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Compile Data Set for Download or QSAR

Found 112 hits of ph data with Target = 'Nicotinamide phosphoribosyltransferase (NAMPT)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180091
PNG
(US9676721, 3 1-({4-[(3-chloro-4-methoxybenzene)sul...)
Show SMILES COc1ccc(cc1Cl)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H18ClN5O3S/c1-30-20-7-6-18(12-19(20)22)31(28,29)17-4-2-15(3-5-17)13-25-21(26-14-23)27-16-8-10-24-11-9-16/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 2.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180065
PNG
(US9676721, 1 (E)-3-({4-[(3-chlorobenzene)sulfonyl]...)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H16ClN5O2S/c21-16-2-1-3-19(12-16)29(27,28)18-6-4-15(5-7-18)13-24-20(25-14-22)26-17-8-10-23-11-9-17/h1-12H,13H2,(H2,23,24,25,26)
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n/an/a 2.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180100
PNG
(US9676721, 2 (E)-3-{[4-(benzenesulfonyl)phenyl]met...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc(CN\C(NCc2cccnc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c22-16-26-21(25-15-18-5-4-12-23-13-18)24-14-17-8-10-20(11-9-17)29(27,28)19-6-2-1-3-7-19/h1-13H,14-15H2,(H2,24,25,26)
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n/an/a 17n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180260
PNG
(US9676721, 4 1-({4-[(3-chloro-4-methylbenzene)sulf...)
Show SMILES Cc1ccc(cc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O2S/c1-15-2-5-19(12-20(15)22)30(28,29)18-6-3-16(4-7-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 1.90n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180279
PNG
(US9676721, 5 1-({4-[(3-chloro-4-propoxybenzene)sul...)
Show SMILES CCCOc1ccc(cc1Cl)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C23H22ClN5O3S/c1-2-13-32-22-8-7-20(14-21(22)24)33(30,31)19-5-3-17(4-6-19)15-27-23(28-16-25)29-18-9-11-26-12-10-18/h3-12,14H,2,13,15H2,1H3,(H2,26,27,28,29)
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n/an/a 4.90n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180911
PNG
(US9676721, 6 1-({4-[(3-chloro-5-fluorobenzene)sulf...)
Show SMILES Fc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H15ClFN5O2S/c21-15-9-16(22)11-19(10-15)30(28,29)18-3-1-14(2-4-18)12-25-20(26-13-23)27-17-5-7-24-8-6-17/h1-11H,12H2,(H2,24,25,26,27)
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n/an/a 5.10n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180877
PNG
(US9676721, 7 1-({4-[(3-chloro-5-methoxybenzene)sul...)
Show SMILES COc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O3S/c1-30-18-10-16(22)11-20(12-18)31(28,29)19-4-2-15(3-5-19)13-25-21(26-14-23)27-17-6-8-24-9-7-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 4.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180254
PNG
(US9676721, 8 1-({4-[(3-chloro-5-methylbenzene)sulf...)
Show SMILES Cc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O2S/c1-15-10-17(22)12-20(11-15)30(28,29)19-4-2-16(3-5-19)13-25-21(26-14-23)27-18-6-8-24-9-7-18/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 3.30n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180129
PNG
(US9676721, 9 1-({4-[(4-acetylbenzene)sulfonyl]phen...)
Show SMILES CC(=O)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H19N5O3S/c1-16(28)18-4-8-21(9-5-18)31(29,30)20-6-2-17(3-7-20)14-25-22(26-15-23)27-19-10-12-24-13-11-19/h2-13H,14H2,1H3,(H2,24,25,26,27)
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n/an/a 5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180259
PNG
(US9676721, 10 1-({4-[(4-chloro-2-methoxybenzene)su...)
Show SMILES COc1cc(Cl)ccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O3S/c1-30-19-12-16(22)4-7-20(19)31(28,29)18-5-2-15(3-6-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 3n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181671
PNG
(US9676721, 11 1-({4-[(4-chloro-3-fluorobenzene)sul...)
