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Compile Data Set for Download or QSAR

Found 91 hits of ph data with Target = 'P2X7 rat'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160085
PNG
(US10047092, 26 | US10053463, 26 | US9040534, 26)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc(C)[nH]n1
Show InChI InChI=1S/C18H16ClF3N6O/c1-9-6-13(24-23-9)15-25-26-16-17(29)27(10(2)7-28(15)16)8-11-4-3-5-12(14(11)19)18(20,21)22/h3-6,10H,7-8H2,1-2H3,(H,23,24)/t10-/m0/s1
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n/an/a 375n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM48901
PNG
(BDBM160086 | US10047092, 27 | US10053463, 27 | US9...)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N6O/c1-10-8-28-15(14-23-6-3-7-24-14)25-26-16(28)17(29)27(10)9-11-4-2-5-12(13(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/m0/s1
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n/an/a 36.1n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160087
PNG
(US10047092, 28 | US10053463, 28 | US9040534, 28)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc[nH]n1
Show InChI InChI=1S/C17H14ClF3N6O/c1-9-7-27-14(12-5-6-22-23-12)24-25-15(27)16(28)26(9)8-10-3-2-4-11(13(10)18)17(19,20)21/h2-6,9H,7-8H2,1H3,(H,22,23)/t9-/m0/s1
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n/an/a 6.90n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160088
PNG
(US10047092, 29 | US10053463, 29 | US9040534, 29)
Show SMILES C[C@H]1Cn2c(nnc2-c2cccnc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5O/c1-11-9-28-16(12-5-3-7-24-8-12)25-26-17(28)18(29)27(11)10-13-4-2-6-14(15(13)20)19(21,22)23/h2-8,11H,9-10H2,1H3/t11-/m0/s1
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n/an/a 122n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160089
PNG
(US10047092, 30 | US10053463, 30 | US9040534, 30)
Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H14ClF4N5O/c1-10-8-29-16(14-6-5-12(21)7-25-14)26-27-17(29)18(30)28(10)9-11-3-2-4-13(15(11)20)19(22,23)24/h2-7,10H,8-9H2,1H3/t10-/m0/s1
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n/an/a 188n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160090
PNG
(US10047092, 31 | US10053463, 31 | US9040534, 31)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1nccs1
Show InChI InChI=1S/C17H13ClF3N5OS/c1-9-7-26-13(15-22-5-6-28-15)23-24-14(26)16(27)25(9)8-10-3-2-4-11(12(10)18)17(19,20)21/h2-6,9H,7-8H2,1H3/t9-/m0/s1
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n/an/a 135n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160091
PNG
(US10047092, 32 | US10053463, 32 | US9040534, 32)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cscn1
Show InChI InChI=1S/C17H13ClF3N5OS/c1-9-5-26-14(12-7-28-8-22-12)23-24-15(26)16(27)25(9)6-10-3-2-4-11(13(10)18)17(19,20)21/h2-4,7-9H,5-6H2,1H3/t9-/m0/s1
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n/an/a 16n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160092
PNG
(US10047092, 33 | US10053463, 33 | US9040534, 33)
Show SMILES C[C@H]1Cn2c(nnc2-c2ccncn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N6O/c1-10-7-28-15(13-5-6-23-9-24-13)25-26-16(28)17(29)27(10)8-11-3-2-4-12(14(11)19)18(20,21)22/h2-6,9-10H,7-8H2,1H3/t10-/m0/s1
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n/an/a 1.43E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160093
PNG
(US10047092, 34 | US10053463, 34 | US9040534, 34)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C18H13ClF4N6O/c1-9-7-29-15(14-24-5-11(20)6-25-14)26-27-16(29)17(30)28(9)8-10-3-2-4-12(13(10)19)18(21,22)23/h2-6,9H,7-8H2,1H3/t9-/m0/s1
