(2)18-21-20-15-9-8-14(10-22(15)18)17-16(19-11-23-17)13-6-4-3-5-7-13/h3-12H,1-2H3
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n/an/a 9.60n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15435
PNG
(5-[4-(4-ethylphenyl)-2-(thiophen-2-yl)-1H-imidazol...)
Show SMILES CCc1ccc(cc1)-c1[nH]c(nc1-c1ccc2n(C)c(=O)n(C)c2c1)-c1cccs1
Show InChI InChI=1S/C24H22N4OS/c1-4-15-7-9-16(10-8-15)21-22(26-23(25-21)20-6-5-13-30-20)17-11-12-18-19(14-17)28(3)24(29)27(18)2/h5-14H,4H2,1-3H3,(H,25,26)
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n/an/a 8.00E+3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15414
PNG
(4-(4-fluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN4O/c1-11(2)18-22-21-15-8-5-13(9-23(15)18)17-16(20-10-24-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3
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n/an/a 5n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16335
PNG
(4-(3-fluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cccc(F)c1
Show InChI InChI=1S/C18H15FN4O/c1-11(2)18-22-21-15-7-6-13(9-23(15)18)17-16(20-10-24-17)12-4-3-5-14(19)8-12/h3-11H,1-2H3
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n/an/a 37.8n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16336
PNG
(4-(4-fluoro-3-methylphenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(C)c1
Show InChI InChI=1S/C19H17FN4O/c1-11(2)19-23-22-16-7-5-14(9-24(16)19)18-17(21-10-25-18)13-4-6-15(20)12(3)8-13/h4-11H,1-3H3
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n/an/a 6.60n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16337
PNG
(4-(2-fluoro-5-methylphenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(C)ccc1F
Show InChI InChI=1S/C19H17FN4O/c1-11(2)19-23-22-16-7-5-13(9-24(16)19)18-17(21-10-25-18)14-8-12(3)4-6-15(14)20/h4-11H,1-3H3
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n/an/a 4.30n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16338
PNG
(4-(4-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H15ClN4O/c1-11(2)18-22-21-15-8-5-13(9-23(15)18)17-16(20-10-24-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3
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n/an/a 17.7n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16339
PNG
(4-(3-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cccc(Cl)c1
Show InChI InChI=1S/C18H15ClN4O/c1-11(2)18-22-21-15-7-6-13(9-23(15)18)17-16(20-10-24-17)12-4-3-5-14(19)8-12/h3-11H,1-2H3
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n/an/a 13.5n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16340
PNG
(4-(2-chlorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccccc1Cl
Show InChI InChI=1S/C18H15ClN4O/c1-11(2)18-22-21-15-8-7-12(9-23(15)18)17-16(20-10-24-17)13-5-3-4-6-14(13)19/h3-11H,1-2H3
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n/an/a 3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16341
PNG
(4-(2,4-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1F
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3
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n/an/a 4.60n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16342
PNG
(4-(2,5-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-7-12(19)4-5-14(13)20/h3-10H,1-2H3
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n/an/a 5.80n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16343
PNG
(4-(2,6-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1c(F)cccc1F
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-14-7-6-11(8-24(14)18)17-16(21-9-25-17)15-12(19)4-3-5-13(15)20/h3-10H,1-2H3
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n/an/a 14.6n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16344
PNG
(4-(3,4-difluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]t...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(F)c1
Show InChI InChI=1S/C18H14F2N4O/c1-10(2)18-23-22-15-6-4-12(8-24(15)18)17-16(21-9-25-17)11-3-5-13(19)14(20)7-11/h3-10H,1-2H3
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n/an/a 22.3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16345
PNG
(4-(3-chloro-4-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-4-12(8-24(15)18)17-16(21-9-25-17)11-3-5-14(20)13(19)7-11/h3-10H,1-2H3
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n/an/a 12.4n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM16346
PNG
(4-(4-chloro-2-fluorophenyl)-5-[3-(propan-2-yl)-[1,...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(Cl)cc1F
Show InChI InChI=1S/C18H14ClFN4O/c1-10(2)18-23-22-15-6-3-11(8-24(15)18)17-16(21-9-25-17)13-5-4-12(19)7-14(13)20/h3-10H,1-2H3
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n/an/a 2.20n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 16: 4339-44 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2251GFZ
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15411
PNG
(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1,3-oxazole | ...)
Show SMILES Fc1ccc(cc1)-c1ncoc1-c1ccncc1
Show InChI InChI=1S/C14H9FN2O/c15-12-3-1-10(2-4-12)13-14(18-9-17-13)11-5-7-16-8-6-11/h1-9H
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n/an/a 1.46E+3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