Show SMILES Fc1cc(ccc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H15ClFN5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)
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n/an/a 2n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180910
PNG
(US9676721, 12 1-({4-[(4-chlorobenzene)sulfonyl]phe...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H16ClN5O2S/c21-16-3-7-19(8-4-16)29(27,28)18-5-1-15(2-6-18)13-24-20(25-14-22)26-17-9-11-23-12-10-17/h1-12H,13H2,(H2,23,24,25,26)
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n/an/a 3.60n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180926
PNG
(US9676721, 13 1-({4-[(5-acetyl-2-methoxybenzene)su...)
Show SMILES COc1ccc(cc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)C(N)=O
Show InChI InChI=1S/C22H20N6O4S/c1-32-19-7-4-16(21(24)29)12-20(19)33(30,31)18-5-2-15(3-6-18)13-26-22(27-14-23)28-17-8-10-25-11-9-17/h2-12H,13H2,1H3,(H2,24,29)(H2,25,26,27,28)
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n/an/a 15n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180263
PNG
(US9676721, 14 1-({4-[(5-chloro-2-methoxybenzene)su...)
Show SMILES COc1ccc(Cl)cc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18ClN5O3S/c1-30-19-7-4-16(22)12-20(19)31(28,29)18-5-2-15(3-6-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180106
PNG
(US9676721, 15 1-({4-[3-chloro-2-(morpholin-4-yl)py...)
Show SMILES Clc1c(ccnc1N1CCOCC1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C23H22ClN7O3S/c24-21-20(7-10-27-22(21)31-11-13-34-14-12-31)35(32,33)19-3-1-17(2-4-19)15-28-23(29-16-25)30-18-5-8-26-9-6-18/h1-10H,11-15H2,(H2,26,28,29,30)
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n/an/a 3.40n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181670
PNG
(US9676721, 16 1-[(4-{[3-chloro-5-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H15ClF3N5O2S/c22-16-9-15(21(23,24)25)10-19(11-16)33(31,32)18-3-1-14(2-4-18)12-28-20(29-13-26)30-17-5-7-27-8-6-17/h1-11H,12H2,(H2,27,28,29,30)
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n/an/a 3.30n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180067
PNG
(US9676721, 17 1-[(4-{[4-chloro-3-(trifluoromethyl)...)
Show SMILES FC(F)(F)c1cc(ccc1Cl)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H15ClF3N5O2S/c22-19-6-5-17(11-18(19)21(23,24)25)33(31,32)16-3-1-14(2-4-16)12-28-20(29-13-26)30-15-7-9-27-10-8-15/h1-11H,12H2,(H2,27,28,29,30)
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n/an/a 1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180072
PNG
(US9676721, 18 1-[4-(benzenesulfonyl)phenyl]-2-cyan...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc(N\C(NCc2cccnc2)=N/C#N)cc1
Show InChI InChI=1S/C20H17N5O2S/c21-15-24-20(23-14-16-5-4-12-22-13-16)25-17-8-10-19(11-9-17)28(26,27)18-6-2-1-3-7-18/h1-13H,14H2,(H2,23,24,25)
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n/an/a 32n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180262
PNG
(US9676721, 19 1-{[4-(2H-1,3-benzodioxole-4-sulfony...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1cccc2OCOc12
Show InChI InChI=1S/C21H17N5O4S/c22-13-25-21(26-16-8-10-23-11-9-16)24-12-15-4-6-17(7-5-15)31(27,28)19-3-1-2-18-20(19)30-14-29-18/h1-11H,12,14H2,(H2,23,24,25,26)
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n/an/a 5.10n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180101
PNG
(US9676721, 20 1-{[4-(2H-1,3-benzodioxole-5-sulfony...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1ccc2OCOc2c1
Show InChI InChI=1S/C21H17N5O4S/c22-13-25-21(26-16-7-9-23-10-8-16)24-12-15-1-3-17(4-2-15)31(27,28)18-5-6-19-20(11-18)30-14-29-19/h1-11H,12,14H2,(H2,23,24,25,26)
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n/an/a 1.80n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180915
PNG
(US9676721, 21 1-{2-[4-(benzenesulfonyl)phenyl]ethy...)
