BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 3 hits of ph data with Target = 'NAD-dependent deacetylase sirtuin 2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
NAD-dependent deacetylase sirtuin 2


(Homo sapiens (human))
BDBM227595
PNG
(AEM1)
Show SMILES NC(=O)c1ccc2NC(C3C4CCC(C4)C3c2c1)c1ccccc1
Show InChI InChI=1S/C21H22N2O/c22-21(24)15-8-9-17-16(11-15)18-13-6-7-14(10-13)19(18)20(23-17)12-4-2-1-3-5-12/h1-5,8-9,11,13-14,18-20,23H,6-7,10H2,(H2,22,24)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.85E+4n/an/an/an/a8.037



Universitšt Duisburg-Essen



Assay Description
Deacetylation assays using Boc(Ac)Lys-7-amino-4-methyl-coumarin (MAL; Bachem, Bubendorf, Switzerland) as a substrate were performed in a volume of 20...


J Biol Chem 289: 5208-16 (2014)


Article DOI: 10.1074/jbc.M113.487736
BindingDB Entry DOI: 10.7270/Q2HD7THQ
More data for this
Ligand-Target Pair
NAD-dependent deacetylase sirtuin 2


(Homo sapiens (human))
BDBM227597
PNG
(AEM1 derivative, 1)
Show SMILES COCCCNC(=O)c1ccc2NC(C3C4CCC(C4)C3c2c1)c1ccccc1
Show InChI InChI=1S/C25H30N2O2/c1-29-13-5-12-26-25(28)19-10-11-21-20(15-19)22-17-8-9-18(14-17)23(22)24(27-21)16-6-3-2-4-7-16/h2-4,6-7,10-11,15,17-18,22-24,27H,5,8-9,12-14H2,1H3,(H,26,28)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.87E+4n/an/an/an/a8.037



Universitšt Duisburg-Essen



Assay Description
Deacetylation assays using Boc(Ac)Lys-7-amino-4-methyl-coumarin (MAL; Bachem, Bubendorf, Switzerland) as a substrate were performed in a volume of 20...


J Biol Chem 289: 5208-16 (2014)


Article DOI: 10.1074/jbc.M113.487736
BindingDB Entry DOI: 10.7270/Q2HD7THQ
More data for this
Ligand-Target Pair
NAD-dependent deacetylase sirtuin 2


(Homo sapiens (human))
BDBM227596
PNG
(AEM2)
Show SMILES O=C(NCc1cccnc1)c1ccc2NC(C3C4CCC(C4)C3c2c1)c1ccccc1
Show InChI InChI=1S/C27H27N3O/c31-27(29-16-17-5-4-12-28-15-17)21-10-11-23-22(14-21)24-19-8-9-20(13-19)25(24)26(30-23)18-6-2-1-3-7-18/h1-7,10-12,14-15,19-20,24-26,30H,8-9,13,16H2,(H,29,31)
PDB
MMDB

NCI pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.80E+3n/an/an/an/a8.037



Universitšt Duisburg-Essen



Assay Description
Deacetylation assays using Boc(Ac)Lys-7-amino-4-methyl-coumarin (MAL; Bachem, Bubendorf, Switzerland) as a substrate were performed in a volume of 20...


J Biol Chem 289: 5208-16 (2014)


Article DOI: 10.1074/jbc.M113.487736
BindingDB Entry DOI: 10.7270/Q2HD7THQ
More data for this
Ligand-Target Pair