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Compile Data Set for Download or QSAR

Found 32 hits of ph data with Target = 'Papain'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Papain


(Carica papaya)
BDBM20107
PNG
(dipeptide-derived nitrile, 28 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(Br)cc1)C(=O)NCC#N
Show InChI InChI=1S/C16H20BrN3O3/c1-16(2,3)23-15(22)20-13(14(21)19-9-8-18)10-11-4-6-12(17)7-5-11/h4-7,13H,9-10H2,1-3H3,(H,19,21)(H,20,22)/t13-/m0/s1
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Article
PubMed
29 -43.0n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20102
PNG
(dipeptide-derived nitrile, 23 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC#N
Show InChI InChI=1S/C16H21N3O4/c1-16(2,3)23-15(22)19-13(14(21)18-9-8-17)10-11-4-6-12(20)7-5-11/h4-7,13,20H,9-10H2,1-3H3,(H,18,21)(H,19,22)/t13-/m0/s1
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Article
PubMed
190 -38.4n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20098
PNG
(dipeptide-derived nitrile, 19 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1cccs1)C(=O)NCC#N
Show InChI InChI=1S/C14H19N3O3S/c1-14(2,3)20-13(19)17-11(12(18)16-7-6-15)9-10-5-4-8-21-10/h4-5,8,11H,7,9H2,1-3H3,(H,16,18)(H,17,19)/t11-/m0/s1
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190 -38.4n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM92334
PNG
(Dipeptide nitrile, 7)
Show SMILES CSCCC(NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)C#N
Show InChI InChI=1S/C19H27N3O3S/c1-19(2,3)25-18(24)22-16(12-14-8-6-5-7-9-14)17(23)21-15(13-20)10-11-26-4/h5-9,15-16H,10-12H2,1-4H3,(H,21,23)(H,22,24)/t15?,16-/m0/s1
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PubMed
250 -37.7n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat



Assay Description
Papain enzyme activities were determined by spectrophotometric detection of the product p-nitroaniline at 25 C in a a multicell holder (parallel meas...


J Enzyme Inhib Med Chem 24: 1245-52 (2009)