Show SMILES O=S(=O)(c1ccccc1)c1ccc(CCN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c22-16-25-21(26-18-11-13-23-14-12-18)24-15-10-17-6-8-20(9-7-17)29(27,28)19-4-2-1-3-5-19/h1-9,11-14H,10,15H2,(H2,23,24,25,26)
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n/an/a 1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180047
PNG
(US9676721, 22 2-cyano-1-({4-[(2,3-dimethylbenzene)...)
Show SMILES Cc1cccc(c1C)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-16-4-3-5-21(17(16)2)30(28,29)20-8-6-18(7-9-20)14-25-22(26-15-23)27-19-10-12-24-13-11-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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n/an/a 4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181669
PNG
(US9676721, 23 2-cyano-1-({4-[(2,4-dimethylbenzene)...)
Show SMILES Cc1ccc(c(C)c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-16-3-8-21(17(2)13-16)30(28,29)20-6-4-18(5-7-20)14-25-22(26-15-23)27-19-9-11-24-12-10-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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n/an/a 2.40n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180251
PNG
(US9676721, 24 2-cyano-1-({4-[(2-ethoxybenzene)sulf...)
Show SMILES CCOc1ccccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-2-30-20-5-3-4-6-21(20)31(28,29)19-9-7-17(8-10-19)15-25-22(26-16-23)27-18-11-13-24-14-12-18/h3-14H,2,15H2,1H3,(H2,24,25,26,27)
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n/an/a 7.10n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180108
PNG
(US9676721, 25 2-cyano-1-({4-[(2-methoxybenzene)sul...)
Show SMILES COc1ccccc1S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O3S/c1-29-19-4-2-3-5-20(19)30(27,28)18-8-6-16(7-9-18)14-24-21(25-15-22)26-17-10-12-23-13-11-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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n/an/a 7.20n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181672
PNG
(US9676721, 26 2-cyano-1-({4-[(2-methylbenzene)sulf...)
Show SMILES Cc1ccccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c1-16-4-2-3-5-20(16)29(27,28)19-8-6-17(7-9-19)14-24-21(25-15-22)26-18-10-12-23-13-11-18/h2-13H,14H2,1H3,(H2,23,24,25,26)
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n/an/a 7.90n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180095
PNG
(US9676721, 27 2-cyano-1-({4-[(3,4-dichlorobenzene)...)
Show SMILES Clc1ccc(cc1Cl)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H15Cl2N5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)
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n/an/a 1.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180912
PNG
(US9676721, 28 2-cyano-1-({4-[(3,4-difluorobenzene)...)
Show SMILES Fc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H15F2N5O2S/c21-18-6-5-17(11-19(18)22)30(28,29)16-3-1-14(2-4-16)12-25-20(26-13-23)27-15-7-9-24-10-8-15/h1-11H,12H2,(H2,24,25,26,27)
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n/an/a 0.800n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180109
PNG
(US9676721, 29 2-cyano-1-({4-[(3,4-dimethoxybenzene...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O4S/c1-30-20-8-7-19(13-21(20)31-2)32(28,29)18-5-3-16(4-6-18)14-25-22(26-15-23)27-17-9-11-24-12-10-17/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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n/an/a 4n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180083
PNG
(US9676721, 30 2-cyano-1-({4-[(3,4-dimethylbenzene)...)
Show SMILES Cc1ccc(cc1C)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-16-3-6-21(13-17(16)2)30(28,29)20-7-4-18(5-8-20)14-25-22(26-15-23)27-19-9-11-24-12-10-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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n/an/a 2.20n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180125
PNG
(US9676721, 31 2-cyano-1-({4-[(3,5-dichlorobenzene)...)
Show SMILES Clc1cc(Cl)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H15Cl2N5O2S/c21-15-9-16(22)11-19(10-15)30(28,29)18-3-1-14(2-4-18)12-25-20(26-13-23)27-17-5-7-24-8-6-17/h1-11H,12H2,(H2,24,25,26,27)
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n/an/a 11n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180103
PNG
(US9676721, 32 2-cyano-1-({4-[(3,5-difluorobenzene)...)