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n/an/a 175n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160094
PNG
(US10047092, 35 | US10053463, 35 | US9040534, 35)
Show SMILES C[C@H]1Cn2c(nnc2-c2cc(CO)ccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H17ClF3N5O2/c1-11-8-29-17(15-7-12(10-30)5-6-25-15)26-27-18(29)19(31)28(11)9-13-3-2-4-14(16(13)21)20(22,23)24/h2-7,11,30H,8-10H2,1H3/t11-/m0/s1
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n/an/a 10.6n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160095
PNG
(US10047092, 36 | US10053463, 36 | US9040534, 36)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1csc(C)n1
Show InChI InChI=1S/C18H15ClF3N5OS/c1-9-6-27-15(13-8-29-10(2)23-13)24-25-16(27)17(28)26(9)7-11-4-3-5-12(14(11)19)18(20,21)22/h3-5,8-9H,6-7H2,1-2H3/t9-/m0/s1
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n/an/a 1.06E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160096
PNG
(US10047092, 37 | US10053463, 37 | US9040534, 37)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cncs1
Show InChI InChI=1S/C17H13ClF3N5OS/c1-9-6-26-14(12-5-22-8-28-12)23-24-15(26)16(27)25(9)7-10-3-2-4-11(13(10)18)17(19,20)21/h2-5,8-9H,6-7H2,1H3/t9-/m0/s1
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n/an/a 1.21E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160097
PNG
(US10047092, 38 | US9040534, 38)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1csc(n1)C(F)(F)F
Show InChI InChI=1S/C18H12ClF6N5OS/c1-8-5-30-13(11-7-32-16(26-11)18(23,24)25)27-28-14(30)15(31)29(8)6-9-3-2-4-10(12(9)19)17(20,21)22/h2-4,7-8H,5-6H2,1H3/t8-/m0/s1
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n/an/a 2.61E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160098
PNG
(US10047092, 39 | US10053463, 39 | US9040534, 39)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1sc(C)nc1C
Show InChI InChI=1S/C19H17ClF3N5OS/c1-9-7-28-16(15-10(2)24-11(3)30-15)25-26-17(28)18(29)27(9)8-12-5-4-6-13(14(12)20)19(21,22)23/h4-6,9H,7-8H2,1-3H3/t9-/m0/s1
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n/an/a 8.67E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160099
PNG
(US10047092, 40 | US10053463, 40 | US9040534, 40)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1scnc1C
Show InChI InChI=1S/C18H15ClF3N5OS/c1-9-6-27-15(14-10(2)23-8-29-14)24-25-16(27)17(28)26(9)7-11-4-3-5-12(13(11)19)18(20,21)22/h3-5,8-9H,6-7H2,1-2H3/t9-/m0/s1
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n/an/a 1.30E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160100
PNG
(US10047092, 41 | US10053463, 41 | US9040534, 41)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1ccon1
Show InChI InChI=1S/C17H13ClF3N5O2/c1-9-7-26-14(12-5-6-28-24-12)22-23-15(26)16(27)25(9)8-10-3-2-4-11(13(10)18)17(19,20)21/h2-6,9H,7-8H2,1H3/t9-/m0/s1
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n/an/a 2.78E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160101
PNG
(US10047092, 42 | US10053463, 42 | US9040534, 42)
Show SMILES C[C@H]1Cn2c(nnc2-c2ncc(Br)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C18H13BrClF3N6O/c1-9-7-29-15(14-24-5-11(19)6-25-14)26-27-16(29)17(30)28(9)8-10-3-2-4-12(13(10)20)18(21,22)23/h2-6,9H,7-8H2,1H3/t9-/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160103
PNG
(US10047092, 44 | US10053463, 44 | US9040534, 44)
Show SMILES C[C@H]1Cn2c(nnc2-c2cccnn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3N6O/c1-10-8-28-15(13-6-3-7-23-24-13)25-26-16(28)17(29)27(10)9-11-4-2-5-12(14(11)19)18(20,21)22/h2-7,10H,8-9H2,1H3/t10-/m0/s1