J Med Chem 48: 5728-37 (2005)


Article DOI: 10.1021/jm050346q
BindingDB Entry DOI: 10.7270/Q2CR5RMP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15412
PNG
(5-[4-(4-Fluoro-phenyl)-oxazol-5-yl]-1-isopropyl-3-...)
Show SMILES CC(C)n1c2ccc(cc2n(C)c1=O)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C20H18FN3O2/c1-12(2)24-16-9-6-14(10-17(16)23(3)20(24)25)19-18(22-11-26-19)13-4-7-15(21)8-5-13/h4-12H,1-3H3
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n/an/a 30n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


J Med Chem 48: 5728-37 (2005)


Article DOI: 10.1021/jm050346q
BindingDB Entry DOI: 10.7270/Q2CR5RMP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15413
PNG
(4-(4-fluorophenyl)-5-[1-(propan-2-yl)-1H-1,2,3-ben...)
Show SMILES CC(C)n1nnc2ccc(cc12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN4O/c1-11(2)23-16-9-13(5-8-15(16)21-22-23)18-17(20-10-24-18)12-3-6-14(19)7-4-12/h3-11H,1-2H3
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n/an/a 0.900n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


J Med Chem 48: 5728-37 (2005)


Article DOI: 10.1021/jm050346q
BindingDB Entry DOI: 10.7270/Q2CR5RMP
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15414
PNG
(4-(4-fluorophenyl)-5-[3-(propan-2-yl)-[1,2,4]triaz...)
Show SMILES CC(C)c1nnc2ccc(cn12)-c1ocnc1-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN4O/c1-11(2)18-22-21-15-8-5-13(9-23(15)18)17-16(20-10-24-17)12-3-6-14(19)7-4-12/h3-11H,1-2H3
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n/an/a 5n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


J Med Chem 48: 5728-37 (2005)


