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Compile Data Set for Download or QSAR

Found 57 hits of ph data with Target = 'PKC alpha and beta-2'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33964
PNG
(maleimide derivative, 3)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2cccc3ccccc23)c2ccccc12
Show InChI InChI=1S/C27H25N3O2/c1-29(2)15-8-16-30-17-22(20-12-5-6-14-23(20)30)25-24(26(31)28-27(25)32)21-13-7-10-18-9-3-4-11-19(18)21/h3-7,9-14,17H,8,15-16H2,1-2H3,(H,28,31,32)
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n/an/a 60n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM2683
PNG
(2-[1-(3-dimethylaminopropyl)-indol-3-yl]-3-(indol-...)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31)
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n/an/a 1.60n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33972
PNG
(maleimide derivative, 13)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCOCC1
Show InChI InChI=1S/C24H19N5O3/c30-22-19(16-13-25-17-7-3-1-5-14(16)17)20(23(31)28-22)21-15-6-2-4-8-18(15)26-24(27-21)29-9-11-32-12-10-29/h1-8,13,25H,9-12H2,(H,28,30,31)
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n/an/a 1.27E+3n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33971
PNG
(AEB071 | Sotrastaurin)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2n1
Show InChI InChI=1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 2n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33965
PNG
(maleimide derivative, 4)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2n[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C24H23N5O2/c1-28(2)12-7-13-29-14-17(15-8-4-6-11-19(15)29)20-21(24(31)25-23(20)30)22-16-9-3-5-10-18(16)26-27-22/h3-6,8-11,14H,7,12-13H2,1-2H3,(H,26,27)(H,25,30,31)
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n/an/a>315n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33969
PNG
(maleimide derivative, 11)
Show SMILES CN1CCN(CC1)c1cccc(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C23H22N4O2/c1-26-9-11-27(12-10-26)16-6-4-5-15(13-16)20-21(23(29)25-22(20)28)18-14-24-19-8-3-2-7-17(18)19/h2-8,13-14,24H,9-12H2,1H3,(H,25,28,29)
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n/an/a 36n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33968
PNG
(maleimide derivative, 10)
Show SMILES CN(C)CCOc1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C26H23N3O3/c1-29(2)11-12-32-17-13-16-7-3-4-8-18(16)20(14-17)23-24(26(31)28-25(23)30)21-15-27-22-10-6-5-9-19(21)22/h3-10,13-15,27H,11-12H2,1-2H3,(H,28,30,31)
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n/an/a 2.10n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33967
PNG
(maleimide derivative, 9)
Show SMILES CN(C)CCOc1cccc(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C22H21N3O3/c1-25(2)10-11-28-15-7-5-6-14(12-15)19-20(22(27)24-21(19)26)17-13-23-18-9-4-3-8-16(17)18/h3-9,12-13,23H,10-11H2,1-2H3,(H,24,26,27)
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n/an/a 58n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33966
PNG
(maleimide derivative, 5)
Show SMILES CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c2csc3ccccc23)c2ccccc12
Show InChI InChI=1S/C25H23N3O2S/c1-27(2)12-7-13-28-14-18(16-8-3-5-10-20(16)28)22-23(25(30)26-24(22)29)19-15-31-21-11-6-4-9-17(19)21/h3-6,8-11,14-15H,7,12-13H2,1-2H3,(H,26,29,30)
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n/an/a 47n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM33970
PNG
(maleimide derivative, 12)
Show SMILES CN1CCN(CC1)c1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc2c1
Show InChI InChI=1S/C27H24N4O2/c1-30-10-12-31(13-11-30)18-14-17-6-2-3-7-19(17)21(15-18)24-25(27(33)29-26(24)32)22-16-28-23-9-5-4-8-20(22)23/h2-9,14-16,28H,10-13H2,1H3,(H,29,32,33)
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n/an/a 1.80n/an/an/an/a7.423



Novartis



Assay Description
Classical and novel PKC isotypes were assayed by scintillation proximity assay technology. In brief, the assay was performed in reaction buffer by in...