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n/an/a 1.99E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160104
PNG
(US10047092, 45 | US10053463, 45 | US9040534, 45)
Show SMILES C[C@H]1Cn2c(nnc2-c2cncc(F)c2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H14ClF4N5O/c1-10-8-29-16(12-5-13(21)7-25-6-12)26-27-17(29)18(30)28(10)9-11-3-2-4-14(15(11)20)19(22,23)24/h2-7,10H,8-9H2,1H3/t10-/m0/s1
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n/an/a 1.26E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160105
PNG
(US10047092, 46 | US10053463, 46 | US9040534, 46)
Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(C)n2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H17ClF3N5O/c1-11-5-3-8-15(25-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-6-4-7-14(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1
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n/an/a 154n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160106
PNG
(US10047092, 47 | US10053463, 47 | US9040534, 47)
Show SMILES C[C@H]1Cn2c(nnc2-c2ccncc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF3N5O/c1-11-9-28-16(12-5-7-24-8-6-12)25-26-17(28)18(29)27(11)10-13-3-2-4-14(15(13)20)19(21,22)23/h2-8,11H,9-10H2,1H3/t11-/m0/s1
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n/an/a 1.44E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160107
PNG
(US10047092, 48 | US10053463, 48 | US9040534, 48)
Show SMILES C[C@H]1Cn2c(nnc2-c2cccnc2C)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H17ClF3N5O/c1-11-9-29-17(14-6-4-8-25-12(14)2)26-27-18(29)19(30)28(11)10-13-5-3-7-15(16(13)21)20(22,23)24/h3-8,11H,9-10H2,1-2H3/t11-/m0/s1
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n/an/a 543n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160108
PNG
(US10047092, 49 | US10053463, 49 | US9040534, 49)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)C1CCC1
Show InChI InChI=1S/C18H18ClF3N4O/c1-10-8-26-15(11-4-2-5-11)23-24-16(26)17(27)25(10)9-12-6-3-7-13(14(12)19)18(20,21)22/h3,6-7,10-11H,2,4-5,8-9H2,1H3/t10-/m0/s1
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n/an/a 1.32E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160109
PNG
(US10047092, 50 | US10053463, 50 | US9040534, 50)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)C1CC1
Show InChI InChI=1S/C17H16ClF3N4O/c1-9-7-25-14(10-5-6-10)22-23-15(25)16(26)24(9)8-11-3-2-4-12(13(11)18)17(19,20)21/h2-4,9-10H,5-8H2,1H3/t9-/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160110
PNG
(US10047092, 51 | US10053463, 51 | US9040534, 51)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)C1CCCCC1
Show InChI InChI=1S/C20H22ClF3N4O/c1-12-10-28-17(13-6-3-2-4-7-13)25-26-18(28)19(29)27(12)11-14-8-5-9-15(16(14)21)20(22,23)24/h5,8-9,12-13H,2-4,6-7,10-11H2,1H3/t12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160111
PNG
(US10047092, 52 | US10053463, 52 | US9040534, 52)
Show SMILES C[C@H]1Cn2c(nnc2-c2cncc(Cl)c2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H14Cl2F3N5O/c1-10-8-29-16(12-5-13(20)7-25-6-12)26-27-17(29)18(30)28(10)9-11-3-2-4-14(15(11)21)19(22,23)24/h2-7,10H,8-9H2,1H3/t10-/m0/s1
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n/an/a 9.10E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160112
PNG
(US10047092, 53 | US10053463, 53 | US9040534, 53)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)C1CCOCC1
Show InChI InChI=1S/C19H20ClF3N4O2/c1-11-9-27-16(12-5-7-29-8-6-12)24-25-17(27)18(28)26(11)10-13-3-2-4-14(15(13)20)19(21,22)23/h2-4,11-12H,5-10H2,1H3/t11-/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160113
PNG
(US10047092, 54 | US10053463, 54 | US9040534, 54)
