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Compile Data Set for Download or QSAR

Found 1930 hits of ph data with Target = 'Nicotinamide phosphoribosyltransferase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM50438936
PNG
(CHEMBL2420629 | GNE-617)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3nccn3c2)cc1
Show InChI InChI=1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27)
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n/an/a 5n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM112625
PNG
(GNE-643)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccn3ccnc3c2)cc1
Show InChI InChI=1S/C21H15F2N3O3S/c22-16-10-17(23)12-19(11-16)30(28,29)18-3-1-14(2-4-18)13-25-21(27)15-5-7-26-8-6-24-20(26)9-15/h1-12H,13H2,(H,25,27)
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n/an/a 10n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM112626
PNG
(GNE-200)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccc3cccn3c2)cc1
Show InChI InChI=1S/C22H16F2N2O3S/c23-17-10-18(24)12-21(11-17)30(28,29)20-7-3-15(4-8-20)13-25-22(27)16-5-6-19-2-1-9-26(19)14-16/h1-12,14H,13H2,(H,25,27)
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n/an/a 57n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM112627
PNG
(GNE-201)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(=O)c2ccn3cccc3c2)cc1
Show InChI InChI=1S/C22H16F2N2O3S/c23-17-11-18(24)13-21(12-17)30(28,29)20-5-3-15(4-6-20)14-25-22(27)16-7-9-26-8-1-2-19(26)10-16/h1-13H,14H2,(H,25,27)
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n/an/a 78n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM81396
PNG
(GMX1778)
Show SMILES Clc1ccc(OCCCCCCNC(NC#N)=Nc2ccncc2)cc1
Show InChI InChI=1S/C19H22ClN5O/c20-16-5-7-18(8-6-16)26-14-4-2-1-3-11-23-19(24-15-21)25-17-9-12-22-13-10-17/h5-10,12-13H,1-4,11,14H2,(H2,22,23,24,25)
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n/an/a 2n/an/an/an/a7.525



Genentech, Inc. 1 DNA Way, South San Francisco, California 94080 (USA).



Assay Description
The reaction was carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well plates. NAMPT protein was added to 1 B...


Chembiochem 15: 1121-30 (2014)


Article DOI: 10.1002/cbic.201402023
BindingDB Entry DOI: 10.7270/Q2X065QR
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM60806
PNG
(US9169209, Table 3, Compound 3)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)N1CC2CCC(C1)O2)\C=C\c1cccnc1
Show InChI InChI=1S/C20H21N3O4S/c24-20(10-3-15-2-1-11-21-12-15)22-16-4-8-19(9-5-16)28(25,26)23-13-17-6-7-18(14-23)27-17/h1-5,8-12,17-18H,6-7,13-14H2,(H,22,24)/b10-3+
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n/an/a 3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186970
PNG
(US9169209, Table 3, Compound 1)
Show SMILES FC(F)(F)Oc1ccccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H15F3N2O4S/c22-21(23,24)30-18-5-1-2-6-19(18)31(28,29)17-10-8-16(9-11-17)26-20(27)12-7-15-4-3-13-25-14-15/h1-14H,(H,26,27)/b12-7+
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n/an/a 3.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186971
PNG
(US9169209, Table 3, Compound 2)
Show SMILES FC(F)(F)Oc1ccccc1NS(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H16F3N3O4S/c22-21(23,24)31-19-6-2-1-5-18(19)27-32(29,30)17-10-8-16(9-11-17)26-20(28)12-7-15-4-3-13-25-14-15/h1-14,27H,(H,26,28)/b12-7+
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n/an/a 375n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186972
PNG
(US9169209, Table 3, Compound 3)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H15F3N2O4S/c22-21(23,24)30-17-4-1-5-19(13-17)31(28,29)18-9-7-16(8-10-18)26-20(27)11-6-15-3-2-12-25-14-15/h1-14H,(H,26,27)/b11-6+
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n/an/a 61.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186973
PNG
(US9169209, Table 3, Compound 4)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H15F3N2O3S/c22-21(23,24)16-4-1-5-19(13-16)30(28,29)18-9-7-17(8-10-18)26-20(27)11-6-15-3-2-12-25-14-15/h1-14H,(H,26,27)/b11-6+