J Med Chem 52: 6193-6 (2009)


Article DOI: 10.1021/jm901108b
BindingDB Entry DOI: 10.7270/Q25X278Q
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3154
PNG
(2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1C2CCC(C2)C1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C29H25NO10/c31-17-8-6-13(7-9-17)27(36)30-24-14-4-5-15(10-14)26(24)40-29(39)16-11-20(33)23(21(34)12-16)25(35)22-18(28(37)38)2-1-3-19(22)32/h1-3,6-9,11-12,14-15,24,26,31-34H,4-5,10H2,(H,30,36)(H,37,38)
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n/an/a 1.70E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 4.40E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 2.20E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3158
PNG
(2-{[2,6-dihydroxy-4-({[(4S)-3-[(4-hydroxybenzene)a...)
Show InChI InChI=1S/C30H28N2O10/c33-18-6-4-16(5-7-18)28(38)31-20-14-32-10-8-15(9-11-32)27(20)42-30(41)17-12-22(35)25(23(36)13-17)26(37)24-19(29(39)40)2-1-3-21(24)34/h1-7,12-13,15,20,27,33-36H,8-11,14H2,(H,31,38)(H,39,40)/t20?,27-/m0/s1
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n/an/a 26n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3159
PNG
(2-{[2,6-dihydroxy-4-({[(4S)-3-[(4-hydroxybenzene)a...)
Show InChI InChI=1S/C30H28N2O10/c33-18-6-4-16(5-7-18)28(38)31-20-14-32-10-8-15(9-11-32)27(20)42-30(41)17-12-22(35)25(23(36)13-17)26(37)24-19(29(39)40)2-1-3-21(24)34/h1-7,12-13,15,20,27,33-36H,8-11,14H2,(H,31,38)(H,39,40)/t20?,27-/m0/s1
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n/an/a 6.30E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3160
PNG
(2-{[2,6-dihydroxy-4-({[(8R,9R)-9-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1C2CC(C3CCCC23)[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C32H29NO10/c34-16-9-7-14(8-10-16)30(39)33-27-20-13-21(18-4-1-3-17(18)20)29(27)43-32(42)15-11-23(36)26(24(37)12-15)28(38)25-19(31(40)41)5-2-6-22(25)35/h2,5-12,17-18,20-21,27,29,34-37H,1,3-4,13H2,(H,33,39)(H,40,41)/t17?,18?,20?,21?,27-,29-/m1/s1
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n/an/a 150n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3161
PNG
(2-{[2,6-dihydroxy-4-({[(8S,9R)-9-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@H]1C2CC(C3CCCC23)[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C32H29NO10/c34-16-9-7-14(8-10-16)30(39)33-27-20-13-21(18-4-1-3-17(18)20)29(27)43-32(42)15-11-23(36)26(24(37)12-15)28(38)25-19(31(40)41)5-2-6-22(25)35/h2,5-12,17-18,20-21,27,29,34-37H,1,3-4,13H2,(H,33,39)(H,40,41)/t17?,18?,20?,21?,27-,29+/m1/s1
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n/an/a 3.30E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3162
PNG
(2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]...)
Show SMILES CC1(C)C2CCC1(C)C(OC(=O)c1cc(O)c(C(=O)c3c(O)cccc3C(O)=O)c(O)c1)C2NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C32H31NO10/c1-31(2)19-11-12-32(31,3)27(25(19)33-28(39)15-7-9-17(34)10-8-15)43-30(42)16-13-21(36)24(22(37)14-16)26(38)23-18(29(40)41)5-4-6-20(23)35/h4-10,13-14,19,25,27,34-37H,11-12H2,1-3H3,(H,33,39)(H,40,41)/t19?,25?,27?,32-/m0/s1
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n/an/a 310n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3154
PNG
(2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1C2CCC(C2)C1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C29H25NO10/c31-17-8-6-13(7-9-17)27(36)30-24-14-4-5-15(10-14)26(24)40-29(39)16-11-20(33)23(21(34)12-16)25(35)22-18(28(37)38)2-1-3-19(22)32/h1-3,6-9,11-12,14-15,24,26,31-34H,4-5,10H2,(H,30,36)(H,37,38)
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n/an/a 30n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3154
PNG
(2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1C2CCC(C2)C1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C29H25NO10/c31-17-8-6-13(7-9-17)27(36)30-24-14-4-5-15(10-14)26(24)40-29(39)16-11-20(33)23(21(34)12-16)25(35)22-18(28(37)38)2-1-3-19(22)32/h1-3,6-9,11-12,14-15,24,26,31-34H,4-5,10H2,(H,30,36)(H,37,38)
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n/an/a 6.90E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 1.40E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3156
PNG
(2-{[2,6-dihydroxy-4-({[(3S,5R)-2-[(4-hydroxybenzen...)
Show SMILES CN1[C@@H]2CCC1C(NC(=O)c1ccc(O)cc1)[C@H](C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1
Show InChI InChI=1S/C30H28N2O10/c1-32-16-7-10-19(32)26(31-28(38)14-5-8-17(33)9-6-14)23(13-16)42-30(41)15-11-21(35)25(22(36)12-15)27(37)24-18(29(39)40)3-2-4-20(24)34/h2-6,8-9,11-12,16,19,23,26,33-36H,7,10,13H2,1H3,(H,31,38)(H,39,40)/t16-,19?,23+,26+/m1/s1
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n/an/a 2.20E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3158
PNG
(2-{[2,6-dihydroxy-4-({[(4S)-3-[(4-hydroxybenzene)a...)
Show InChI InChI=1S/C30H28N2O10/c33-18-6-4-16(5-7-18)28(38)31-20-14-32-10-8-15(9-11-32)27(20)42-30(41)17-12-22(35)25(23(36)13-17)26(37)24-19(29(39)40)2-1-3-21(24)34/h1-7,12-13,15,20,27,33-36H,8-11,14H2,(H,31,38)(H,39,40)/t20?,27-/m0/s1
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n/an/a 69n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3159
PNG
(2-{[2,6-dihydroxy-4-({[(4S)-3-[(4-hydroxybenzene)a...)
Show InChI InChI=1S/C30H28N2O10/c33-18-6-4-16(5-7-18)28(38)31-20-14-32-10-8-15(9-11-32)27(20)42-30(41)17-12-22(35)25(23(36)13-17)26(37)24-19(29(39)40)2-1-3-21(24)34/h1-7,12-13,15,20,27,33-36H,8-11,14H2,(H,31,38)(H,39,40)/t20?,27-/m0/s1
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n/an/a 3.40E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3160
PNG
(2-{[2,6-dihydroxy-4-({[(8R,9R)-9-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1C2CC(C3CCCC23)[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C32H29NO10/c34-16-9-7-14(8-10-16)30(39)33-27-20-13-21(18-4-1-3-17(18)20)29(27)43-32(42)15-11-23(36)26(24(37)12-15)28(38)25-19(31(40)41)5-2-6-22(25)35/h2,5-12,17-18,20-21,27,29,34-37H,1,3-4,13H2,(H,33,39)(H,40,41)/t17?,18?,20?,21?,27-,29-/m1/s1
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n/an/a 30n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3161
PNG
(2-{[2,6-dihydroxy-4-({[(8S,9R)-9-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@H]1C2CC(C3CCCC23)[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C32H29NO10/c34-16-9-7-14(8-10-16)30(39)33-27-20-13-21(18-4-1-3-17(18)20)29(27)43-32(42)15-11-23(36)26(24(37)12-15)28(38)25-19(31(40)41)5-2-6-22(25)35/h2,5-12,17-18,20-21,27,29,34-37H,1,3-4,13H2,(H,33,39)(H,40,41)/t17?,18?,20?,21?,27-,29+/m1/s1