Show SMILES C[C@H]1Cn2c(nnc2-c2nccc(n2)C(F)(F)F)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H13ClF6N6O/c1-9-7-32-15(14-27-6-5-12(28-14)19(24,25)26)29-30-16(32)17(33)31(9)8-10-3-2-4-11(13(10)20)18(21,22)23/h2-6,9H,7-8H2,1H3/t9-/m0/s1
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n/an/a 17.6n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160114
PNG
(US10047092, 55 | US10053463, 55 | US9040534, 55)
Show SMILES C[C@H]1Cn2c(nnc2-c2cccc(n2)C(F)(F)F)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H14ClF6N5O/c1-10-8-32-16(13-6-3-7-14(28-13)20(25,26)27)29-30-17(32)18(33)31(10)9-11-4-2-5-12(15(11)21)19(22,23)24/h2-7,10H,8-9H2,1H3/t10-/m0/s1
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n/an/a 743n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160115
PNG
(US10047092, 56 | US10053463, 56 | US9040534, 56)
Show SMILES C[C@H]1Cn2c(nnc2-c2ccc(Cl)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H14Cl2F3N5O/c1-10-8-29-16(14-6-5-12(20)7-25-14)26-27-17(29)18(30)28(10)9-11-3-2-4-13(15(11)21)19(22,23)24/h2-7,10H,8-9H2,1H3/t10-/m0/s1
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n/an/a 824n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160116
PNG
(US10047092, 57 | US10053463, 57 | US9040534, 57)
Show SMILES C[C@H]1Cn2c(nnc2-c2cncc(C)c2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H17ClF3N5O/c1-11-6-14(8-25-7-11)17-26-27-18-19(30)28(12(2)9-29(17)18)10-13-4-3-5-15(16(13)21)20(22,23)24/h3-8,12H,9-10H2,1-2H3/t12-/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160117
PNG
(US10047092, 58 | US10053463, 58 | US9040534, 58)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)C1CCN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C23H27ClF3N5O3/c1-13-10-32-18(15-8-9-30(11-15)21(34)35-22(2,3)4)28-29-19(32)20(33)31(13)12-14-6-5-7-16(17(14)24)23(25,26)27/h5-7,13,15H,8-12H2,1-4H3/t13-,15?/m0/s1
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n/an/a 2.47E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160118
PNG
(US10047092, 59 | US10053463, 59 | US9040534, 59)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)C1CCCN(C1)C(=O)OC(C)(C)C
Show InChI InChI=1S/C24H29ClF3N5O3/c1-14-11-33-19(16-8-6-10-31(12-16)22(35)36-23(2,3)4)29-30-20(33)21(34)32(14)13-15-7-5-9-17(18(15)25)24(26,27)28/h5,7,9,14,16H,6,8,10-13H2,1-4H3/t14-,16?/m0/s1
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n/an/a 1.14E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160119
PNG
(US10047092, 60 | US10053463, 60 | US9040534, 60)
Show SMILES C[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)C1CCCNC1
Show InChI InChI=1S/C19H21ClF3N5O/c1-11-9-28-16(12-5-3-7-24-8-12)25-26-17(28)18(29)27(11)10-13-4-2-6-14(15(13)20)19(21,22)23/h2,4,6,11-12,24H,3,5,7-10H2,1H3/t11-,12?/m0/s1
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n/an/a>1.00E+4n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160120
PNG
(US10047092, 61 | US10053463, 61 | US9040534, 61)
Show SMILES FC(F)(F)c1cccc(CN2C(Cn3c(nnc3-c3cnccn3)C2=O)C2CC2)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(2-1-3-13(16)20(22,23)24)9-29-15(11-4-5-11)10-30-17(14-8-25-6-7-26-14)27-28-18(30)19(29)31/h1-3,6-8,11,15H,4-5,9-10H2
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n/an/a 16n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160121
PNG
(US10047092, 62 | US10053463, 62 | US9040534, 62)
Show SMILES FC(F)(F)c1cccc(CN2[C@@H](Cn3c(nnc3-c3cnccn3)C2=O)C2CC2)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(2-1-3-13(16)20(22,23)24)9-29-15(11-4-5-11)10-30-17(14-8-25-6-7-26-14)27-28-18(30)19(29)31/h1-3,6-8,11,15H,4-5,9-10H2/t15-/m0/s1