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n/an/a 31.9n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186974
PNG
(US9169209, Table 3, Compound 5)
Show SMILES FC(F)(F)Oc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H15F3N2O4S/c22-21(23,24)30-17-6-10-19(11-7-17)31(28,29)18-8-4-16(5-9-18)26-20(27)12-3-15-2-1-13-25-14-15/h1-14H,(H,26,27)/b12-3+
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n/an/a 167n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186975
PNG
(US9169209, Table 3, Compound 6)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H15F3N2O3S/c22-21(23,24)16-4-8-18(9-5-16)30(28,29)19-10-6-17(7-11-19)26-20(27)12-3-15-2-1-13-25-14-15/h1-14H,(H,26,27)/b12-3+
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n/an/a 56.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186976
PNG
(US9169209, Table 3, Compound 7)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccnc1)\C=C\c1cccnc1
Show InChI InChI=1S/C19H15N3O3S/c23-19(10-5-15-3-1-11-20-13-15)22-16-6-8-17(9-7-16)26(24,25)18-4-2-12-21-14-18/h1-14H,(H,22,23)/b10-5+
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n/an/a 18.3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186977
PNG
(US9169209, Table 3, Compound 8)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cnc2ccccc2c1)\C=C\c1cccnc1
Show InChI InChI=1S/C23H17N3O3S/c27-23(12-7-17-4-3-13-24-15-17)26-19-8-10-20(11-9-19)30(28,29)21-14-18-5-1-2-6-22(18)25-16-21/h1-16H,(H,26,27)/b12-7+
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n/an/a 3.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186978
PNG
(US9169209, Table 3, Compound 9)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1ccc2ncccc2c1)\C=C\c1cccnc1
Show InChI InChI=1S/C23H17N3O3S/c27-23(12-5-17-3-1-13-24-16-17)26-19-6-8-20(9-7-19)30(28,29)21-10-11-22-18(15-21)4-2-14-25-22/h1-16H,(H,26,27)/b12-5+
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n/an/a 5.40n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186979
PNG
(US9169209, Table 3, Compound 10)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc2cccnc12)\C=C\c1cccnc1
Show InChI InChI=1S/C23H17N3O3S/c27-22(13-8-17-4-2-14-24-16-17)26-19-9-11-20(12-10-19)30(28,29)21-7-1-5-18-6-3-15-25-23(18)21/h1-16H,(H,26,27)/b13-8+
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n/an/a 3.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186980
PNG
(US9169209, Table 3, Compound 11)
Show SMILES NS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H17N3O5S2/c21-30(27,28)19-5-1-4-18(13-19)29(25,26)17-9-7-16(8-10-17)23-20(24)11-6-15-3-2-12-22-14-15/h1-14H,(H,23,24)(H2,21,27,28)/b11-6+
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n/an/a 9.90n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186981
PNG
(US9169209, Table 3, Compound 12)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cncc(c1)N1CCCC1)\C=C\c1cccnc1
Show InChI InChI=1S/C23H22N4O3S/c28-23(10-5-18-4-3-11-24-15-18)26-19-6-8-21(9-7-19)31(29,30)22-14-20(16-25-17-22)27-12-1-2-13-27/h3-11,14-17H,1-2,12-13H2,(H,26,28)/b10-5+
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n/an/a 1.40n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186982
PNG
(US9169209, Table 3, Compound 13)
Show SMILES FC(F)(F)Oc1ccc(Cl)c(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H14ClF3N2O4S/c22-18-9-6-16(31-21(23,24)25)12-19(18)32(29,30)17-7-4-15(5-8-17)27-20(28)10-3-14-2-1-11-26-13-14/h1-13H,(H,27,28)/b10-3+
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n/an/a 21n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186983
PNG
(US9169209, Table 3, Compound 14)
Show SMILES COc1cc(ccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1)C(F)(F)F
Show InChI InChI=1S/C22H17F3N2O4S/c1-31-19-13-16(22(23,24)25)5-10-20(19)32(29,30)18-8-6-17(7-9-18)27-21(28)11-4-15-3-2-12-26-14-15/h2-14H,1H3,(H,27,28)/b11-4+