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n/an/a 2.10E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3162
PNG
(2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]...)
Show SMILES CC1(C)C2CCC1(C)C(OC(=O)c1cc(O)c(C(=O)c3c(O)cccc3C(O)=O)c(O)c1)C2NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C32H31NO10/c1-31(2)19-11-12-32(31,3)27(25(19)33-28(39)15-7-9-17(34)10-8-15)43-30(42)16-13-21(36)24(22(37)14-16)26(38)23-18(29(40)41)5-4-6-20(23)35/h4-10,13-14,19,25,27,34-37H,11-12H2,1-3H3,(H,33,39)(H,40,41)/t19?,25?,27?,32-/m0/s1
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n/an/a 80n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3181
PNG
(2-[[2,6-Dihydroxy-4-[[2-[[(4-hydroxyphenyl)carbony...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OCCNC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C24H19NO10/c26-14-6-4-12(5-7-14)22(31)25-8-9-35-24(34)13-10-17(28)20(18(29)11-13)21(30)19-15(23(32)33)2-1-3-16(19)27/h1-7,10-11,26-29H,8-9H2,(H,25,31)(H,32,33)
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n/an/a 4.50E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3182
PNG
(2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1CCCNCC1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)
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n/an/a 30n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3183
PNG
(2-({2,6-dihydroxy-4-[({2-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1CCCC1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)
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n/an/a 40n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3184
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC[C@@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(O)=O)c(O)c2)[C@@H](C1)NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C35H32N2O12S/c1-19-7-13-23(14-8-19)50(47,48)37-15-3-6-29(25(18-37)36-33(43)20-9-11-22(38)12-10-20)49-35(46)21-16-27(40)31(28(41)17-21)32(42)30-24(34(44)45)4-2-5-26(30)39/h2,4-5,7-14,16-17,25,29,38-41H,3,6,15,18H2,1H3,(H,36,43)(H,44,45)/t25-,29-/m1/s1
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n/an/a 70n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3181
PNG
(2-[[2,6-Dihydroxy-4-[[2-[[(4-hydroxyphenyl)carbony...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OCCNC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C24H19NO10/c26-14-6-4-12(5-7-14)22(31)25-8-9-35-24(34)13-10-17(28)20(18(29)11-13)21(30)19-15(23(32)33)2-1-3-16(19)27/h1-7,10-11,26-29H,8-9H2,(H,25,31)(H,32,33)
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n/an/a 7.50E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3182
PNG
(2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1CCCNCC1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)
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n/an/a 30n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3183
PNG
(2-({2,6-dihydroxy-4-[({2-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1CCCC1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)
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n/an/a 50n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3184
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCC[C@@H](OC(=O)c2cc(O)c(C(=O)c3c(O)cccc3C(O)=O)c(O)c2)[C@@H](C1)NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C35H32N2O12S/c1-19-7-13-23(14-8-19)50(47,48)37-15-3-6-29(25(18-37)36-33(43)20-9-11-22(38)12-10-20)49-35(46)21-16-27(40)31(28(41)17-21)32(42)30-24(34(44)45)4-2-5-26(30)39/h2,4-5,7-14,16-17,25,29,38-41H,3,6,15,18H2,1H3,(H,36,43)(H,44,45)/t25-,29-/m1/s1
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n/an/a 20n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3207
PNG
(10''-Deoxybalanol, 4 | 2-{[2,6-dihydroxy-4-({[(3R,...)
Show SMILES OC(=O)c1ccccc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h1-2,4-5,7-10,12-13,20,23,29,31-33H,3,6,11,14H2,(H,30,35)(H,36,37)/t20-,23-/m1/s1
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n/an/a 3.70E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3208
PNG
((1S,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19+,20-,23-/m1/s1
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n/an/a 1.24E+5n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3209
PNG
((1R,2R)-2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydro...)
Show SMILES OC(=O)[C@@H]1CCCC[C@H]1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H32N2O9/c31-17-9-7-15(8-10-17)26(35)30-20-14-29-11-3-6-23(20)39-28(38)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-19(18)27(36)37/h7-10,12-13,18-20,23,29,31-33H,1-6,11,14H2,(H,30,35)(H,36,37)/t18-,19-,20-,23-/m1/s1
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n/an/a>1.50E+5n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3210
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccnc1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H25N3O9/c31-16-7-5-14(6-8-16)25(35)30-18-13-28-9-2-4-21(18)39-27(38)15-11-19(32)22(20(33)12-15)24(34)23-17(26(36)37)3-1-10-29-23/h1,3,5-8,10-12,18,21,28,31-33H,2,4,9,13H2,(H,30,35)(H,36,37)/t18-,21-/m1/s1
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n/an/a 1.30E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3211
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 3,5...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2ccccc2O)c(O)c1
Show InChI InChI=1S/C27H26N2O8/c30-17-9-7-15(8-10-17)26(35)29-19-14-28-11-3-6-23(19)37-27(36)16-12-21(32)24(22(33)13-16)25(34)18-4-1-2-5-20(18)31/h1-2,4-5,7-10,12-13,19,23,28,30-33H,3,6,11,14H2,(H,29,35)/t19-,23-/m1/s1
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n/an/a 3.80E+4n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3212
PNG
((3R,4R)-3-[(4-hydroxybenzene)amido]azepan-4-yl 4-[...)
Show SMILES Oc1ccc(cc1)C(=O)N[C@@H]1CNCCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2O)c(O)c1
Show InChI InChI=1S/C27H26N2O9/c30-16-8-6-14(7-9-16)26(36)29-17-13-28-10-2-5-22(17)38-27(37)15-11-20(33)24(21(34)12-15)25(35)23-18(31)3-1-4-19(23)32/h1,3-4,6-9,11-12,17,22,28,30-34H,2,5,10,13H2,(H,29,36)/t17-,22-/m1/s1
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n/an/a 7.60E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 45: 2624-43 (2002)