Article DOI: 10.3109/14756360902797328
BindingDB Entry DOI: 10.7270/Q2Q23XVB
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20095
PNG
(dipeptide-derived nitrile, 16 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#N
Show InChI InChI=1S/C16H21N3O3/c1-16(2,3)22-15(21)19-13(14(20)18-10-9-17)11-12-7-5-4-6-8-12/h4-8,13H,10-11H2,1-3H3,(H,18,20)(H,19,21)/t13-/m0/s1
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Article
PubMed
260 -37.6n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20103
PNG
(dipeptide-derived nitrile, 24 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccc(F)cc1)C(=O)NCC#N
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,3)23-15(22)20-13(14(21)19-9-8-18)10-11-4-6-12(17)7-5-11/h4-7,13H,9-10H2,1-3H3,(H,19,21)(H,20,22)/t13-/m0/s1
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Article
PubMed
270 -37.5n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20108
PNG
(dipeptide-derived nitrile, 29 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1cccc(Br)c1)C(=O)NCC#N
Show InChI InChI=1S/C16H20BrN3O3/c1-16(2,3)23-15(22)20-13(14(21)19-8-7-18)10-11-5-4-6-12(17)9-11/h4-6,9,13H,8,10H2,1-3H3,(H,19,21)(H,20,22)/t13-/m0/s1
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PubMed
330 -37.0n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20096
PNG
(CHEMBL344174 | benzyl N-[(1S)-1-[(cyanomethyl)carb...)
Show SMILES O=C(N[C@@H](Cc1ccccc1)C(=O)NCC#N)OCc1ccccc1
Show InChI InChI=1S/C19H19N3O3/c20-11-12-21-18(23)17(13-15-7-3-1-4-8-15)22-19(24)25-14-16-9-5-2-6-10-16/h1-10,17H,12-14H2,(H,21,23)(H,22,24)/t17-/m0/s1
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Article
PubMed
360 -36.8n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20105
PNG
(dipeptide-derived nitrile, 26 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1F)C(=O)NCC#N
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,3)23-15(22)20-13(14(21)19-9-8-18)10-11-6-4-5-7-12(11)17/h4-7,13H,9-10H2,1-3H3,(H,19,21)(H,20,22)/t13-/m0/s1
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PubMed
400 -36.5n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20109
PNG
(dipeptide-derived nitrile, 30 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1Br)C(=O)NCC#N
Show InChI InChI=1S/C16H20BrN3O3/c1-16(2,3)23-15(22)20-13(14(21)19-9-8-18)10-11-6-4-5-7-12(11)17/h4-7,13H,9-10H2,1-3H3,(H,19,21)(H,20,22)/t13-/m0/s1
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Article
PubMed
460 -36.2n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20104
PNG
(dipeptide-derived nitrile, 25 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1cccc(F)c1)C(=O)NCC#N
Show InChI InChI=1S/C16H20FN3O3/c1-16(2,3)23-15(22)20-13(14(21)19-8-7-18)10-11-5-4-6-12(17)9-11/h4-6,9,13H,8,10H2,1-3H3,(H,19,21)(H,20,22)/t13-/m0/s1
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500 -36.0n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20099
PNG
(dipeptide-derived nitrile, 20 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccsc1)C(=O)NCC#N
Show InChI InChI=1S/C14H19N3O3S/c1-14(2,3)20-13(19)17-11(12(18)16-6-5-15)8-10-4-7-21-9-10/h4,7,9,11H,6,8H2,1-3H3,(H,16,18)(H,17,19)/t11-/m0/s1
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570 -35.6n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20091
PNG
(dipeptide-derived nitrile, 12 | tert-butyl N-[(1S)...)
Show SMILES CSCC[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N
Show InChI InChI=1S/C12H21N3O3S/c1-12(2,3)18-11(17)15-9(5-8-19-4)10(16)14-7-6-13/h9H,5,7-8H2,1-4H3,(H,14,16)(H,15,17)/t9-/m0/s1
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PubMed
650 -35.3n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20086
PNG
(dipeptide-derived nitrile, 6 | tert-butyl N-[(1S)-...)
Show SMILES CCC[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N
Show InChI InChI=1S/C12H21N3O3/c1-5-6-9(10(16)14-8-7-13)15-11(17)18-12(2,3)4/h9H,5-6,8H2,1-4H3,(H,14,16)(H,15,17)/t9-/m0/s1
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750 -35.0n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM92336
PNG
(Dipeptide nitrile, 10)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC#N)C#N
Show InChI InChI=1S/C18H22N4O3/c1-18(2,3)25-17(24)22-15(11-13-7-5-4-6-8-13)16(23)21-14(12-20)9-10-19/h4-8,14-15H,9,11H2,1-3H3,(H,21,23)(H,22,24)/t14-,15-/m0/s1
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PubMed
1.10E+3 -34.0n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat



Assay Description
Papain enzyme activities were determined by spectrophotometric detection of the product p-nitroaniline at 25 C in a a multicell holder (parallel meas...


J Enzyme Inhib Med Chem 24: 1245-52 (2009)