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n/an/a 59.6n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186984
PNG
(US9169209, Table 3, Compound 15)
Show SMILES COc1ccc(cc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1)C(C)C
Show InChI InChI=1S/C24H24N2O4S/c1-17(2)19-7-12-22(30-3)23(15-19)31(28,29)21-10-8-20(9-11-21)26-24(27)13-6-18-5-4-14-25-16-18/h4-17H,1-3H3,(H,26,27)/b13-6+
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n/an/a 2.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186985
PNG
(US9169209, Table 3, Compound 16)
Show SMILES COc1ccc(OC(F)(F)F)cc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H17F3N2O5S/c1-31-19-10-7-17(32-22(23,24)25)13-20(19)33(29,30)18-8-5-16(6-9-18)27-21(28)11-4-15-3-2-12-26-14-15/h2-14H,1H3,(H,27,28)/b11-4+
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n/an/a 16.8n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186986
PNG
(US9169209, Table 3, Compound 17)
Show SMILES COc1ccc(cc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1)C(F)(F)F
Show InChI InChI=1S/C22H17F3N2O4S/c1-31-19-10-5-16(22(23,24)25)13-20(19)32(29,30)18-8-6-17(7-9-18)27-21(28)11-4-15-3-2-12-26-14-15/h2-14H,1H3,(H,27,28)/b11-4+
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n/an/a 24.2n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186987
PNG
(US9169209, Table 3, Compound 18)
Show SMILES Cc1cc(ccc1S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1)C(F)(F)F
Show InChI InChI=1S/C22H17F3N2O3S/c1-15-13-17(22(23,24)25)5-10-20(15)31(29,30)19-8-6-18(7-9-19)27-21(28)11-4-16-3-2-12-26-14-16/h2-14H,1H3,(H,27,28)/b11-4+
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n/an/a 62.8n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186988
PNG
(US9169209, Table 3, Compound 19)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc(c1)-n1cccn1)\C=C\c1cccnc1
Show InChI InChI=1S/C23H18N4O3S/c28-23(12-7-18-4-2-13-24-17-18)26-19-8-10-21(11-9-19)31(29,30)22-6-1-5-20(16-22)27-15-3-14-25-27/h1-17H,(H,26,28)/b12-7+
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n/an/a 4.80n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186989
PNG
(US9169209, Table 3, Compound 20)
Show SMILES CC(C)COc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C24H24N2O4S/c1-18(2)17-30-21-6-3-7-23(15-21)31(28,29)22-11-9-20(10-12-22)26-24(27)13-8-19-5-4-14-25-16-19/h3-16,18H,17H2,1-2H3,(H,26,27)/b13-8+
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n/an/a 56.7n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186990
PNG
(US9169209, Table 3, Compound 21)
Show SMILES Cc1cc(C)n(n1)-c1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C25H22N4O3S/c1-18-15-19(2)29(28-18)22-6-3-7-24(16-22)33(31,32)23-11-9-21(10-12-23)27-25(30)13-8-20-5-4-14-26-17-20/h3-17H,1-2H3,(H,27,30)/b13-8+
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n/an/a 9.10n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186991
PNG
(US9169209, Table 3, Compound 22)
Show SMILES CCS(=O)(=O)c1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O5S2/c1-2-30(26,27)20-6-3-7-21(15-20)31(28,29)19-11-9-18(10-12-19)24-22(25)13-8-17-5-4-14-23-16-17/h3-16H,2H2,1H3,(H,24,25)/b13-8+
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n/an/a 17.3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186992
PNG
(US9169209, Table 3, Compound 23)
Show SMILES COCc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H20N2O4S/c1-28-16-18-4-2-6-21(14-18)29(26,27)20-10-8-19(9-11-20)24-22(25)12-7-17-5-3-13-23-15-17/h2-15H,16H2,1H3,(H,24,25)/b12-7+
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n/an/a 7.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186993
PNG
(US9169209, Table 3, Compound 24)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc(c1)N1CCOCC1)\C=C\c1cccnc1
Show InChI InChI=1S/C24H23N3O4S/c28-24(11-6-19-3-2-12-25-18-19)26-20-7-9-22(10-8-20)32(29,30)23-5-1-4-21(17-23)27-13-15-31-16-14-27/h1-12,17-18H,13-16H2,(H,26,28)/b11-6+