Show SMILES Fc1cc(F)cc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C20H15F2N5O2S/c21-15-9-16(22)11-19(10-15)30(28,29)18-3-1-14(2-4-18)12-25-20(26-13-23)27-17-5-7-24-8-6-17/h1-11H,12H2,(H2,24,25,26,27)
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n/an/a 1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180256
PNG
(US9676721, 33 2-cyano-1-({4-[(3,5-dimethylbenzene)...)
Show SMILES Cc1cc(C)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O2S/c1-16-11-17(2)13-21(12-16)30(28,29)20-5-3-18(4-6-20)14-25-22(26-15-23)27-19-7-9-24-10-8-19/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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n/an/a 3.30n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180786
PNG
(US9676721, 34 2-cyano-1-({4-[(3-cyanobenzene)sulfo...)
Show SMILES O=S(=O)(c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1)c1cccc(c1)C#N
Show InChI InChI=1S/C21H16N6O2S/c22-13-17-2-1-3-20(12-17)30(28,29)19-6-4-16(5-7-19)14-25-21(26-15-23)27-18-8-10-24-11-9-18/h1-12H,14H2,(H2,24,25,26,27)
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n/an/a 1.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180110
PNG
(US9676721, 35 2-cyano-1-({4-[(3-ethoxybenzene)sulf...)
Show SMILES CCOc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-2-30-19-4-3-5-21(14-19)31(28,29)20-8-6-17(7-9-20)15-25-22(26-16-23)27-18-10-12-24-13-11-18/h3-14H,2,15H2,1H3,(H2,24,25,26,27)
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n/an/a 4.30n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180918
PNG
(US9676721, 36 2-cyano-1-({4-[(3-fluoro-4-methoxybe...)
Show SMILES COc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O3S/c1-30-20-7-6-18(12-19(20)22)31(28,29)17-4-2-15(3-5-17)13-25-21(26-14-23)27-16-8-10-24-11-9-16/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 1n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180916
PNG
(US9676721, 37 2-cyano-1-({4-[(3-fluoro-4-methylben...)
Show SMILES Cc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-2-5-19(12-20(15)22)30(28,29)18-6-3-16(4-7-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 15n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180927
PNG
(US9676721, 40 2-cyano-1-({4-[(3-fluorobenzene)sulf...)
Show SMILES Fc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C20H16FN5O2S/c21-16-2-1-3-19(12-16)29(27,28)18-6-4-15(5-7-18)13-24-20(25-14-22)26-17-8-10-23-11-9-17/h1-12H,13H2,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180255
PNG
(US9676721, 38 2-cyano-1-({4-[(3-fluoro-5-methoxybe...)
Show SMILES COc1cc(F)cc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O3S/c1-30-18-10-16(22)11-20(12-18)31(28,29)19-4-2-15(3-5-19)13-25-21(26-14-23)27-17-6-8-24-9-7-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 2.30n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180920
PNG
(US9676721, 39 2-cyano-1-({4-[(3-fluoro-5-methylben...)
Show SMILES Cc1cc(F)cc(c1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-10-17(22)12-20(11-15)30(28,29)19-4-2-16(3-5-19)13-25-21(26-14-23)27-18-6-8-24-9-7-18/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 1.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181033
PNG
(US9676721, 41 2-cyano-1-({4-[(3-methoxy-4-methylbe...)
Show SMILES COc1cc(ccc1C)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-16-3-6-20(13-21(16)30-2)31(28,29)19-7-4-17(5-8-19)14-25-22(26-15-23)27-18-9-11-24-12-10-18/h3-13H,14H2,1-2H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180272
PNG
(US9676721, 42 2-cyano-1-({4-[(3-methoxybenzene)sul...)
Show SMILES COc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H19N5O3S/c1-29-18-3-2-4-20(13-18)30(27,28)19-7-5-16(6-8-19)14-24-21(25-15-22)26-17-9-11-23-12-10-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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n/an/a 1.5n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180924
PNG
(US9676721, 43 2-cyano-1-({4-[(3-methylbenzene)sulf...)