Article DOI: 10.1021/jm050346q
BindingDB Entry DOI: 10.7270/Q2CR5RMP
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15415
PNG
(1,3-diethyl-5-(1H-imidazol-5-yl)-2,3-dihydro-1H-1,...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1c[nH]cn1
Show InChI InChI=1S/C14H16N4O/c1-3-17-12-6-5-10(11-8-15-9-16-11)7-13(12)18(4-2)14(17)19/h5-9H,3-4H2,1-2H3,(H,15,16)
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n/an/a>1.00E+3n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15416
PNG
(1,3-dimethyl-5-(4-phenyl-1H-imidazol-5-yl)-2,3-dih...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc[nH]c1-c1ccccc1
Show InChI InChI=1S/C18H16N4O/c1-21-14-9-8-13(10-15(14)22(2)18(21)23)17-16(19-11-20-17)12-6-4-3-5-7-12/h3-11H,1-2H3,(H,19,20)
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n/an/a 290n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15417
PNG
(1,3-diethyl-5-(4-phenyl-1H-imidazol-5-yl)-2,3-dihy...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nc[nH]c1-c1ccccc1
Show InChI InChI=1S/C20H20N4O/c1-3-23-16-11-10-15(12-17(16)24(4-2)20(23)25)19-18(21-13-22-19)14-8-6-5-7-9-14/h5-13H,3-4H2,1-2H3,(H,21,22)
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n/an/a 140n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15418
PNG
(1,3-dimethyl-5-[4-(3-methylphenyl)-1H-imidazol-5-y...)
Show SMILES Cc1cccc(c1)-c1[nH]cnc1-c1ccc2n(C)c(=O)n(C)c2c1
Show InChI InChI=1S/C19H18N4O/c1-12-5-4-6-13(9-12)17-18(21-11-20-17)14-7-8-15-16(10-14)23(3)19(24)22(15)2/h4-11H,1-3H3,(H,20,21)
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n/an/a 100n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15419
PNG
(1,3-diethyl-5-[4-(3-methylphenyl)-1H-imidazol-5-yl...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nc[nH]c1-c1cccc(C)c1
Show InChI InChI=1S/C21H22N4O/c1-4-24-17-10-9-16(12-18(17)25(5-2)21(24)26)20-19(22-13-23-20)15-8-6-7-14(3)11-15/h6-13H,4-5H2,1-3H3,(H,22,23)
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n/an/a 50n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15420
PNG
(5-[4-(4-fluorophenyl)-1H-imidazol-5-yl]-1,3-dimeth...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc[nH]c1-c1ccc(F)cc1
Show InChI InChI=1S/C18H15FN4O/c1-22-14-8-5-12(9-15(14)23(2)18(22)24)17-16(20-10-21-17)11-3-6-13(19)7-4-11/h3-10H,1-2H3,(H,20,21)
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n/an/a 140n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15421
PNG
(1,3-diethyl-5-[4-(4-fluorophenyl)-1H-imidazol-5-yl...)
Show SMILES CCn1c2ccc(cc2n(CC)c1=O)-c1nc[nH]c1-c1ccc(F)cc1
Show InChI InChI=1S/C20H19FN4O/c1-3-24-16-10-7-14(11-17(16)25(4-2)20(24)26)19-18(22-12-23-19)13-5-8-15(21)9-6-13/h5-12H,3-4H2,1-2H3,(H,22,23)
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n/an/a 100n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15422
PNG
(1,3-dimethyl-5-[4-phenyl-2-(thiophen-2-yl)-1H-imid...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccccc1)-c1cccs1
Show InChI InChI=1S/C22H18N4OS/c1-25-16-11-10-15(13-17(16)26(2)22(25)27)20-19(14-7-4-3-5-8-14)23-21(24-20)18-9-6-12-28-18/h3-13H,1-2H3,(H,23,24)
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n/an/a 260n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15423
PNG
(5-[4-(2-fluorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccccc1F)-c1cccs1
Show InChI InChI=1S/C22H17FN4OS/c1-26-16-10-9-13(12-17(16)27(2)22(26)28)19-20(14-6-3-4-7-15(14)23)25-21(24-19)18-8-5-11-29-18/h3-12H,1-2H3,(H,24,25)
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n/an/a 370n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15424
PNG
(5-[4-(3-fluorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1cccc(F)c1)-c1cccs1
Show InChI InChI=1S/C22H17FN4OS/c1-26-16-9-8-14(12-17(16)27(2)22(26)28)20-19(13-5-3-6-15(23)11-13)24-21(25-20)18-7-4-10-29-18/h3-12H,1-2H3,(H,24,25)
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n/an/a 390n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15425
PNG
(5-[4-(4-fluorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccc(F)cc1)-c1cccs1
Show InChI InChI=1S/C22H17FN4OS/c1-26-16-10-7-14(12-17(16)27(2)22(26)28)20-19(13-5-8-15(23)9-6-13)24-21(25-20)18-4-3-11-29-18/h3-12H,1-2H3,(H,24,25)
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n/an/a 270n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15426
PNG
(5-[4-(2-chlorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccccc1Cl)-c1cccs1
Show InChI InChI=1S/C22H17ClN4OS/c1-26-16-10-9-13(12-17(16)27(2)22(26)28)19-20(14-6-3-4-7-15(14)23)25-21(24-19)18-8-5-11-29-18/h3-12H,1-2H3,(H,24,25)
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n/an/a 540n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15427
PNG
(5-[4-(3-chlorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1cccc(Cl)c1)-c1cccs1
Show InChI InChI=1S/C22H17ClN4OS/c1-26-16-9-8-14(12-17(16)27(2)22(26)28)20-19(13-5-3-6-15(23)11-13)24-21(25-20)18-7-4-10-29-18/h3-12H,1-2H3,(H,24,25)
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n/an/a 380n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 14


(Homo sapiens (human))
BDBM15428
PNG
(5-[4-(4-chlorophenyl)-2-(thiophen-2-yl)-1H-imidazo...)
Show SMILES Cn1c2ccc(cc2n(C)c1=O)-c1nc([nH]c1-c1ccc(Cl)cc1)-c1cccs1
Show InChI InChI=1S/C22H17ClN4OS/c1-26-16-10-7-14(12-17(16)27(2)22(26)28)20-19(13-5-8-15(23)9-6-13)24-21(25-20)18-4-3-11-29-18/h3-12H,1-2H3,(H,24,25)
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n/an/a 680n/an/an/an/a7.230



Pfizer



Assay Description
The IC50s were determined by incubating each test compound with activated p38-alpha in a 96-well plate that had been pre-treated with ATF-2-GST to al...


Bioorg Med Chem Lett 14: 919-23 (2004)


Article DOI: 10.1016/j.bmcl.2003.12.023
BindingDB Entry DOI: 10.7270/Q28050V6
More data for this
Ligand-Target Pair
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