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n/an/a 9.20n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186994
PNG
(US9169209, Table 3, Compound 25)
Show SMILES CC(C)Oc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H22N2O4S/c1-17(2)29-20-6-3-7-22(15-20)30(27,28)21-11-9-19(10-12-21)25-23(26)13-8-18-5-4-14-24-16-18/h3-17H,1-2H3,(H,25,26)/b13-8+
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n/an/a 1.10n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186995
PNG
(US9169209, Table 3, Compound 26)
Show SMILES FC(F)(F)c1ccc(cc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H14ClF3N2O3S/c22-19-12-17(8-9-18(19)21(23,24)25)31(29,30)16-6-4-15(5-7-16)27-20(28)10-3-14-2-1-11-26-13-14/h1-13H,(H,27,28)/b10-3+
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n/an/a 43.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186996
PNG
(US9169209, Table 3, Compound 27)
Show SMILES FC(F)(F)c1cc(Cl)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H14ClF3N2O3S/c22-16-10-15(21(23,24)25)11-19(12-16)31(29,30)18-6-4-17(5-7-18)27-20(28)8-3-14-2-1-9-26-13-14/h1-13H,(H,27,28)/b8-3+
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n/an/a 8.10n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186997
PNG
(US9169209, Table 3, Compound 28)
Show SMILES CC(C)COc1cc(F)cc(c1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C24H23FN2O4S/c1-17(2)16-31-21-12-19(25)13-23(14-21)32(29,30)22-8-6-20(7-9-22)27-24(28)10-5-18-4-3-11-26-15-18/h3-15,17H,16H2,1-2H3,(H,27,28)/b10-5+
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n/an/a 35.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186998
PNG
(US9169209, Table 3, Compound 29)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)-n1cccn1)\C=C\c1cccnc1
Show InChI InChI=1S/C23H18N4O3S/c28-23(13-4-18-3-1-14-24-17-18)26-19-5-9-21(10-6-19)31(29,30)22-11-7-20(8-12-22)27-16-2-15-25-27/h1-17H,(H,26,28)/b13-4+
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n/an/a 17.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM186999
PNG
(US9169209, Table 3, Compound 30)
Show SMILES CCOCc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H22N2O4S/c1-2-29-17-19-5-10-21(11-6-19)30(27,28)22-12-8-20(9-13-22)25-23(26)14-7-18-4-3-15-24-16-18/h3-16H,2,17H2,1H3,(H,25,26)/b14-7+
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n/an/a 7.80n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187000
PNG
(US9169209, Table 3, Compound 31)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1ccc(cc1)N1CCOCC1)\C=C\c1cccnc1
Show InChI InChI=1S/C24H23N3O4S/c28-24(12-3-19-2-1-13-25-18-19)26-20-4-8-22(9-5-20)32(29,30)23-10-6-21(7-11-23)27-14-16-31-17-15-27/h1-13,18H,14-17H2,(H,26,28)/b12-3+
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n/an/a 24.8n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187001
PNG
(US9169209, Table 3, Compound 32)
Show SMILES CC(C)Oc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H22N2O4S/c1-17(2)29-20-8-12-22(13-9-20)30(27,28)21-10-6-19(7-11-21)25-23(26)14-5-18-4-3-15-24-16-18/h3-17H,1-2H3,(H,25,26)/b14-5+
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n/an/a 5.40n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187002
PNG
(US9169209, Table 3, Compound 33)
Show SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C21H14ClF3N2O3S/c22-19-9-8-17(12-18(19)21(23,24)25)31(29,30)16-6-4-15(5-7-16)27-20(28)10-3-14-2-1-11-26-13-14/h1-13H,(H,27,28)/b10-3+
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n/an/a 18.4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187003
PNG
(US9169209, Table 3, Compound 34)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc2c3ccccc3oc12)\C=C\c1cccnc1
Show InChI InChI=1S/C26H18N2O4S/c29-25(15-10-18-5-4-16-27-17-18)28-19-11-13-20(14-12-19)33(30,31)24-9-3-7-22-21-6-1-2-8-23(21)32-26(22)24/h1-17H,(H,28,29)/b15-10+
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n/an/a 3.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187004
PNG