Article DOI: 10.3109/14756360902797328
BindingDB Entry DOI: 10.7270/Q2Q23XVB
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20097
PNG
(dipeptide-derived nitrile, 18 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1ccco1)C(=O)NCC#N
Show InChI InChI=1S/C14H19N3O4/c1-14(2,3)21-13(19)17-11(12(18)16-7-6-15)9-10-5-4-8-20-10/h4-5,8,11H,7,9H2,1-3H3,(H,16,18)(H,17,19)/t11-/m0/s1
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1.20E+3 -33.8n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20092
PNG
(dipeptide-derived nitrile, 13 | tert-butyl N-[(1S)...)
Show SMILES CCCC[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N
Show InChI InChI=1S/C13H23N3O3/c1-5-6-7-10(11(17)15-9-8-14)16-12(18)19-13(2,3)4/h10H,5-7,9H2,1-4H3,(H,15,17)(H,16,18)/t10-/m0/s1
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PubMed
1.57E+3 -33.1n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20085
PNG
(dipeptide-derived nitrile, 5 | tert-butyl N-[(1S)-...)
Show SMILES CC(C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N
Show InChI InChI=1S/C12H21N3O3/c1-8(2)9(10(16)14-7-6-13)15-11(17)18-12(3,4)5/h8-9H,7H2,1-5H3,(H,14,16)(H,15,17)/t9-/m0/s1
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PubMed
2.00E+3 -32.5n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20087
PNG
(dipeptide-derived nitrile, 7 | tert-butyl N-[(1S)-...)
Show SMILES CC(C)C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N
Show InChI InChI=1S/C13H23N3O3/c1-9(2)8-10(11(17)15-7-6-14)16-12(18)19-13(3,4)5/h9-10H,7-8H2,1-5H3,(H,15,17)(H,16,18)/t10-/m0/s1
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PubMed
2.00E+3 -32.5n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20090
PNG
(dipeptide-derived nitrile, 11 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CC1CCCCC1)C(=O)NCC#N
Show InChI InChI=1S/C16H27N3O3/c1-16(2,3)22-15(21)19-13(14(20)18-10-9-17)11-12-7-5-4-6-8-12/h12-13H,4-8,10-11H2,1-3H3,(H,18,20)(H,19,21)/t13-/m0/s1
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PubMed
2.20E+3 -32.3n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM19768
PNG
(Cbz-Leu-NH-CH2-CN | JMC487688 Compound 8 | benzyl ...)
Show SMILES CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC#N
Show InChI InChI=1S/C16H21N3O3/c1-12(2)10-14(15(20)18-9-8-17)19-16(21)22-11-13-6-4-3-5-7-13/h3-7,12,14H,9-11H2,1-2H3,(H,18,20)(H,19,21)/t14-/m0/s1
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3.10E+3 -31.4n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20084
PNG
(dipeptide-derived nitrile, 4 | tert-butyl N-[(1S)-...)
Show SMILES CC[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N
Show InChI InChI=1S/C11H19N3O3/c1-5-8(9(15)13-7-6-12)14-10(16)17-11(2,3)4/h8H,5,7H2,1-4H3,(H,13,15)(H,14,16)/t8-/m0/s1
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5.40E+3 -30.1n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20101
PNG
(dipeptide-derived nitrile, 22 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](COCc1ccccc1)C(=O)NCC#N
Show InChI InChI=1S/C17H23N3O4/c1-17(2,3)24-16(22)20-14(15(21)19-10-9-18)12-23-11-13-7-5-4-6-8-13/h4-8,14H,10-12H2,1-3H3,(H,19,21)(H,20,22)/t14-/m0/s1
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1.10E+4 -28.3n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20100
PNG
(dipeptide-derived nitrile, 21 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CCc1ccccc1)C(=O)NCC#N
Show InChI InChI=1S/C17H23N3O3/c1-17(2,3)23-16(22)20-14(15(21)19-12-11-18)10-9-13-7-5-4-6-8-13/h4-8,14H,9-10,12H2,1-3H3,(H,19,21)(H,20,22)/t14-/m0/s1