Show SMILES Cc1cccc(c1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H19N5O2S/c1-16-3-2-4-20(13-16)29(27,28)19-7-5-17(6-8-19)14-24-21(25-15-22)26-18-9-11-23-12-10-18/h2-13H,14H2,1H3,(H2,23,24,25,26)
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n/an/a 5.20n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180250
PNG
(US9676721, 44 2-cyano-1-({4-[(4-cyanobenzene)sulfo...)
Show SMILES O=S(=O)(c1ccc(CNC(Nc2ccncc2)=NC#N)cc1)c1ccc(cc1)C#N
Show InChI InChI=1S/C21H16N6O2S/c22-13-16-1-5-19(6-2-16)30(28,29)20-7-3-17(4-8-20)14-25-21(26-15-23)27-18-9-11-24-12-10-18/h1-12H,14H2,(H2,24,25,26,27)
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n/an/a 5.90n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM181459
PNG
(US9676721, 45 2-cyano-1-({4-[(4-ethoxy-3-fluoroben...)
Show SMILES CCOc1ccc(cc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C22H20FN5O3S/c1-2-31-21-8-7-19(13-20(21)23)32(29,30)18-5-3-16(4-6-18)14-26-22(27-15-24)28-17-9-11-25-12-10-17/h3-13H,2,14H2,1H3,(H2,25,26,27,28)
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n/an/a 6n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180266
PNG
(US9676721, 46 2-cyano-1-({4-[(4-ethoxybenzene)sulf...)
Show SMILES CCOc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C22H21N5O3S/c1-2-30-19-5-9-21(10-6-19)31(28,29)20-7-3-17(4-8-20)15-25-22(26-16-23)27-18-11-13-24-14-12-18/h3-14H,2,15H2,1H3,(H2,24,25,26,27)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180276
PNG
(US9676721, 47 2-cyano-1-({4-[(4-ethylbenzene)sulfo...)
Show SMILES COc1ccc(cc1)S(=O)(=O)c1ccc(CN\C(Nc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C21H19N5O3S/c1-29-18-4-8-20(9-5-18)30(27,28)19-6-2-16(3-7-19)14-24-21(25-15-22)26-17-10-12-23-13-11-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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n/an/a 4.70n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180127
PNG
(US9676721, 48 2-cyano-1-({4-[(4-fluoro-2-methylben...)
Show SMILES Cc1cc(F)ccc1S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-12-17(22)4-7-20(15)30(28,29)19-5-2-16(3-6-19)13-25-21(26-14-23)27-18-8-10-24-11-9-18/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 5.40n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180258
PNG
(US9676721, 49 2-cyano-1-({4-[(4-fluoro-3-methylben...)
Show SMILES Cc1cc(ccc1F)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H18FN5O2S/c1-15-12-19(6-7-20(15)22)30(28,29)18-4-2-16(3-5-18)13-25-21(26-14-23)27-17-8-10-24-11-9-17/h2-12H,13H2,1H3,(H2,24,25,26,27)
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n/an/a 3.10n/an/an/an/a7.525



FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
Nicotinamide phosphoribosyltransferase (NAMPT)


(Homo sapiens (Human))
BDBM180087
PNG
(US9676721, 50 2-cyano-1-({4-[(4-methanesulfonylben...)
Show SMILES CS(=O)(=O)c1ccc(cc1)S(=O)(=O)c1ccc(CNC(Nc2ccncc2)=NC#N)cc1
Show InChI InChI=1S/C21H19N5O4S2/c1-31(27,28)18-6-8-20(9-7-18)32(29,30)19-4-2-16(3-5-19)14-24-21(25-15-22)26-17-10-12-23-13-11-17/h2-13H,14H2,1H3,(H2,23,24,25,26)
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FORMA TM, LLC

US Patent


Assay Description
The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 7.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. The...


US Patent US9676721 (2017)


BindingDB Entry DOI: 10.7270/Q2VD6WMM
More data for this
Ligand-Target Pair
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