(US9169209, Table 3, Compound 36)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc2ccsc12)\C=C\c1cccnc1
Show InChI InChI=1S/C22H16N2O3S2/c25-21(11-6-16-3-2-13-23-15-16)24-18-7-9-19(10-8-18)29(26,27)20-5-1-4-17-12-14-28-22(17)20/h1-15H,(H,24,25)/b11-6+
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n/an/a 16.1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187005
PNG
(US9169209, Table 3, Compound 37)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc2[nH]ccc12)\C=C\c1cccnc1
Show InChI InChI=1S/C22H17N3O3S/c26-22(11-6-16-3-2-13-23-15-16)25-17-7-9-18(10-8-17)29(27,28)21-5-1-4-20-19(21)12-14-24-20/h1-15,24H,(H,25,26)/b11-6+
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n/an/a 2.30n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187006
PNG
(US9169209, Table 3, Compound 38)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc2cc[nH]c12)\C=C\c1cccnc1
Show InChI InChI=1S/C22H17N3O3S/c26-21(11-6-16-3-2-13-23-15-16)25-18-7-9-19(10-8-18)29(27,28)20-5-1-4-17-12-14-24-22(17)20/h1-15,24H,(H,25,26)/b11-6+
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n/an/a 8.40n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187007
PNG
(US9169209, Table 3, Compound 39)
Show SMILES Cn1ncc2cc(ccc12)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H18N4O3S/c1-26-21-10-9-20(13-17(21)15-24-26)30(28,29)19-7-5-18(6-8-19)25-22(27)11-4-16-3-2-12-23-14-16/h2-15H,1H3,(H,25,27)/b11-4+
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n/an/a 1.90n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187008
PNG
(US9169209, Table 3, Compound 40)
Show SMILES Cn1ncc2ccc(cc12)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H18N4O3S/c1-26-21-13-20(8-5-17(21)15-24-26)30(28,29)19-9-6-18(7-10-19)25-22(27)11-4-16-3-2-12-23-14-16/h2-15H,1H3,(H,25,27)/b11-4+
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n/an/a 2.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187009
PNG
(US9169209, Table 3, Compound 41)
Show SMILES Cn1ncc2cccc(c12)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C22H18N4O3S/c1-26-22-17(15-24-26)5-2-6-20(22)30(28,29)19-10-8-18(9-11-19)25-21(27)12-7-16-4-3-13-23-14-16/h2-15H,1H3,(H,25,27)/b12-7+
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n/an/a 8.90n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187010
PNG
(US9169209, Table 3, Compound 42)
Show SMILES Cn1c(cc2ccccc12)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C23H19N3O3S/c1-26-21-7-3-2-6-18(21)15-23(26)30(28,29)20-11-9-19(10-12-20)25-22(27)13-8-17-5-4-14-24-16-17/h2-16H,1H3,(H,25,27)/b13-8+
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n/an/a 21.8n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187011
PNG
(US9169209, Table 3, Compound 43)
Show SMILES Cn1cc(cn1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C18H16N4O3S/c1-22-13-17(12-20-22)26(24,25)16-7-5-15(6-8-16)21-18(23)9-4-14-3-2-10-19-11-14/h2-13H,1H3,(H,21,23)/b9-4+
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n/an/a 7.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187012
PNG
(US9169209, Table 3, Compound 44)
Show SMILES CCCn1cc(cn1)S(=O)(=O)c1ccc(NC(=O)\C=C\c2cccnc2)cc1
Show InChI InChI=1S/C20H20N4O3S/c1-2-12-24-15-19(14-22-24)28(26,27)18-8-6-17(7-9-18)23-20(25)10-5-16-4-3-11-21-13-16/h3-11,13-15H,2,12H2,1H3,(H,23,25)/b10-5+
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n/an/a 2.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase


(Homo sapiens (Human))
BDBM187013
PNG
(US9169209, Table 3, Compound 45)
Show SMILES O=C(Nc1ccc(cc1)S(=O)(=O)c1cccc2CCOc12)\C=C\c1cccnc1
Show InChI InChI=1S/C22H18N2O4S/c25-21(11-6-16-3-2-13-23-15-16)24-18-7-9-19(10-8-18)29(26,27)20-5-1-4-17-12-14-28-22(17)20/h1-11,13,15H,12,14H2,(H,24,25)/b11-6+
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n/an/a 4.90n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9169209 (2015)


BindingDB Entry DOI: 10.7270/Q28G8JH9
More data for this
Ligand-Target Pair
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