Article DOI: 10.1021/jm020018f
BindingDB Entry DOI: 10.7270/Q2BG2M50
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3149
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c31-16-8-6-14(7-9-16)26(36)30-18-13-29-10-2-5-22(18)40-28(39)15-11-20(33)24(21(34)12-15)25(35)23-17(27(37)38)3-1-4-19(23)32/h1,3-4,6-9,11-12,18,22,29,31-34H,2,5,10,13H2,(H,30,36)(H,37,38)/t18-,22-/m1/s1
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n/an/a 44n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 33n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3243
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES COC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H24N2O10/c1-38-27(37)16-3-2-4-18(31)22(16)24(34)23-19(32)9-14(10-20(23)33)26(36)39-21-12-28-11-17(21)29-25(35)13-5-7-15(30)8-6-13/h2-10,17,21,28,30-33H,11-12H2,1H3,(H,29,35)/t17-,21-/m1/s1
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n/an/a 290n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3244
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES CCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C28H26N2O10/c1-2-39-28(38)17-4-3-5-19(32)23(17)25(35)24-20(33)10-15(11-21(24)34)27(37)40-22-13-29-12-18(22)30-26(36)14-6-8-16(31)9-7-14/h3-11,18,22,29,31-34H,2,12-13H2,1H3,(H,30,36)/t18-,22-/m1/s1
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n/an/a 1.00E+3n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3245
PNG
((3R,4R)-4-[(4-hydroxybenzene)amido]pyrrolidin-3-yl...)
Show SMILES CCCCOC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C30H30N2O10/c1-2-3-11-41-30(40)19-5-4-6-21(34)25(19)27(37)26-22(35)12-17(13-23(26)36)29(39)42-24-15-31-14-20(24)32-28(38)16-7-9-18(33)10-8-16/h4-10,12-13,20,24,31,33-36H,2-3,11,14-15H2,1H3,(H,32,38)/t20-,24-/m1/s1
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n/an/a 2.20E+3n/an/an/an/a7.530