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1.20E+4 -28.1n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20089
PNG
(dipeptide-derived nitrile, 10 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](CC1CC1)C(=O)NCC#N
Show InChI InChI=1S/C13H21N3O3/c1-13(2,3)19-12(18)16-10(8-9-4-5-9)11(17)15-7-6-14/h9-10H,4-5,7-8H2,1-3H3,(H,15,17)(H,16,18)/t10-/m0/s1
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1.30E+4 -27.9n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20106
PNG
(dipeptide-derived nitrile, 27 | tert-butyl N-[(1S)...)
Show SMILES CC(C)(C)OC(=O)N[C@@H](Cc1c(F)c(F)c(F)c(F)c1F)C(=O)NCC#N
Show InChI InChI=1S/C16H16F5N3O3/c1-16(2,3)27-15(26)24-8(14(25)23-5-4-22)6-7-9(17)11(19)13(21)12(20)10(7)18/h8H,5-6H2,1-3H3,(H,23,25)(H,24,26)/t8-/m0/s1
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1.40E+4 -27.7n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20083
PNG
(dipeptide-derived nitrile, 3 | tert-butyl N-[(1S)-...)
Show SMILES C[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N
Show InChI InChI=1S/C10H17N3O3/c1-7(8(14)12-6-5-11)13-9(15)16-10(2,3)4/h7H,6H2,1-4H3,(H,12,14)(H,13,15)/t7-/m0/s1
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2.20E+4 -26.6n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20088
PNG
(dipeptide-derived nitrile, 9 | tert-butyl N-[(1S,2...)
Show SMILES CC[C@@H](C)[C@H](NC(=O)OC(C)(C)C)C(=O)NCC#N
Show InChI InChI=1S/C13H23N3O3/c1-6-9(2)10(11(17)15-8-7-14)16-12(18)19-13(3,4)5/h9-10H,6,8H2,1-5H3,(H,15,17)(H,16,18)/t9-,10+/m1/s1
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2.60E+4 -26.2n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20094
PNG
(dipeptide-derived nitrile, 15 | tert-butyl N-[(S)-...)
Show SMILES CC(C)(C)OC(=O)N[C@H](C(=O)NCC#N)c1ccccc1
Show InChI InChI=1S/C15H19N3O3/c1-15(2,3)21-14(20)18-12(13(19)17-10-9-16)11-7-5-4-6-8-11/h4-8,12H,10H2,1-3H3,(H,17,19)(H,18,20)/t12-/m0/s1
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8.30E+4 -23.3n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20093
PNG
(dipeptide-derived nitrile, 14 | tert-butyl (2S)-2-...)
Show SMILES CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)NCC#N
Show InChI InChI=1S/C12H19N3O3/c1-12(2,3)18-11(17)15-8-4-5-9(15)10(16)14-7-6-13/h9H,4-5,7-8H2,1-3H3,(H,14,16)/t9-/m0/s1
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5.37E+5 -18.7n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20082
PNG
(benzyl N-{[(cyanomethyl)carbamoyl]methyl}carbamate...)
Show SMILES O=C(CNC(=O)OCc1ccccc1)NCC#N
Show InChI InChI=1S/C12H13N3O3/c13-6-7-14-11(16)8-15-12(17)18-9-10-4-2-1-3-5-10/h1-5H,7-9H2,(H,14,16)(H,15,17)
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1.60E+6 -16.0n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair
Papain


(Carica papaya)
BDBM20080
PNG
(dipeptide-derived nitrile, 1 | tert-butyl N-{[(cya...)
Show SMILES CC(C)(C)OC(=O)NCC(=O)NCC#N
Show InChI InChI=1S/C9H15N3O3/c1-9(2,3)15-8(14)12-6-7(13)11-5-4-10/h5-6H2,1-3H3,(H,11,13)(H,12,14)
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>3.00E+6>-14.4n/an/an/an/an/a6.525



Rheinische Friedrich-Wilhelms-Universitat Bonn



Assay Description
Enzyme activities were calculated from kinetic measurements performed by spectrophotometric detection of the product p-nitroaniline (pNA) at waveleng...


J Med Chem 48: 7688-707 (2005)


Article DOI: 10.1021/jm050686b
BindingDB Entry DOI: 10.7270/Q2GB22BG
More data for this
Ligand-Target Pair