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n/an/a 9.89E+3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160122
PNG
(US10047092, 63 | US10053463, 63 | US9040534, 63)
Show SMILES FC(F)(F)c1cccc(CN2[C@H](Cn3c(nnc3-c3cnccn3)C2=O)C2CC2)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-16-12(2-1-3-13(16)20(22,23)24)9-29-15(11-4-5-11)10-30-17(14-8-25-6-7-26-14)27-28-18(30)19(29)31/h1-3,6-8,11,15H,4-5,9-10H2/t15-/m1/s1
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n/an/a 9.60n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160123
PNG
(US10047092, 64 | US10053463, 64 | US9040534, 64)
Show SMILES FC(F)(F)c1cccc(CN2C(Cn3c(nnc3-c3ncccn3)C2=O)C2CC2)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(3-1-4-13(15)20(22,23)24)9-29-14(11-5-6-11)10-30-17(16-25-7-2-8-26-16)27-28-18(30)19(29)31/h1-4,7-8,11,14H,5-6,9-10H2
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n/an/a 4.60n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160124
PNG
(US10047092, 65 | US10053463, 65 | US9040534, 65)
Show SMILES FC(F)(F)c1cccc(CN2[C@@H](Cn3c(nnc3-c3ncccn3)C2=O)C2CC2)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(3-1-4-13(15)20(22,23)24)9-29-14(11-5-6-11)10-30-17(16-25-7-2-8-26-16)27-28-18(30)19(29)31/h1-4,7-8,11,14H,5-6,9-10H2/t14-/m0/s1
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n/an/a 396n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160125
PNG
(US10047092, 66 | US10053463, 66 | US9040534, 66)
Show SMILES FC(F)(F)c1cccc(CN2[C@H](Cn3c(nnc3-c3ncccn3)C2=O)C2CC2)c1Cl
Show InChI InChI=1S/C20H16ClF3N6O/c21-15-12(3-1-4-13(15)20(22,23)24)9-29-14(11-5-6-11)10-30-17(16-25-7-2-8-26-16)27-28-18(30)19(29)31/h1-4,7-8,11,14H,5-6,9-10H2/t14-/m1/s1
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n/an/a 8.20n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160126
PNG
(US10047092, 67 | US10053463, 67 | US9040534, 67)
Show SMILES FC(F)(F)c1cccc(CN2C(Cn3c(nnc3-c3cccnc3)C2=O)C2CC2)c1Cl
Show InChI InChI=1S/C21H17ClF3N5O/c22-17-14(3-1-5-15(17)21(23,24)25)10-29-16(12-6-7-12)11-30-18(13-4-2-8-26-9-13)27-28-19(30)20(29)31/h1-5,8-9,12,16H,6-7,10-11H2
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n/an/a 282n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160127
PNG
(US10047092, 68 | US10053463, 68 | US9040534, 68)
Show SMILES FC(F)(F)c1cccc(CN2C(Cn3c(nnc3C2=O)-c2cc[nH]n2)C2CC2)c1Cl
Show InChI InChI=1S/C19H16ClF3N6O/c20-15-11(2-1-3-12(15)19(21,22)23)8-28-14(10-4-5-10)9-29-16(13-6-7-24-25-13)26-27-17(29)18(28)30/h1-3,6-7,10,14H,4-5,8-9H2,(H,24,25)
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n/an/a 11.8n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160128
PNG
(US10047092, 69 | US10053463, 69 | US9040534, 69)
Show SMILES Fc1ccc(nc1)-c1nnc2C(=O)N(Cc3cccc(c3Cl)C(F)(F)F)C(Cn12)C1CC1
Show InChI InChI=1S/C21H16ClF4N5O/c22-17-12(2-1-3-14(17)21(24,25)26)9-30-16(11-4-5-11)10-31-18(28-29-19(31)20(30)32)15-7-6-13(23)8-27-15/h1-3,6-8,11,16H,4-5,9-10H2
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n/an/a 398n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160129
PNG
(US10047092, 70 | US10053463, 70 | US9040534, 70)
Show SMILES Fc1cnc(nc1)-c1nnc2C(=O)N(Cc3cccc(c3Cl)C(F)(F)F)C(Cn12)C1CC1
Show InChI InChI=1S/C20H15ClF4N6O/c21-15-11(2-1-3-13(15)20(23,24)25)8-30-14(10-4-5-10)9-31-17(28-29-18(31)19(30)32)16-26-6-12(22)7-27-16/h1-3,6-7,10,14H,4-5,8-9H2
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n/an/a 794n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM227806
PNG
((6S)-7-[2-Chloro-3-(trifluoromethyl)benzyl]-6-ethy...)