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3154
PNG
(2-({2,6-dihydroxy-4-[({3-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1C2CCC(C2)C1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C29H25NO10/c31-17-8-6-13(7-9-17)27(36)30-24-14-4-5-15(10-14)26(24)40-29(39)16-11-20(33)23(21(34)12-16)25(35)22-18(28(37)38)2-1-3-19(22)32/h1-3,6-9,11-12,14-15,24,26,31-34H,4-5,10H2,(H,30,36)(H,37,38)
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n/an/a 45n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2211-6 (1995)


Article DOI: 10.1016/j.chembiol.2004.10.013
BindingDB Entry DOI: 10.7270/Q2QR4V9M
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 50n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3152
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-4-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C26H22N2O10/c29-14-6-4-12(5-7-14)24(34)28-16-10-27-11-20(16)38-26(37)13-8-18(31)22(19(32)9-13)23(33)21-15(25(35)36)2-1-3-17(21)30/h1-9,16,20,27,29-32H,10-11H2,(H,28,34)(H,35,36)/t16-,20-/m1/s1
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n/an/a 33n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
PKC alpha and beta-2


(Homo sapiens (human))
BDBM3151
PNG
(2-{[2,6-dihydroxy-4-({[(3R,4R)-3-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCNC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H24N2O10/c30-15-6-4-13(5-7-15)25(35)29-17-12-28-9-8-21(17)39-27(38)14-10-19(32)23(20(33)11-14)24(34)22-16(26(36)37)2-1-3-18(22)31/h1-7,10-11,17,21,28,30-33H,8-9,12H2,(H,29,35)(H,36,37)/t17-,21-/m1/s1
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Article
n/an/a 4.70E+3n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/j.bmcl.2004.01.050
BindingDB Entry DOI: 10.7270/Q2VH5M1B
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Ligand-Target Pair
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