Show SMILES CC[C@H]1Cn2c(nnc2-c2cnccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H16ClF3N6O/c1-2-12-10-29-16(14-8-24-6-7-25-14)26-27-17(29)18(30)28(12)9-11-4-3-5-13(15(11)20)19(21,22)23/h3-8,12H,2,9-10H2,1H3/t12-/m0/s1
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n/an/a 10.3n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160130
PNG
(US10047092, 72 | US10053463, 72 | US9040534, 71 | ...)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ncccn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H16ClF3N6O/c1-2-12-10-29-16(15-24-7-4-8-25-15)26-27-17(29)18(30)28(12)9-11-5-3-6-13(14(11)20)19(21,22)23/h3-8,12H,2,9-10H2,1H3/t12-/m0/s1
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n/an/a 5.60n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160132
PNG
(US10047092, 73 | US10053463, 73 | US9040534, 73)
Show SMILES CC[C@H]1Cn2c(nnc2-c2cccnc2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H17ClF3N5O/c1-2-14-11-29-17(12-6-4-8-25-9-12)26-27-18(29)19(30)28(14)10-13-5-3-7-15(16(13)21)20(22,23)24/h3-9,14H,2,10-11H2,1H3/t14-/m0/s1
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n/an/a 133n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160133
PNG
(US10047092, 74 | US10053463, 74 | US9040534, 74)
Show SMILES CC[C@H]1Cn2c(nnc2C(=O)N1Cc1cccc(c1Cl)C(F)(F)F)-c1cc[nH]n1
Show InChI InChI=1S/C18H16ClF3N6O/c1-2-11-9-28-15(13-6-7-23-24-13)25-26-16(28)17(29)27(11)8-10-4-3-5-12(14(10)19)18(20,21)22/h3-7,11H,2,8-9H2,1H3,(H,23,24)/t11-/m0/s1
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n/an/a 5.10n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160134
PNG
(US10047092, 75 | US10053463, 75 | US9040534, 75)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ncc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C19H15ClF4N6O/c1-2-12-9-30-16(15-25-6-11(21)7-26-15)27-28-17(30)18(31)29(12)8-10-4-3-5-13(14(10)20)19(22,23)24/h3-7,12H,2,8-9H2,1H3/t12-/m0/s1
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n/an/a 126n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
P2X7 rat


(Rattus norvegicus (Rat))
BDBM160135
PNG
(US10047092, 76 | US10053463, 76 | US9040534, 76)
Show SMILES CC[C@H]1Cn2c(nnc2-c2ccc(F)cn2)C(=O)N1Cc1cccc(c1Cl)C(F)(F)F
Show InChI InChI=1S/C20H16ClF4N5O/c1-2-13-10-30-17(15-7-6-12(22)8-26-15)27-28-18(30)19(31)29(13)9-11-4-3-5-14(16(11)21)20(23,24)25/h3-8,13H,2,9-10H2,1H3/t13-/m0/s1
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n/an/a 158n/an/an/an/a7.4n/a



Janssen Pharmaceutica NV

US Patent


Assay Description
1321N1 cells expressing the recombinant human, rat or mouse P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high ...


US Patent US10047092 (2018)

More data for this
Ligand-Target Pair
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